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Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways.
Sun XL, Zhang JB, Guo YX, Xia TS, Xu LC, Rahmand K, Wang GP, Li XJ, Han T, Wang NN, Xin HL. Sun XL, et al. J Pharm Pharmacol. 2021 Aug 12;73(9):1230-1239. doi: 10.1093/jpp/rgab052. J Pharm Pharmacol. 2021. PMID: 33909081
OBJECTIVES: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. ...CONCLUSIONS: Xanthohumol effectively ameliorates memory impairment of APP/PS1 mice by activating mTOR/LC3 and Bax/Bcl-2 signalling pathwa …
OBJECTIVES: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. ...CONC …
GABAA Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone.
Min B, Ahn Y, Cho HJ, Kwak WK, Suh HJ, Jo K. Min B, et al. Molecules. 2021 Nov 24;26(23):7108. doi: 10.3390/molecules26237108. Molecules. 2021. PMID: 34885687 Free PMC article.
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz-Saphir hops mixture was measured. ...In addition, the GABA(A) receptor antagonist also reduced th …
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this stu …
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice.
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K. Roberson SW, et al. Curr Neuropharmacol. 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. Curr Neuropharmacol. 2021. PMID: 33463474 Free PMC article. Review.
Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous system (CNS), starting with the primary pathology of the inciting trauma and subsequent inflammatory and CNS tissue response. ...In this narrative review, possible etiologic mechanisms …
Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous system (CNS), starting with the primary patho …
Amyloid-β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential for treating Alzheimer's disease (AD). OBJECTIVE: We designed and prepared a series of xanthohumol derivatives to enhance the …
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential …
Protective effect of xanthohumol against age-related brain damage.
Rancán L, Paredes SD, García I, Muñoz P, García C, López de Hontanar G, de la Fuente M, Vara E, Tresguerres JAF. Rancán L, et al. J Nutr Biochem. 2017 Nov;49:133-140. doi: 10.1016/j.jnutbio.2017.07.011. Epub 2017 Jul 27. J Nutr Biochem. 2017. PMID: 28950154
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated pron …
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprot …
Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-β-cyclodextrin Complex Suitable for Parenteral Administration.
Kirchinger M, Bieler L, Tevini J, Vogl M, Haschke-Becher E, Felder TK, Couillard-Després S, Riepl H, Urmann C. Kirchinger M, et al. Planta Med. 2019 Nov;85(16):1233-1241. doi: 10.1055/a-1013-1276. Epub 2019 Oct 14. Planta Med. 2019. PMID: 31610603
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. ...Finally, a small-scaled in vivo experiment in a rat model showed that after i. p. administration of the complex, Xanthohumol C can be detected in serum, the brain
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. ...Finally, a small-scaled in vivo ex …
Targeting the Liver-Brain Axis with Hop-Derived Flavonoids Improves Lipid Metabolism and Cognitive Performance in Mice.
Paraiso IL, Revel JS, Choi J, Miranda CL, Lak P, Kioussi C, Bobe G, Gombart AF, Raber J, Maier CS, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2020 Aug;64(15):e2000341. doi: 10.1002/mnfr.202000341. Epub 2020 Jul 6. Mol Nutr Food Res. 2020. PMID: 32627931 Free PMC article.
Increasing evidence suggests the farnesoid X receptor (FXR) is involved in ceramide metabolism, as bile acid-FXR crosstalk controls ceramide levels along the gut-liver axis. The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavono …
Increasing evidence suggests the farnesoid X receptor (FXR) is involved in ceramide metabolism, as bile acid-FXR crosstalk controls ceramide …
Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways.
Rahman SU, Ali T, Hao Q, He K, Li W, Ullah N, Zhang Z, Jiang Y, Li S. Rahman SU, et al. Neurochem Res. 2021 Dec;46(12):3135-3148. doi: 10.1007/s11064-021-03396-w. Epub 2021 Aug 16. Neurochem Res. 2021. PMID: 34398408
Depression is the most common psychiatric disorder associated with brain and immune system abnormalities. In recent years, xanthohumol (Xn) a bioactive prenylated flavonoid has received ample attention for its polypharmacological effects, therefore, here we aimed to …
Depression is the most common psychiatric disorder associated with brain and immune system abnormalities. In recent years, xanthoh
Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke.
Jiao Y, Cao Y, Lu X, Wang J, Saitgareeva A, Kong X, Song C, Li J, Tian K, Zhang S, Bai M, Li S, Zhang H, Wang L. Jiao Y, et al. Mol Biol Rep. 2020 Apr;47(4):2417-2425. doi: 10.1007/s11033-019-05128-4. Epub 2020 Feb 27. Mol Biol Rep. 2020. PMID: 32108303
Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid extracted from hops, has been reported to have potential function as an antioxidant and can be used for neuro protection. ...Middle cerebral …
Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid e …
Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat.
Donoso F, Egerton S, Bastiaanssen TFS, Fitzgerald P, Gite S, Fouhy F, Ross RP, Stanton C, Dinan TG, Cryan JF. Donoso F, et al. Psychoneuroendocrinology. 2020 Jun;116:104673. doi: 10.1016/j.psyneuen.2020.104673. Epub 2020 Apr 10. Psychoneuroendocrinology. 2020. PMID: 32334345
In this study, we assess the therapeutic potential of a variety of both flavonoid and non-flavonoid polyphenols in reversing the impact of MS on behaviour and the microbiota-gut-brain axis. Rats underwent a dietary intervention with the naturally-derived polyphenols xan
In this study, we assess the therapeutic potential of a variety of both flavonoid and non-flavonoid polyphenols in reversing the impact of M …
24 results