SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells.
Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Hengstschläger M, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ.
Celada SI, et al.
Sci Transl Med. 2023 Sep 13;15(713):eade2581. doi: 10.1126/scitranslmed.ade2581. Epub 2023 Sep 13.
Sci Transl Med. 2023.
PMID: 37703351
Sarcoidosis is an interstitial lung disease (ILD) characterized by interferon-gamma (IFN-gamma) and T-box expressed in T cells (TBET) dysregulation. Although one-third of patients progress from granulomatous inflammation to severe lung damage, the molecular mechanis …
Sarcoidosis is an interstitial lung disease (ILD) characterized by interferon-gamma (IFN-gamma) and T-box expressed in T cells …