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Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo.
Yin S, Song M, Zhao R, Liu X, Kang WK, Lee JM, Kim YE, Zhang C, Shim JH, Liu K, Dong Z, Lee MH. Yin S, et al. Front Cell Dev Biol. 2020 May 19;8:366. doi: 10.3389/fcell.2020.00366. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32509787 Free PMC article.
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death worldwide. Xanthohumol is a prenylated flavonoid isolated from hops. Although xanthohumol has been reported to exert anti-obesity, hypoglycemic, anti-hyperlipid …
Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death worldwide. Xanthohumol is a prenylated flavonoid …
Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity.
Borah AK, Sharma P, Singh A, Kalita KJ, Saha S, Chandra Borah J. Borah AK, et al. J Ethnopharmacol. 2021 Nov 15;280:114410. doi: 10.1016/j.jep.2021.114410. Epub 2021 Jul 15. J Ethnopharmacol. 2021. PMID: 34273447 Review.
CONCLUSION: Due to high molecular diversity and a greater ratio of benefit to risk, plant derived compounds hold high therapeutic potential to tackle obesity and associated risks. This review has been able to generate fresh perspectives on the anti-diabetic/anti
CONCLUSION: Due to high molecular diversity and a greater ratio of benefit to risk, plant derived compounds hold high therapeutic potential …
Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.
Samuels JS, Shashidharamurthy R, Rayalam S. Samuels JS, et al. Nutr Metab (Lond). 2018 Jun 15;15:42. doi: 10.1186/s12986-018-0277-8. eCollection 2018. Nutr Metab (Lond). 2018. PMID: 29946343 Free PMC article.
Likewise, an XN-induced decrease in adipogenesis was reversed in the presence of dorsomorphin. CONCLUSIONS: Taken together, XN demonstrates anti-obesity effects by not only inducing beiging but also decreasing adipogenesis and inducing lipolysis. The anti- …
Likewise, an XN-induced decrease in adipogenesis was reversed in the presence of dorsomorphin. CONCLUSIONS: Taken together, XN demonstrates …
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF. Kirkwood JS, et al. J Biol Chem. 2013 Jun 28;288(26):19000-13. doi: 10.1074/jbc.M112.445452. Epub 2013 May 14. J Biol Chem. 2013. PMID: 23673658 Free PMC article.
Together, these strategies target energy imbalance and oxidative stress, both underlying factors of obesity and related conditions such as type 2 diabetes. Here we describe a metabolomics-driven effort to uncover the anti-obesity mechanism(s) of xanthohumo
Together, these strategies target energy imbalance and oxidative stress, both underlying factors of obesity and related conditions su …
Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.
Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. Rayalam S, et al. J Med Food. 2009 Aug;12(4):846-53. doi: 10.1089/jmf.2008.0158. J Med Food. 2009. PMID: 19735186
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. ...Finally, XN + GS caused an enhanced stimulation of lipolysis. Thus, combination of XN and GS is more potent in exerting anti-obesity ef
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. ...Finally,
Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.
Karimi-Sales E, Mohaddes G, Alipour MR. Karimi-Sales E, et al. Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Pharmacol Res. 2018. PMID: 29175112 Review.
Chalcones form an important group of natural compounds and flavonoid precursors which are abundant in fruits, vegetables, and edible plants. These compounds have many beneficial properties including anti-inflammatory, anti-microbial, antioxidant, anti-cancer, …
Chalcones form an important group of natural compounds and flavonoid precursors which are abundant in fruits, vegetables, and edible plants. …
Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice.
Takahashi K, Osada K. Takahashi K, et al. J Oleo Sci. 2017 May 1;66(5):531-541. doi: 10.5650/jos.ess16234. Epub 2017 Apr 13. J Oleo Sci. 2017. PMID: 28413193 Free article.
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high-fat diet through regulation of fatty acid metabolism. In this study, we examined the effects of dietary purified xanthohum
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in r …
Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes.
Kiyofuji A, Yui K, Takahashi K, Osada K. Kiyofuji A, et al. J Oleo Sci. 2014;63(6):593-7. doi: 10.5650/jos.ess14009. Epub 2014 May 15. J Oleo Sci. 2014. PMID: 24829131 Free article.
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In
Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.
Yui K, Kiyofuji A, Osada K. Yui K, et al. J Oleo Sci. 2014;63(2):159-68. doi: 10.5650/jos.ess13136. Epub 2014 Jan 14. J Oleo Sci. 2014. PMID: 24420065 Free article.
We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. ...The excreted of triacylglycerol into feces also was promoted by dietary xanthohumol-rich hop extract. Plasma adiponectin levels in the rats …
We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. ...The exc …