Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
2003 1
2006 1
2007 1
2008 2
2009 3
2010 5
2011 3
2012 3
2013 2
2014 5
2015 7
2016 9
2017 12
2018 9
2019 13
2020 10
2021 10
2022 9
2023 6

Text availability

Article attribute

Article type

Publication date

Search Results

96 results

Results by year

Filters applied: . Clear all
Page 1
Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects.
Mandlik Ingawale DS, Namdeo AG. Mandlik Ingawale DS, et al. J Diet Suppl. 2021;18(2):183-226. doi: 10.1080/19390211.2020.1741484. Epub 2020 Apr 3. J Diet Suppl. 2021. PMID: 32242751 Review.
Furthermore, W. somnifera has revealed the capability to decrease reactive oxygen species and inflammation, modulation of mitochondrial function, apoptosis regulation and improve endothelial function. Withaferin-A is an important phytoconstituents of W. somnifera be …
Furthermore, W. somnifera has revealed the capability to decrease reactive oxygen species and inflammation, modulation of mitochondri …
Tackling Chronic Inflammation with Withanolide Phytochemicals-A Withaferin a Perspective.
Logie E, Vanden Berghe W. Logie E, et al. Antioxidants (Basel). 2020 Nov 10;9(11):1107. doi: 10.3390/antiox9111107. Antioxidants (Basel). 2020. PMID: 33182809 Free PMC article. Review.
Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades. In this context, Withaferin A (WA), a natural bioactive compound isolated from Withania somnifera, has been identified as a promisi …
Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades …
Pharmacologic overview of Withania somnifera, the Indian Ginseng.
Dar NJ, Hamid A, Ahmad M. Dar NJ, et al. Cell Mol Life Sci. 2015 Dec;72(23):4445-60. doi: 10.1007/s00018-015-2012-1. Epub 2015 Aug 26. Cell Mol Life Sci. 2015. PMID: 26306935 Review.
Additionally, it has demonstrated the ability to reduce reactive oxygen species, modulate mitochondrial function, regulate apoptosis, and reduce inflammation and enhance endothelial function. In view of these pharmacologic properties, W. somnifera is a potential drug candi …
Additionally, it has demonstrated the ability to reduce reactive oxygen species, modulate mitochondrial function, regulate apoptosis, and re …
Withaferin A attenuates ovalbumin induced airway inflammation.
Zhao HM, Gao ZW, Xie SX, Han X, Sun QS. Zhao HM, et al. Front Biosci (Landmark Ed). 2019 Jan 1;24(3):576-596. doi: 10.2741/4737. Front Biosci (Landmark Ed). 2019. PMID: 30468675 Free article.
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) is a natural phytochemical isolated from the plant Withania somnifera. ...The results indicate that WA may be an effective novel candidate for the treatment of air …
The molecular mechanism of how airway inflammation develops is not fully understood. Withaferin A (WA) is a natural phytochemi …
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.
Ferrero-Andrés A, Panisello-Roselló A, Roselló-Catafau J, Folch-Puy E. Ferrero-Andrés A, et al. Int J Mol Sci. 2020 Jul 29;21(15):5386. doi: 10.3390/ijms21155386. Int J Mol Sci. 2020. PMID: 32751171 Free PMC article. Review.
The NLR pyrin domain-containing protein 3 (NLRP3) has emerged as the most versatile and well-characterized inflammasome, consisting of an intracellular multi-protein complex that acts as a central driver of inflammation. Its activation depends on a tightly regulated two-st …
The NLR pyrin domain-containing protein 3 (NLRP3) has emerged as the most versatile and well-characterized inflammasome, consisting of an in …
Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction.
Chen CM, Chung YP, Liu CH, Huang KT, Guan SS, Chiang CK, Wu CT, Liu SH. Chen CM, et al. Phytomedicine. 2020 Dec;79:153352. doi: 10.1016/j.phymed.2020.153352. Epub 2020 Sep 21. Phytomedicine. 2020. PMID: 33007732
The protein levels of endoplasmic reticulum (ER) stress-associated molecules (GRP78, GRP94, ATF4, CHOP, phosphorylated eIF2alpha, and cleaved caspase 12) were increased in the kidneys of UUO mice, which could be significantly reversed by withaferin A treatment. CONCLUSION: …
The protein levels of endoplasmic reticulum (ER) stress-associated molecules (GRP78, GRP94, ATF4, CHOP, phosphorylated eIF2alpha, and cleave …
Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach.
Murugan R, Rajesh R, Seenivasan B, Haridevamuthu B, Sudhakaran G, Guru A, Rajagopal R, Kuppusamy P, Juliet A, Gopinath P, Arockiaraj J. Murugan R, et al. Microb Pathog. 2022 Nov;172:105778. doi: 10.1016/j.micpath.2022.105778. Epub 2022 Sep 15. Microb Pathog. 2022. PMID: 36116607
Withaferin A exhibits strong antibacterial activity against P. aeruginosa with a minimum inhibitory concentration of 60 muM and minimum bactericidal concentration of 80 muM. Results obtained from membrane stabilization assay and electron microscopic analysis showed that …
Withaferin A exhibits strong antibacterial activity against P. aeruginosa with a minimum inhibitory concentration of 60 muM and minim …
Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights.
Xia Y, Yan M, Wang P, Hamada K, Yan N, Hao H, Gonzalez FJ, Yan T. Xia Y, et al. Drug Metab Dispos. 2022 May;50(5):685-693. doi: 10.1124/dmd.121.000455. Epub 2021 Dec 13. Drug Metab Dispos. 2022. PMID: 34903587 Free PMC article. Review.
Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and elsewhere. ...SIGNIFICANCE STATEMENT: This review outlines the current experimental progress of Withaferin A (WA) hepatoprotective activities and highlights gaps in the field. …
Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and elsewhere. ...SIGNIFICANCE STATEMENT: This …
Evaluation of the Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects of Withaferin A (WA) against Lipopolysaccharide (LPS)-Induced Inflammation in Immune Cells Derived from BALB/c Mice.
Alnuqaydan AM, Almutary A, Bhat GR, Mir TA, Wani SI, Rather MY, Mir SA, Alshehri B, Alnasser S, Ali Zainy FM, Rah B. Alnuqaydan AM, et al. Pharmaceutics. 2022 Jun 13;14(6):1256. doi: 10.3390/pharmaceutics14061256. Pharmaceutics. 2022. PMID: 35745829 Free PMC article.
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation activities with re …
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of vari …
Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug.
Hassannia B, Logie E, Vandenabeele P, Vanden Berghe T, Vanden Berghe W. Hassannia B, et al. Biochem Pharmacol. 2020 Mar;173:113602. doi: 10.1016/j.bcp.2019.08.004. Epub 2019 Aug 9. Biochem Pharmacol. 2020. PMID: 31404528 Review.
Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in traditional Ayurvedic and Unani folk medicine) have identified Withaferin A (WA) as the most bioactive compound for treatment of inflammatory …
Reverse pharmacology approaches of Withania somnifera leaves and roots (alternatively also called Ashwagandha or Indian ginseng in tradition …
96 results