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Prostate and breast cancer cells death induced by xanthohumol investigated with Fourier transform infrared spectroscopy.
Gieroba B, Arczewska M, Sławińska-Brych A, Rzeski W, Stepulak A, Gagoś M. Gieroba B, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 15;231:118112. doi: 10.1016/j.saa.2020.118112. Epub 2020 Jan 25. Spectrochim Acta A Mol Biomol Spectrosc. 2020. PMID: 32014658 Free article.
Fourier Transform Infrared spectroscopy was applied to detect in vitro cell death induced in prostate (PC-3) and breast (T47D) cancer cell lines treated with xanthohumol (XN). After incubation of the cancer cells with XN, specific spectral shifts in the infrared spe …
Fourier Transform Infrared spectroscopy was applied to detect in vitro cell death induced in prostate (PC-3) and breast (T47D) cancer …
Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture.
Gholizadeh Siahmazgi Z, Irani S, Ghiaseddin A, Fallah P, Haghpanah V. Gholizadeh Siahmazgi Z, et al. Cancer Cell Int. 2023 Aug 2;23(1):153. doi: 10.1186/s12935-023-03009-2. Cancer Cell Int. 2023. PMID: 37533078 Free PMC article.
BACKGROUND: Despite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. Xanthohumol (XN) is known as a bioactive compound that shows an anticancer effect on cancer cells. ...The spheroids of the breast …
BACKGROUND: Despite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. …
The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway.
Gupta KK, Sharma KK, Chandra H, Panwar H, Bhardwaj N, Altwaijry NA, Alsfouk AA, Dlamini Z, Afzal O, Altamimi ASA, Khan S, Mishra AP. Gupta KK, et al. Front Oncol. 2022 Dec 15;12:950835. doi: 10.3389/fonc.2022.950835. eCollection 2022. Front Oncol. 2022. PMID: 36591523 Free PMC article.
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targeting phosphoinositide-3-kinase (PI3K), serine/threonine kinase (AKT) receptors, and human epidermal growth factor receptor 2 (HER2) for brea …
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targetin …
2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
Kim SY, Lee IS, Moon A. Kim SY, et al. Chem Biol Interact. 2013 May 25;203(3):565-72. doi: 10.1016/j.cbi.2013.03.012. Epub 2013 Apr 3. Chem Biol Interact. 2013. PMID: 23562496
Breast cancer is estimated as one of the most common causes of cancer death among women. ...Xanthohumol and 2-hydroxychalcone induced apoptosis by Bcl-2 downregulation. Importantly, 2-hydroxychalcone and xanthohumol exerted more potent inhibitory effects on t …
Breast cancer is estimated as one of the most common causes of cancer death among women. ...Xanthohumol and 2-hydroxychalcone …
Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro.
Sun Z, Zhou C, Liu F, Zhang W, Chen J, Pan Y, Ma L, Liu Q, Du Y, Yang J, Wang Q. Sun Z, et al. Oncol Lett. 2018 Jan;15(1):908-916. doi: 10.3892/ol.2017.7434. Epub 2017 Nov 17. Oncol Lett. 2018. PMID: 29422966 Free PMC article.
Nevertheless, limited studies indicate that xanthohumol (XN), a major prenylated flavonoid in hop plants (Humulus lupulus), may possess anticarcinogenic properties. The purpose of the present study was to clarify the antitumorigenic effects and the underlying mechanism of …
Nevertheless, limited studies indicate that xanthohumol (XN), a major prenylated flavonoid in hop plants (Humulus lupulus), may posse …
Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression.
Blanquer-Rosselló MM, Oliver J, Valle A, Roca P. Blanquer-Rosselló MM, et al. J Cell Biochem. 2013 Dec;114(12):2785-94. doi: 10.1002/jcb.24627. J Cell Biochem. 2013. PMID: 23836544
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on certain cancer types. The breast cancer line MCF-7 was treated with doses ranging from 0.001 to 20 M of XN or 8PN in order to assess t …
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on c …
Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts.
Monteiro R, Calhau C, Silva AO, Pinheiro-Silva S, Guerreiro S, Gärtner F, Azevedo I, Soares R. Monteiro R, et al. J Cell Biochem. 2008 Aug 1;104(5):1699-707. doi: 10.1002/jcb.21738. J Cell Biochem. 2008. PMID: 18348194
Xanthohumol (XN), a natural polyphenol present in beer, is known to exert anti-cancer effects. ...These novel findings indicate that XN is able to target both breast cancer and host cells, namely inflammatory and endothelial cells, suggesting its potential use as a …
Xanthohumol (XN), a natural polyphenol present in beer, is known to exert anti-cancer effects. ...These novel findings indicate that …
The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
Kang Y, Park MA, Heo SW, Park SY, Kang KW, Park PH, Kim JA. Kang Y, et al. Biochim Biophys Acta. 2013 Mar;1830(3):2638-48. doi: 10.1016/j.bbagen.2012.12.005. Biochim Biophys Acta. 2013. PMID: 23246576
METHODS: Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells. ...CONCLUSIONS: Xanthohu …
METHODS: Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its …
The influence of a single and double biotinylation of xanthohumol on its anticancer activity.
Stompor M, Świtalska M, Wietrzyk J. Stompor M, et al. Acta Biochim Pol. 2019 Dec 10;66(4):559-565. doi: 10.18388/abp.2019_2876. Acta Biochim Pol. 2019. PMID: 31820895 Free article.

For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 values < 9 muM). Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types

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For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 …
Controlled release of resveratrol and xanthohumol via coaxial electrospinning fibers.
Zhang X, Han L, Sun Q, Xia W, Zhou Q, Zhang Z, Song X. Zhang X, et al. J Biomater Sci Polym Ed. 2020 Mar;31(4):456-471. doi: 10.1080/09205063.2019.1700600. Epub 2019 Dec 17. J Biomater Sci Polym Ed. 2020. PMID: 31801405
Synergistic delivery of two drugs is a desirable choice to overcome drug resistance. Resveratrol (RES) and xanthohumol (XAN) which are both new drugs originated from plants exhibit great potential in the treatment of cancer, but there are few studies on combining them in a …
Synergistic delivery of two drugs is a desirable choice to overcome drug resistance. Resveratrol (RES) and xanthohumol (XAN) which ar …
51 results