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1991 1
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2002 1
2003 1
2004 3
2005 2
2006 4
2008 1
2009 4
2010 3
2012 1
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2020 1
2021 3
2022 3
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M. Pfister D, et al. Among authors: weber a. Nature. 2021 Apr;592(7854):450-456. doi: 10.1038/s41586-021-03362-0. Epub 2021 Mar 24. Nature. 2021. PMID: 33762733 Free PMC article.
Here we report the progressive accumulation of exhausted, unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In preclinical models of NASH-induced HCC, therapeutic immunotherapy targeted at programmed death-1 (PD1) expanded activated CD8(+)PD1(+) T ce …
Here we report the progressive accumulation of exhausted, unconventionally activated CD8(+)PD1(+) T cells in NASH-affected livers. In …
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Deczkowska A, David E, Ramadori P, Pfister D, Safran M, Li B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A, Ben-Ari Z, Heikenwälder M, Elinav E, Amit I. Deczkowska A, et al. Among authors: weber a. Nat Med. 2021 Jun;27(6):1043-1054. doi: 10.1038/s41591-021-01344-3. Epub 2021 May 20. Nat Med. 2021. PMID: 34017133 Free article.
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. ...Finally, depletion of cDC1 in XCR1(DTA) mi …
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underli …
Hepatocyte transplantation techniques: large animal models.
Weber A, Groyer-Picard MT, Dagher I. Weber A, et al. Methods Mol Biol. 2009;481:83-96. doi: 10.1007/978-1-59745-201-4_8. Methods Mol Biol. 2009. PMID: 19096791 Review.
The poor hepatocyte engraftment efficiency and the low level of their expansion in the host liver are a major limitation to cell therapy for the treatment of life-threatening liver diseases. Many rodent models have shown that liver repopulation via transplant …
The poor hepatocyte engraftment efficiency and the low level of their expansion in the host liver are a major limitation to cell ther …
Immortalization of a primate bipotent epithelial liver stem cell.
Allain JE, Dagher I, Mahieu-Caputo D, Loux N, Andreoletti M, Westerman K, Briand P, Franco D, Leboulch P, Weber A. Allain JE, et al. Among authors: weber a. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3639-44. doi: 10.1073/pnas.062038599. Proc Natl Acad Sci U S A. 2002. PMID: 11904425 Free PMC article.
Liver regeneration after partial hepatectomy results primarily from the simple division of mature hepatocytes. ...The ability to identify, isolate, and transplant epithelial liver stem cells from fetal liver would greatly facilitate the treatment of hepatic d
Liver regeneration after partial hepatectomy results primarily from the simple division of mature hepatocytes. ...The ability to iden
Human pluripotent stem cells for modelling human liver diseases and cell therapy.
Dianat N, Steichen C, Vallier L, Weber A, Dubart-Kupperschmitt A. Dianat N, et al. Among authors: weber a. Curr Gene Ther. 2013 Apr;13(2):120-32. doi: 10.2174/1566523211313020006. Curr Gene Ther. 2013. PMID: 23444872 Free PMC article. Review.
The liver is affected by many types of diseases, including metabolic disorders and acute liver failure. Orthotopic liver transplantation (OLT) is currently the only effective treatment for life-threatening liver diseases but transplantation of allogene …
The liver is affected by many types of diseases, including metabolic disorders and acute liver failure. Orthotopic liver
The potential of induced pluripotent stem cell derived hepatocytes.
Hannoun Z, Steichen C, Dianat N, Weber A, Dubart-Kupperschmitt A. Hannoun Z, et al. Among authors: weber a. J Hepatol. 2016 Jul;65(1):182-199. doi: 10.1016/j.jhep.2016.02.025. Epub 2016 Feb 22. J Hepatol. 2016. PMID: 26916529 Review.
Orthotopic liver transplantation remains the only curative treatment for liver disease. ...This review will discuss the potential applications and existing limitations of hiPSC-derived hepatocytes in regenerative medicine, drug screening, in vitro disease modelling …
Orthotopic liver transplantation remains the only curative treatment for liver disease. ...This review will discuss the potent …
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. Namineni S, et al. Among authors: weber a. J Hepatol. 2020 May;72(5):960-975. doi: 10.1016/j.jhep.2019.12.019. Epub 2020 Jan 15. J Hepatol. 2020. PMID: 31954207 Free article.
BACKGROUND & AIMS: Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition t …
BACKGROUND & AIMS: Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resi …
Hepatocyte transplantation in animal models.
Weber A, Groyer-Picard MT, Franco D, Dagher I. Weber A, et al. Liver Transpl. 2009 Jan;15(1):7-14. doi: 10.1002/lt.21670. Liver Transpl. 2009. PMID: 19109838 Free article. Review.
Although other cell sources, particularly hepatic and extrahepatic stem cells, are being explored, adult hepatocytes remain the cells of choice for the treatment of liver diseases by cell therapy. In recent years, diverse approaches have been developed in various animal mo …
Although other cell sources, particularly hepatic and extrahepatic stem cells, are being explored, adult hepatocytes remain the cells of cho …
[Human pluripotent stem cells and liver disorders].
Dianat N, Weber A, Dubart-Kupperschmitt A. Dianat N, et al. Among authors: weber a. Biol Aujourdhui. 2016;210(1):19-26. doi: 10.1051/jbio/2016006. Epub 2016 Jun 10. Biol Aujourdhui. 2016. PMID: 27286577 Review. French.
The liver is associated with many diseases including metabolic and cholestatic diseases, cirrhosis as well as chronic and acute hepatitis. ...The liver is the main organ responsible for the elimination of xenobiotics and thus hepatocytes have a key role in toxicolog …
The liver is associated with many diseases including metabolic and cholestatic diseases, cirrhosis as well as chronic and acute hepat …
Transplantation of hESC-derived hepatocytes protects mice from liver injury.
Tolosa L, Caron J, Hannoun Z, Antoni M, López S, Burks D, Castell JV, Weber A, Gomez-Lechon MJ, Dubart-Kupperschmitt A. Tolosa L, et al. Among authors: weber a. Stem Cell Res Ther. 2015 Dec 12;6:246. doi: 10.1186/s13287-015-0227-6. Stem Cell Res Ther. 2015. PMID: 26652177 Free PMC article.
When transplanted into mice with acetaminophen-induced acute liver failure, a model of liver damage, the VAL9-derived hepatocytes efficiently engrafted and proliferated, repopulating up to 10 % of the liver. In these transplanted livers, we observed a …
When transplanted into mice with acetaminophen-induced acute liver failure, a model of liver damage, the VAL9-derived hepatocy …
43 results