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2012 6
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2017 2
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2021 8
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Xanthohumol from Hop: Hope for cancer prevention and treatment.
Girisa S, Saikia Q, Bordoloi D, Banik K, Monisha J, Daimary UD, Verma E, Ahn KS, Kunnumakkara AB. Girisa S, et al. IUBMB Life. 2021 Aug;73(8):1016-1044. doi: 10.1002/iub.2522. Epub 2021 Jul 6. IUBMB Life. 2021. PMID: 34170599 Review.
The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies for the prevention and treatment of this disease. Xanthohumol (XN), a prenylated chalcone present in Hop (Humulus lupu …
The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative str …
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
Chen CY, Kao CL, Liu CM. Chen CY, et al. Int J Mol Sci. 2018 Sep 12;19(9):2729. doi: 10.3390/ijms19092729. Int J Mol Sci. 2018. PMID: 30213077 Free PMC article. Review.
Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response and cancer progression. Dietary phytochemicals are potential modulators of immu …
Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signa …
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Gupta SC, et al. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Front Immunol. 2018. PMID: 30319623 Free PMC article. Review.
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. ...The …
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediate …
Prenylated chalcones and flavonoids for the prevention and treatment of cancer.
Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Venturelli S, et al. Nutrition. 2016 Nov-Dec;32(11-12):1171-8. doi: 10.1016/j.nut.2016.03.020. Epub 2016 Apr 8. Nutrition. 2016. PMID: 27238957 Review.
Prenylated chalcones and flavonoids gained increasing attention not only in nutrition but also in cancer prevention because of their biological and molecular activities in humans, which have been extensively investigated in vitro or in preclinical studies. ...This r …
Prenylated chalcones and flavonoids gained increasing attention not only in nutrition but also in cancer prevention because of …
Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.
Harish V, Haque E, Śmiech M, Taniguchi H, Jamieson S, Tewari D, Bishayee A. Harish V, et al. Int J Mol Sci. 2021 Apr 25;22(9):4478. doi: 10.3390/ijms22094478. Int J Mol Sci. 2021. PMID: 33923053 Free PMC article. Review.
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and tr
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. ...Lastly, we focu
Antiproliferative and palliative activity of flavonoids in colorectal cancer.
Fernández J, Silván B, Entrialgo-Cadierno R, Villar CJ, Capasso R, Uranga JA, Lombó F, Abalo R. Fernández J, et al. Biomed Pharmacother. 2021 Nov;143:112241. doi: 10.1016/j.biopha.2021.112241. Epub 2021 Sep 30. Biomed Pharmacother. 2021. PMID: 34649363 Free article. Review.
These cell lines represent three different stages of this tumor, one of which is metastatic. Xanthohumol showed the best antitumor activity on the three cancer cell lines, even better than that of the clinical drug 5-fluorouracil (5-FU), although no synergistic effe …
These cell lines represent three different stages of this tumor, one of which is metastatic. Xanthohumol showed the best antitumor ac …
Angiogenesis and cancer prevention: a vision.
Noonan DM, Benelli R, Albini A. Noonan DM, et al. Recent Results Cancer Res. 2007;174:219-24. doi: 10.1007/978-3-540-37696-5_19. Recent Results Cancer Res. 2007. PMID: 17302199 Review.
N-acetyl-cysteine, and the green tea flavonoid epigallocatechin-3-gallate (EGCG) and the beer/ hops-derived chalcone Xanthohumol all prevent angiogenesis in the Matrigel sponge angiogenic assay in vivo and inhibit the growth of the highly angiogenic Kaposi's
N-acetyl-cysteine, and the green tea flavonoid epigallocatechin-3-gallate (EGCG) and the beer/ hops-derived chalcone Xanthohumol all …
Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Diseases and Cancer.
Albini A, Bassani B, Baci D, Dallaglio K, Gallazzi M, Corradino P, Bruno A, Noonan DM. Albini A, et al. Curr Med Chem. 2019;26(6):973-987. doi: 10.2174/0929867324666170920144130. Curr Med Chem. 2019. PMID: 28933290 Review.
For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. ...We summarize the beneficial effects of several compounds in conferring protection and supporting therap …
For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current …
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.
Liu W, Li W, Liu H, Yu X. Liu W, et al. Int J Biol Sci. 2019 Sep 7;15(11):2497-2508. doi: 10.7150/ijbs.37481. eCollection 2019. Int J Biol Sci. 2019. PMID: 31595166 Free PMC article.
Xanthohumol suppressed CRC cell growth both in vitro and in vivo. Treatment with xanthohumol promoted the release of cytochrome C and activated the intrinsic apoptosis pathway. Moreover, our results revealed that xanthohumol down-regulated the EGFR-Akt signal
Xanthohumol suppressed CRC cell growth both in vitro and in vivo. Treatment with xanthohumol promoted the release of cytochrom
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Stevens JF, Page JE. Stevens JF, et al. Phytochemistry. 2004 May;65(10):1317-30. doi: 10.1016/j.phytochem.2004.04.025. Phytochemistry. 2004. PMID: 15231405 Review.
Xanthohumol has been characterized a 'broad-spectrum' cancer chemopreventive agent in in vitro studies, while 8-prenylnaringenin enjoys fame as the most potent phytoestrogen known to date. These biological activities suggest that prenylflavonoids from hops have pote
Xanthohumol has been characterized a 'broad-spectrum' cancer chemopreventive agent in in vitro studies, while 8-prenylnaringen
57 results