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Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells.
Carvalho DO, Freitas J, Nogueira P, Henriques SN, Carmo AM, Castro MA, Guido LF. Carvalho DO, et al. Food Chem Toxicol. 2018 Nov;121:450-457. doi: 10.1016/j.fct.2018.09.021. Epub 2018 Sep 18. Food Chem Toxicol. 2018. PMID: 30240731
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyroid cancer cells is reported. ...Furthermore, XN exposure triggered an increase in caspase-3 and caspase-7 activity, supporting its role in …
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyr …
Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines.
Engelsgjerd S, Kunnimalaiyaan S, Kandil E, Gamblin TC, Kunnimalaiyaan M. Engelsgjerd S, et al. PLoS One. 2019 Mar 14;14(3):e0213776. doi: 10.1371/journal.pone.0213776. eCollection 2019. PLoS One. 2019. PMID: 30870485 Free PMC article.
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various cancer types suggesting that XN could be a useful small molecule compound against cancer. The TNF-Related Apoptosis-Inducing Ligand (TRAI …
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various canc …
Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells.
Yong WK, Ho YF, Malek SN. Yong WK, et al. Pharmacogn Mag. 2015 Oct;11(Suppl 2):S275-83. doi: 10.4103/0973-1296.166069. Pharmacogn Mag. 2015. PMID: 26664015 Free PMC article.
OBJECTIVE: This study aimed to investigate the effects of xanthohumol on apoptosis in A549 human NSCLC cells. MATERIALS AND METHODS: A549 cell proliferation was determined by sulforhodamine B assay. ...CONCLUSION: This work suggests that xanthohumol as an …
OBJECTIVE: This study aimed to investigate the effects of xanthohumol on apoptosis in A549 human NSCLC cells. MATERIALS AND ME …
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known, 8-prenylnari
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises co
Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production.
Sławińska-Brych A, Zdzisińska B, Czerwonka A, Mizerska-Kowalska M, Dmoszyńska-Graniczka M, Stepulak A, Gagoś M. Sławińska-Brych A, et al. Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129408. doi: 10.1016/j.bbagen.2019.08.001. Epub 2019 Aug 3. Biochim Biophys Acta Gen Subj. 2019. PMID: 31386885
BACKGROUND: Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. However, the mechanisms by which XN affects the survival of multiple myeloma cells (MM) are little known. ...Cytotoxicity was determined with the LDH …
BACKGROUND: Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. However, t …
Xanthohumol induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI3K/Akt/mTOR-kinase in human gastric cancer cells.
Guo D, Zhang B, Liu S, Jin M. Guo D, et al. Biomed Pharmacother. 2018 Oct;106:1300-1306. doi: 10.1016/j.biopha.2018.06.166. Epub 2018 Jul 21. Biomed Pharmacother. 2018. PMID: 30119200
We assessed the effect of xanthohumol (XN) on gastric cancer (GC) in vitro and in vivo. XN reduced the viability of SGC-7901, SNU216, and SNU668 cells, but not GES-1 non-tumorigenic human gastric epithelial cells. ...Our data indicate that XN induces apoptosis of hu …
We assessed the effect of xanthohumol (XN) on gastric cancer (GC) in vitro and in vivo. XN reduced the viability of SGC-7901, SNU216, …
Xanthohumol chalcone acts as a powerful inhibitor of carcinogenesis in drug-resistant human colon carcinoma and these effects are mediated via G2/M phase cell cycle arrest, activation of apoptotic pathways, caspase activation and targeting Ras /MEK/ERK pathway.
Liu X, An LJ, Li Y, Wang Y, Zhao L, Lv X, Guo J, Song AL. Liu X, et al. J BUON. 2019 Nov-Dec;24(6):2442-2447. J BUON. 2019. PMID: 31983118 Free article.
DAPI staining revealed nuclear fragmentation, suggesting xanthohumol induces apoptosis in HT-29 cells. Xanthohumol also caused activation of caspase-3 and 9 and increased the Bax/Bcl-2 ratio. ...The effects of Xanthohumol were also investigated on the …
DAPI staining revealed nuclear fragmentation, suggesting xanthohumol induces apoptosis in HT-29 cells. Xanthohumol also …
Xanthohumol induces growth inhibition and apoptosis in ca ski human cervical cancer cells.
Yong WK, Abd Malek SN. Yong WK, et al. Evid Based Complement Alternat Med. 2015;2015:921306. doi: 10.1155/2015/921306. Epub 2015 Apr 9. Evid Based Complement Alternat Med. 2015. PMID: 25949267 Free PMC article.
We investigate induction of apoptosis by xanthohumol on Ca Ski cervical cancer cell line. Xanthohumol is a prenylated chalcone naturally found in hop plants, previously reported to be an effective anticancer agent in various cancer cell lines. ...This work su …
We investigate induction of apoptosis by xanthohumol on Ca Ski cervical cancer cell line. Xanthohumol is a prenylated c …
Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregates.
Zhang M , Wu Q , Yao X , Zhao J , Zhong W , Liu Q , Xiao S . Zhang M , et al. Food Funct. 2019 Dec 11;10(12):7865-7874. doi: 10.1039/c9fo02133g. Food Funct. 2019. PMID: 31793596
In this study, xanthohumol (XN), a natural botanic compound, is found to inhibit tau protein aggregation and disaggregate tau fibrils. ...Cellular experiments showed that XN exhibits little cytotoxicity and attenuates apoptosis induced by tau oligomers. The results …
In this study, xanthohumol (XN), a natural botanic compound, is found to inhibit tau protein aggregation and disaggregate tau fibrils …
Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma.
Kunnimalaiyaan S, Sokolowski KM, Balamurugan M, Gamblin TC, Kunnimalaiyaan M. Kunnimalaiyaan S, et al. PLoS One. 2015 May 26;10(5):e0127464. doi: 10.1371/journal.pone.0127464. eCollection 2015. PLoS One. 2015. PMID: 26011160 Free PMC article.
Xanthohumol (XN), a prenylated chalcone has been shown to have anti-proliferative effects in various cancers types in vitro. ...Furthermore, growth suppression due to apoptosis was evidenced by increased expression of pro-apoptotic and reduced expression of anti-apo
Xanthohumol (XN), a prenylated chalcone has been shown to have anti-proliferative effects in various cancers types in vitro. ...Furth
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