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Page 1
Assembly of bacterial ribosomes.
Shajani Z, Sykes MT, Williamson JR. Shajani Z, et al. Among authors: williamson jr. Annu Rev Biochem. 2011;80:501-26. doi: 10.1146/annurev-biochem-062608-160432. Annu Rev Biochem. 2011. PMID: 21529161 Review.
The assembly of ribosomes from a discrete set of components is a key aspect of the highly coordinated process of ribosome biogenesis. In this review, we present a brief history of the early work on ribosome assembly in Escherichia coli, includin …
The assembly of ribosomes from a discrete set of components is a key aspect of the highly coordinated process of ribosome …
Quantitative mining of compositional heterogeneity in cryo-EM datasets of ribosome assembly intermediates.
Rabuck-Gibbons JN, Lyumkis D, Williamson JR. Rabuck-Gibbons JN, et al. Among authors: williamson jr. Structure. 2022 Apr 7;30(4):498-509.e4. doi: 10.1016/j.str.2021.12.005. Epub 2022 Jan 5. Structure. 2022. PMID: 34990602 Free PMC article.
We identified more detailed branchpoints in the assembly process and characterized the interactions of an assembly factor with immature intermediates. While the tools described here were developed for ribosome assembly, they should be broadly applicabl …
We identified more detailed branchpoints in the assembly process and characterized the interactions of an assembly factor with …
Role of Era in assembly and homeostasis of the ribosomal small subunit.
Razi A, Davis JH, Hao Y, Jahagirdar D, Thurlow B, Basu K, Jain N, Gomez-Blanco J, Britton RA, Vargas J, Guarné A, Woodson SA, Williamson JR, Ortega J. Razi A, et al. Among authors: williamson jr. Nucleic Acids Res. 2019 Sep 5;47(15):8301-8317. doi: 10.1093/nar/gkz571. Nucleic Acids Res. 2019. PMID: 31265110 Free PMC article.
Assembly factors provide speed and directionality to the maturation process of the 30S subunit in bacteria. ...We also found that binding of Era to the mature 30S subunit destabilized helix 44 and the decoding center preventing binding of YjeQ, another assembly …
Assembly factors provide speed and directionality to the maturation process of the 30S subunit in bacteria. ...We also found t …
Quantitative proteomic analysis of ribosome assembly and turnover in vivo.
Sykes MT, Shajani Z, Sperling E, Beck AH, Williamson JR. Sykes MT, et al. Among authors: williamson jr. J Mol Biol. 2010 Oct 29;403(3):331-45. doi: 10.1016/j.jmb.2010.08.005. Epub 2010 Aug 13. J Mol Biol. 2010. PMID: 20709079 Free PMC article.
Here, a general method is presented for studying the dynamics of ribosome assembly and ribosomal assembly intermediates. Since significant quantities of assembly intermediates are not present under normal growth conditions, the antibiotic neomyc …
Here, a general method is presented for studying the dynamics of ribosome assembly and ribosomal assembly interm …
Biophysical studies of bacterial ribosome assembly.
Williamson JR. Williamson JR. Curr Opin Struct Biol. 2008 Jun;18(3):299-304. doi: 10.1016/j.sbi.2008.05.001. Epub 2008 Jun 7. Curr Opin Struct Biol. 2008. PMID: 18541423 Free PMC article. Review.
The assembly of the bacterial ribosome involves the association of over 50 proteins to 3 large RNA molecules, and it represents a major metabolic activity for rapidly growing bacteria. The availability of atomic structures of the ribosome and the appli …
The assembly of the bacterial ribosome involves the association of over 50 proteins to 3 large RNA molecules, and it represent …
Assembly landscape for the bacterial large ribosomal subunit.
Sheng K, Li N, Rabuck-Gibbons JN, Dong X, Lyumkis D, Williamson JR. Sheng K, et al. Among authors: williamson jr. Nat Commun. 2023 Aug 26;14(1):5220. doi: 10.1038/s41467-023-40859-w. Nat Commun. 2023. PMID: 37633970 Free PMC article.
Assembly of ribosomes in bacteria is highly efficient, taking ~2-3 min, but this makes the abundance of assembly intermediates very low, which is a challenge for mechanistic understanding. ...We use cryo-electron microscopy, with iterative subclassific …
Assembly of ribosomes in bacteria is highly efficient, taking ~2-3 min, but this makes the abundance of assembly …
The effect of ribosome assembly cofactors on in vitro 30S subunit reconstitution.
Bunner AE, Nord S, Wikström PM, Williamson JR. Bunner AE, et al. Among authors: williamson jr. J Mol Biol. 2010 Apr 23;398(1):1-7. doi: 10.1016/j.jmb.2010.02.036. Epub 2010 Feb 24. J Mol Biol. 2010. PMID: 20188109 Free PMC article.
Ribosome biogenesis is facilitated by a growing list of assembly cofactors, including helicases, GTPases, chaperones, and other proteins, but the specific functions of many of these assembly cofactors are still unclear. The effect of three assembly cof …
Ribosome biogenesis is facilitated by a growing list of assembly cofactors, including helicases, GTPases, chaperones, and othe …
After the ribosome structures: how are the subunits assembled?
Williamson JR. Williamson JR. RNA. 2003 Feb;9(2):165-7. doi: 10.1261/rna.2164903. RNA. 2003. PMID: 12554857 Free PMC article. Review.
The recent structures of the ribosome and the ribosomal subunits only heighten the intrigue of trying to understand how the ribosome is assembled. ...Recent studies point to roles of protein folding chaperones and RNA helicases as facilitators of ribosome …
The recent structures of the ribosome and the ribosomal subunits only heighten the intrigue of trying to understand how the …
Modular Assembly of the Bacterial Large Ribosomal Subunit.
Davis JH, Tan YZ, Carragher B, Potter CS, Lyumkis D, Williamson JR. Davis JH, et al. Among authors: williamson jr. Cell. 2016 Dec 1;167(6):1610-1622.e15. doi: 10.1016/j.cell.2016.11.020. Cell. 2016. PMID: 27912064 Free PMC article.
The ribosome is a complex macromolecular machine and serves as an ideal system for understanding biological macromolecular assembly. ...This work reveals the complex landscape of ribosome assembly in vivo and provides the requisite tools to characteriz …
The ribosome is a complex macromolecular machine and serves as an ideal system for understanding biological macromolecular assembl …
Characterization of the ribosome biogenesis landscape in E. coli using quantitative mass spectrometry.
Chen SS, Williamson JR. Chen SS, et al. Among authors: williamson jr. J Mol Biol. 2013 Feb 22;425(4):767-79. doi: 10.1016/j.jmb.2012.11.040. Epub 2012 Dec 7. J Mol Biol. 2013. PMID: 23228329 Free PMC article.
The model-free clustering analysis of the resultant protein levels for the different ribosomal particles produced four 30S assembly groups that correlate very well with previous in vitro assembly studies of the small ribosomal subunit and six 50S as …
The model-free clustering analysis of the resultant protein levels for the different ribosomal particles produced four 30S assembl …
31 results