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Page 1
Did you mean gobble (95 results)?
Celebrating wobble decoding: Half a century and still much is new.
Agris PF, Eruysal ER, Narendran A, Väre VYP, Vangaveti S, Ranganathan SV. Agris PF, et al. RNA Biol. 2018;15(4-5):537-553. doi: 10.1080/15476286.2017.1356562. Epub 2017 Sep 21. RNA Biol. 2018. PMID: 28812932 Free PMC article. Review.
A simple post-transcriptional modification of tRNA, deamination of adenosine to inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble Hypothesis 50 years ago. ...Their contribution with regards to chemistry, structure and dynami …
A simple post-transcriptional modification of tRNA, deamination of adenosine to inosine at the first, or wobble, position of the anti …
Wobble uridine modifications-a reason to live, a reason to die?!
Schaffrath R, Leidel SA. Schaffrath R, et al. RNA Biol. 2017 Sep 2;14(9):1209-1222. doi: 10.1080/15476286.2017.1295204. Epub 2017 Feb 23. RNA Biol. 2017. PMID: 28277930 Free PMC article. Review.
Wobble uridines (U(34)) are generally modified in all species. U(34) modifications can be essential in metazoans but are not required for viability in fungi. ...We highlight the activity of anticodon specific RNases that target U(34) containing tRNA. Finally, we discuss ho …
Wobble uridines (U(34)) are generally modified in all species. U(34) modifications can be essential in metazoans but are not required …
Anticodon Wobble Uridine Modification by Elongator at the Crossroad of Cell Signaling, Differentiation, and Diseases.
Hermand D. Hermand D. Epigenomes. 2020 May 12;4(2):7. doi: 10.3390/epigenomes4020007. Epigenomes. 2020. PMID: 34968241 Free PMC article. Review.
First identified 20 years ago as an RNA polymerase II-associated putative histone acetyltransferase, the conserved Elongator complex has since been recognized as the central player of a complex, regulated, and biologically relevant epitranscriptomic pathway targeting the wobbl …
First identified 20 years ago as an RNA polymerase II-associated putative histone acetyltransferase, the conserved Elongator complex has sin …
"Superwobbling" and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code.
Lei L, Burton ZF. Lei L, et al. Life (Basel). 2022 Feb 8;12(2):252. doi: 10.3390/life12020252. Life (Basel). 2022. PMID: 35207539 Free PMC article. Review.
The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code. We posit that EF-Tu, the closing mechanism of the 30S ribosomal subunit, methylation of wobble U34 at t …
The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modificat …
Wobble board instability enhances proactive postural control.
Kelty-Stephen DG, Deligiannis T, Fujimoto Y, Kiyono K, Mangalam M. Kelty-Stephen DG, et al. Chaos Solitons Fractals. 2025 Nov;200(Pt 1):116924. doi: 10.1016/j.chaos.2025.116924. Epub 2025 Aug 5. Chaos Solitons Fractals. 2025. PMID: 42639495 Free PMC article.
We tested 48 healthy young adults standing on a wobble board, inducing mediolateral (ML) instability, to examine how wobble board training influences multijoint coordination. ...So, wobble board training promotes robust postural control strategies, shifting c …
We tested 48 healthy young adults standing on a wobble board, inducing mediolateral (ML) instability, to examine how wobble bo …
tRNA's wobble decoding of the genome: 40 years of modification.
Agris PF, Vendeix FA, Graham WD. Agris PF, et al. J Mol Biol. 2007 Feb 9;366(1):1-13. doi: 10.1016/j.jmb.2006.11.046. Epub 2006 Nov 15. J Mol Biol. 2007. PMID: 17187822 Review.
The ambiguity of that recognition resided in the third base-pair, giving rise to the Wobble Hypothesis. Post-transcriptional modifications at tRNA's wobble position 34, especially modifications of uridine 34, enable wobble to occur. The Modified Wobble …
The ambiguity of that recognition resided in the third base-pair, giving rise to the Wobble Hypothesis. Post-transcriptional modifica …
Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand.
Giguère S, Wang X, Huber S, Xu L, Warner J, Weldon SR, Hu J, Phan QA, Tumang K, Prum T, Ma D, Kirsch KH, Nair U, Dedon P, Batista FD. Giguère S, et al. Science. 2024 Jan 12;383(6679):205-211. doi: 10.1126/science.adi1763. Epub 2024 Jan 11. Science. 2024. PMID: 38207021 Free PMC article.
One feature thereof is the hyperutilization of codons that lack genome-encoded Watson-Crick transfer RNAs (tRNAs), instead relying on the posttranscriptional tRNA modification inosine (I34), which expands the decoding capacity of specific tRNAs through wobbling. Antibody-s …
One feature thereof is the hyperutilization of codons that lack genome-encoded Watson-Crick transfer RNAs (tRNAs), instead relying on the po …
Why Do We Need Wobble Rooms during COVID-19?
Gurney L, Lockington J, Quinn L, MacPhee M. Gurney L, et al. Nurs Leadersh (Tor Ont). 2020 Dec;33(4):45-50. doi: 10.12927/cjnl.2021.26421. Nurs Leadersh (Tor Ont). 2020. PMID: 33616525
The "wobble room" is a wellness intervention designed to guide staff through unpredictable times that are not going away quickly. Emergency department teams are accustomed to trauma events and trauma debriefing, but the prolonged uncertainties and fears associated with COV …
The "wobble room" is a wellness intervention designed to guide staff through unpredictable times that are not going away quickly. Eme …
Crick Wobble and Superwobble in Standard Genetic Code Evolution.
Yarus M. Yarus M. J Mol Evol. 2021 Feb;89(1-2):50-61. doi: 10.1007/s00239-020-09985-7. Epub 2021 Jan 7. J Mol Evol. 2021. PMID: 33409542 Free PMC article.
In contrast, late-arising superwobble shares late Crick wobble's frequent resemblance to SGC order. Thus late superwobble is possible, but yields SGC-like assignments less frequently than late Crick wobble. Ancient coding ambiguity, most simply, arose from Crick …
In contrast, late-arising superwobble shares late Crick wobble's frequent resemblance to SGC order. Thus late superwobble is possible …
Elongator, a conserved complex required for wobble uridine modifications in eukaryotes.
Karlsborn T, Tükenmez H, Mahmud AK, Xu F, Xu H, Byström AS. Karlsborn T, et al. RNA Biol. 2014;11(12):1519-28. doi: 10.4161/15476286.2014.992276. RNA Biol. 2014. PMID: 25607684 Free PMC article. Review.
However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the …
However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbo …
3,049 results