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Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes-associated oxidative stress by downregulating galectin-3.
Luís C, Costa R, Rodrigues I, Castela Â, Coelho P, Guerreiro S, Gomes J, Reis C, Soares R. Luís C, et al. Porto Biomed J. 2018 Aug 8;4(1):e23. doi: 10.1016/j.pbj.0000000000000023. eCollection 2019 Jan-Feb. Porto Biomed J. 2018. PMID: 31595252 Free PMC article.
Because natural polyphenols are known to play antioxidant and anti-inflammatory roles and to modulate metabolic activity, we further evaluated the effect of xanthohumol and 8-prenylnaringenin polyphenols in this crosstalk. ...In conclusion, our results indicate that …
Because natural polyphenols are known to play antioxidant and anti-inflammatory roles and to modulate metabolic activity, we further …
Determination of Xanthohumol in Hops, Food Supplements and Beers by HPLC.
Vázquez Loureiro P, Hernández Jiménez I, Sendón R, Rodriguez-Bernaldo de Quirós A, Barbosa-Pereira L. Vázquez Loureiro P, et al. Foods. 2019 Sep 24;8(10):435. doi: 10.3390/foods8100435. Foods. 2019. PMID: 31554235 Free PMC article.
Xanthohumol (XN) is the main prenylated chalcone present in hops (Humulus lupulus) with high biological activity, and it is of great importance for human health because of its antioxidant, anti-inflammatory, immunosuppressive and chemopreventive properties. ...
Xanthohumol (XN) is the main prenylated chalcone present in hops (Humulus lupulus) with high biological activity, and it is of great
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Liu X, Song Z, Bai J, Nauwynck H, Zhao Y, Jiang P. Liu X, et al. Vet Res. 2019 Sep 11;50(1):61. doi: 10.1186/s13567-019-0679-2. Vet Res. 2019. PMID: 31506103 Free PMC article.
In this study, we first screened a library of 386 natural products and found that xanthohumol (Xn), a prenylated flavonoid found in hops, displayed high anti-PRRSV activity by inhibiting PRRSV adsorption onto and internalization into cells. Transcriptome sequencing reveale …
In this study, we first screened a library of 386 natural products and found that xanthohumol (Xn), a prenylated flavonoid found in h …
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
Chen CY, Kao CL, Liu CM. Chen CY, et al. Int J Mol Sci. 2018 Sep 12;19(9):2729. doi: 10.3390/ijms19092729. Int J Mol Sci. 2018. PMID: 30213077 Free PMC article. Review.
Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid phenethyl ester, xanthohumol, genistein, berberine, and sulforaphane can inhibit TLR4 activation. ...
Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid p …
Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury.
Hartkorn A, Hoffmann F, Ajamieh H, Vogel S, Heilmann J, Gerbes AL, Vollmar AM, Zahler S. Hartkorn A, et al. J Nat Prod. 2009 Oct;72(10):1741-7. doi: 10.1021/np900230p. J Nat Prod. 2009. PMID: 19757857
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kappaB activ …
Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a promin …
Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers.
Teng Y, Li X, Yang K, Li X, Zhang Z, Wang L, Deng Z, Song B, Yan Z, Zhang Y, Lu K, Yu P. Teng Y, et al. Eur J Med Chem. 2017 Jan 5;125:335-345. doi: 10.1016/j.ejmech.2016.09.024. Epub 2016 Sep 13. Eur J Med Chem. 2017. PMID: 27688188
The antioxidant activity of the new chalcone derivatives were evaluated in a PC12 cell model of H(2)O(2)-induced oxidative damage. The SAR studies suggested that the catechol motif was essential for the antioxidant activity. Moreover, the dimers showed better ant
The antioxidant activity of the new chalcone derivatives were evaluated in a PC12 cell model of H(2)O(2)-induced oxidative damage. Th …
Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration.
Henneman NF, Foster SL, Chrenek MA, Sellers JT, Wright CB, Schmidt RH, Nickerson JM, Boatright JH. Henneman NF, et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):45-53. doi: 10.1167/iovs.17-22132. Invest Ophthalmol Vis Sci. 2018. PMID: 29305606 Free PMC article.
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD). ...Preservation of retinal CYS and of GSSG and CYSS redox potentia …
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Xanthohumol (Xn), a principal prenylflavonoid, possesses anti-inflammation and anti-oxidant activities. However, whether Xn could protect from LPS-induced ALI through inducing AMPK/Nrf2 activation and its downstream signals, are still poorly elucidated. ...
Xanthohumol (Xn), a principal prenylflavonoid, possesses anti-inflammation and anti-oxidant activities. However, whether Xn could pro
Antioxidant and antiproliferative activity of glycosides obtained by biotransformation of xanthohumol.
Tronina T, Bartmańska A, Milczarek M, Wietrzyk J, Popłoński J, Rój E, Huszcza E. Tronina T, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1957-60. doi: 10.1016/j.bmcl.2013.02.031. Epub 2013 Feb 15. Bioorg Med Chem Lett. 2013. PMID: 23466227
The biotransformation of xanthohumol (1), a prenylated chalcone isolated from hops by selected fungi, was investigated. Microbial regioselective glycosylation at the C-4' position led to xanthohumol 4'-O-β-d-glucopyranoside (2) and xanthohumol 4'-O-β-d-(4'''- …
The biotransformation of xanthohumol (1), a prenylated chalcone isolated from hops by selected fungi, was investigated. Microbial reg …
Xanthohumol exerts protective effects in liver alterations associated with aging.
Fernández-García C, Rancan L, Paredes SD, Montero C, de la Fuente M, Vara E, Tresguerres JAF. Fernández-García C, et al. Eur J Nutr. 2019 Mar;58(2):653-663. doi: 10.1007/s00394-018-1657-6. Epub 2018 Mar 13. Eur J Nutr. 2019. PMID: 29536163
Xanthohumol is the main preylated chalcone present in hops (Humulus lupulus L.) whose antioxidant, anti-inflammatory and chemopreventive properties have been shown in recent years. ...METHODS: Male young and old senescence-accelerated prone mice (SAMP8), aged 2 and
Xanthohumol is the main preylated chalcone present in hops (Humulus lupulus L.) whose antioxidant, anti-inflammatory and chemo
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