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Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3β/Nrf2 pathway.
Sun X, Xia T, Zhang S, Zhang J, Xu L, Han T, Xin H. Sun X, et al. J Bone Miner Metab. 2022 May;40(3):375-388. doi: 10.1007/s00774-021-01295-2. Epub 2022 Feb 1. J Bone Miner Metab. 2022. PMID: 35106609
This study aimed to investigate whether hops extract (HLE) and its active component xanthohumol (XAN) could ameliorate bone loss caused by iron overload, and explored its potential mechanism. ...Bone metabolism markers and oxidation indexes in serum and bo
This study aimed to investigate whether hops extract (HLE) and its active component xanthohumol (XAN) could ameliorate bone lo …
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.
Li J, Zeng L, Xie J, Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J, Liu M. Li J, et al. Sci Rep. 2015 Dec 1;5:17605. doi: 10.1038/srep17605. Sci Rep. 2015. PMID: 26620037 Free PMC article.
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. ...Furthermore, XN inhibited osteoclast actin-ring formation and bone resorption in a dose-dependent manner. In …
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone
Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.
Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Schilling T, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20. J Steroid Biochem Mol Biol. 2014. PMID: 23262262 Review.
Besides their well-known estrogenic, i.e. mainly antiresorptive effects on bone via estrogen receptor (ER) signalling, they also directly or indirectly affect osteogenic and adipogenic pathways. ...Preventing the age- and hormone deficiency-related shift towards adipogenes …
Besides their well-known estrogenic, i.e. mainly antiresorptive effects on bone via estrogen receptor (ER) signalling, they also dire …
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss.
Xia T, Liu X, Wang N, Jiang Y, Bai H, Xu W, Feng K, Han T, Xin H. Xia T, et al. J Pharm Pharmacol. 2022 Mar 30:rgac007. doi: 10.1093/jpp/rgac007. Online ahead of print. J Pharm Pharmacol. 2022. PMID: 35353176
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative stress and osteoporosis (OP). ...METHODS: Osteoblasts were pretreated with XAN followed by stimulation with Abeta1-42. Cell proliferation, ALP …
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative st …
The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD.
Całkosińska A, Dominiak M, Sobolewska S, Leśków A, Tarnowska M, Całkosiński A, Dobrzyński M. Całkosińska A, et al. Int J Environ Res Public Health. 2020 Aug 13;17(16):5883. doi: 10.3390/ijerph17165883. Int J Environ Res Public Health. 2020. PMID: 32823692 Free PMC article.
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has the ability to eliminate the negative effects of TCDD on bone tissue. ...Our results indicate that the administration of TCDD at a low …
The aim of the study is to assess whether xanthohumol, as a substance with strong antioxidant and anti-inflammatory properties, has t …
Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (Humulus lupulus L.).
Aggarwal D, Upadhyay SK, Singh R, Tuli HS. Aggarwal D, et al. Pharm Pat Anal. 2021 Jan;10(1):37-49. doi: 10.4155/ppa-2020-0026. Epub 2021 Jan 15. Pharm Pat Anal. 2021. PMID: 33445965 Review.
There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent - asid …
There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compoun …
A safety study of oral tangeretin and xanthohumol administration to laboratory mice.
Vanhoecke BW, Delporte F, Van Braeckel E, Heyerick A, Depypere HT, Nuytinck M, De Keukeleire D, Bracke ME. Vanhoecke BW, et al. In Vivo. 2005 Jan-Feb;19(1):103-7. In Vivo. 2005. PMID: 15796161 Free article.
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatment with either tangeretin or xanthohumol. The parameters encompassed an integrity check of the following tissues and organs: bone
RESULTS: A reduction of the circulating lymphocyte number was noticed for tangeretin, while all other parameters were unaffected by treatmen …
Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model.
Kim MR, Kim HJ, Yu SH, Lee BS, Jeon SY, Lee JJ, Lee YC. Kim MR, et al. Evid Based Complement Alternat Med. 2020 May 23;2020:7941391. doi: 10.1155/2020/7941391. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32595737 Free PMC article.
A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover extract and xanthohumol in hops extract. An in vivo study was conducted using an ovariectomized rat model treated with RHEC (125, 250, …
A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover ex …
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL. Liou SF, et al. Antioxidants (Basel). 2020 Oct 6;9(10):956. doi: 10.3390/antiox9100956. Antioxidants (Basel). 2020. PMID: 33036258 Free PMC article.
In blood vessels, VC is associated with major adverse cardiovascular events. Xanthohumol (XN), a main prenylated chalcone found in hops, has antioxidant effects to inhibit VC. ...Moreover, overexpression of osteogenic transcription factors bone morphogenetic protein …
In blood vessels, VC is associated with major adverse cardiovascular events. Xanthohumol (XN), a main prenylated chalcone found in ho …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
Moreover, RANKL-induced expressions of c-Fos and NFATc1, which are crucial transcription factors for osteoclastogenesis, were reduced by treatment with xanthohumol. Xanthohumol also inhibited RANKL-induced expression of bone-resorption related osteoclast-spec …
Moreover, RANKL-induced expressions of c-Fos and NFATc1, which are crucial transcription factors for osteoclastogenesis, were reduced by tre …
15 results