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The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men.
Zitzmann M, Gromoll J, von Eckardstein A, Nieschlag E. Zitzmann M, et al. Diabetologia. 2003 Jan;46(1):31-9. doi: 10.1007/s00125-002-0980-9. Epub 2002 Dec 20. Diabetologia. 2003. PMID: 12637980
METHODS: The hypothesis was investigated in a cross-sectional study involving 106 healthy 20-50 year old males. RESULTS: Multiple regression models showed a positive independent correlation of the CAG repeat number with body fat content, leptin and insulin (partial …
METHODS: The hypothesis was investigated in a cross-sectional study involving 106 healthy 20-50 year old males. RESULTS: Multiple reg …
The CAG repeat polymorphism in the androgen receptor gene is associated with HDL-cholesterol but not with coronary atherosclerosis or myocardial infarction.
Hersberger M, Muntwyler J, Funke H, Marti-Jaun J, Schulte H, Assmann G, Lüscher TF, von Eckardstein A. Hersberger M, et al. Clin Chem. 2005 Jul;51(7):1110-5. doi: 10.1373/clinchem.2005.049262. Epub 2005 May 12. Clin Chem. 2005. PMID: 15890890 Clinical Trial.
The genomic effect of androgens is mediated by the androgen receptor (AR), which has a polymorphic CAG repeat in exon 1. The number of repeats is inversely related to the transcriptional activity of the AR on target genes. ...This effect was independent of triglycerides, b …
The genomic effect of androgens is mediated by the androgen receptor (AR), which has a polymorphic CAG repeat in exon 1. The number o …
Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease.
Fischer F, Schulte H, Mohan S, Tataru MC, Köhler E, Assmann G, von Eckardstein A. Fischer F, et al. Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602. doi: 10.1111/j.1365-2265.2004.02136.x. Clin Endocrinol (Oxf). 2004. PMID: 15521962
As growth promoters, they may play a role in atherosclerosis. DESIGN: Case-control, cross-sectional. PATIENTS: A total of 95 nondiabetic male patients with coronary heart disease (CHD) and 92 probands from the Prospective Cardiovascular Munster (PROCAM) who were bel …
As growth promoters, they may play a role in atherosclerosis. DESIGN: Case-control, cross-sectional. PATIENTS: A total of 95 n …
Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women.
Reinecke H, Bogdanski J, Woltering A, Breithardt G, Assmann G, Kerber S, von Eckardstein A. Reinecke H, et al. Am J Cardiol. 2002 Aug 15;90(4):364-8. doi: 10.1016/s0002-9149(02)02490-6. Am J Cardiol. 2002. PMID: 12161223
Implications of emerging risk factors for therapeutic intervention.
Assmann G, Cullen P, Fruchart JC, Greten H, Naruszewicz M, Olsson A, Paoletti R, Riesen W, Stoll M, Tikkanen M, von Eckardstein A; International Task Force for Prevention of Coronary Heart Disease. Assmann G, et al. Nutr Metab Cardiovasc Dis. 2005 Oct;15(5):373-81. doi: 10.1016/j.numecd.2005.06.011. Nutr Metab Cardiovasc Dis. 2005. PMID: 16216724

In ATP III, these "moderately high" risk patients had been classified as moderate risk with an LDL treatment goal of < or = 130 mg/dL, while the "very high" risk patients had been classified as high risk with a treatment goal of < or = 100 mg/dL. ...However, the Task

In ATP III, these "moderately high" risk patients had been classified as moderate risk with an LDL treatment goal of < or = 130 mg/dL, wh

