von Eckardstein A - Search Results

1

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

Garofalo K, Penno A, Schmidt BP, Lee HJ, Frosch MP, von Eckardstein A, Brown RH, Hornemann T, Eichler FS. Garofalo K, et al. Among authors: von eckardstein a. J Clin Invest. 2011 Dec;121(12):4735-45. doi: 10.1172/JCI57549. J Clin Invest. 2011. PMID: 22045570 Free PMC article. Clinical Trial.

2

Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.

Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH Jr. Eichler FS, et al. Among authors: von eckardstein a. J Neurosci. 2009 Nov 18;29(46):14646-51. doi: 10.1523/JNEUROSCI.2536-09.2009. J Neurosci. 2009. PMID: 19923297 Free PMC article.

3

Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.

Othman A, Bianchi R, Alecu I, Wei Y, Porretta-Serapiglia C, Lombardi R, Chiorazzi A, Meregalli C, Oggioni N, Cavaletti G, Lauria G, von Eckardstein A, Hornemann T. Othman A, et al. Among authors: von eckardstein a. Diabetes. 2015 Mar;64(3):1035-45. doi: 10.2337/db14-1325. Epub 2014 Oct 2. Diabetes. 2015. PMID: 25277395 Free article.

4

Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids.

Penno A, Reilly MM, Houlden H, Laurá M, Rentsch K, Niederkofler V, Stoeckli ET, Nicholson G, Eichler F, Brown RH Jr, von Eckardstein A, Hornemann T. Penno A, et al. Among authors: von eckardstein a. J Biol Chem. 2010 Apr 9;285(15):11178-87. doi: 10.1074/jbc.M109.092973. Epub 2010 Jan 22. J Biol Chem. 2010. PMID: 20097765 Free PMC article.

5

A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated.

Hornemann T, Penno A, Richard S, Nicholson G, van Dijk FS, Rotthier A, Timmerman V, von Eckardstein A. Hornemann T, et al. Among authors: von eckardstein a. Neurogenetics. 2009 Apr;10(2):135-43. doi: 10.1007/s10048-008-0168-7. Epub 2009 Jan 9. Neurogenetics. 2009. PMID: 19132419 Free article.

6

Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway.

Alecu I, Othman A, Penno A, Saied EM, Arenz C, von Eckardstein A, Hornemann T. Alecu I, et al. Among authors: von eckardstein a. J Lipid Res. 2017 Jan;58(1):60-71. doi: 10.1194/jlr.M072421. Epub 2016 Nov 21. J Lipid Res. 2017. PMID: 27872144 Free PMC article.

7

Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.

Tamehiro N, Mujawar Z, Zhou S, Zhuang DZ, Hornemann T, von Eckardstein A, Fitzgerald ML. Tamehiro N, et al. Among authors: von eckardstein a. J Biol Chem. 2009 Sep 11;284(37):24881-90. doi: 10.1074/jbc.M109.014365. Epub 2009 Jul 10. J Biol Chem. 2009. PMID: 19592499 Free PMC article.

8

A Novel Variant (Asn177Asp) in SPTLC2 Causing Hereditary Sensory Autonomic Neuropathy Type 1C.

Suriyanarayanan S, Othman A, Dräger B, Schirmacher A, Young P, Mulahasanovic L, Hörtnagel K, Biskup S, von Eckardstein A, Hornemann T, Lone MA. Suriyanarayanan S, et al. Among authors: von eckardstein a. Neuromolecular Med. 2019 Jun;21(2):182-191. doi: 10.1007/s12017-019-08534-w. Epub 2019 Apr 6. Neuromolecular Med. 2019. PMID: 30955194

9

The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.

Hornemann T, Penno A, Rütti MF, Ernst D, Kivrak-Pfiffner F, Rohrer L, von Eckardstein A. Hornemann T, et al. Among authors: von eckardstein a. J Biol Chem. 2009 Sep 25;284(39):26322-30. doi: 10.1074/jbc.M109.023192. Epub 2009 Aug 1. J Biol Chem. 2009. PMID: 19648650 Free PMC article.

10

Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?

Othman A, Benghozi R, Alecu I, Wei Y, Niesor E, von Eckardstein A, Hornemann T. Othman A, et al. Among authors: von eckardstein a. J Clin Lipidol. 2015 Jul-Aug;9(4):568-75. doi: 10.1016/j.jacl.2015.03.011. Epub 2015 Apr 4. J Clin Lipidol. 2015. PMID: 26228675 Clinical Trial.

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