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Year Number of Results
1997 2
1999 3
2000 6
2001 4
2002 2
2003 5
2004 7
2005 30
2006 15
2007 27
2008 24
2009 21
2010 31
2011 28
2012 38
2013 40
2014 26
2015 33
2016 31
2017 46
2018 52
2019 54
2020 46
2021 47
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537 results
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Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3beta-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injur …
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activat …
Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis.
Yuan J, Peng G, Xiao G, Yang Z, Huang J, Liu Q, Yang Z, Liu D. Yuan J, et al. J Cancer. 2020 Apr 6;11(14):4047-4058. doi: 10.7150/jca.33045. eCollection 2020. J Cancer. 2020. PMID: 32368287 Free PMC article.
We demonstrated that down-regulation of c-Myc was required for xanthohumol-induced decrease of HK2. Xanthohumol destabilization of c-Myc, and promoted FBW7-mediated ubiquitination of c-Myc. ...Finally, the animal results demonstrated that xanthohumol substant …
We demonstrated that down-regulation of c-Myc was required for xanthohumol-induced decrease of HK2. Xanthohumol destabilizatio …
Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo.
Yin S, Song M, Zhao R, Liu X, Kang WK, Lee JM, Kim YE, Zhang C, Shim JH, Liu K, Dong Z, Lee MH. Yin S, et al. Front Cell Dev Biol. 2020 May 19;8:366. doi: 10.3389/fcell.2020.00366. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32509787 Free PMC article.
Using xanthohumol-sepharose conjugated bead pull-down and mass/mass analysis, we found that KRT18 is a novel target of xanthohumol in KYSE30 cells. ...Overall these results suggest that xanthohumol acts as a KRT18 regulator to suppress the growth of ESCC....
Using xanthohumol-sepharose conjugated bead pull-down and mass/mass analysis, we found that KRT18 is a novel target of xanthohumol
Xanthohumol, an active constituent from hope, affords protection against kainic acid-induced excitotoxicity in rats.
Wang CC, Ho YH, Hung CF, Kuo JR, Wang SJ. Wang CC, et al. Neurochem Int. 2020 Feb;133:104629. doi: 10.1016/j.neuint.2019.104629. Epub 2019 Dec 6. Neurochem Int. 2020. PMID: 31816340
However, it is unknown whether xanthohumol has protective effects against glutamate-induced excitotoxicity. ...The decrease of mitochondrial fusion protein Mfn-2 and antiapoptotic protein Bcl-2 expression in hippocampal tissues following KA injection were reversed by xa
However, it is unknown whether xanthohumol has protective effects against glutamate-induced excitotoxicity. ...The decrease of mitoch …
Xanthohumol microbiome and signature in healthy adults (the XMaS trial): a phase I triple-masked, placebo-controlled clinical trial.
Bradley R, Langley BO, Ryan JJ, Phipps J, Hanes DA, Stack E, Jansson JK, Metz TO, Stevens JF. Bradley R, et al. Trials. 2020 Oct 7;21(1):835. doi: 10.1186/s13063-020-04769-2. Trials. 2020. PMID: 33028396 Free PMC article. Clinical Trial.
The main objective is to examine the clinical safety and subjective tolerability of xanthohumol in healthy adults compared to placebo. Additional aims are to monitor biomarkers related to inflammation, gut permeability, bile acid metabolism, routes, and in vivo products of …
The main objective is to examine the clinical safety and subjective tolerability of xanthohumol in healthy adults compared to placebo …
Xanthohumol protects against Azoxymethane-induced colorectal cancer in Sprague-Dawley rats.
Liu H, Zhang L, Li G, Gao Z. Liu H, et al. Environ Toxicol. 2020 Feb;35(2):136-144. doi: 10.1002/tox.22849. Epub 2019 Nov 12. Environ Toxicol. 2020. PMID: 31714664
Dietary interventions together with modified dietary style can prevent the CRC in humans. Xanthohumol (XHA), a polyphenol isolated from Humulus lupulus L. contains many beneficial effects. ...
Dietary interventions together with modified dietary style can prevent the CRC in humans. Xanthohumol (XHA), a polyphenol isolated fr …
Xanthohumol Inhibits TGF-beta1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway.
Jiang C, Xie N, Sun T, Ma W, Zhang B, Li W. Jiang C, et al. Drug Des Devel Ther. 2020 Dec 7;14:5431-5439. doi: 10.2147/DDDT.S282206. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 33324040 Free PMC article.
BACKGROUND: Xanthohumol (Xn) is the most abundant prenylated flavonoid in Hops (Humulus lupulus L.), and exhibits a range of pharmacological activities. ...
BACKGROUND: Xanthohumol (Xn) is the most abundant prenylated flavonoid in Hops (Humulus lupulus L.), and exhibits a range of pharmaco …
Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke.
Jiao Y, Cao Y, Lu X, Wang J, Saitgareeva A, Kong X, Song C, Li J, Tian K, Zhang S, Bai M, Li S, Zhang H, Wang L. Jiao Y, et al. Mol Biol Rep. 2020 Apr;47(4):2417-2425. doi: 10.1007/s11033-019-05128-4. Epub 2020 Feb 27. Mol Biol Rep. 2020. PMID: 32108303
Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid extracted from hops, has been reported to have potential function as an antioxidant and can be used for neuro protection. ...
Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid e …
Xanthohumol regulates miR-4749-5p-inhibited RFC2 signaling in enhancing temozolomide cytotoxicity to glioblastoma.
Ho KH, Kuo TC, Lee YT, Chen PH, Shih CM, Cheng CH, Liu AJ, Lee CC, Chen KC. Ho KH, et al. Life Sci. 2020 Aug 1;254:117807. doi: 10.1016/j.lfs.2020.117807. Epub 2020 May 16. Life Sci. 2020. PMID: 32422304
AIMS: Xanthohumol (XN), a natural prenylated flavonoid isolated from Humulus lupulus L. ...
AIMS: Xanthohumol (XN), a natural prenylated flavonoid isolated from Humulus lupulus L. ...
Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-kappaB and activating Nrf2 signaling pathways.
Li F, Yao Y, Huang H, Hao H, Ying M. Li F, et al. Int Immunopharmacol. 2018 Aug;61:277-282. doi: 10.1016/j.intimp.2018.05.017. Epub 2018 Jun 12. Int Immunopharmacol. 2018. PMID: 29906742
The levels of TNF-alpha, IL-1ss and IL-6 in kidney tissues were suppressed by xanthohumol. The levels of malondialdehyde (MDA) and ROS were suppressed by treatment of xanthohumol. ...The expression of Nrf2 and HO-1 were dose-dependently up-regulated by the treatment …
The levels of TNF-alpha, IL-1ss and IL-6 in kidney tissues were suppressed by xanthohumol. The levels of malondialdehyde (MDA) and RO …
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