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Page 1
Novel insights into UDP-glucuronosyltransferase 1A1 dysfunction and Gilbert's syndrome on estrogen metabolism and breast cancer.
Shameem S, Avery G, Monti F, du Toit EF, Wegiel B, Wagner KH, Bulmer AC. Shameem S, et al. Among authors: wagner kh. Crit Rev Oncol Hematol. 2026 May;221:105265. doi: 10.1016/j.critrevonc.2026.105265. Epub 2026 Mar 8. Crit Rev Oncol Hematol. 2026. PMID: 41806906 Free article. Review.
This pathway is shared between estrogen and other metabolites including unconjugated bilirubin (UCB), which has an overlapping binding site within UGT1A1. Ex vivo metabolic studies demonstrate reciprocal substrate-dependent competitive inhibition of glucuronidation between …
This pathway is shared between estrogen and other metabolites including unconjugated bilirubin (UCB), which has an overlapping bindin …
A Standardised Exercise Protocol to Induce Oxidative Stress in Humans: Validation with a Dietary Polyphenol Intervention.
Kamati OV, Bragagna L, Bester DJ, Wagner KH, Stürmer V, Gassner M, Maqboul L, Louw R, West S, Davies S, Marnewick JL. Kamati OV, et al. Among authors: wagner kh. Nutrients. 2025 Sep 16;17(18):2971. doi: 10.3390/nu17182971. Nutrients. 2025. PMID: 41010497 Free PMC article. Clinical Trial.

Results: The exercise regime reliably and repeatably induced oxidative stress, evidenced by increased levels of oxidative damage markers, i.e., oxidised glutathione (p = 0.003), malondialdehyde (p = 0.004), and a Comet assay tail moment (p < 0.05), while unconjugated biliru

…
Results: The exercise regime reliably and repeatably induced oxidative stress, evidenced by increased levels of oxidative damage markers, i. …
A high-protein diet with and without strength training shows no negative effects on oxidative stress markers in older adults.
Bragagna L, Maqboul L, Baron R, Harloff M, Spasova M, Noori S, Draxler A, Franzke B, Strasser EM, Zöhrer PA, Unterberger S, Aschauer R, Wessner B, Wagner KH. Bragagna L, et al. Among authors: wagner kh. Redox Biol. 2025 Sep;85:103707. doi: 10.1016/j.redox.2025.103707. Epub 2025 May 30. Redox Biol. 2025. PMID: 40541063 Free PMC article. Clinical Trial.
Blood was drawn at three time points (baseline T1, week 8 T2, and after study completion T3) and analyzed for chemical blood parameters and the oxidative stress markers superoxide dismutase (SOD), glutathione-peroxidase (GSH-Px), catalase (CAT), ferric reducing ability potential …
Blood was drawn at three time points (baseline T1, week 8 T2, and after study completion T3) and analyzed for chemical blood parameters and …
Bilirubin Metabolism Does Not Influence Serum Bile Acid Profiles According to LC-MS: A Human Case-Control Study.
Stelzer TC, Krüger R, Ferrario PG, Mölzer C, Wallner M, Marculescu R, Doberer D, Bulmer AC, Wagner KH. Stelzer TC, et al. Among authors: wagner kh. Int J Mol Sci. 2025 Mar 10;26(6):2475. doi: 10.3390/ijms26062475. Int J Mol Sci. 2025. PMID: 40141122 Free PMC article.
Furthermore, moderately elevated unconjugated bilirubin levels, as observed in Gilbert's syndrome (GS), may protect against NCDs. We therefore hypothesized that the BA profile in GS subjects differs from that of normo-bilirubinemic individuals. ...These data suggest that b …
Furthermore, moderately elevated unconjugated bilirubin levels, as observed in Gilbert's syndrome (GS), may protect against NCDs. We …
Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study.
Noh H, Lee J, Seyed Khoei N, Peruchet-Noray L, Kang D, Fervers B, Wagner KH, Shin A, Freisling H. Noh H, et al. Among authors: wagner kh. Br J Cancer. 2024 Nov;131(10):1635-1643. doi: 10.1038/s41416-024-02847-9. Epub 2024 Oct 8. Br J Cancer. 2024. PMID: 39379570 Free PMC article.
BACKGROUND: Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent. METHODS: In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CR …
BACKGROUND: Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent. METHODS: …
Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort.
