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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 3
2001 2
2002 2
2004 1
2005 15
2006 6
2007 13
2008 10
2009 5
2010 7
2011 9
2012 19
2013 12
2014 8
2015 13
2016 14
2017 12
2018 21
2019 20
2020 13
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182 results
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Page 1
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
Chen CY, Kao CL, Liu CM. Chen CY, et al. Int J Mol Sci. 2018 Sep 12;19(9):2729. doi: 10.3390/ijms19092729. Int J Mol Sci. 2018. PMID: 30213077 Free PMC article. Review.
Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response and cancer progression. ...Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-ginger …
Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signa …
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Gupta SC, et al. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Front Immunol. 2018. PMID: 30319623 Free PMC article. Review.
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. ...The …
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediate …
Prenylated chalcones and flavonoids for the prevention and treatment of cancer.
Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Venturelli S, et al. Nutrition. 2016 Nov-Dec;32(11-12):1171-8. doi: 10.1016/j.nut.2016.03.020. Epub 2016 Apr 8. Nutrition. 2016. PMID: 27238957 Review.
This review focuses on the great potential of these plant- and nutrient-derived compounds for cancer prevention and therapy. Provided here is a comprehensive summary of the current knowledge and inherent modes of action, focusing on the prenylated chalcones xanthohumol …
This review focuses on the great potential of these plant- and nutrient-derived compounds for cancer prevention and therapy. Provided …
Xanthohumol inhibits angiogenesis by suppressing nuclear factor-κB activation in pancreatic cancer.
Saito K, Matsuo Y, Imafuji H, Okubo T, Maeda Y, Sato T, Shamoto T, Tsuboi K, Morimoto M, Takahashi H, Ishiguro H, Takiguchi S. Saito K, et al. Cancer Sci. 2018 Jan;109(1):132-140. doi: 10.1111/cas.13441. Epub 2017 Dec 3. Cancer Sci. 2018. PMID: 29121426 Free PMC article.
.), has been shown to inhibit proliferation in some cancers. However, little is known regarding the effects of xanthohumol in pancreatic cancer. ...Accordingly, xanthohumol may represent a novel therapeutic agent for the management of pancreatic can …
.), has been shown to inhibit proliferation in some cancers. However, little is known regarding the effects of xanthohumol in …
Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.
Yang J, Li B, He QY. Yang J, et al. Cell Death Dis. 2018 May 21;9(6):580. doi: 10.1038/s41419-018-0661-3. Cell Death Dis. 2018. PMID: 29784973 Free PMC article. Review.
Most studies have confirmed differential expression of PHB1 and PHB2 in cancers compared to corresponding normal tissues. Furthermore, studies verified that PHB1 and PHB2 are involved in the biological processes of tumorigenesis, including cancer cell proliferation, …
Most studies have confirmed differential expression of PHB1 and PHB2 in cancers compared to corresponding normal tissues. Furthermore …
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.
Liu W, Li W, Liu H, Yu X. Liu W, et al. Int J Biol Sci. 2019 Sep 7;15(11):2497-2508. doi: 10.7150/ijbs.37481. eCollection 2019. Int J Biol Sci. 2019. PMID: 31595166 Free PMC article.
Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC). In the present study, we reported that Hexokinase 2 (HK2) is overexpressed in human CRC tissues and cell lines, knockout of HK2 inhibited cell proliferation, colony formation, and xenograft …
Deregulation of glycolysis is a common phenomenon in human colorectal cancer (CRC). In the present study, we reported that Hexokinase …
The influence of a single and double biotinylation of xanthohumol on its anticancer activity.
Stompor M, Åšwitalska M, Wietrzyk J. Stompor M, et al. Acta Biochim Pol. 2019 Dec 10;66(4):559-565. doi: 10.18388/abp.2019_2876. Acta Biochim Pol. 2019. PMID: 31820895 Free article.

For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 values < 9 μM). Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types o

…
For all three tested compounds the best activity was noted in the case of human (MCF-7) and mice (4T1) breast cancer cell lines (IC50 …
Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways.
Li F, Yao Y, Huang H, Hao H, Ying M. Li F, et al. Int Immunopharmacol. 2018 Aug;61:277-282. doi: 10.1016/j.intimp.2018.05.017. Epub 2018 Jun 12. Int Immunopharmacol. 2018. PMID: 29906742
Cisplatin is a chemotherapeutic agent that widely used in the treatment of cancer. However, cisplatin has been reported to induce nephrotoxicity by directly inducing inflammatory response and oxidative stress. ...The levels of TNF-α, IL-1ß and IL-6 in kidney tissues were s …
Cisplatin is a chemotherapeutic agent that widely used in the treatment of cancer. However, cisplatin has been reported to induce nep …
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known …
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use ra …
Xanthohumol chalcone acts as a powerful inhibitor of carcinogenesis in drug-resistant human colon carcinoma and these effects are mediated via G2/M phase cell cycle arrest, activation of apoptotic pathways, caspase activation and targeting Ras /MEK/ERK pathway.
Liu X, An LJ, Li Y, Wang Y, Zhao L, Lv X, Guo J, Song AL. Liu X, et al. J BUON. 2019 Nov-Dec;24(6):2442-2447. J BUON. 2019. PMID: 31983118 Free article.
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer cells. This study was undertaken to evaluate the anticancer effects of Xanthohumol against the human colon cancer cell line HT-29 a …
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer cells …
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