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Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation.
Wang Q, Chen T, Shuqing Z, Yu L, Chen S, Lu H, Zhu H, Min X, Li X, Liu L. Wang Q, et al. Mol Pain. 2023 Jan-Dec;19:17448069231204051. doi: 10.1177/17448069231204051. Mol Pain. 2023. PMID: 37699859 Free PMC article.
Chronic pain is the most common symptom for people who suffer from rheumatoid arthritis and it affects approximately 1% of the global population. Neuroinflammation in the spinal cord induces chronic arthritis pain. In this study, a collagen-induced arthritis …
Chronic pain is the most common symptom for people who suffer from rheumatoid arthritis and it affects approximately 1% of the global …
Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice.
Chen X, Li Z, Hong H, Wang N, Chen J, Lu S, Zhang H, Zhang X, Bei C. Chen X, et al. Biomed Pharmacother. 2021 May;137:111238. doi: 10.1016/j.biopha.2021.111238. Epub 2021 Jan 28. Biomed Pharmacother. 2021. PMID: 33517187 Free article.
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related disease. The current in vivo and in vitro study aimed to investigate the therapeutic effect of XN on OA as well as its working mechanism. ...
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related dise …
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Gupta SC, et al. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Front Immunol. 2018. PMID: 30319623 Free PMC article. Review.
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. The in …
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediate …
Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Diseases and Cancer.
Albini A, Bassani B, Baci D, Dallaglio K, Gallazzi M, Corradino P, Bruno A, Noonan DM. Albini A, et al. Curr Med Chem. 2019;26(6):973-987. doi: 10.2174/0929867324666170920144130. Curr Med Chem. 2019. PMID: 28933290 Review.
For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. ...We summarize the beneficial effects of several compounds in conferring protection and supporting therap …
For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current …
Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate.
Han J, Xia T, Jiang Y, Fan W, Wang N, Zhang Y, Liu A, Zhao K, Xin H. Han J, et al. Cell Biochem Biophys. 2024 Dec;82(4):3425-3435. doi: 10.1007/s12013-024-01429-z. Epub 2024 Jul 21. Cell Biochem Biophys. 2024. PMID: 39033477
Xanthohumol (XAN) is an isoprenyl flavonoid from Humulus lupulus L. known for beer brewing, and an osteoprotective agent due to its active improvement in bone loss of osteoporosis. This study was first time to investigate its effects on anti-gouty bone injury in rats of go …
Xanthohumol (XAN) is an isoprenyl flavonoid from Humulus lupulus L. known for beer brewing, and an osteoprotective agent due to its a …
Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.
Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB. Gupta SC, et al. Arch Biochem Biophys. 2014 Oct 1;559:91-9. doi: 10.1016/j.abb.2014.06.006. Epub 2014 Jun 16. Arch Biochem Biophys. 2014. PMID: 24946050 Review.
Thus TNF and the related pro-inflammatory cytokines have been shown to play a key role in most chronic diseases such as cancer, rheumatoid arthritis, cardiovascular diseases, psoriasis, neurologic diseases, Crohn's disease, and metabolic diseases. ...These polyphenols incl …
Thus TNF and the related pro-inflammatory cytokines have been shown to play a key role in most chronic diseases such as cancer, rheumatoid …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...These data demonstrate that xanthohumol inhibits osteoclastogenesis by modulating RANKL signaling and may be useful for the prevention …
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...Th …
Micellar solubilization enhances the anti-inflammatory effect of xanthohumol.
Khayyal MT, El-Hazek RM, El-Sabbagh WA, Frank J, Behnam D, Abdel-Tawab M. Khayyal MT, et al. Phytomedicine. 2020 Jun;71:153233. doi: 10.1016/j.phymed.2020.153233. Epub 2020 May 16. Phytomedicine. 2020. PMID: 32454348 Free article.
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...PURPOSE: In the present study, we compared the chronic anti-inflammatory activities of native and micellar xanthohumol in the rat adjuvant arthritis m …
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...PURPOSE: In the present …
Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions.
Stracke D, Schulz T, Prehm P. Stracke D, et al. Mol Nutr Food Res. 2011 Mar;55(3):485-94. doi: 10.1002/mnfr.201000210. Epub 2010 Sep 16. Mol Nutr Food Res. 2011. PMID: 20848398
METHODS AND RESULTS: Prenylflavonoids from hop xanthohumol, isoxanthohumol and 8-prenylnaringenin inhibited MRP5 export at lower concentrations than phosphodiesterase 5 activity. They were analyzed for their effect on IL-induced osteoarthritic reactions in bovine chondrocy …
METHODS AND RESULTS: Prenylflavonoids from hop xanthohumol, isoxanthohumol and 8-prenylnaringenin inhibited MRP5 export at lower conc …