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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
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717 results

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Page 1
The G x U wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems.
Varani G, McClain WH. Varani G, et al. EMBO Rep. 2000 Jul;1(1):18-23. doi: 10.1093/embo-reports/kvd001. EMBO Rep. 2000. PMID: 11256617 Free PMC article. Review.
The G x U wobble base pair is a fundamental unit of RNA secondary structure that is present in nearly every class of RNA from organisms of all three phylogenetic domains. ...The G x U wobble base pair also has unique chemical, structural, …
The G x U wobble base pair is a fundamental unit of RNA secondary structure that is present in nearly every class of RN …
Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA.
Reautschnig P, Fruhner C, Wahn N, Wiegand CP, Kragness S, Yung JF, Hofacker DT, Fisk J, Eidelman M, Waffenschmidt N, Feige M, Pfeiffer LS, Schulz AE, Füll Y, Levanon EY, Mandel G, Stafforst T. Reautschnig P, et al. Nat Biotechnol. 2025 Apr;43(4):545-557. doi: 10.1038/s41587-024-02313-0. Epub 2024 Jul 12. Nat Biotechnol. 2025. PMID: 38997581 Free PMC article.
Here, we find that in 5'-UAN triplets, which dominate bystander editing, G U wobble base pairs effectively mitigate off-target events while maintaining high on-target efficiency. ...Combining wobble base pairing with a circularized format of the …
Here, we find that in 5'-UAN triplets, which dominate bystander editing, G U wobble base pairs effectively mitigate off-target …
Structure of a purine-purine wobble base pair in the decoding center of the ribosome.
Murphy FV 4th, Ramakrishnan V. Murphy FV 4th, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1251-2. doi: 10.1038/nsmb866. Epub 2004 Nov 21. Nat Struct Mol Biol. 2004. PMID: 15558050
Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures en …
Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearl …
Role of wobble base pair geometry for codon degeneracy: purine-type bases at the anticodon wobble position.
Das G, Lyngdoh RH. Das G, et al. J Mol Model. 2012 Aug;18(8):3805-20. doi: 10.1007/s00894-012-1385-4. Epub 2012 Mar 8. J Mol Model. 2012. PMID: 22399149
Codon degeneracy is a key feature of the genetic code, explained by Crick (J Mol Biol 19:548-555, 1966) in terms of imprecision of base pairing at the codon third position (the wobble position) of the codon-anticodon duplex. ...The exclusion of adenine from t …
Codon degeneracy is a key feature of the genetic code, explained by Crick (J Mol Biol 19:548-555, 1966) in terms of imprecision of base …
RNA architecture influences plant biology.
Zhu J, Li C, Peng X, Zhang X. Zhu J, et al. J Exp Bot. 2021 May 18;72(11):4144-4160. doi: 10.1093/jxb/erab030. J Exp Bot. 2021. PMID: 33484251 Free PMC article. Review.
RNA transcripts can form astonishing arrays of secondary and tertiary structures via Watson-Crick, Hoogsteen, or wobble base pairing. In vivo, RNA folding is not a simple thermodynamic event of minimizing free energy. ...
RNA transcripts can form astonishing arrays of secondary and tertiary structures via Watson-Crick, Hoogsteen, or wobble base …
Electron Attachment to Wobble Base Pairs.
Narayanan S J J, Bachhar A, Tripathi D, Dutta AK. Narayanan S J J, et al. J Phys Chem A. 2023 Jan 19;127(2):457-467. doi: 10.1021/acs.jpca.2c07469. J Phys Chem A. 2023. PMID: 36622294
We have analyzed the low-energy electron attachment to wobble base pairs using the equation of motion coupled cluster method and extended basis sets. ...The formation of the valence-bound anion is associated with proton transfer in hypoxanthine-cytosine and hypoxant …
We have analyzed the low-energy electron attachment to wobble base pairs using the equation of motion coupled cluster method a …
An innate twist between Crick's wobble and Watson-Crick base pairs.
Ananth P, Goldsmith G, Yathindra N. Ananth P, et al. RNA. 2013 Aug;19(8):1038-53. doi: 10.1261/rna.036905.112. RNA. 2013. PMID: 23861536 Free PMC article. Review.
Non-Watson-Crick pairs like the G.U wobble are frequent in RNA duplexes. Their geometric dissimilarity (nonisostericity) with the Watson-Crick base pairs and among themselves imparts structural variations decisive for biological functions. Through a novel circular r …
Non-Watson-Crick pairs like the G.U wobble are frequent in RNA duplexes. Their geometric dissimilarity (nonisostericity) with the Wat …
O6-carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine.
Zhang F, Tsunoda M, Kikuchi Y, Wilkinson O, Millington CL, Margison GP, Williams DM, Takénaka A. Zhang F, et al. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1669-79. doi: 10.1107/S1399004714006178. Epub 2014 May 30. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24914978
Previously, the crystal structure of the DNA dodecamer d(CGCG[O(6)-CMG]ATTCGCG) has been reported, in which O(6)-CMG forms a Watson-Crick-type pair with thymine similar to the canonical A:T pair. In order to further investigate the versatility of O(6)-CMG in base …
Previously, the crystal structure of the DNA dodecamer d(CGCG[O(6)-CMG]ATTCGCG) has been reported, in which O(6)-CMG forms a Watson-Crick-ty …
The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.
Strobel SA, Cech TR, Usman N, Beigelman L. Strobel SA, et al. Biochemistry. 1994 Nov 22;33(46):13824-35. doi: 10.1021/bi00250a037. Biochemistry. 1994. PMID: 7524665
The DAP.MeiC pair at the end of an RNA duplex is as stable as a G.U pair, consistent with formation of a wobble base pair with two hydrogen bonds. ...These pairs present a diversity of functional group substitutions in the context of a wobble …
The DAP.MeiC pair at the end of an RNA duplex is as stable as a G.U pair, consistent with formation of a wobble base …
717 results