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113 results
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Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis.
Wang CM, Chen J, Zhao J, Hu SS, Zhang SQ, Mi XQ, Shi X, Cao XH, Li Z. Wang CM, et al. Oxid Med Cell Longev. 2021 Nov 10;2021:9877170. doi: 10.1155/2021/9877170. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34804373 Free PMC article.
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (Humulus lupulus L.) and was reported to indu …
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely rela …
Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines.
Engelsgjerd S, Kunnimalaiyaan S, Kandil E, Gamblin TC, Kunnimalaiyaan M. Engelsgjerd S, et al. PLoS One. 2019 Mar 14;14(3):e0213776. doi: 10.1371/journal.pone.0213776. eCollection 2019. PLoS One. 2019. PMID: 30870485 Free PMC article.
The TNF-Related Apoptosis-Inducing Ligand (TRAIL) is an endogenous ligand that is expressed in various immune cells. TRAIL mediates apoptosis through binding of transmembrane receptors, death receptor 4 (DR4) and/or death receptor 5 (DR5). ...
The TNF-Related Apoptosis-Inducing Ligand (TRAIL) is an endogenous ligand that is expressed in various immune cells. TRAIL mediates …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injur …
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activat …
Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production.
Sławińska-Brych A, Zdzisińska B, Czerwonka A, Mizerska-Kowalska M, Dmoszyńska-Graniczka M, Stepulak A, Gagoś M. Sławińska-Brych A, et al. Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129408. doi: 10.1016/j.bbagen.2019.08.001. Epub 2019 Aug 3. Biochim Biophys Acta Gen Subj. 2019. PMID: 31386885
BACKGROUND: Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. ...The expression of cell cycle- and apoptosis-related proteins and the activation status of signaling pathways were estimated by immunoblottin …
BACKGROUND: Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. ...The exp …
Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells.
Carvalho DO, Freitas J, Nogueira P, Henriques SN, Carmo AM, Castro MA, Guido LF. Carvalho DO, et al. Food Chem Toxicol. 2018 Nov;121:450-457. doi: 10.1016/j.fct.2018.09.021. Epub 2018 Sep 18. Food Chem Toxicol. 2018. PMID: 30240731
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyroid cancer cells is reported. ...Furthermore, XN exposure triggered an increase in caspase-3 and caspase-7 activity, supporting its role in …
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyr …
Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.
Harish V, Haque E, Śmiech M, Taniguchi H, Jamieson S, Tewari D, Bishayee A. Harish V, et al. Int J Mol Sci. 2021 Apr 25;22(9):4478. doi: 10.3390/ijms22094478. Int J Mol Sci. 2021. PMID: 33923053 Free PMC article. Review.
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...
Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.
Meresman GF, Götte M, Laschke MW. Meresman GF, et al. Hum Reprod Update. 2021 Feb 19;27(2):367-392. doi: 10.1093/humupd/dmaa039. Hum Reprod Update. 2021. PMID: 33124671 Review.
The most studied specific plant-derived bioactive compounds are resveratrol, epigallocatechin-3-gallate, curcumin, puerarin, ginsenosides, xanthohumol, 4-hydroxybenzyl alcohol, quercetin, apigenin, carnosic acid, rosmarinic acid, wogonin, baicalein, parthenolide, andrograp …
The most studied specific plant-derived bioactive compounds are resveratrol, epigallocatechin-3-gallate, curcumin, puerarin, ginsenosides, …
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis.
Yang JY, Della-Fera MA, Rayalam S, Baile CA. Yang JY, et al. Apoptosis. 2007 Nov;12(11):1953-63. doi: 10.1007/s10495-007-0130-4. Apoptosis. 2007. PMID: 17874298
Xanthohumol (XN), the chalcone from beer hops has several biological activities. XN has been shown to induce apoptosis in cancer cells and also has been reported to be involved in lipid metabolism. ...
Xanthohumol (XN), the chalcone from beer hops has several biological activities. XN has been shown to induce apoptosis in canc
Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells.
Yong WK, Ho YF, Malek SN. Yong WK, et al. Pharmacogn Mag. 2015 Oct;11(Suppl 2):S275-83. doi: 10.4103/0973-1296.166069. Pharmacogn Mag. 2015. PMID: 26664015 Free PMC article.
OBJECTIVE: This study aimed to investigate the effects of xanthohumol on apoptosis in A549 human NSCLC cells. MATERIALS AND METHODS: A549 cell proliferation was determined by sulforhodamine B assay. ...CONCLUSION: This work suggests that xanthohumol as an …
OBJECTIVE: This study aimed to investigate the effects of xanthohumol on apoptosis in A549 human NSCLC cells. MATERIALS AND ME …
Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma.
Walden D, Kunnimalaiyaan S, Sokolowski K, Clark TG, Kunnimalaiyaan M. Walden D, et al. Oncotarget. 2017 Sep 30;8(50):88069-88078. doi: 10.18632/oncotarget.21422. eCollection 2017 Oct 20. Oncotarget. 2017. PMID: 29152142 Free PMC article.
Xanthohumol induced cell cycle arrest as well as apoptosis through the reduction of cell cycle regulatory proteins as well as an increase in pro-apoptotic markers (cleaved poly ADP ribose polymerase, cleaved caspase-3) and a decrease in anti-apoptotic markers (X-lin
Xanthohumol induced cell cycle arrest as well as apoptosis through the reduction of cell cycle regulatory proteins as well as
113 results