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Pathology and molecular genetics of oligodendroglial tumors.
Hartmann C, Mueller W, von Deimling A. Hartmann C, et al. J Mol Med (Berl). 2004 Oct;82(10):638-55. doi: 10.1007/s00109-004-0565-9. J Mol Med (Berl). 2004. PMID: 15322700 Review.
Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q.
Tews B, Roerig P, Hartmann C, Hahn M, Felsberg J, Blaschke B, Sabel M, Kunitz A, Toedt G, Neben K, Benner A, von Deimling A, Reifenberger G, Lichter P. Tews B, et al. Oncogene. 2007 Jul 26;26(34):5010-6. doi: 10.1038/sj.onc.1210297. Epub 2007 Feb 19. Oncogene. 2007. PMID: 17311001
In line with the latter finding, treatment of CITED4 hypermethylated glioma cell lines with 5-aza-2'-deoxycytidine and trichostatine A resulted in a marked increase of the CITED4 transcript levels. ...Taken together, our results indicate that CITED4 is epigeneticall …
In line with the latter finding, treatment of CITED4 hypermethylated glioma cell lines with 5-aza-2'-deoxycytidine and trichostatine A
PTEN mutations in gliomas and glioneuronal tumors.
Duerr EM, Rollbrocker B, Hayashi Y, Peters N, Meyer-Puttlitz B, Louis DN, Schramm J, Wiestler OD, Parsons R, Eng C, von Deimling A. Duerr EM, et al. Oncogene. 1998 Apr 30;16(17):2259-64. doi: 10.1038/sj.onc.1201756. Oncogene. 1998. PMID: 9619835
In order to systematically evaluate the involvement of PTEN in gliomas, we have analysed the entire PTEN coding sequence by SSCP and direct sequencing in a series of 331 gliomas and glioneuronal tumors. ...
In order to systematically evaluate the involvement of PTEN in gliomas, we have analysed the entire PTEN coding sequence by SSCP and direct …
Identification of subgroups of high-grade oligodendroglial tumors by comparative genomic hybridization.
Jeuken JW, Sprenger SH, Wesseling P, Macville MV, von Deimling A, Teepen HL, van Overbeeke JJ, Boerman RH. Jeuken JW, et al. J Neuropathol Exp Neurol. 1999 Jun;58(6):606-12. doi: 10.1097/00005072-199906000-00005. J Neuropathol Exp Neurol. 1999. PMID: 10374751
In order to elucidate oligodendroglial oncogenesis and to find specific genetic aberrations that may have prognostic and therapeutic implications, we performed comparative genomic hybridization (CGH) to detect chromosomal copy number changes in 17 low-grade OTs (LG-OTs) and 12 hi …
In order to elucidate oligodendroglial oncogenesis and to find specific genetic aberrations that may have prognostic and therapeutic implica …
Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens.
Louis DN, Rubio MP, Correa KM, Gusella JF, von Deimling A. Louis DN, et al. J Neuropathol Exp Neurol. 1993 Sep;52(5):507-15. doi: 10.1097/00005072-199309000-00009. J Neuropathol Exp Neurol. 1993. PMID: 8103086
Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme.
von Deimling A, Louis DN, von Ammon K, Petersen I, Hoell T, Chung RY, Martuza RL, Schoenfeld DA, Yaşargil MG, Wiestler OD, et al. von Deimling A, et al. J Neurosurg. 1992 Aug;77(2):295-301. doi: 10.3171/jns.1992.77.2.0295. J Neurosurg. 1992. PMID: 1320666
In order to examine a possible correlation between these two genetic aberrations, the authors studied 106 gliomas (58 glioblastomas, 14 anaplastic astrocytomas, five astrocytomas, nine pilocytic astrocytomas, seven mixed gliomas, six oligodendrogliomas, two ependymomas, on …
In order to examine a possible correlation between these two genetic aberrations, the authors studied 106 gliomas (58 glioblastomas, …
No evidence of hSNF5/INI1 point mutations in choroid plexus papilloma.
Mueller W, Eum JH, Lass U, Paulus W, Sarkar C, Bruck W, von Deimling A. Mueller W, et al. Neuropathol Appl Neurobiol. 2004 Jun;30(3):304-7. doi: 10.1046/j.0305-1846.2004.00538.x. Neuropathol Appl Neurobiol. 2004. PMID: 15175083
A recent study on choroid plexus papillomas (CPP) and CPC revealed frequent losses of chromosomal portions on the long arm of chromosome 22 (-22q). ...These findings may indicate a potential tumour suppressor gene function of hSNF5/INI1 in a subset of choroid
A recent study on choroid plexus papillomas (CPP) and CPC revealed frequent losses of chromosomal portions on the long arm of chromos
Mutational analysis of INI1 in sporadic human brain tumors.
Weber M, Stockhammer F, Schmitz U, von Deimling A. Weber M, et al. Acta Neuropathol. 2001 May;101(5):479-82. doi: 10.1007/s004010000316. Acta Neuropathol. 2001. PMID: 11484819
In the present study we examined a series of 200 brain tumors by Single-strand conformation polymorphism analysis and direct sequencing for point mutations in INI1. ...However, a point mutation could be identified in the single case of plexus carcinoma. Our data sug …
In the present study we examined a series of 200 brain tumors by Single-strand conformation polymorphism analysis and direct sequenci …
INI1 mutations in meningiomas at a potential hotspot in exon 9.
Schmitz U, Mueller W, Weber M, Sévenet N, Delattre O, von Deimling A. Schmitz U, et al. Br J Cancer. 2001 Jan;84(2):199-201. doi: 10.1054/bjoc.2000.1583. Br J Cancer. 2001. PMID: 11161377 Free PMC article.
Our observations were reproduced both by using DNA from a new round of extraction and by employing overlapping primers. This mutational hotspot therefore appears to be an important target in the formation of a fraction of meningiomas. ...Our data indicate that the I …
Our observations were reproduced both by using DNA from a new round of extraction and by employing overlapping primers. This mutation …
Clonal analysis in glioblastoma with epithelial differentiation.
Mueller W, Lass U, Herms J, Kuchelmeister K, Bergmann M, von Deimling A. Mueller W, et al. Brain Pathol. 2001 Jan;11(1):39-43. doi: 10.1111/j.1750-3639.2001.tb00379.x. Brain Pathol. 2001. PMID: 11145202
Therefore these rare lesions can pose a diagnostic problem suggesting coincidental occurrence of two separate neoplasms. However molecular analysis should succeed in establishing a common origin of seemingly unrelated tumor samples. ...A G-->T transversion …
Therefore these rare lesions can pose a diagnostic problem suggesting coincidental occurrence of two separate neoplasms. However mole …
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