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[Human pluripotent stem cells and liver disorders].
Dianat N, Weber A, Dubart-Kupperschmitt A. Dianat N, et al. Among authors: weber a. Biol Aujourdhui. 2016;210(1):19-26. doi: 10.1051/jbio/2016006. Epub 2016 Jun 10. Biol Aujourdhui. 2016. PMID: 27286577 Review. French.
The liver is associated with many diseases including metabolic and cholestatic diseases, cirrhosis as well as chronic and acute hepatitis. ...The liver is the main organ responsible for the elimination of xenobiotics and thus hepatocytes have a key role in toxicolog …
The liver is associated with many diseases including metabolic and cholestatic diseases, cirrhosis as well as chronic and acute hepat …
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. Namineni S, et al. Among authors: weber a. J Hepatol. 2020 May;72(5):960-975. doi: 10.1016/j.jhep.2019.12.019. Epub 2020 Jan 15. J Hepatol. 2020. PMID: 31954207 Free article.
BACKGROUND & AIMS: Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. ...Similar to livers of Ikkβ(ΔHep) mice, enhanced hepatocytic LCMV accumulation was observed in livers of If …
BACKGROUND & AIMS: Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resi …
Immortalization of a primate bipotent epithelial liver stem cell.
Allain JE, Dagher I, Mahieu-Caputo D, Loux N, Andreoletti M, Westerman K, Briand P, Franco D, Leboulch P, Weber A. Allain JE, et al. Among authors: weber a. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3639-44. doi: 10.1073/pnas.062038599. Proc Natl Acad Sci U S A. 2002. PMID: 11904425 Free PMC article.
The ability to identify, isolate, and transplant epithelial liver stem cells from fetal liver would greatly facilitate the treatment of hepatic diseases currently requiring orthotopic liver transplantation. ...These results provide strong evidence for the exi …
The ability to identify, isolate, and transplant epithelial liver stem cells from fetal liver would greatly facilitate the tre …
Transplantation of hESC-derived hepatocytes protects mice from liver injury.
Tolosa L, Caron J, Hannoun Z, Antoni M, López S, Burks D, Castell JV, Weber A, Gomez-Lechon MJ, Dubart-Kupperschmitt A. Tolosa L, et al. Among authors: weber a. Stem Cell Res Ther. 2015 Dec 12;6:246. doi: 10.1186/s13287-015-0227-6. Stem Cell Res Ther. 2015. PMID: 26652177 Free PMC article.
BACKGROUND: Hepatic cell therapy has become a viable alternative to liver transplantation for life-threatening liver diseases. ...In these transplanted livers, we observed a significant decrease of liver transaminases and found no evidence of tumourige …
BACKGROUND: Hepatic cell therapy has become a viable alternative to liver transplantation for life-threatening liver diseases. …
Human pluripotent stem cells for modelling human liver diseases and cell therapy.
Dianat N, Steichen C, Vallier L, Weber A, Dubart-Kupperschmitt A. Dianat N, et al. Among authors: weber a. Curr Gene Ther. 2013 Apr;13(2):120-32. doi: 10.2174/1566523211313020006. Curr Gene Ther. 2013. PMID: 23444872 Free PMC article. Review.
The liver is affected by many types of diseases, including metabolic disorders and acute liver failure. Orthotopic liver transplantation (OLT) is currently the only effective treatment for life-threatening liver diseases but transplantation of allogene …
The liver is affected by many types of diseases, including metabolic disorders and acute liver failure. Orthotopic liver
Hepatocyte transplantation techniques: large animal models.
Weber A, Groyer-Picard MT, Dagher I. Weber A, et al. Methods Mol Biol. 2009;481:83-96. doi: 10.1007/978-1-59745-201-4_8. Methods Mol Biol. 2009. PMID: 19096791 Review.
The poor hepatocyte engraftment efficiency and the low level of their expansion in the host liver are a major limitation to cell therapy for the treatment of life-threatening liver diseases. Many rodent models have shown that liver repopulation via transplant …
The poor hepatocyte engraftment efficiency and the low level of their expansion in the host liver are a major limitation to cell ther …
The potential of induced pluripotent stem cell derived hepatocytes.
Hannoun Z, Steichen C, Dianat N, Weber A, Dubart-Kupperschmitt A. Hannoun Z, et al. Among authors: weber a. J Hepatol. 2016 Jul;65(1):182-199. doi: 10.1016/j.jhep.2016.02.025. Epub 2016 Feb 22. J Hepatol. 2016. PMID: 26916529 Review.
Orthotopic liver transplantation remains the only curative treatment for liver disease. However, the number of patients who die while on the waiting list (15%) has increased in recent years as a result of severe organ shortages; furthermore the incidence of liver
Orthotopic liver transplantation remains the only curative treatment for liver disease. However, the number of patients who di …
Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In Vitro.
Goulinet-Mainot S, Tranchart H, Groyer-Picard MT, Lainas P, Saloum Diop P, Holopherne D, Gonin P, Benihoud K, Ba N, Gauthier O, Franco D, Guettier C, Pariente D, Weber A, Dagher I, Huy Nguyen T. Goulinet-Mainot S, et al. Among authors: weber a. Cell Med. 2012 May 8;4(2):85-98. doi: 10.3727/215517912X647136. eCollection 2012 Feb. Cell Med. 2012. PMID: 26858856 Free PMC article.
Innovative cell-based therapies are considered as alternatives to liver transplantation. Recent progress in lentivirus-mediated hepatocyte transduction has renewed interest in cell therapy for the treatment of inherited liver diseases. ...In conclusion, our results …
Innovative cell-based therapies are considered as alternatives to liver transplantation. Recent progress in lentivirus-mediated hepat …
Liver regeneration and recanalization time course following reversible portal vein embolization.
Lainas P, Boudechiche L, Osorio A, Coulomb A, Weber A, Pariente D, Franco D, Dagher I. Lainas P, et al. Among authors: weber a. J Hepatol. 2008 Sep;49(3):354-62. doi: 10.1016/j.jhep.2008.01.034. Epub 2008 Mar 10. J Hepatol. 2008. PMID: 18387688
One month after the embolization, the non-embolized liver volume had increased from 38.4+/-1.3% to 54.8+/-0.5% of total liver volume. ...CONCLUSIONS: Reversible PVE efficiently induces liver regeneration. The use of absorbable material avoids long-term liv
One month after the embolization, the non-embolized liver volume had increased from 38.4+/-1.3% to 54.8+/-0.5% of total liver
Portal branch ligation induces efficient retrovirus-mediated gene delivery in rat liver.
Lorand I, Vons C, Nguyen T, Di Rico V, Coulomb A, Franco D, Capron F, Weber A. Lorand I, et al. Among authors: weber a. J Gene Med. 2004 May;6(5):507-13. doi: 10.1002/jgm.532. J Gene Med. 2004. PMID: 15133761
METHODS: We ligated the portal branch serving 70% of the liver and measured the kinetics of liver mass restoration and cell proliferation and the distribution of dividing hepatocytes after administration of 5-bromo-2'-deoxyuridine. ...The viruses were administered i …
METHODS: We ligated the portal branch serving 70% of the liver and measured the kinetics of liver mass restoration and cell pr …
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