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Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells.
Torrens-Mas M, Alorda-Clara M, Martínez-Vigara M, Roca P, Sastre-Serra J, Oliver J, Pons DG. Torrens-Mas M, et al. Int J Food Sci Nutr. 2022 Jun;73(4):471-479. doi: 10.1080/09637486.2021.2012561. Epub 2021 Dec 8. Int J Food Sci Nutr. 2022. PMID: 34879764
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-cancer agent. ...
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti- …
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.
Pan L, Becker H, Gerhäuser C. Pan L, et al. Mol Nutr Food Res. 2005 Sep;49(9):837-43. doi: 10.1002/mnfr.200500065. Mol Nutr Food Res. 2005. PMID: 15995977
In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells. Cell proliferation was measured by sulforhodamine B staining. Poly(ADP-ribose)polymerase (PARP) cleavage, activation of caspases-3, -7, -8, and -9, and Bc …
In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells. Cell prolifera …
Nobiletin and xanthohumol counteract the TNFalpha-mediated activation of endothelial cells through the inhibition of the NF-kappaB signaling pathway.
Corrado C, Barreca MM, Raimondo S, Diana P, Pepe G, Basilicata MG, Conigliaro A, Alessandro R. Corrado C, et al. Cell Biol Int. 2023 Mar;47(3):634-647. doi: 10.1002/cbin.11963. Epub 2022 Nov 15. Cell Biol Int. 2023. PMID: 36378586
Recently, increased attention has been addressed to the ability of flavonoids, the most abundant polyphenols in the diet, to prevent cancer by suppressing angiogenesis. Here we investigate the mechanisms by which xanthohumol (the major prenylated flavonoid of the ho …
Recently, increased attention has been addressed to the ability of flavonoids, the most abundant polyphenols in the diet, to prevent canc …
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known, 8-pre …
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use ra …
In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
Gonçalves P, Araújo JR, Pinho MJ, Martel F. Gonçalves P, et al. Nutr Cancer. 2011;63(2):282-94. doi: 10.1080/01635581.2011.523166. Nutr Cancer. 2011. PMID: 21207318
Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin. . …
Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, c …
Xanthohumol, a hop-derived prenylflavonoid present in beer, impairs mitochondrial functionality of SW620 colon cancer cells.
Sastre-Serra J, Ahmiane Y, Roca P, Oliver J, Pons DG. Sastre-Serra J, et al. Int J Food Sci Nutr. 2019 Jun;70(4):396-404. doi: 10.1080/09637486.2018.1540558. Epub 2018 Nov 20. Int J Food Sci Nutr. 2019. PMID: 30458656
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of cancer. It presents a great interest against colon cancer due to high exposure of this compound in this tissue. Metastatic SW6 …
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of canc …
Xanthohumol chalcone acts as a powerful inhibitor of carcinogenesis in drug-resistant human colon carcinoma and these effects are mediated via G2/M phase cell cycle arrest, activation of apoptotic pathways, caspase activation and targeting Ras /MEK/ERK pathway.
Liu X, An LJ, Li Y, Wang Y, Zhao L, Lv X, Guo J, Song AL. Liu X, et al. J BUON. 2019 Nov-Dec;24(6):2442-2447. J BUON. 2019. PMID: 31983118 Free article.
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer cells. This study was undertaken to evaluate the anticancer effects of Xanthohumol against the human colon cancer cel …
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer …
Prenylated Flavonoids with Selective Toxicity against Human Cancers.
Tronina T, Bartmańska A, Popłoński J, Rychlicka M, Sordon S, Filip-Psurska B, Milczarek M, Wietrzyk J, Huszcza E. Tronina T, et al. Int J Mol Sci. 2023 Apr 18;24(8):7408. doi: 10.3390/ijms24087408. Int J Mol Sci. 2023. PMID: 37108571 Free PMC article.
Both flavonoids, as well as cisplatin as a reference anticancer drug, were tested in vivo against ten human cancer cell lines (breast cancer (MCF-7, SK-BR-3, T47D), colon cancer (HT-29, LoVo, LoVo/Dx), prostate cancer (PC-3, Du145), lung canc …
Both flavonoids, as well as cisplatin as a reference anticancer drug, were tested in vivo against ten human cancer cell lines (breast …
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Scagliarini A, Mathey A, Aires V, Delmas D. Scagliarini A, et al. Cells. 2020 Apr 10;9(4):932. doi: 10.3390/cells9040932. Cells. 2020. PMID: 32290112 Free PMC article.
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated with high resist …
In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consisten …
Isoxanthohumol--Biologically active hop flavonoid.
Żołnierczyk AK, Mączka WK, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Żołnierczyk AK, et al. Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12. Fitoterapia. 2015. PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...IXN exhibits an antiproliferative activity against human cell lines typical for breast cancer (MCF-7), ovarian cancer …
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i …
21 results