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Year Number of Results
1999 1
2000 1
2001 1
2005 5
2006 2
2007 2
2008 1
2010 1
2011 1
2012 5
2013 6
2014 3
2015 3
2016 2
2017 2
2018 4
2019 3
2020 2
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The influence of a single and double biotinylation of xanthohumol on its anticancer activity.
Stompor M, Świtalska M, Wietrzyk J. Stompor M, et al. Acta Biochim Pol. 2019 Dec 10;66(4):559-565. doi: 10.18388/abp.2019_2876. Acta Biochim Pol. 2019. PMID: 31820895 Free article.

For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 values < 9 μM). Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types o

For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 …
Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model.
Zhang W, Pan Y, Gou P, Zhou C, Ma L, Liu Q, Du Y, Yang J, Wang Q. Zhang W, et al. Oncol Rep. 2018 Jan;39(1):280-288. doi: 10.3892/or.2017.6094. Epub 2017 Nov 13. Oncol Rep. 2018. PMID: 29138867
Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous studies have reported that XN inhibits the growth of many types of cancer cells, but the effects of XN on tumor immunity have not yet been stu
Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous st
Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro.
Sun Z, Zhou C, Liu F, Zhang W, Chen J, Pan Y, Ma L, Liu Q, Du Y, Yang J, Wang Q. Sun Z, et al. Oncol Lett. 2018 Jan;15(1):908-916. doi: 10.3892/ol.2017.7434. Epub 2017 Nov 17. Oncol Lett. 2018. PMID: 29422966 Free PMC article.
Nevertheless, limited studies indicate that xanthohumol (XN), a major prenylated flavonoid in hop plants (Humulus lupulus), may possess anticarcinogenic properties. The purpose of the present study was to clarify the antitumorigenic effects and the underlying mechanism of …
Nevertheless, limited studies indicate that xanthohumol (XN), a major prenylated flavonoid in hop plants (Humulus lupulus), may posse …
2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
Kim SY, Lee IS, Moon A. Kim SY, et al. Chem Biol Interact. 2013 May 25;203(3):565-72. doi: 10.1016/j.cbi.2013.03.012. Epub 2013 Apr 3. Chem Biol Interact. 2013. PMID: 23562496
Breast cancer is estimated as one of the most common causes of cancer death among women. In particular, triple negative breast cancers (TNBCs), which do not express the genes for estrogen/progesterone receptors (ER/PR) and human epidermal growth factor receptor 2 (H
Breast cancer is estimated as one of the most common causes of cancer death among women. In particular, triple negative breast
Controlled release of resveratrol and xanthohumol via coaxial electrospinning fibers.
Zhang X, Han L, Sun Q, Xia W, Zhou Q, Zhang Z, Song X. Zhang X, et al. J Biomater Sci Polym Ed. 2020 Mar;31(4):456-471. doi: 10.1080/09205063.2019.1700600. Epub 2019 Dec 17. J Biomater Sci Polym Ed. 2020. PMID: 31801405
Resveratrol (RES) and xanthohumol (XAN) which are both new drugs originated from plants exhibit great potential in the treatment of cancer, but there are few studies on combining them in a delivery system. ...The medicated fibers presented good characteristics of inhibitin …
Resveratrol (RES) and xanthohumol (XAN) which are both new drugs originated from plants exhibit great potential in the treatment of c …
Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells.
Liu M, Yin H, Qian X, Dong J, Qian Z, Miao J. Liu M, et al. Molecules. 2016 Dec 28;22(1):36. doi: 10.3390/molecules22010036. Molecules. 2016. PMID: 28036030 Free PMC article.
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities. ...These results demonstrate that xanthohumol is a promising compound targeting the doxorubicin
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a va
Xanthohumol inhibits cellular proliferation in a breast cancer cell line (MDA-MB231) through an intrinsic mitochondrial-dependent pathway.
Yoo YB, Park KS, Kim JB, Kang HJ, Yang JH, Lee EK, Kim HY. Yoo YB, et al. Indian J Cancer. 2014 Oct-Dec;51(4):518-23. doi: 10.4103/0019-509X.175328. Indian J Cancer. 2014. PMID: 26842182 Free article.
The purpose of this study was to investigate the effects of xanthohumol on breast cancer cell proliferation. MATERIALS AND METHODS: After treatment with 5 μM, 10 μM, and 20 μM xanthohumol for 48 h, cells from the human breast cancer cell line MDA-MB-23 …
The purpose of this study was to investigate the effects of xanthohumol on breast cancer cell proliferation. MATERIALS AND MET …
Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression.
Blanquer-Rosselló MM, Oliver J, Valle A, Roca P. Blanquer-Rosselló MM, et al. J Cell Biochem. 2013 Dec;114(12):2785-94. doi: 10.1002/jcb.24627. J Cell Biochem. 2013. PMID: 23836544
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on certain cancer types. The breast cancer line MCF-7 was treated with doses ranging from 0.001 to 20 µM of XN or 8PN in order to assess
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on c
Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.
Bartmańska A, Tronina T, Popłoński J, Milczarek M, Filip-Psurska B, Wietrzyk J. Bartmańska A, et al. Molecules. 2018 Nov 9;23(11):2922. doi: 10.3390/molecules23112922. Molecules. 2018. PMID: 30423918 Free PMC article.
Xanthohumol, α,β-dihydroxanthohumol and 6-prenylnaringenin were the most active compounds. Xanthohumol exhibited higher antiproliferative activity than cisplatin (CP) against five cancer cell lines: ovarian resistant to cisplatin A2780cis, breast MDA-MB-231 a
Xanthohumol, α,β-dihydroxanthohumol and 6-prenylnaringenin were the most active compounds. Xanthohumol exhibited higher antipr
Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis.
Viola K, Kopf S, Rarova L, Jarukamjorn K, Kretschy N, Teichmann M, Vonach C, Atanasov AG, Giessrigl B, Huttary N, Raab I, Krieger S, Strnad M, de Martin R, Saiko P, Szekeres T, Knasmüller S, Dirsch VM, Jäger W, Grusch M, Dolznig H, Mikulits W, Krupitza G. Viola K, et al. Arch Toxicol. 2013 Jul;87(7):1301-12. doi: 10.1007/s00204-013-1028-2. Epub 2013 Mar 17. Arch Toxicol. 2013. PMID: 23503627
Therefore, this study investigated the anti-metastatic potential of xanthohumol. MCF-7 breast cancer spheroids which are placed on lymphendothelial cells (LECs) induce "circular chemorepellent-induced defects" (CCIDs) in the LEC monolayer resembling gates for intrav …
Therefore, this study investigated the anti-metastatic potential of xanthohumol. MCF-7 breast cancer spheroids which are place …
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