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21 results

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Page 1
Multiciliated cells.
Brooks ER, Wallingford JB. Brooks ER, et al. Among authors: wallingford jb. Curr Biol. 2014 Oct 6;24(19):R973-82. doi: 10.1016/j.cub.2014.08.047. Curr Biol. 2014. PMID: 25291643 Free PMC article. Review.
Despite their importance, multiciliated cells are relatively poorly studied and we are only beginning to understand the mechanisms underlying their development and function. Here, we review the general phylogeny and physiology of multiciliation and detail our current under …
Despite their importance, multiciliated cells are relatively poorly studied and we are only beginning to understand the mechanisms underlyin …
The developmental biology of kinesins.
Konjikusic MJ, Gray RS, Wallingford JB. Konjikusic MJ, et al. Among authors: wallingford jb. Dev Biol. 2021 Jan 1;469:26-36. doi: 10.1016/j.ydbio.2020.09.009. Epub 2020 Sep 19. Dev Biol. 2021. PMID: 32961118 Free PMC article. Review.
Interestingly, many of the ~45 distinct kinesin genes in vertebrate genomes have also been associated with specific phenotypes in embryonic development. In this review, we highlight the specific developmental roles of kinesins, link these to cellular roles reported in vitr …
Interestingly, many of the ~45 distinct kinesin genes in vertebrate genomes have also been associated with specific phenotypes in embryonic …
Morpholinos: Antisense and Sensibility.
Blum M, De Robertis EM, Wallingford JB, Niehrs C. Blum M, et al. Among authors: wallingford jb. Dev Cell. 2015 Oct 26;35(2):145-9. doi: 10.1016/j.devcel.2015.09.017. Dev Cell. 2015. PMID: 26506304 Free article. Review.
Planar cell polarity in development and disease.
Butler MT, Wallingford JB. Butler MT, et al. Among authors: wallingford jb. Nat Rev Mol Cell Biol. 2017 Jun;18(6):375-388. doi: 10.1038/nrm.2017.11. Epub 2017 Mar 15. Nat Rev Mol Cell Biol. 2017. PMID: 28293032 Free PMC article. Review.
Cilia proteins getting to work - how do they commute from the cytoplasm to the base of cilia?
Hibbard JVK, Vázquez N, Wallingford JB. Hibbard JVK, et al. Among authors: wallingford jb. J Cell Sci. 2022 Sep 1;135(17):jcs259444. doi: 10.1242/jcs.259444. Epub 2022 Sep 8. J Cell Sci. 2022. PMID: 36073764 Free PMC article. Review.
Despite a now-advanced understanding of how such proteins are transported within cilia, we still know very little about how they are transported from their sites of synthesis through the cytoplasm to the ciliary base. Here, we review the literature concerning this underapp …
Despite a now-advanced understanding of how such proteins are transported within cilia, we still know very little about how they are transpo …
Planar cell polarity signaling, cilia and polarized ciliary beating.
Wallingford JB. Wallingford JB. Curr Opin Cell Biol. 2010 Oct;22(5):597-604. doi: 10.1016/j.ceb.2010.07.011. Curr Opin Cell Biol. 2010. PMID: 20817501 Free PMC article. Review.
Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. This review will synthesize these recent papers and place them in context with previous studies of PCP signaling in polari …
Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very diffe …
Planar cell polarity, ciliogenesis and neural tube defects.
Wallingford JB. Wallingford JB. Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R227-34. doi: 10.1093/hmg/ddl216. Hum Mol Genet. 2006. PMID: 16987888 Review.
Long studied by cell biologists, these organelles have recently caught the attention of developmental biologists and human geneticists. In this review, I will discuss recent findings suggesting a link between cilia and the planar cell polarity signaling cascade. ...
Long studied by cell biologists, these organelles have recently caught the attention of developmental biologists and human geneticists. In t …
21 results