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Novel Combination of Choline with Withania somnifera (L.) Dunal, and Bacopa monnieri (L.) Wetts Reduced Oxidative Stress in Microglia Cells, Promoting Neuroprotection.
Borgonetti V, Galeotti N. Borgonetti V, et al. Int J Mol Sci. 2023 Sep 13;24(18):14038. doi: 10.3390/ijms241814038. Int J Mol Sci. 2023. PMID: 37762339 Free PMC article.
Withania somnifera (L.) Dunal (WS) and Bacopa monnieri (L.) Wettst (BM), are traditional herbal medicinal products used for the temporary relief of symptoms of stress. ...In conclusion, combining choline with adaptogen plant extracts might represent a promising interventio …
Withania somnifera (L.) Dunal (WS) and Bacopa monnieri (L.) Wettst (BM), are traditional herbal medicinal products used for the tempo …
Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation.
Gupta M, Kaur G. Gupta M, et al. Neuromolecular Med. 2018 Sep;20(3):343-362. doi: 10.1007/s12017-018-8497-7. Epub 2018 May 30. Neuromolecular Med. 2018. PMID: 29846872
Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. In Ayurveda, Ashwagandha (Withania somnifera) is well known for its immunomodulatory properties. ...
Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. In Ayurve …
Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation.
Gupta M, Kaur G. Gupta M, et al. BMC Complement Altern Med. 2019 Aug 15;19(1):217. doi: 10.1186/s12906-019-2635-0. BMC Complement Altern Med. 2019. PMID: 31416451 Free PMC article.
Therefore, in this contemporary study, the neuroprotective activity of Ashwagandha (Withania somnifera) was elucidated against the inflammation associated neurodegeneration and cognitive impairments induced by systemic LPS administration using in vivo rat model system. ...
Therefore, in this contemporary study, the neuroprotective activity of Ashwagandha (Withania somnifera) was elucidated against the in …
Anti oxidative/neuro-inflammation properties of Withania somnifera root extract on rotenone induced stress in rat brain.
Epuri V, Prathap L, Reddy V, Krishnan M. Epuri V, et al. Bioinformation. 2023 Jun 30;19(6):729-738. doi: 10.6026/97320630019729. eCollection 2023. Bioinformation. 2023. PMID: 37885788 Free PMC article.
Parkinson's disease (PD) pathology results in the degeneration of dopaminergic (DAergic) neurons by accumulating lewy bodies, alpha-synuclein (-syn), lowering anti-oxidants, increasing neuronal inflammation, and altering neuron shape. A well-researched natural substance called …
Parkinson's disease (PD) pathology results in the degeneration of dopaminergic (DAergic) neurons by accumulating lewy bodies, alpha-synuclei …
Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study.
Gupta M, Kaur G. Gupta M, et al. J Neuroinflammation. 2016 Aug 22;13(1):193. doi: 10.1186/s12974-016-0650-3. J Neuroinflammation. 2016. PMID: 27550017 Free PMC article.
RESULTS: ASH-WEX and FIV pretreatment was seen to suppress the proliferation of activated microglia by causing cell cycle arrest at Go/G1 and G2/M phase along with decrease in cell cycle regulatory protein expression such as PCNA and Cyclin D1. ...ASH-WEX and FIV also rest …
RESULTS: ASH-WEX and FIV pretreatment was seen to suppress the proliferation of activated microglia by causing cell cycle arrest at G …
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.
Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V. Sehgal N, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3510-5. doi: 10.1073/pnas.1112209109. Epub 2012 Jan 30. Proc Natl Acad Sci U S A. 2012. PMID: 22308347 Free PMC article.
A 30-d course of oral administration of a semipurified extract of the root of Withania somnifera consisting predominantly of withanolides and withanosides reversed behavioral deficits, plaque pathology, accumulation of beta-amyloid peptides (Abeta) and oligomers in the bra …
A 30-d course of oral administration of a semipurified extract of the root of Withania somnifera consisting predominantly of withanol …
Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells.
Sun GY, Li R, Cui J, Hannink M, Gu Z, Fritsche KL, Lubahn DB, Simonyi A. Sun GY, et al. Neuromolecular Med. 2016 Sep;18(3):241-52. doi: 10.1007/s12017-016-8411-0. Epub 2016 May 21. Neuromolecular Med. 2016. PMID: 27209361
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. ...
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of …
Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
Dutta K, Patel P, Rahimian R, Phaneuf D, Julien JP. Dutta K, et al. Neurotherapeutics. 2017 Apr;14(2):447-462. doi: 10.1007/s13311-016-0499-2. Neurotherapeutics. 2017. PMID: 27928708 Free PMC article.
Our previous work suggested that nuclear factor kappa B (NF-kappaB) may constitute a therapeutic target for TDP-43-mediated disease. Here, we investigated the effects of root extract of Withania somnifera (Ashwagandha), an herbal medicine with anti-inflammatory properties, …
Our previous work suggested that nuclear factor kappa B (NF-kappaB) may constitute a therapeutic target for TDP-43-mediated disease. Here, w …
Withanolide-A treatment exerts a neuroprotective effect via inhibiting neuroinflammation in the hippocampus after pilocarpine-induced status epilepticus.
Zhu J, Park S, Jeong KH, Kim WJ. Zhu J, et al. Epilepsy Res. 2020 Sep;165:106394. doi: 10.1016/j.eplepsyres.2020.106394. Epub 2020 Jun 10. Epilepsy Res. 2020. PMID: 32540785
Given that effective treatments for the pathophysiology following SE are still lacking, suppressing pathophysiological mechanisms of SE may be important to inhibit epileptogenesis. Withanolide-A (WA), a major bioactive component of Withania somnifera, is a potential medici …
Given that effective treatments for the pathophysiology following SE are still lacking, suppressing pathophysiological mechanisms of SE may …
Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach.
Narayan M, Seeley KW, Jinwal UK. Narayan M, et al. J Ethnopharmacol. 2015 Dec 4;175:86-92. doi: 10.1016/j.jep.2015.09.024. Epub 2015 Sep 24. J Ethnopharmacol. 2015. PMID: 26392330
ETHNOPHARMACOLOGICAL RELEVANCE: Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as "Ashwagandha". A number of published reports suggest various uses for WA including its function as an anti-inflammatory …
ETHNOPHARMACOLOGICAL RELEVANCE: Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera …
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