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Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known, 8-pre
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use ra
Xanthohumol chalcone acts as a powerful inhibitor of carcinogenesis in drug-resistant human colon carcinoma and these effects are mediated via G2/M phase cell cycle arrest, activation of apoptotic pathways, caspase activation and targeting Ras /MEK/ERK pathway.
Liu X, An LJ, Li Y, Wang Y, Zhao L, Lv X, Guo J, Song AL. Liu X, et al. J BUON. 2019 Nov-Dec;24(6):2442-2447. J BUON. 2019. PMID: 31983118 Free article.
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer cells. This study was undertaken to evaluate the anticancer effects of Xanthohumol against the human colon cancer cel …
However, the anticancer properties of Xanthohumol have not been thoroughly evaluated against drug-resistant colon cancer
Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin.
Seliger JM, Martin HJ, Maser E, Hintzpeter J. Seliger JM, et al. Chem Biol Interact. 2019 May 25;305:156-162. doi: 10.1016/j.cbi.2019.02.031. Epub 2019 Mar 6. Chem Biol Interact. 2019. PMID: 30849340
Also with regard to their effects by means of interacting with cancer-related molecular pathways, XN and related prenylated flavonoids in particular have been in the focus of recent studies. ...XN, IX and 8-PN also efficiently inhibited DAUN reduction by SW480 colon
Also with regard to their effects by means of interacting with cancer-related molecular pathways, XN and related prenylated flavonoid …
Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.
Bartmańska A, Tronina T, Popłoński J, Milczarek M, Filip-Psurska B, Wietrzyk J. Bartmańska A, et al. Molecules. 2018 Nov 9;23(11):2922. doi: 10.3390/molecules23112922. Molecules. 2018. PMID: 30423918 Free PMC article.
Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), and 6-prenylnaringenin (6PN), were tested for antiproliferative activity towards human cancer and normal cell lines. ...Xanthohum
Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN),
Xanthohumol, a hop-derived prenylflavonoid present in beer, impairs mitochondrial functionality of SW620 colon cancer cells.
Sastre-Serra J, Ahmiane Y, Roca P, Oliver J, Pons DG. Sastre-Serra J, et al. Int J Food Sci Nutr. 2019 Jun;70(4):396-404. doi: 10.1080/09637486.2018.1540558. Epub 2018 Nov 20. Int J Food Sci Nutr. 2019. PMID: 30458656
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of cancer. It presents a great interest against colon cancer due to high exposure of this compound in this tissue. Metastatic SW6
Xanthohumol (XN) is a hop-derived prenylflavonoid and have been reported to exhibit anticancer properties in several types of canc
Synthesis and Antiproliferative Activity of Minor Hops Prenylflavonoids and New Insights on Prenyl Group Cyclization.
Popłoński J, Turlej E, Sordon S, Tronina T, Bartmańska A, Wietrzyk J, Huszcza E. Popłoński J, et al. Molecules. 2018 Mar 28;23(4):776. doi: 10.3390/molecules23040776. Molecules. 2018. PMID: 29597299 Free PMC article.
The antiproliferative activity of the obtained compounds against some human cancer cell lines was investigated. Using xanthohumol isolated from spent hops as a lead compound, a series of minor hop prenylflavonoids and synthetic derivatives were obtained by isomeriza …
The antiproliferative activity of the obtained compounds against some human cancer cell lines was investigated. Using xanthohumol
In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
Gonçalves P, Araújo JR, Pinho MJ, Martel F. Gonçalves P, et al. Nutr Cancer. 2011;63(2):282-94. doi: 10.1080/01635581.2011.523166. Nutr Cancer. 2011. PMID: 21207318
Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 μM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it. ...EGCG, myricetin, and catechin decreased MCT1 mRNA expression, while chrysin increased it; quercetin, rutin, and xanthohumol had …
Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 μM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it …
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.
Pan L, Becker H, Gerhäuser C. Pan L, et al. Mol Nutr Food Res. 2005 Sep;49(9):837-43. doi: 10.1002/mnfr.200500065. Mol Nutr Food Res. 2005. PMID: 15995977
Xanthohumol (XN) is one of the major prenylflavonoids found in hop cones (Humulus lupulus L.). In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells. ...XN significantly reduced proliferation of the HCT
Xanthohumol (XN) is one of the major prenylflavonoids found in hop cones (Humulus lupulus L.). In this study, we investigated the cel
Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ).
Ferk F, Huber WW, Filipic M, Bichler J, Haslinger E, Misík M, Nersesyan A, Grasl-Kraupp B, Zegura B, Knasmüller S. Ferk F, et al. Mutat Res. 2010 Sep 10;691(1-2):17-22. doi: 10.1016/j.mrfmmm.2010.06.006. Epub 2010 Jun 12. Mutat Res. 2010. PMID: 20547166
Furthermore, it was found that XN inhibits DNA synthesis and proliferation of cancer cells in vitro, inactivates oxygen radicals and induces apoptosis. ...DNA migration was decreased significantly in both, colon mucosa and liver cells, but no alterations of the acti …
Furthermore, it was found that XN inhibits DNA synthesis and proliferation of cancer cells in vitro, inactivates oxygen radicals and …
Isoxanthohumol--Biologically active hop flavonoid.
Żołnierczyk AK, Mączka WK, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Żołnierczyk AK, et al. Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12. Fitoterapia. 2015. PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...IXN exhibits an antiproliferative activity against human cell lines typical for breast cancer (MCF-7), ovarian cancer
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i …
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