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Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.
Samuels JS, Shashidharamurthy R, Rayalam S. Samuels JS, et al. Nutr Metab (Lond). 2018 Jun 15;15:42. doi: 10.1186/s12986-018-0277-8. eCollection 2018. Nutr Metab (Lond). 2018. PMID: 29946343 Free PMC article.
CONCLUSIONS: Taken together, XN demonstrates anti-obesity effects by not only inducing beiging but also decreasing adipogenesis and inducing lipolysis. The anti-obesity effects of XN are partly mediated by AMPK signaling pathway suggesting that XN may …
CONCLUSIONS: Taken together, XN demonstrates anti-obesity effects by not only inducing beiging but also decreasing adipogenesi …
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q. Sun W, et al. Heliyon. 2023 Oct 27;9(11):e21282. doi: 10.1016/j.heliyon.2023.e21282. eCollection 2023 Nov. Heliyon. 2023. PMID: 37964828 Free PMC article.
Obesity has been linked to OA, and increased free fatty acid levels (e.g., palmitate) contribute to inflammatory responses and cartilage degradation. Xanthohumol (Xn), a bioactive prenylated chalcone, was shown to exhibit antioxidative, anti-inflammatory, and anti- …
Obesity has been linked to OA, and increased free fatty acid levels (e.g., palmitate) contribute to inflammatory responses and cartilage deg …
Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity.
Borah AK, Sharma P, Singh A, Kalita KJ, Saha S, Chandra Borah J. Borah AK, et al. J Ethnopharmacol. 2021 Nov 15;280:114410. doi: 10.1016/j.jep.2021.114410. Epub 2021 Jul 15. J Ethnopharmacol. 2021. PMID: 34273447 Review.
They have been affirmed as potential anti-obesity drugs of future because of their effectiveness yet having no threat to adipose or systemic insulin sensitivity. ...This review has been able to generate fresh perspectives on the anti-diabetic/anti-hyperglycemic/a …
They have been affirmed as potential anti-obesity drugs of future because of their effectiveness yet having no threat to adipo …
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF. Kirkwood JS, et al. J Biol Chem. 2013 Jun 28;288(26):19000-13. doi: 10.1074/jbc.M112.445452. Epub 2013 May 14. J Biol Chem. 2013. PMID: 23673658 Free PMC article.
Here we describe a metabolomics-driven effort to uncover the anti-obesity mechanism(s) of xanthohumol (XN), a prenylated flavonoid from hops. Metabolomics analysis of fasting plasma from obese, Zucker rats treated with XN revealed decreases in products of dys …
Here we describe a metabolomics-driven effort to uncover the anti-obesity mechanism(s) of xanthohumol (XN), a prenylate …
Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.
Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. Rayalam S, et al. J Med Food. 2009 Aug;12(4):846-53. doi: 10.1089/jmf.2008.0158. J Med Food. 2009. PMID: 19735186
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. ...Thus, combination of XN and GS is more potent in exerting anti-obesity effects than additive effects of the individual compounds....
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. ...Thus, com …
Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.
Karimi-Sales E, Mohaddes G, Alipour MR. Karimi-Sales E, et al. Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Pharmacol Res. 2018. PMID: 29175112 Review.
These compounds have many beneficial properties including anti-inflammatory, anti-microbial, antioxidant, anti-cancer, anti-amyloid, anti-diabetic, anti-obesity, hypolipidemic, and cytoprotective. Chalcone derivatives have protective effects on the liver in nonalcoh …
These compounds have many beneficial properties including anti-inflammatory, anti-microbial, antioxidant, anti-cancer, anti-amyloid, anti-di …
Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo.
Yin S, Song M, Zhao R, Liu X, Kang WK, Lee JM, Kim YE, Zhang C, Shim JH, Liu K, Dong Z, Lee MH. Yin S, et al. Front Cell Dev Biol. 2020 May 19;8:366. doi: 10.3389/fcell.2020.00366. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32509787 Free PMC article.
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death worldwide. Xanthohumol is a prenylated flavonoid isolated from hops. Although xanthohumol has been reported to exert anti-obesity, hypoglycemic, anti-hyperlipidemia an …
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death worldwide. Xanthohumol is a prenylated flavonoid …
Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice.
Takahashi K, Osada K. Takahashi K, et al. J Oleo Sci. 2017 May 1;66(5):531-541. doi: 10.5650/jos.ess16234. Epub 2017 Apr 13. J Oleo Sci. 2017. PMID: 28413193 Free article.
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high-fat diet through regulation of fatty acid metabolism. In this study, we examined the effects of dietary purified xanthohum …
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in r …
Xanthohumol ameliorates dextran sodium sulfate-induced colitis in mice by inhibiting of NF-kappaB signaling pathways and modulating intestinal microbiota.
Han N, Li J, Li Y, Zhao F, Wang J, Ye P, Zeng Z. Han N, et al. Eur J Nutr. 2024 Nov 22;64(1):21. doi: 10.1007/s00394-024-03525-5. Eur J Nutr. 2024. PMID: 39576384
ETHNOPHARMACOLOGICAL RELEVANCE: Xanthohumol (XN), an isoprenylated flavonoid natural product found only in hops, possesses a variety of biological activities such as anticancer, anti-inflammatory, hepatoprotective, and anti-obesity. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Xanthohumol (XN), an isoprenylated flavonoid natural product found only in hops, possesses a variety …
Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes.
Kiyofuji A, Yui K, Takahashi K, Osada K. Kiyofuji A, et al. J Oleo Sci. 2014;63(6):593-7. doi: 10.5650/jos.ess14009. Epub 2014 May 15. J Oleo Sci. 2014. PMID: 24829131 Free article.
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on …
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In …
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