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Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway.
Sun X, Xia T, Zhang S, Zhang J, Xu L, Han T, Xin H. Sun X, et al. J Bone Miner Metab. 2022 May;40(3):375-388. doi: 10.1007/s00774-021-01295-2. Epub 2022 Feb 1. J Bone Miner Metab. 2022. PMID: 35106609
This study aimed to investigate whether hops extract (HLE) and its active component xanthohumol (XAN) could ameliorate bone loss caused by iron overload, and explored its potential mechanism. ...Bone metabolism markers and oxidation indexes in serum and bo
This study aimed to investigate whether hops extract (HLE) and its active component xanthohumol (XAN) could ameliorate bone lo …
Cell death regulation: A new way for natural products to treat osteoporosis.
Li Z, Li D, Chen R, Gao S, Xu Z, Li N. Li Z, et al. Pharmacol Res. 2023 Jan;187:106635. doi: 10.1016/j.phrs.2022.106635. Epub 2022 Dec 26. Pharmacol Res. 2023. PMID: 36581167 Free article. Review.
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic balance between bone resorption by osteoclasts and bone formation by mesench …
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid beta-induced oxidative damage and bone loss.
Xia T, Liu X, Wang N, Jiang Y, Bai H, Xu W, Feng K, Han T, Xin H. Xia T, et al. J Pharm Pharmacol. 2022 Jul 15;74(7):1017-1026. doi: 10.1093/jpp/rgac007. J Pharm Pharmacol. 2022. PMID: 35353176
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative stress and osteoporosis (OP). ...METHODS: Osteoblasts were pretreated with XAN followed by stimulation with Abeta1-42. Cell proliferation, ALP …
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative st …
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.
Li J, Zeng L, Xie J, Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J, Liu M. Li J, et al. Sci Rep. 2015 Dec 1;5:17605. doi: 10.1038/srep17605. Sci Rep. 2015. PMID: 26620037 Free PMC article.
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. Therefore, targeting RANKL or its signaling pathway has been a promising and successful strategy for this osteoclast-r …
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone
Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.
Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Schilling T, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20. J Steroid Biochem Mol Biol. 2014. PMID: 23262262 Review.
Besides their well-known estrogenic, i.e. mainly antiresorptive effects on bone via estrogen receptor (ER) signalling, they also directly or indirectly affect osteogenic and adipogenic pathways. ...Preventing the age- and hormone deficiency-related shift towards adipogenes …
Besides their well-known estrogenic, i.e. mainly antiresorptive effects on bone via estrogen receptor (ER) signalling, they also dire …
The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD.
Całkosińska A, Dominiak M, Sobolewska S, Leśków A, Tarnowska M, Całkosiński A, Dobrzyński M. Całkosińska A, et al. Int J Environ Res Public Health. 2020 Aug 13;17(16):5883. doi: 10.3390/ijerph17165883. Int J Environ Res Public Health. 2020. PMID: 32823692 Free PMC article.
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has the ability to eliminate the negative effects of TCDD on bone tissue. ...Our results indicate that the administration of TCDD at a low …
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has t …
Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate.
Han J, Xia T, Jiang Y, Fan W, Wang N, Zhang Y, Liu A, Zhao K, Xin H. Han J, et al. Cell Biochem Biophys. 2024 Dec;82(4):3425-3435. doi: 10.1007/s12013-024-01429-z. Epub 2024 Jul 21. Cell Biochem Biophys. 2024. PMID: 39033477
Xanthohumol (XAN) is an isoprenyl flavonoid from Humulus lupulus L. known for beer brewing, and an osteoprotective agent due to its active improvement in bone loss of osteoporosis. ...Meanwhile, XAN could also fight against gouty bone damage by improving path
Xanthohumol (XAN) is an isoprenyl flavonoid from Humulus lupulus L. known for beer brewing, and an osteoprotective agent due to its a
Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (Humulus lupulus L.).
Aggarwal D, Upadhyay SK, Singh R, Tuli HS. Aggarwal D, et al. Pharm Pat Anal. 2021 Jan;10(1):37-49. doi: 10.4155/ppa-2020-0026. Epub 2021 Jan 15. Pharm Pat Anal. 2021. PMID: 33445965 Review.
There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent - asid …
There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compoun …
A safety study of oral tangeretin and xanthohumol administration to laboratory mice.
Vanhoecke BW, Delporte F, Van Braeckel E, Heyerick A, Depypere HT, Nuytinck M, De Keukeleire D, Bracke ME. Vanhoecke BW, et al. In Vivo. 2005 Jan-Feb;19(1):103-7. In Vivo. 2005. PMID: 15796161 Free article.
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatment with either tangeretin or xanthohumol. The parameters encompassed an integrity check of the following tissues and organs: bone
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatmen …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
Moreover, RANKL-induced expressions of c-Fos and NFATc1, which are crucial transcription factors for osteoclastogenesis, were reduced by treatment with xanthohumol. Xanthohumol also inhibited RANKL-induced expression of bone-resorption related osteoclast-spec …
Moreover, RANKL-induced expressions of c-Fos and NFATc1, which are crucial transcription factors for osteoclastogenesis, were reduced by tre …
18 results