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Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Talbot S, et al. Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25. Neuron. 2015. PMID: 26119026 Free PMC article.
Bacteria activate sensory neurons that modulate pain and inflammation.
Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Chiu IM, et al. Among authors: von hehn ca. Nature. 2013 Sep 5;501(7465):52-7. doi: 10.1038/nature12479. Epub 2013 Aug 21. Nature. 2013. PMID: 23965627 Free PMC article.
TRPA1 is a major oxidant sensor in murine airway sensory neurons.
Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. Bessac BF, et al. Among authors: von hehn ca. J Clin Invest. 2008 May;118(5):1899-910. doi: 10.1172/JCI34192. J Clin Invest. 2008. PMID: 18398506 Free PMC article.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
16 results