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Bioavailability and Cardiometabolic Effects of Xanthohumol: Evidence from Animal and Human Studies.
Neumann HF, Frank J, Venturelli S, Egert S. Neumann HF, et al. Mol Nutr Food Res. 2022 Mar;66(6):e2100831. doi: 10.1002/mnfr.202100831. Epub 2022 Jan 14. Mol Nutr Food Res. 2022. PMID: 34967501 Review.
In addition, it provides insights into the pharmacokinetics of xanthohumol intake. Animal studies show that xanthohumol exerts beneficial effects on body weight, lipid profile, glucose metabolism, and other biochemical parameters associated with metabolic syndrome a …
In addition, it provides insights into the pharmacokinetics of xanthohumol intake. Animal studies show that xanthohumol exerts …
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.
Sahoo DK, Heilmann RM, Paital B, Patel A, Yadav VK, Wong D, Jergens AE. Sahoo DK, et al. Front Endocrinol (Lausanne). 2023 Aug 28;14:1217165. doi: 10.3389/fendo.2023.1217165. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37701897 Free PMC article. Review.
Nuclear factor kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural …
Nuclear factor kappa B (NF-kappaB) and nuclear factor erythroid 2-related factor 2 (Nrf2) represent two important signaling pathways in inte …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3beta-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injur …
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activat …
Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells.
Torrens-Mas M, Alorda-Clara M, Martínez-Vigara M, Roca P, Sastre-Serra J, Oliver J, Pons DG. Torrens-Mas M, et al. Int J Food Sci Nutr. 2022 Jun;73(4):471-479. doi: 10.1080/09637486.2021.2012561. Epub 2021 Dec 8. Int J Food Sci Nutr. 2022. PMID: 34879764
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-cancer agent. ...Results showed no significant effects on cell viability and a general decrease in pro-inflammatory, antioxidant
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an
Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.
Meresman GF, Götte M, Laschke MW. Meresman GF, et al. Hum Reprod Update. 2021 Feb 19;27(2):367-392. doi: 10.1093/humupd/dmaa039. Hum Reprod Update. 2021. PMID: 33124671 Review.
The most studied specific plant-derived bioactive compounds are resveratrol, epigallocatechin-3-gallate, curcumin, puerarin, ginsenosides, xanthohumol, 4-hydroxybenzyl alcohol, quercetin, apigenin, carnosic acid, rosmarinic acid, wogonin, baicalein, parthenolide, andrograp …
The most studied specific plant-derived bioactive compounds are resveratrol, epigallocatechin-3-gallate, curcumin, puerarin, ginsenosides, …
Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury.
Hartkorn A, Hoffmann F, Ajamieh H, Vogel S, Heilmann J, Gerbes AL, Vollmar AM, Zahler S. Hartkorn A, et al. J Nat Prod. 2009 Oct;72(10):1741-7. doi: 10.1021/np900230p. J Nat Prod. 2009. PMID: 19757857 Free article.
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kappaB activ …
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a promin …
Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.
Harish V, Haque E, Śmiech M, Taniguchi H, Jamieson S, Tewari D, Bishayee A. Harish V, et al. Int J Mol Sci. 2021 Apr 25;22(9):4478. doi: 10.3390/ijms22094478. Int J Mol Sci. 2021. PMID: 33923053 Free PMC article. Review.
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflamm
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...XH is an import
Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster.
Wongchum N, Dechakhamphu A. Wongchum N, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Jun;244:108994. doi: 10.1016/j.cbpc.2021.108994. Epub 2021 Feb 4. Comp Biochem Physiol C Toxicol Pharmacol. 2021. PMID: 33549830
Drosophila or fruit fly is one of the most effective models for the evaluation of anti-aging compounds. Xanthohumol (XN) is a potential bioactive substance for the prevention and treatment of many diseases. The previous studies have reported its potent activities as ant
Drosophila or fruit fly is one of the most effective models for the evaluation of anti-aging compounds. Xanthohumol (XN) is a potenti …
Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers.
Teng Y, Li X, Yang K, Li X, Zhang Z, Wang L, Deng Z, Song B, Yan Z, Zhang Y, Lu K, Yu P. Teng Y, et al. Eur J Med Chem. 2017 Jan 5;125:335-345. doi: 10.1016/j.ejmech.2016.09.024. Epub 2016 Sep 13. Eur J Med Chem. 2017. PMID: 27688188
The structures of the eight new derivatives were confirmed using(1)H NMR, (13)C NMR and HRMS. The antioxidant activity of the new chalcone derivatives were evaluated in a PC12 cell model of H(2)O(2)-induced oxidative damage. The SAR studies suggested that the catechol moti …
The structures of the eight new derivatives were confirmed using(1)H NMR, (13)C NMR and HRMS. The antioxidant activity of the new cha …
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q. Sun W, et al. Heliyon. 2023 Oct 27;9(11):e21282. doi: 10.1016/j.heliyon.2023.e21282. eCollection 2023 Nov. Heliyon. 2023. PMID: 37964828 Free PMC article.
., palmitate) contribute to inflammatory responses and cartilage degradation. Xanthohumol (Xn), a bioactive prenylated chalcone, was shown to exhibit antioxidative, anti-inflammatory, and anti-obesity capacities in multiple diseases. ...
., palmitate) contribute to inflammatory responses and cartilage degradation. Xanthohumol (Xn), a bioactive prenylated chalcone, was …
168 results