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RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice.

Karunakaran D, Nguyen MA, Geoffrion M, Vreeken D, Lister Z, Cheng HS, Otte N, Essebier P, Wyatt H, Kandiah JW, Jung R, Alenghat FJ, Mompeon A, Lee R, Pan C, Gordon E, Rasheed A, Lusis AJ, Liu P, Matic LP, Hedin U, Fish JE, Guo L, Kolodgie F, Virmani R, van Gils JM, Rayner KJ. Karunakaran D, et al. Among authors: vreeken d. Circulation. 2021 Jan 12;143(2):163-177. doi: 10.1161/CIRCULATIONAHA.118.038379. Epub 2020 Nov 23. Circulation. 2021. PMID: 33222501

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Ephs and Ephrins in Adult Endothelial Biology.

Vreeken D, Zhang H, van Zonneveld AJ, van Gils JM. Vreeken D, et al. Int J Mol Sci. 2020 Aug 6;21(16):5623. doi: 10.3390/ijms21165623. Int J Mol Sci. 2020. PMID: 32781521 Free PMC article. Review.

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Understanding netrins and semaphorins in mature endothelial cell biology.

Zhang H, Vreeken D, Bruikman CS, van Zonneveld AJ, van Gils JM. Zhang H, et al. Among authors: vreeken d. Pharmacol Res. 2018 Nov;137:1-10. doi: 10.1016/j.phrs.2018.09.015. Epub 2018 Sep 18. Pharmacol Res. 2018. PMID: 30240825 Free article. Review.

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Obesity affects brain structure and function- rescue by bariatric surgery?

Nota MHC, Vreeken D, Wiesmann M, Aarts EO, Hazebroek EJ, Kiliaan AJ. Nota MHC, et al. Among authors: vreeken d. Neurosci Biobehav Rev. 2020 Jan;108:646-657. doi: 10.1016/j.neubiorev.2019.11.025. Epub 2019 Nov 30. Neurosci Biobehav Rev. 2020. PMID: 31794778 Free article. Review.

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Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition.

Olsthoorn L, Vreeken D, Kiliaan AJ. Olsthoorn L, et al. Among authors: vreeken d. Front Neurosci. 2021 Dec 6;15:761456. doi: 10.3389/fnins.2021.761456. eCollection 2021. Front Neurosci. 2021. PMID: 34938153 Free PMC article. Review.

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Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence.

Zhang H, Vreeken D, Leuning DG, Bruikman CS, Junaid A, Stam W, de Bruin RG, Sol WMPJ, Rabelink TJ, van den Berg BM, van Zonneveld AJ, van Gils JM. Zhang H, et al. Among authors: vreeken d. Int J Biochem Cell Biol. 2021 May;134:105960. doi: 10.1016/j.biocel.2021.105960. Epub 2021 Feb 23. Int J Biochem Cell Biol. 2021. PMID: 33636396 Free article.

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Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity.

Vreeken D, Bruikman CS, Stam W, Cox SML, Nagy Z, Zhang H, Postma RJ, van Zonneveld AJ, Hovingh GK, van Gils JM. Vreeken D, et al. Front Cardiovasc Med. 2021 May 4;8:633609. doi: 10.3389/fcvm.2021.633609. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34017863 Free PMC article.

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Netrin-1 and the Grade of Atherosclerosis Are Inversely Correlated in Humans.

Bruikman CS, Vreeken D, Hoogeveen RM, Bom MJ, Danad I, Pinto-Sietsma SJ, van Zonneveld AJ, Knaapen P, Hovingh GK, Stroes ESG, van Gils JM. Bruikman CS, et al. Among authors: vreeken d. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):462-472. doi: 10.1161/ATVBAHA.119.313624. Epub 2019 Dec 5. Arterioscler Thromb Vasc Biol. 2020. PMID: 31801376 Free article.

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The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis.

Bruikman CS, Vreeken D, Zhang H, van Gils MJ, Peter J, van Zonneveld AJ, Hovingh GK, van Gils JM. Bruikman CS, et al. Among authors: vreeken d. Atherosclerosis. 2020 May;301:84-92. doi: 10.1016/j.atherosclerosis.2020.02.015. Epub 2020 Feb 28. Atherosclerosis. 2020. PMID: 32151395 Free article.

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Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration.

Zhang H, Vreeken D, Junaid A, Wang G, Sol WMPJ, de Bruin RG, van Zonneveld AJ, van Gils JM. Zhang H, et al. Among authors: vreeken d. Int J Mol Sci. 2020 Feb 21;21(4):1471. doi: 10.3390/ijms21041471. Int J Mol Sci. 2020. PMID: 32098168 Free PMC article.

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