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Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4α and Inhibits Cholesterol Uptake in Caco-2 Cells.
Thang SK, Chen PY, Gao WY, Wu MJ, Pan MH, Yen JH. Thang SK, et al. J Agric Food Chem. 2019 Oct 9;67(40):11119-11128. doi: 10.1021/acs.jafc.9b05221. Epub 2019 Sep 26. J Agric Food Chem. 2019. PMID: 31525874
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and atherosclerosis. ...Our findings suggest Xan could serve as a potential cholesterol-lowering agent and supplement …
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, h …
Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport.
Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K. Hirata H, et al. J Nutr Biochem. 2017 Sep;47:29-34. doi: 10.1016/j.jnutbio.2017.04.011. Epub 2017 Apr 22. J Nutr Biochem. 2017. PMID: 28501703
Ex vivo experiments were then employed to investigate the detailed mechanism by which xanthohumol enhanced RCT. Cholesterol efflux capacity from macrophages was 1.5-fold higher in xanthohumol-fed hamsters compared with the control group. In addition, protein …
Ex vivo experiments were then employed to investigate the detailed mechanism by which xanthohumol enhanced RCT. Cholesterol ef …
Xanthohumol prevents atherosclerosis by reducing arterial cholesterol content via CETP and apolipoprotein E in CETP-transgenic mice.
Hirata H, Yimin, Segawa S, Ozaki M, Kobayashi N, Shigyo T, Chiba H. Hirata H, et al. PLoS One. 2012;7(11):e49415. doi: 10.1371/journal.pone.0049415. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166663 Free PMC article.
In CETP-Tg mice, xanthohumol significantly decreased accumulated cholesterol in the aortic arch and increased HDL cholesterol (HDL-C) when compared to the control group (without xanthohumol). ...CONCLUSIONS: Our results suggest xanthohumol preve …
In CETP-Tg mice, xanthohumol significantly decreased accumulated cholesterol in the aortic arch and increased HDL cholester …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. ...Both XN and 8PN treatments prevented body weight gain; decrease …
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in live …
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. ...Fecal cholesterol concentrations were also markedly increased in XN-fed ApoE⁻/⁻ mice compared with mice fed we …
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and …
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. ...Plasma levels of glucose, total triglycerides, …
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. ...Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The f …
Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commerc …
Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.
Miyata S, Inoue J, Shimizu M, Sato R. Miyata S, et al. J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3. J Biol Chem. 2015. PMID: 26140926 Free PMC article.
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP …
Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that stimulate the expression of genes involved in fatty a …
Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy.
Dostálek P, Karabín M, Jelínek L. Dostálek P, et al. Molecules. 2017 Oct 19;22(10):1761. doi: 10.3390/molecules22101761. Molecules. 2017. PMID: 29048380 Free PMC article. Review.
Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. ...
Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. ...
Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein.
Hirata H, Takazumi K, Segawa S, Okada Y, Kobayashi N, Shigyo T, Chiba H. Hirata H, et al. Food Chem. 2012 Oct 1;134(3):1432-7. doi: 10.1016/j.foodchem.2012.03.043. Epub 2012 Mar 19. Food Chem. 2012. PMID: 25005963
High density lipoprotein (HDL)-cholesterol levels are correlated with a low risk of atherosclerosis. The inhibition of cholesteryl ester transfer protein (CETP), which catalyses cholesterol transfer between lipoproteins, leads to an increase in HDL-cholesterol …
High density lipoprotein (HDL)-cholesterol levels are correlated with a low risk of atherosclerosis. The inhibition of cholesteryl es …
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