Schoissengeier V, Maqboul L, Weber D, Grune T, Bürkle A, Moreno-Villaneuva M, Franceschi C, Capri M, Bernhard J, Toussaint O, Debacq-Chainiaux F, Weinberger B, Gonos ES, Sikora E, Dollé M, Jansen E, Slagboom PE, Hervonnen A, Hurme M, Breusing N, Frank J, Bulmer AC, Wagner KH. Schoissengeier V, et al. Among authors: wagner kh. iScience. 2024 Jun 9;27(7):110234. doi: 10.1016/j.isci.2024.110234. eCollection 2024 Jul 19. iScience. 2024. PMID: 39021797 Free PMC article.
Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. ...
Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the de …
Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls.
Draxler A, Blaschke A, Binar J, Weber M, Haslacher M, Bartak V, Bragagna L, Mare G, Maqboul L, Klapp R, Herzog T, Széll M, Petrera A, Laky B, Wagner KH, Thell R. Draxler A, et al. Among authors: wagner kh. Redox Biol. 2023 Nov;67:102914. doi: 10.1016/j.redox.2023.102914. Epub 2023 Oct 3. Redox Biol. 2023. PMID: 37832397 Free PMC article.
The aim of this case-control study was to examine whether COVID-19 patients show differences in oxidative stress-related markers, unconjugated bilirubin (UCB), an inflammation panel and DNA damage compared to healthy, age-and sex-matched controls. ...
The aim of this case-control study was to examine whether COVID-19 patients show differences in oxidative stress-related markers, unconjugat …
Effect of Repeated Bolus and Continuous Glucose Infusion on DNA Damage and Oxidative Stress Biomarkers in Healthy Male Volunteers.
Bragagna L, Polak C, Schütz L, Maqboul L, Klammer C, Feldbauer R, Draxler A, Clodi M, Wagner KH. Bragagna L, et al. Among authors: wagner kh. Int J Mol Sci. 2023 Sep 2;24(17):13608. doi: 10.3390/ijms241713608. Int J Mol Sci. 2023. PMID: 37686414 Free PMC article.
Whole blood and plasma were analyzed for DNA damage using a comet assay with 3 different treatments (lysis buffer, H(2)O(2), and the lesion-specific enzyme formamidopyrimidine DNA glycosylase (FPG)) as well as for the oxidative stress markers protein carbonyls (PC), unconjugated …
Whole blood and plasma were analyzed for DNA damage using a comet assay with 3 different treatments (lysis buffer, H(2)O(2), and the lesion- …
Bilirubin as an indicator of cardiometabolic health: a cross-sectional analysis in the UK Biobank.
Seyed Khoei N, Wagner KH, Sedlmeier AM, Gunter MJ, Murphy N, Freisling H. Seyed Khoei N, et al. Among authors: wagner kh. Cardiovasc Diabetol. 2022 Apr 18;21(1):54. doi: 10.1186/s12933-022-01484-x. Cardiovasc Diabetol. 2022. PMID: 35436955 Free PMC article.
For example, women with mildly elevated bilirubin (95(th) percentile equal to 15.0 mol/L), compared to women with low bilirubin (5(th) percentile equal to 4.5 mol/L), had on average a 2.0 kg/m(2) (99% CI 1.9-2.1) lower BMI. ...Multiple-trait analyses using PCA con …
For example, women with mildly elevated bilirubin (95(th) percentile equal to 15.0 mol/L), compared to women with low bilirubin …
Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats.
Vidimce J, Pillay J, Ronda O, Boon AC, Pennell E, Ashton KJ, van Dijk TH, Wagner KH, Verkade HJ, Bulmer AC. Vidimce J, et al. Among authors: wagner kh. J Physiol. 2022 Apr;600(8):1889-1911. doi: 10.1113/JP282395. Epub 2022 Mar 1. J Physiol. 2022. PMID: 35156712 Free PMC article.
Circulating bilirubin is associated with reduced serum cholesterol concentrations in humans and in hyperbilirubinaemic Gunn rats. ...Therefore, elevated LDL receptor expression potentially leads to reduced circulating cholesterol levels in female Gunn rats providing an exp …
Circulating bilirubin is associated with reduced serum cholesterol concentrations in humans and in hyperbilirubinaemic Gunn rats. ... …
55 results