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Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.
Zhong Q, Li Q, Jia X, Hu L, Zhang Y, Zu J, He Y, Li X, Wang Y, Feng H, Hao J, Zhao Z, He J, Zhong Z. Zhong Q, et al. Phytomedicine. 2025 Nov;147:157187. doi: 10.1016/j.phymed.2025.157187. Epub 2025 Aug 21. Phytomedicine. 2025. PMID: 40913986 Free article.
METHODS: In the BO-stress model, the Th and WP combination was assessed for its effects on stress levels and the expression of neurotransmitters (GABA: Gamma-Aminobutyric Acid; 5-HT: serotonin; DA: dopamine; Ach: acetylcholine), as well as brain-derived neurotrop …
METHODS: In the BO-stress model, the Th and WP combination was assessed for its effects on stress levels and the expression of neurotransmit …
Treatment with walnut peptide ameliorates memory impairment in zebrafish and rats: promoting the expression of neurotrophic factors and suppressing oxidative stress.
Wei W, Wu Q, Wang S, Dong C, Shao S, Zhang Z, Zhang X, Zhang X, Kan J, Liu F. Wei W, et al. Food Funct. 2024 Jul 29;15(15):8043-8052. doi: 10.1039/d4fo00074a. Food Funct. 2024. PMID: 38988249
Walnut peptide, a low molecular weight peptide separated from walnuts by enzymatic hydrolysis, is considered as a potential nutraceutical with a variety of biological activities. ...Furthermore, the walnut peptide upregulated the expression of neurotrophic …
Walnut peptide, a low molecular weight peptide separated from walnuts by enzymatic hydrolysis, is considered as a potential nu …
Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices.
Li Q, Jia X, Zhong Q, Zhong Z, Wang Y, Tang C, Zhao B, Feng H, Hao J, Zhao Z, He J, Zhang Y. Li Q, et al. Front Nutr. 2023 Oct 6;10:1273531. doi: 10.3389/fnut.2023.1273531. eCollection 2023. Front Nutr. 2023. PMID: 37867495 Free PMC article.
This supplementation also elevated the expression of brain-derived neurotrophic factor mRNA, indicating protective effects against the neurological stresses of anxiety. Additionally, there were strong correlations among behavioral indicators, BDNF …
This supplementation also elevated the expression of brain-derived neurotrophic factor mRNA, indicating protecti …
Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice.
Ji J, Yi X, Gao X, Wang B, Zhang X, Shen X, Xia G. Ji J, et al. J Sci Food Agric. 2024 Jul;104(9):5419-5434. doi: 10.1002/jsfa.13369. Epub 2024 Feb 22. J Sci Food Agric. 2024. PMID: 38334319
Here, we investigated the synergistic effects of tilapia head protein hydrolysate (THPH) and walnut protein hydrolysate (WPH) in mitigating CI induced by scopolamine in mice. RESULTS: The results showed that the combined supplementation of THPH and WPH (mass ratio, 1:1) wa …
Here, we investigated the synergistic effects of tilapia head protein hydrolysate (THPH) and walnut protein hydrolysate (WPH) in miti …
α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology.
Piermartiri T, Pan H, Figueiredo TH, Marini AM. Piermartiri T, et al. Molecules. 2015 Nov 12;20(11):20355-80. doi: 10.3390/molecules201119698. Molecules. 2015. PMID: 26569216 Free PMC article. Review.
alpha-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and walnuts. The pleiotropic properties of ALA target endogenous neuroprotective and neurorestorative pathways in brain and involve the transcription factor nuclear fact …
alpha-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and walnuts. The pleiotropic properties of ALA …
Walnut polyphenols and the active metabolite urolithin A improve oxidative damage in SH-SY5Y cells by up-regulating PKA/CREB/BDNF signaling.
