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Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells.
Torrens-Mas M, Alorda-Clara M, Martínez-Vigara M, Roca P, Sastre-Serra J, Oliver J, Pons DG. Torrens-Mas M, et al. Int J Food Sci Nutr. 2022 Jun;73(4):471-479. doi: 10.1080/09637486.2021.2012561. Epub 2021 Dec 8. Int J Food Sci Nutr. 2022. PMID: 34879764
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-cancer agent. ...
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known, 8-pre
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use ra
Xanthohumol chalcone acts as a powerful inhibitor of carcinogenesis in drug-resistant human colon carcinoma and these effects are mediated via G2/M phase cell cycle arrest, activation of apoptotic pathways, caspase activation and targeting Ras /MEK/ERK pathway.
Liu X, An LJ, Li Y, Wang Y, Zhao L, Lv X, Guo J, Song AL. Liu X, et al. J BUON. 2019 Nov-Dec;24(6):2442-2447. J BUON. 2019. PMID: 31983118 Free article.
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer cells. This study was undertaken to evaluate the anticancer effects of Xanthohumol against the human colon cancer cel …
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.
Pan L, Becker H, Gerhäuser C. Pan L, et al. Mol Nutr Food Res. 2005 Sep;49(9):837-43. doi: 10.1002/mnfr.200500065. Mol Nutr Food Res. 2005. PMID: 15995977
In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells. Cell proliferation was measured by sulforhodamine B staining. ...XN significantly reduced proliferation of the HCT 116-derived colon cancer
In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells. Cell prolifera …
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Scagliarini A, Mathey A, Aires V, Delmas D. Scagliarini A, et al. Cells. 2020 Apr 10;9(4):932. doi: 10.3390/cells9040932. Cells. 2020. PMID: 32290112 Free PMC article.
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. ...We demonstrate for the first time that Xn exerts its anticancer activity in models of colon
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consisten …
In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
Gonçalves P, Araújo JR, Pinho MJ, Martel F. Gonçalves P, et al. Nutr Cancer. 2011;63(2):282-94. doi: 10.1080/01635581.2011.523166. Nutr Cancer. 2011. PMID: 21207318
Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin. . …
Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, c …
Xanthohumol, a hop-derived prenylflavonoid present in beer, impairs mitochondrial functionality of SW620 colon cancer cells.
Sastre-Serra J, Ahmiane Y, Roca P, Oliver J, Pons DG. Sastre-Serra J, et al. Int J Food Sci Nutr. 2019 Jun;70(4):396-404. doi: 10.1080/09637486.2018.1540558. Epub 2018 Nov 20. Int J Food Sci Nutr. 2019. PMID: 30458656
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of cancer. It presents a great interest against colon cancer due to high exposure of this compound in this tissue. ...
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of canc
Antioxidant and antiproliferative activity of glycosides obtained by biotransformation of xanthohumol.
Tronina T, Bartmańska A, Milczarek M, Wietrzyk J, Popłoński J, Rój E, Huszcza E. Tronina T, et al. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1957-60. doi: 10.1016/j.bmcl.2013.02.031. Epub 2013 Feb 15. Bioorg Med Chem Lett. 2013. PMID: 23466227
Microbial regioselective glycosylation at the C-4' position led to xanthohumol 4'-O-beta-d-glucopyranoside (2) and xanthohumol 4'-O-beta-d-(4'''-O-methyl)-glucopyranoside (3). ...The biological activity of isolated metabolites has been evaluated. Compared to xant
Microbial regioselective glycosylation at the C-4' position led to xanthohumol 4'-O-beta-d-glucopyranoside (2) and xanthohumol
Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ).
Ferk F, Huber WW, Filipic M, Bichler J, Haslinger E, Misík M, Nersesyan A, Grasl-Kraupp B, Zegura B, Knasmüller S. Ferk F, et al. Mutat Res. 2010 Sep 10;691(1-2):17-22. doi: 10.1016/j.mrfmmm.2010.06.006. Epub 2010 Jun 12. Mutat Res. 2010. PMID: 20547166
Xanthohumol (XN) is a hop derived prenylated flavonoid contained in beer. ...Furthermore, it was found that XN inhibits DNA synthesis and proliferation of cancer cells in vitro, inactivates oxygen radicals and induces apoptosis. ...
Xanthohumol (XN) is a hop derived prenylated flavonoid contained in beer. ...Furthermore, it was found that XN inhibits DNA synthesis
Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin.
Seliger JM, Martin HJ, Maser E, Hintzpeter J. Seliger JM, et al. Chem Biol Interact. 2019 May 25;305:156-162. doi: 10.1016/j.cbi.2019.02.031. Epub 2019 Mar 6. Chem Biol Interact. 2019. PMID: 30849340
Also with regard to their effects by means of interacting with cancer-related molecular pathways, XN and related prenylated flavonoids in particular have been in the focus of recent studies. ...XN, IX and 8-PN also efficiently inhibited DAUN reduction by SW480 colon
Also with regard to their effects by means of interacting with cancer-related molecular pathways, XN and related prenylated flavonoid …
17 results