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Protective effect of xanthohumol against age-related brain damage.
Rancán L, Paredes SD, García I, Muñoz P, García C, López de Hontanar G, de la Fuente M, Vara E, Tresguerres JAF. Rancán L, et al. J Nutr Biochem. 2017 Nov;49:133-140. doi: 10.1016/j.jnutbio.2017.07.011. Epub 2017 Jul 27. J Nutr Biochem. 2017. PMID: 28950154
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated pron …
However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprot …
Amyloid-β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential for treating Alzheimer's disease (AD). OBJECTIVE: We designed and prepared a series of xanthohumol derivatives to enhance the …
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential …
Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-β-cyclodextrin Complex Suitable for Parenteral Administration.
Kirchinger M, Bieler L, Tevini J, Vogl M, Haschke-Becher E, Felder TK, Couillard-Després S, Riepl H, Urmann C. Kirchinger M, et al. Planta Med. 2019 Nov;85(16):1233-1241. doi: 10.1055/a-1013-1276. Epub 2019 Oct 14. Planta Med. 2019. PMID: 31610603
Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not significantly differ, suggesting the release of Xanthohumol C from 2-hydroxypropyl-β-cyclodextrin. Finally, a small-scaled in vivo experiment in a rat model showed that after i. p. …
Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not significantly differ, suggesting the release of …
Xanthohumol, an active constituent from hope, affords protection against kainic acid-induced excitotoxicity in rats.
Wang CC, Ho YH, Hung CF, Kuo JR, Wang SJ. Wang CC, et al. Neurochem Int. 2020 Feb;133:104629. doi: 10.1016/j.neuint.2019.104629. Epub 2019 Dec 6. Neurochem Int. 2020. PMID: 31816340
Excitotoxicity induced by excessive glutamate has been implicated in many brain disorders. Xanthohumol is a natural product derived from hops (Humulus lupulus L.), which is reported to have glutamate release-inhibiting activity. However, it is unknown whether xan …
Excitotoxicity induced by excessive glutamate has been implicated in many brain disorders. Xanthohumol is a natural product de …
Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells.
Gite S, Ross RP, Kirke D, Guihéneuf F, Aussant J, Stengel DB, Dinan TG, Cryan JF, Stanton C. Gite S, et al. Nutr Neurosci. 2019 Aug;22(8):551-568. doi: 10.1080/1028415X.2017.1418728. Epub 2018 Jan 29. Nutr Neurosci. 2019. PMID: 29378496
Among crude extracts, xanthohumol, phlorotannin extract (Ecklonia cava), petroleum ether extract (Nannochloropsis oculata), and phlorotannin extract (F. vesiculosus) showed a significant increase in BDNF-VI mRNA expression. ...As an adjunct of fluoxetine, phlorotannin extr …
Among crude extracts, xanthohumol, phlorotannin extract (Ecklonia cava), petroleum ether extract (Nannochloropsis oculata), and phlor …
Naturally Derived Polyphenols Protect Against Corticosterone-Induced Changes in Primary Cortical Neurons.
Donoso F, Ramírez VT, Golubeva AV, Moloney GM, Stanton C, Dinan TG, Cryan JF. Donoso F, et al. Int J Neuropsychopharmacol. 2019 Dec 1;22(12):765-777. doi: 10.1093/ijnp/pyz052. Int J Neuropsychopharmacol. 2019. PMID: 31812985 Free PMC article.
In this study, the neuroprotective effects and mechanisms of the naturally derived polyphenols xanthohumol and quercetin against cytotoxicity induced by corticosterone were investigated in primary cortical cells. ...Interestingly, the Nrf2 inhibitor blocked xanthohumol …
In this study, the neuroprotective effects and mechanisms of the naturally derived polyphenols xanthohumol and quercetin against cyto …
Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat.
Donoso F, Egerton S, Bastiaanssen TFS, Fitzgerald P, Gite S, Fouhy F, Ross RP, Stanton C, Dinan TG, Cryan JF. Donoso F, et al. Psychoneuroendocrinology. 2020 Jun;116:104673. doi: 10.1016/j.psyneuen.2020.104673. Epub 2020 Apr 10. Psychoneuroendocrinology. 2020. PMID: 32334345
Rats underwent a dietary intervention with the naturally-derived polyphenols xanthohumol and quercetin, as well as with a phlorotannin extract for 8 weeks. ...We observed profound changes in microbial composition and diversity produced by MS condition and by xanthohumol …
Rats underwent a dietary intervention with the naturally-derived polyphenols xanthohumol and quercetin, as well as with a phlorotanni …
In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells-Cellular Accumulation and Cytotoxicity.
Stompor M, Uram Ł, Podgórski R. Stompor M, et al. Molecules. 2017 Jun 30;22(7):1092. doi: 10.3390/molecules22071092. Molecules. 2017. PMID: 28665345 Free PMC article.
Gliomas are one of the most aggressive and treatment-resistant types of human brain cancer. Identification and evaluation of anticancer properties of compounds found in plants, such as naringenin (N) and 8-prenylnaringenin (8PN), are among the most promising applications i …
Gliomas are one of the most aggressive and treatment-resistant types of human brain cancer. Identification and evaluation of anticanc …
Targeting the Liver-Brain Axis with Hop-Derived Flavonoids Improves Lipid Metabolism and Cognitive Performance in Mice.
Paraiso IL, Revel JS, Choi J, Miranda CL, Lak P, Kioussi C, Bobe G, Gombart AF, Raber J, Maier CS, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2020 Aug;64(15):e2000341. doi: 10.1002/mnfr.202000341. Epub 2020 Jul 6. Mol Nutr Food Res. 2020. PMID: 32627931
The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavonoid in hops (Humulus lupulus), and its hydrogenated derivatives, α,β-dihydroxanthohumol (DXN), and tetrahydroxanthohumol (TXN), ameliorated obesity-mediated insulin resistance …
The authors previously reported that FXR agonist xanthohumol (XN), the principal prenylated flavonoid in hops (Humulus lupulus), and …
Xanthohumol improved cognitive flexibility in young mice.
Zamzow DR, Elias V, Legette LL, Choi J, Stevens JF, Magnusson KR. Zamzow DR, et al. Behav Brain Res. 2014 Dec 15;275:1-10. doi: 10.1016/j.bbr.2014.08.045. Epub 2014 Sep 1. Behav Brain Res. 2014. PMID: 25192637 Free PMC article.
What is not known is whether the application of xanthohumol could influence the palmitoylation status of proteins. In this study, young and old mice were fed a diet supplemented with xanthohumol for 8 weeks. ...The old mice receiving xanthohumol did not signi …
What is not known is whether the application of xanthohumol could influence the palmitoylation status of proteins. In this study, you …
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