Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach.
Murugan R, Rajesh R, Seenivasan B, Haridevamuthu B, Sudhakaran G, Guru A, Rajagopal R, Kuppusamy P, Juliet A, Gopinath P, Arockiaraj J.
Murugan R, et al.
Microb Pathog. 2022 Nov;172:105778. doi: 10.1016/j.micpath.2022.105778. Epub 2022 Sep 15.
Microb Pathog. 2022.
PMID: 36116607
Withaferin A exhibits strong antibacterial activity against P. aeruginosa with a minimum inhibitory concentration of 60 muM and minimum bactericidal concentration of 80 muM. Results obtained from membrane stabilization assay and electron microscopic analysis showed that …
Withaferin A exhibits strong antibacterial activity against P. aeruginosa with a minimum inhibitory concentration of 60 muM and minim …