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Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4α and Inhibits Cholesterol Uptake in Caco-2 Cells.
Thang SK, Chen PY, Gao WY, Wu MJ, Pan MH, Yen JH. Thang SK, et al. J Agric Food Chem. 2019 Oct 9;67(40):11119-11128. doi: 10.1021/acs.jafc.9b05221. Epub 2019 Sep 26. J Agric Food Chem. 2019. PMID: 31525874
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and atherosclerosis. ...These findings reveal that Xan suppresses NPC1L1 expression via downregulation of HNF-4alpha and exer …
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, h …
Xanthohumol prevents atherosclerosis by reducing arterial cholesterol content via CETP and apolipoprotein E in CETP-transgenic mice.
Hirata H, Yimin, Segawa S, Ozaki M, Kobayashi N, Shigyo T, Chiba H. Hirata H, et al. PLoS One. 2012;7(11):e49415. doi: 10.1371/journal.pone.0049415. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166663 Free PMC article.
In CETP-Tg mice, xanthohumol significantly decreased accumulated cholesterol in the aortic arch and increased HDL cholesterol (HDL-C) when compared to the control group (without xanthohumol). ...Furthermore, apolipoprotein E (apoE) was enriched in seru …
In CETP-Tg mice, xanthohumol significantly decreased accumulated cholesterol in the aortic arch and increased HDL cholester …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipi …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to …
Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport.
Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K. Hirata H, et al. J Nutr Biochem. 2017 Sep;47:29-34. doi: 10.1016/j.jnutbio.2017.04.011. Epub 2017 Apr 22. J Nutr Biochem. 2017. PMID: 28501703
Ex vivo experiments were then employed to investigate the detailed mechanism by which xanthohumol enhanced RCT. Cholesterol efflux capacity from macrophages was 1.5-fold higher in xanthohumol-fed hamsters compared with the control group. In addition, protein …
Ex vivo experiments were then employed to investigate the detailed mechanism by which xanthohumol enhanced RCT. Cholesterol ef …
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. ...METHODS AND RESULTS: XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosc …
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and …
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. ...Treatment with XN at 60 mg/kg/day resulted in reduced plasma LDL-cholesterol (LDL-C), IL-6, insulin and leptin levels by 80%, 78%, 42%, and 41%, respectively, compared to the veh …
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. ...Treatment with XN at 60 mg/kg/day resulted in …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food …
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received …
Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.
Miyata S, Inoue J, Shimizu M, Sato R. Miyata S, et al. J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3. J Biol Chem. 2015. PMID: 26140926 Free PMC article.
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP …
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty a …
ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways.
Kundu P, Holden S, Paraiso IL, Sudhakar R, McQuesten C, Choi J, Miranda CL, Maier CS, Bobe G, Stevens JF, Raber J. Kundu P, et al. Front Pharmacol. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980. eCollection 2022. Front Pharmacol. 2022. PMID: 36278228 Free PMC article.
This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer's disease (AD). Apolipoprotein E (apoE) is involved in cholesterol metabolism. ...Compared to E3, E4 increases ACD and AD risk and vulnerability to the de …
This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer's disease (AD). Apoli …
Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy.
Dostálek P, Karabín M, Jelínek L. Dostálek P, et al. Molecules. 2017 Oct 19;22(10):1761. doi: 10.3390/molecules22101761. Molecules. 2017. PMID: 29048380 Free PMC article. Review.
Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are su …
Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols a …
18 results