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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 2
2012 10
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2015 16
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2018 21
2019 22
2020 13
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2023 13
2024 22
2025 15
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159 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Vortioxetine for depression in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.
Yang X, Fang S, Lyu W, Hu Y, Xu H, Jiang X, Zhao Y, Zhang Y, Li J, Kuang W. Yang X, et al. Psychiatry Clin Neurosci. 2024 Sep;78(9):536-545. doi: 10.1111/pcn.13709. Epub 2024 Jul 3. Psychiatry Clin Neurosci. 2024. PMID: 38957929 Free article.
AIM: Major depressive disorder (MDD) is a prevalent psychiatric condition and vortioxetine offers promising antidepressant effects due to its unique pharmacological profile. However, the dose-response relationships of vortioxetine for MDD is not well established. We …
AIM: Major depressive disorder (MDD) is a prevalent psychiatric condition and vortioxetine offers promising antidepressant effects du …
Vortioxetine versus reuptake inhibitors in adults with major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.
Barbosa EC, da Silva GHS, Sbardelotto ÂEE, Barroso DC, de Lima FR, E Paez LEF, Lança SB, Petrucci ABC, Guimarães FBM, Nascimento AL. Barbosa EC, et al. Asian J Psychiatr. 2024 Nov;101:104222. doi: 10.1016/j.ajp.2024.104222. Epub 2024 Sep 6. Asian J Psychiatr. 2024. PMID: 39276484
Thus, we aimed to perform a systematic review and meta-analysis comparing vortioxetine vs reuptake inhibitors in adults with MDD, analyzing two classes separately: (i) vortioxetine vs SSRIs and (ii) vortioxetine vs SNRIs. ...RESULTS: We included 6 trials (n=4 …
Thus, we aimed to perform a systematic review and meta-analysis comparing vortioxetine vs reuptake inhibitors in adults with MDD, ana …
Vortioxetine in patients with major depressive disorder and high levels of anxiety symptoms: An updated analysis of efficacy and tolerability.
Adair M, Christensen MC, Florea I, Loft H, Fagiolini A. Adair M, et al. J Affect Disord. 2023 May 1;328:345-354. doi: 10.1016/j.jad.2023.01.074. Epub 2023 Jan 26. J Affect Disord. 2023. PMID: 36708956 Free article. Clinical Trial.
Vortioxetine 20 mg/day demonstrated significant effects versus placebo from week 4 onwards. ...Up-titration of vortioxetine to 20 mg/day was not associated with an increase in adverse events. LIMITATIONS: Short-term trials. ...
Vortioxetine 20 mg/day demonstrated significant effects versus placebo from week 4 onwards. ...Up-titration of vortioxetine to …
Vortioxetine for generalised anxiety disorder in adults.
Meza N, Leyton F. Meza N, et al. Medwave. 2021 Apr 28;21(3):e8172. doi: 10.5867/medwave.2021.03.8171. Medwave. 2021. PMID: 34038400 English, Spanish.
We conclude that there is uncertainty whether vortioxetine increases the response to treatment or improves anxious symptoms, because the certainty of the existing evidence has been assessed as very low. Furthermore, vortioxetine may increase nausea (low certainty ev …
We conclude that there is uncertainty whether vortioxetine increases the response to treatment or improves anxious symptoms, because …
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR. Cipriani A, et al. Lancet. 2018 Apr 7;391(10128):1357-1366. doi: 10.1016/S0140-6736(17)32802-7. Epub 2018 Feb 21. Lancet. 2018. PMID: 29477251 Free PMC article.
In head-to-head studies, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more effective than other antidepressants (range of ORs 1.19-1.96), whereas fluoxetine, fluvoxamine, reboxetine, and trazodone were the least effi …
In head-to-head studies, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine were more e …
Vortioxetine for depression in adults.
Koesters M, Ostuzzi G, Guaiana G, Breilmann J, Barbui C. Koesters M, et al. Cochrane Database Syst Rev. 2017 Jul 5;7(7):CD011520. doi: 10.1002/14651858.CD011520.pub2. Cochrane Database Syst Rev. 2017. PMID: 28677828 Free PMC article.
The latest available antidepressant is vortioxetine. It is assumed that vortioxetine's antidepressant action is related to a direct modulation of serotonergic receptor activity and inhibition of the serotonin transporter. ...In comparison to SNRIs, we found n …
The latest available antidepressant is vortioxetine. It is assumed that vortioxetine's antidepressant action is related …
Vortioxetine Treatment for Anxiety Disorder: A Meta-Analysis Study.
Yee A, Ng CG, Seng LH. Yee A, et al. Curr Drug Targets. 2018;19(12):1412-1423. doi: 10.2174/1389450118666171117131151. Curr Drug Targets. 2018. PMID: 29149828 Review.
The aim of this review is to quantitatively synthesize all data of the efficacy, safety and tolerability of Vortioxetine in treating anxiety disorder. METHOD: Terms of "Vortioxetine" OR "LuAA21004" AND "anxiety" OR "fear" OR "panic" OR "phobia" were searched. ...Mos …
The aim of this review is to quantitatively synthesize all data of the efficacy, safety and tolerability of Vortioxetine in treating …
Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset.
Iovieno N, Papakostas GI, Feeney A, Fava M, Mathew SJ, Iosifescu DI, Murrough JW, Macaluso M, Hock RS, Jha MK. Iovieno N, et al. J Clin Psychiatry. 2021 Jun 15;82(4):20r13682. doi: 10.4088/JCP.20r13682. J Clin Psychiatry. 2021. PMID: 34133089
Objective: To conduct a meta-analysis of studies of vortioxetine in adults with major depressive disorder (MDD). Data Sources: Abstracts were identified using PubMed by cross-referencing vortioxetine with placebo and randomized. ...Results: 7,269 subjects randomized …
Objective: To conduct a meta-analysis of studies of vortioxetine in adults with major depressive disorder (MDD). Data Sources: Abstra …
The efficacy of vortioxetine in the acute treatment of major depressive disorder: A systematic review and meta-analysis.
Berardelli I, Rogante E, Formica F, Iannazzo R, Mammoliti AV, Riccioni R, Veizi S, McIntyre RS, Pompili M. Berardelli I, et al. J Psychopharmacol. 2025 Feb;39(2):92-105. doi: 10.1177/02698811241309612. Epub 2025 Feb 1. J Psychopharmacol. 2025. PMID: 39891526
Twenty-four studies were included in the review and two meta-analyses were conducted to determine whether the mean Montgomery-Asberg Depression Rating Scale (MADRS) scale values in the placebo groups differ significantly from the mean MADRS scale values in the group receiving …
Twenty-four studies were included in the review and two meta-analyses were conducted to determine whether the mean Montgomery-Asberg Depress …
Vortioxetine treatment for generalised anxiety disorder: a meta-analysis of anxiety, quality of life and safety outcomes.
Qin B, Huang G, Yang Q, Zhao M, Chen H, Gao W, Yang M. Qin B, et al. BMJ Open. 2019 Nov 28;9(11):e033161. doi: 10.1136/bmjopen-2019-033161. BMJ Open. 2019. PMID: 31784448 Free PMC article.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES: All published RCTs, which assessed the effect of vortioxetine treatment for patients with GAD when compared with a placebo group, were included. ...Moreover, there was no statistically significant difference regarding the remissi …
ELIGIBILITY CRITERIA FOR SELECTING STUDIES: All published RCTs, which assessed the effect of vortioxetine treatment for patients with …
159 results