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Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice.
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K. Roberson SW, et al. Curr Neuropharmacol. 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. Curr Neuropharmacol. 2021. PMID: 33463474 Free PMC article. Review.
Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous system (CNS), starting with the primary pathology of the inciting trauma and subsequent inflammatory and CNS tissue response. ...In this narrative review, possible etiologic mechanisms …
Traumatic brain injury (TBI) can initiate a very complex disease of the central nervous system (CNS), starting with the primary patho …
Protective effect of xanthohumol against age-related brain damage.
Rancán L, Paredes SD, García I, Muñoz P, García C, López de Hontanar G, de la Fuente M, Vara E, Tresguerres JAF. Rancán L, et al. J Nutr Biochem. 2017 Nov;49:133-140. doi: 10.1016/j.jnutbio.2017.07.011. Epub 2017 Jul 27. J Nutr Biochem. 2017. PMID: 28950154
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated pron …
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprot …
Amyloid-beta Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential for treating Alzheimer's disease (AD). OBJECTIVE: We designed and prepared a series of xanthohumol derivatives to enhance the desira …
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential …
Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-beta-cyclodextrin Complex Suitable for Parenteral Administration.
Kirchinger M, Bieler L, Tevini J, Vogl M, Haschke-Becher E, Felder TK, Couillard-Després S, Riepl H, Urmann C. Kirchinger M, et al. Planta Med. 2019 Nov;85(16):1233-1241. doi: 10.1055/a-1013-1276. Epub 2019 Oct 14. Planta Med. 2019. PMID: 31610603
Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not significantly differ, suggesting the release of Xanthohumol C from 2-hydroxypropyl-beta-cyclodextrin. Finally, a small-scaled in vivo experiment in a rat model showed that after i. …
Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not significantly differ, suggesting the release of …
Xanthohumol ameliorates memory impairment and reduces the deposition of beta-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways.
Sun XL, Zhang JB, Guo YX, Xia TS, Xu LC, Rahmand K, Wang GP, Li XJ, Han T, Wang NN, Xin HL. Sun XL, et al. J Pharm Pharmacol. 2021 Aug 12;73(9):1230-1239. doi: 10.1093/jpp/rgab052. J Pharm Pharmacol. 2021. PMID: 33909081
OBJECTIVES: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. ...CONCLUSIONS: Xanthohumol effectively ameliorates memory impairment of APP/PS1 mice by activating mTOR/LC3 and Bax/Bcl-2 signalling pathwa …
OBJECTIVES: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. ...CONC …
Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA(A) receptor.
Lee H, Chung SH, Kwon DJ, Nam MJ, Choi JH, Suh HJ, Choi HS, Han SH. Lee H, et al. J Ethnopharmacol. 2025 Feb 10;338(Pt 2):119019. doi: 10.1016/j.jep.2024.119019. Epub 2024 Nov 9. J Ethnopharmacol. 2025. PMID: 39522843
RESULTS: The extract contained 7.44 mg/g of xanthohumol, 133.04 mg/g of alpha-acids including 13.74 mg/g of humulone and 84.52 mg/g of beta-acids. ...Administration of the extract for 3 weeks increased the expression and protein levels of 5-HT(1A) receptors in addition to …
RESULTS: The extract contained 7.44 mg/g of xanthohumol, 133.04 mg/g of alpha-acids including 13.74 mg/g of humulone and 84.52 mg/g o …
GABA(A) Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone.
Min B, Ahn Y, Cho HJ, Kwak WK, Suh HJ, Jo K. Min B, et al. Molecules. 2021 Nov 24;26(23):7108. doi: 10.3390/molecules26237108. Molecules. 2021. PMID: 34885687 Free PMC article.
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz-Saphir hops mixture was measured. ...In addition, the GABA(A) receptor antagonist also reduced th …
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this stu …
Xanthohumol improves cognitive impairment by regulating miRNA-532-3p/Mpped1 in ovariectomized mice.
Liu Y, Shao J, Qiao R, Li J, Li C, Cao W. Liu Y, et al. Psychopharmacology (Berl). 2023 May;240(5):1169-1178. doi: 10.1007/s00213-023-06355-1. Epub 2023 Mar 20. Psychopharmacology (Berl). 2023. PMID: 36939856
RATIONALE: Studies have shown the potential neuroprotective effect of xanthohumol, while whether xanthohumol has the ability of repairing cognitive impairment and its underlying mechanism still remains obscure. ...MiR-532-3p and its downstream gene Mpped1 were scree …
RATIONALE: Studies have shown the potential neuroprotective effect of xanthohumol, while whether xanthohumol has the ability o …
Targeting the Liver-Brain Axis with Hop-Derived Flavonoids Improves Lipid Metabolism and Cognitive Performance in Mice.
Paraiso IL, Revel JS, Choi J, Miranda CL, Lak P, Kioussi C, Bobe G, Gombart AF, Raber J, Maier CS, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2020 Aug;64(15):e2000341. doi: 10.1002/mnfr.202000341. Epub 2020 Jul 6. Mol Nutr Food Res. 2020. PMID: 32627931 Free PMC article.
The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavonoid in hops (Humulus lupulus), and its hydrogenated derivatives, alpha,beta-dihydroxanthohumol (DXN), and tetrahydroxanthohumol (TXN), ameliorated obesity-mediated insulin res …
The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavonoid in hops (Humulus lupulus), and …
Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP/PS1 Mice: An Omics-Based Study.
Hu FF, Pan SY, Chu JY, Liu JJ, Duan TT, Luo Y, Zhou W, Wang ZM, Liu W, Zeng Y. Hu FF, et al. Nutrients. 2024 Oct 31;16(21):3754. doi: 10.3390/nu16213754. Nutrients. 2024. PMID: 39519590 Free PMC article.
Our previous work suggested that the natural compound xanthohumol, the most abundant prenylated flavonoid in hops, prevents memory deficits in APP/PS1 mice; however, the underlying mechanisms remain unclear. ...Further mechanistic analyses suggested systemic regulatory eff …
Our previous work suggested that the natural compound xanthohumol, the most abundant prenylated flavonoid in hops, prevents memory de …
34 results