Dietary mono- and polyunsaturated fatty acids similarly increase plasma apolipoprotein A-IV concentrations in healthy men and women.
Kratz M, Wahrburg U, von Eckardstein A, Ezeh B, Assmann G, Kronenberg F. Kratz M, et al. J Nutr. 2003 Jun;133(6):1821-5. doi: 10.1093/jn/133.6.1821. J Nutr. 2003. PMID: 12771323
We investigated the effect of dietary fatty acid composition on plasma apolipoprotein (apo) A-IV concentrations. Plasma apo A-IV concentrations were measured by ELISA in plasma of 48 healthy men and women in a controlled dietary study. ...The increase was not …
We investigated the effect of dietary fatty acid composition on plasma apolipoprotein (apo) A-IV concentrations. Plasma apo A- …
Lowering of HDL cholesterol in post-menopausal women by tibolone is not associated with changes in cholesterol efflux capacity or paraoxonase activity.
von Eckardstein A, Schmiddem K, Hövels A, Gülbahçe E, Schuler-Lüttmann S, Elbers J, Helmond F, Bennink HJ, Assmann G. von Eckardstein A, et al. Atherosclerosis. 2001 Dec;159(2):433-9. doi: 10.1016/s0021-9150(01)00522-6. Atherosclerosis. 2001. PMID: 11730824 Clinical Trial.
We elucidated the consequences of this unwanted side effect in a randomized, double-blind study, where 12 women received 2.5 mg tibolone per day and 6 women, placebo. ...Compared to placebo, treatment with tibolone led to statistically significant decreases of HDL choleste …
We elucidated the consequences of this unwanted side effect in a randomized, double-blind study, where 12 women received 2.5 mg tibol …
Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.
Uehara Y, Engel T, Li Z, Goepfert C, Rust S, Zhou X, Langer C, Schachtrup C, Wiekowski J, Lorkowski S, Assmann G, von Eckardstein A. Uehara Y, et al. Diabetes. 2002 Oct;51(10):2922-8. doi: 10.2337/diabetes.51.10.2922. Diabetes. 2002. PMID: 12351428
Low HDL cholesterol is a frequent cardiovascular risk factor in diabetes. Because of its pivotal role for the regulation of HDL plasma levels, we investigated in vivo and in vitro regulation of the ATP-binding cassette transporter A1 (ABCA1) by insulin and metabolites accu …
Low HDL cholesterol is a frequent cardiovascular risk factor in diabetes. Because of its pivotal role for the regulation of HDL plasm …
The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women.
Kratz M, von Eckardstein A, Fobker M, Buyken A, Posny N, Schulte H, Assmann G, Wahrburg U. Kratz M, et al. J Clin Endocrinol Metab. 2002 Nov;87(11):5008-14. doi: 10.1210/jc.2002-020496. J Clin Endocrinol Metab. 2002. PMID: 12414865 Clinical Trial.
First, all participants received a baseline high-fat diet, rich in saturated fat, for 2 wk and were then randomly assigned to one of three high-fat dietary treatments, which contained refined olive oil (rich in monounsaturated fatty acids, n = 19), rapeseed oil [rich in mo …
First, all participants received a baseline high-fat diet, rich in saturated fat, for 2 wk and were then randomly assigned to one of …
Tibolone lowers high density lipoprotein cholesterol by increasing hepatic lipase activity but does not impair cholesterol efflux.
von Eckardstein A, Crook D, Elbers J, Ragoobir J, Ezeh B, Helmond F, Miller N, Dieplinger H, Bennink HC, Assmann G. von Eckardstein A, et al. Clin Endocrinol (Oxf). 2003 Jan;58(1):49-58. doi: 10.1046/j.1365-2265.2003.01666.x. Clin Endocrinol (Oxf). 2003. PMID: 12519412 Clinical Trial.
METHODS: In a randomized, double-blind study, 34 women received 2.5 mg tibolone daily and 34 women received placebo. Serum concentrations of lipids, lipoprotein subclasses and apolipoproteins, together with plasma activities of lipid transfer proteins and lipolytic enzymes …
METHODS: In a randomized, double-blind study, 34 women received 2.5 mg tibolone daily and 34 women received placebo. Serum concentrat …
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