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110 results

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Page 1
Tackling Chronic Inflammation with Withanolide Phytochemicals-A Withaferin a Perspective.
Logie E, Vanden Berghe W. Logie E, et al. Antioxidants (Basel). 2020 Nov 10;9(11):1107. doi: 10.3390/antiox9111107. Antioxidants (Basel). 2020. PMID: 33182809 Free PMC article. Review.
Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades. In this context, Withaferin A (WA), a natural bioactive compound isolated from Withania somnifera, has been identified as a promisi …
Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades …
Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects.
Mandlik Ingawale DS, Namdeo AG. Mandlik Ingawale DS, et al. J Diet Suppl. 2021;18(2):183-226. doi: 10.1080/19390211.2020.1741484. Epub 2020 Apr 3. J Diet Suppl. 2021. PMID: 32242751 Review.
Furthermore, W. somnifera has revealed the capability to decrease reactive oxygen species and inflammation, modulation of mitochondrial function, apoptosis regulation and improve endothelial function. Withaferin-A is an important phytoconstituents of W. somnifera be …
Furthermore, W. somnifera has revealed the capability to decrease reactive oxygen species and inflammation, modulation of mitochondri …
Withaferin A attenuates ovalbumin induced airway inflammation.
Zhao HM, Gao ZW, Xie SX, Han X, Sun QS. Zhao HM, et al. Front Biosci (Landmark Ed). 2019 Jan 1;24(3):576-596. doi: 10.2741/4737. Front Biosci (Landmark Ed). 2019. PMID: 30468675 Free article.
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) is a natural phytochemical isolated from the plant Withania somnifera. ...The results indicate that WA may be an effective novel candidate for the treatment of air …
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) is a natural phytochemi …
Withaferin A alleviates inflammation in animal models of arthritis by inhibiting the NF-kappaB pathway and cytokine release.
Alenazi F, Moursi S, Mahmoud MR, Shahid SMA, Khatoon F, Shahid Khan M, Khan MA, Alam MJ, Saleem M, Syed Khaja AS. Alenazi F, et al. Chem Biol Interact. 2024 Aug 1;398:111114. doi: 10.1016/j.cbi.2024.111114. Epub 2024 Jun 17. Chem Biol Interact. 2024. PMID: 38897341
Withaferin A, a steroid lactone from Withania somnifera, exhibits anti-inflammatory, immunomodulatory, and antioxidant properties. ...To confirm the results obtained from biochemical and molecular studies and to determine the molecular target of withaferin A, we per …
Withaferin A, a steroid lactone from Withania somnifera, exhibits anti-inflammatory, immunomodulatory, and antioxidant properties. .. …
Withaferin A alleviates inflammation and joint injury in arthritic rats via elevating microRNA-1297 to target karyopherin alpha2.
Sheng JD, Liu J, Du JW, Wang YP. Sheng JD, et al. J Physiol Pharmacol. 2023 Dec;74(6). doi: 10.26402/jpp.2023.6.08. Epub 2024 Feb 7. J Physiol Pharmacol. 2023. PMID: 38345447 Free article.
Withaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. ...In short, WFA alleviated inflammation and joint damage in arthritic rats via elevating miR-1297 to target KPNA2....
Withaferin A (WFA) is a natural compound separated from the medicinal plant Withania somnifera. ...In short, WFA alleviated inflam …
Pharmacologic overview of Withania somnifera, the Indian Ginseng.
Dar NJ, Hamid A, Ahmad M. Dar NJ, et al. Cell Mol Life Sci. 2015 Dec;72(23):4445-60. doi: 10.1007/s00018-015-2012-1. Epub 2015 Aug 26. Cell Mol Life Sci. 2015. PMID: 26306935 Free PMC article. Review.
Additionally, it has demonstrated the ability to reduce reactive oxygen species, modulate mitochondrial function, regulate apoptosis, and reduce inflammation and enhance endothelial function. In view of these pharmacologic properties, W. somnifera is a potential drug candi …
Additionally, it has demonstrated the ability to reduce reactive oxygen species, modulate mitochondrial function, regulate apoptosis, and re …
Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction.
Chen CM, Chung YP, Liu CH, Huang KT, Guan SS, Chiang CK, Wu CT, Liu SH. Chen CM, et al. Phytomedicine. 2020 Dec;79:153352. doi: 10.1016/j.phymed.2020.153352. Epub 2020 Sep 21. Phytomedicine. 2020. PMID: 33007732
The protein levels of endoplasmic reticulum (ER) stress-associated molecules (GRP78, GRP94, ATF4, CHOP, phosphorylated eIF2alpha, and cleaved caspase 12) were increased in the kidneys of UUO mice, which could be significantly reversed by withaferin A treatment. CONCLUSION: …
The protein levels of endoplasmic reticulum (ER) stress-associated molecules (GRP78, GRP94, ATF4, CHOP, phosphorylated eIF2alpha, and cleave …
Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach.
Murugan R, Rajesh R, Seenivasan B, Haridevamuthu B, Sudhakaran G, Guru A, Rajagopal R, Kuppusamy P, Juliet A, Gopinath P, Arockiaraj J. Murugan R, et al. Microb Pathog. 2022 Nov;172:105778. doi: 10.1016/j.micpath.2022.105778. Epub 2022 Sep 15. Microb Pathog. 2022. PMID: 36116607
We demonstrated the antibacterial activity of Withaferin A extracted from the traditional herb, ashwagandha or winter cherry (Withania somnifera). ...Results obtained from membrane stabilization assay and electron microscopic analysis showed that Withaferin A acts b …
We demonstrated the antibacterial activity of Withaferin A extracted from the traditional herb, ashwagandha or winter cherry (Withani …
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.
Ferrero-Andrés A, Panisello-Roselló A, Roselló-Catafau J, Folch-Puy E. Ferrero-Andrés A, et al. Int J Mol Sci. 2020 Jul 29;21(15):5386. doi: 10.3390/ijms21155386. Int J Mol Sci. 2020. PMID: 32751171 Free PMC article. Review.
The NLR pyrin domain-containing protein 3 (NLRP3) has emerged as the most versatile and well-characterized inflammasome, consisting of an intracellular multi-protein complex that acts as a central driver of inflammation. Its activation depends on a tightly regulated two-st …
The NLR pyrin domain-containing protein 3 (NLRP3) has emerged as the most versatile and well-characterized inflammasome, consisting of an in …
Evaluation of the Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects of Withaferin A (WA) against Lipopolysaccharide (LPS)-Induced Inflammation in Immune Cells Derived from BALB/c Mice.
Alnuqaydan AM, Almutary A, Bhat GR, Mir TA, Wani SI, Rather MY, Mir SA, Alshehri B, Alnasser S, Ali Zainy FM, Rah B. Alnuqaydan AM, et al. Pharmaceutics. 2022 Jun 13;14(6):1256. doi: 10.3390/pharmaceutics14061256. Pharmaceutics. 2022. PMID: 35745829 Free PMC article.
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation activities with re …
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of vari …
110 results