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Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.
Li J, Zeng L, Xie J, Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J, Liu M. Li J, et al. Sci Rep. 2015 Dec 1;5:17605. doi: 10.1038/srep17605. Sci Rep. 2015. PMID: 26620037 Free PMC article.
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. ...In this study, we examined the effects of xanthohumol (XN), an abundant prenylflavonoid from hops plant, on …
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone
Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.
Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Schilling T, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20. J Steroid Biochem Mol Biol. 2014. PMID: 23262262 Review.
As a novel mechanism, phytoestrogens and plant-derived saponins and flavonoids like kaempferol and xanthohumol have been described to reciprocally affect the osteogenic versus the adipogenic differentiation pathway. ...Preventing the age- and hormone deficiency-related shi …
As a novel mechanism, phytoestrogens and plant-derived saponins and flavonoids like kaempferol and xanthohumol have been described to …
A safety study of oral tangeretin and xanthohumol administration to laboratory mice.
Vanhoecke BW, Delporte F, Van Braeckel E, Heyerick A, Depypere HT, Nuytinck M, De Keukeleire D, Bracke ME. Vanhoecke BW, et al. In Vivo. 2005 Jan-Feb;19(1):103-7. In Vivo. 2005. PMID: 15796161 Free article.
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatment with either tangeretin or xanthohumol. The parameters encompassed an integrity check of the following tissues and organs: bone
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatmen …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
RANKL has been shown to play a critical role in osteoclast formation and bone resorption. Thus, agents that suppress RANKL signaling have a potential to suppress bone loss. ...Xanthohumol also inhibited RANKL-induced expression of bone-resorption relat …
RANKL has been shown to play a critical role in osteoclast formation and bone resorption. Thus, agents that suppress RANKL signaling …
The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD.
Całkosińska A, Dominiak M, Sobolewska S, Leśków A, Tarnowska M, Całkosiński A, Dobrzyński M. Całkosińska A, et al. Int J Environ Res Public Health. 2020 Aug 13;17(16):5883. doi: 10.3390/ijerph17165883. Int J Environ Res Public Health. 2020. PMID: 32823692 Free PMC article.
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has the ability to eliminate the negative effects of TCDD on bone tissue. ...Results show also that higher doses of the XN cause the linea …
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has t …
Triggering of dendritic cell apoptosis by xanthohumol.
Xuan NT, Shumilina E, Gulbins E, Gu S, Götz F, Lang F. Xuan NT, et al. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S214-24. doi: 10.1002/mnfr.200900324. Mol Nutr Food Res. 2010. PMID: 20333722
Xanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol further has anti-inflammatory activity. ...In conclusion, xanthohumol stimulated Asm leading to caspase activation and apoptosis
Xanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol
Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.
Effenberger KE, Johnsen SA, Monroe DG, Spelsberg TC, Westendorf JJ. Effenberger KE, et al. J Steroid Biochem Mol Biol. 2005 Sep;96(5):387-99. doi: 10.1016/j.jsbmb.2005.04.038. Epub 2005 Jul 12. J Steroid Biochem Mol Biol. 2005. PMID: 16019205
In the current study, we tested the effects of the hop-derived compounds 8-prenylnaringenin, 6-prenylnaringenin, xanthohumol and isoxanthohumol (1) to modulate markers of differentiation and gene expression in osteoblasts and (2) to regulate proliferation in MCF-7 breast c …
In the current study, we tested the effects of the hop-derived compounds 8-prenylnaringenin, 6-prenylnaringenin, xanthohumol and isox …
Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation.
Jeong HM, Han EH, Jin YH, Choi YH, Lee KY, Jeong HG. Jeong HM, et al. Biochem Biophys Res Commun. 2011 May 27;409(1):82-9. doi: 10.1016/j.bbrc.2011.04.113. Epub 2011 May 1. Biochem Biophys Res Commun. 2011. PMID: 21565172
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer, is known to be a potent phytoestrogen. Although XN has been identified as a chemopreventive agent and as an anti-infective agent, its effect
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer,
Effect of blending HA-g-PLLA on xanthohumol-loaded PLGA fiber membrane.
Qiao T, Jiang S, Song P, Song X, Liu Q, Wang L, Chen X. Qiao T, et al. Colloids Surf B Biointerfaces. 2016 Oct 1;146:221-7. doi: 10.1016/j.colsurfb.2016.06.011. Epub 2016 Jun 11. Colloids Surf B Biointerfaces. 2016. PMID: 27343844
Electropsun poly (lactide-co-glycolide) (PLGA) fiber membrane loaded xanthohumol (XN) has been developed using a co-solvent system of chloroform and dimethylformamide. To enhance its biological functionality as bone tissue engineering scaffolds, 5wt% hydroxyapatite …
Electropsun poly (lactide-co-glycolide) (PLGA) fiber membrane loaded xanthohumol (XN) has been developed using a co-solvent system of …
Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model.
Kim MR, Kim HJ, Yu SH, Lee BS, Jeon SY, Lee JJ, Lee YC. Kim MR, et al. Evid Based Complement Alternat Med. 2020 May 23;2020:7941391. doi: 10.1155/2020/7941391. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32595737 Free PMC article.
A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover extract and xanthohumol in hops extract. ...Changes in body weight, tail skin temperature (TST), serum lipid profile, bone metab …
A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover ex …
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