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Page 1
Multiciliated cells.
Brooks ER, Wallingford JB. Brooks ER, et al. Among authors: wallingford jb. Curr Biol. 2014 Oct 6;24(19):R973-82. doi: 10.1016/j.cub.2014.08.047. Curr Biol. 2014. PMID: 25291643 Free PMC article. Review.
Cilia are microtubule-based projections that serve a wide variety of essential functions in animal cells. ...While many eukaryotic cells possess only one or two cilia, some cells, including those of many unicellular organisms, exhibit many cilia. ...
Cilia are microtubule-based projections that serve a wide variety of essential functions in animal cells. ...While many eukaryotic ce …
The developmental biology of kinesins.
Konjikusic MJ, Gray RS, Wallingford JB. Konjikusic MJ, et al. Among authors: wallingford jb. Dev Biol. 2021 Jan 1;469:26-36. doi: 10.1016/j.ydbio.2020.09.009. Epub 2020 Sep 19. Dev Biol. 2021. PMID: 32961118 Free PMC article. Review.
The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
Vazquez N, Lee C, Valenzuela I, Phan TP, Derderian C, Chávez M, Mooney NA, Demeter J, Aziz-Zanjani MO, Cusco I, Codina M, Martínez-Gil N, Valverde D, Solarat C, Bruel AL, Thauvin-Robinet C, Steichen E, Filges I, Joset P, De Geyter J, Vaidyanathan K, Gardner TP, Toriyama M, Marcotte EM, Drew K, Roberson EC, Jackson PK, Reiter JF, Tizzano EF, Wallingford JB. Vazquez N, et al. Among authors: wallingford jb. Nat Commun. 2025 Jul 1;16(1):5701. doi: 10.1038/s41467-025-61005-8. Nat Commun. 2025. PMID: 40593758 Free PMC article.
Cilia are essential organelles, and variants in genes governing ciliary function result in ciliopathic diseases. ...
Cilia are essential organelles, and variants in genes governing ciliary function result in ciliopathic diseases. ...
An amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes.
McCafferty CL, Papoulas O, Lee C, Bui KH, Taylor DW, Marcotte EM, Wallingford JB. McCafferty CL, et al. Among authors: wallingford jb. Dev Cell. 2025 Mar 24;60(6):965-978.e3. doi: 10.1016/j.devcel.2024.11.019. Epub 2024 Dec 13. Dev Cell. 2025. PMID: 39674175 Free PMC article.
Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human diseases. Motile cilia contain a myriad of different proteins that assemble into an array of distinct machines, and understanding th …
Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human …
The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
Vazquez N, Lee C, Valenzuela I, Phan TP, Derderian C, Chávez M, Mooney NA, Demeter J, Aziz-Zanjani MO, Cusco I, Codina M, Martínez-Gil N, Valverde D, Solarat C, Buel AL, Thauvin-Robinet C, Steichen E, Filges I, Joset P, De Geyter J, Vaidyanathan K, Gardner T, Toriyama M, Marcotte EM, Roberson EC, Jackson PK, Reiter JF, Tizzano EF, Wallingford JB. Vazquez N, et al. Among authors: wallingford jb. bioRxiv [Preprint]. 2024 Sep 26:2024.09.25.614984. doi: 10.1101/2024.09.25.614984. bioRxiv. 2024. Update in: Nat Commun. 2025 Jul 1;16(1):5701. doi: 10.1038/s41467-025-61005-8. PMID: 39386566 Free PMC article. Updated. Preprint.
Cilia are essential organelles and variants in genes governing ciliary function result in ciliopathic diseases. ...
Cilia are essential organelles and variants in genes governing ciliary function result in ciliopathic diseases. ...
A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.
Hong J, Lee C, Madhu G, Papoulas O, Atayeter E, Hoogerbrugge G, Pan J, Takagishi M, Manzi NI, Dickinson DJ, Horani A, Brody SL, Marcotte EM, Prakash VN, Park TJ, Wallingford JB. Hong J, et al. Among authors: wallingford jb. Nat Commun. 2025 Dec 21;17(1):394. doi: 10.1038/s41467-025-67086-9. Nat Commun. 2025. PMID: 41423487 Free PMC article.
The beating of cilia on multi-ciliated cells (MCCs) is essential for normal development and homeostasis in animals. ...Ccdc78 and Ccdc33 each display robust microtubule-bundling activity both in vivo and in vitro, yet each is independently required for normal length regula …
The beating of cilia on multi-ciliated cells (MCCs) is essential for normal development and homeostasis in animals. ...Ccdc78 and Ccd …
Cilia proteins getting to work - how do they commute from the cytoplasm to the base of cilia?
Hibbard JVK, Vázquez N, Wallingford JB. Hibbard JVK, et al. Among authors: wallingford jb. J Cell Sci. 2022 Sep 1;135(17):jcs259444. doi: 10.1242/jcs.259444. Epub 2022 Sep 8. J Cell Sci. 2022. PMID: 36073764 Free PMC article. Review.
Cilia are multifunctional organelles that originated with the last eukaryotic common ancestor and play central roles in the life cycles of diverse organisms. The motile flagella that move single cells like sperm or unicellular organisms, the motile cilia on animal m …
Cilia are multifunctional organelles that originated with the last eukaryotic common ancestor and play central roles in the life cycl …
Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.
Takagishi M, Yue Y, Gray RS, Verhey KJ, Wallingford JB. Takagishi M, et al. Among authors: wallingford jb. Dis Model Mech. 2024 Feb 1;17(2):dmm050137. doi: 10.1242/dmm.050137. Epub 2024 Feb 29. Dis Model Mech. 2024. PMID: 38235522 Free PMC article.
Motile cilia on ependymal cells that line brain ventricular walls beat in concert to generate a flow of laminar cerebrospinal fluid (CSF). Dyneins and kinesins are ATPase microtubule motor proteins that promote the rhythmic beating of cilia axonemes. Despite common …
Motile cilia on ependymal cells that line brain ventricular walls beat in concert to generate a flow of laminar cerebrospinal fluid ( …
Kif6 regulates cilia motility and polarity in brain ependymal cells.
Takagishi M, Yue Y, Gray RS, Verhey KJ, Wallingford JB. Takagishi M, et al. Among authors: wallingford jb. bioRxiv [Preprint]. 2023 Feb 16:2023.02.15.528715. doi: 10.1101/2023.02.15.528715. bioRxiv. 2023. Update in: Dis Model Mech. 2024 Feb 1;17(2):dmm050137. doi: 10.1242/dmm.050137. PMID: 36824804 Free PMC article. Updated. Preprint.
The ciliary axonemes of multiciliated ependymal cells display a 9+2 microtubule array common to motile cilia. Dyneins and kinesins are ATPase microtubule motor proteins that promote the rhythmic beating of cilia axonemes. ...In vitro analysis shows that Kif6 moves o …
The ciliary axonemes of multiciliated ependymal cells display a 9+2 microtubule array common to motile cilia. Dyneins and kinesins ar …
Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz.
Brooks ER, Wallingford JB. Brooks ER, et al. Among authors: wallingford jb. J Cell Biol. 2012 Jul 9;198(1):37-45. doi: 10.1083/jcb.201204072. J Cell Biol. 2012. PMID: 22778277 Free PMC article.
Cilia play key roles in development and homeostasis, and defects in cilia structure or function lead to an array of human diseases. ...Using this platform, we show that the planar cell polarity (PCP) effector Fuz was required for normal IFT dynamics in vertebrate …
Cilia play key roles in development and homeostasis, and defects in cilia structure or function lead to an array of human dise …
56 results