An L, Li M, Zou C, Wang K, Zhang W, Huang X, Wang Y. An L, et al. Food Funct. 2023 Mar 20;14(6):2698-2709. doi: 10.1039/d2fo03310k. Food Funct. 2023. PMID: 36847209
Accumulating evidence has confirmed the health benefits of walnut diets in maintaining brain function with age. Recent studies have indicated that walnut polyphenols (WP) and their active metabolites urolithins may play an important role in the health benefit …
Accumulating evidence has confirmed the health benefits of walnut diets in maintaining brain function with age. Recent studies …
Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration.
Fu J, Song W, Song X, Fang L, Wang X, Leng Y, Wang J, Liu C, Min W. Fu J, et al. Foods. 2023 Jun 9;12(12):2329. doi: 10.3390/foods12122329. Foods. 2023. PMID: 37372540 Free PMC article.
The Morris water maze trial, hippocampal neuron morphology, neurotransmitters, and synaptic ultrastructure were examined, along with brain-derived neurotrophic factor (BDNF)-related signaling pathway proteins. The results of the Morris water maz …
The Morris water maze trial, hippocampal neuron morphology, neurotransmitters, and synaptic ultrastructure were examined, along with brai …
Nuts4Brain-RCT: Protocol for a Three-Arm Randomized Controlled Trial Examining the Dose-Response Effects of Nut Consumption on Mental Health in Young Adults.
Mesas AE, Peral-Martínez F, Olivo-Martins-de-Passos T, Jiménez-López E, Beneit N, Martínez-Ortega IA, Díaz-Goñi V, Herraiz-Garrote S, Martínez-García I, Casanova-Rodríguez D, Rodríguez-Gutiérrez E, Bizzozero-Peroni B, Ballesta-Castillejos A, Cekrezi S, Marcilla-Toribio I, Núñez de Arenas-Arroyo S, Álvarez-Herraiz C, Maia CSC, Machado SP, Oliveira LFN, Serrano-Martínez S, Martínez-Madrid V, Calderón-Alva MC, López-Gil JF, Fernández-Rodríguez R, Cadenas-Sánchez C, Medrano M, Visier-Alfonso ME, Martínez-Vizcaíno V, Garrido-Miguel M. Mesas AE, et al. Healthcare (Basel). 2026 Feb 9;14(4):435. doi: 10.3390/healthcare14040435. Healthcare (Basel). 2026. PMID: 41753948 Free PMC article.
Current evidence also lacks robust data on the dose-response effects of nut consumption and mechanistic pathways involving biomarkers relevant to brain function and mental health. The Nuts4Brain-RCT will investigate the impact of a 6-month mixed-nut consumption interventio …
Current evidence also lacks robust data on the dose-response effects of nut consumption and mechanistic pathways involving biomarkers releva …
Walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats.
An L , Sun Y , Zhang W , Huang X , Xue R , Zhang Y , Wang Y . An L , et al. Food Funct. 2018 Sep 19;9(9):4755-4762. doi: 10.1039/c8fo00702k. Food Funct. 2018. PMID: 30101966
Recently, dietary intervention has been considered as a prospective strategy in delaying age-related cognitive dysfunction and brain plasticity degeneration. This study explored the effect of walnut diets (6% and 9%, 8 weeks) on cognitive behavior, hippocampal neuro …
Recently, dietary intervention has been considered as a prospective strategy in delaying age-related cognitive dysfunction and brain …
Walnut protein hydrolysates ameliorate alcohol-induced cognitive impairment (AICI) by alleviating oxidative stress and inflammation in the brain and improving hippocampal synaptic plasticity in Sprague-Dawley rats.
Xu D, Zhao M. Xu D, et al. Food Funct. 2022 Nov 14;13(22):11615-11626. doi: 10.1039/d2fo01709a. Food Funct. 2022. PMID: 36268846
Moreover, a reduction of oxidative stress and inflammation in brain tissues was observed and the significant enhancement of brain-derived neurotrophic factor (BDNF), postsynaptic density protein (PSD95) and cAMP-response element binding p …
Moreover, a reduction of oxidative stress and inflammation in brain tissues was observed and the significant enhancement of brain …
16 results