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Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.
Gandhi GR, Vasconcelos ABS, Wu DT, Li HB, Antony PJ, Li H, Geng F, Gurgel RQ, Narain N, Gan RY. Gandhi GR, et al. Nutrients. 2020 Sep 23;12(10):2907. doi: 10.3390/nu12102907. Nutrients. 2020. PMID: 32977511 Free PMC article.
A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized fo …
A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using …
Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes-associated oxidative stress by downregulating galectin-3.
Luís C, Costa R, Rodrigues I, Castela Â, Coelho P, Guerreiro S, Gomes J, Reis C, Soares R. Luís C, et al. Porto Biomed J. 2018 Aug 8;4(1):e23. doi: 10.1016/j.pbj.0000000000000023. eCollection 2019 Jan-Feb. Porto Biomed J. 2018. PMID: 31595252 Free PMC article.
BACKGROUND: Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in diabetes mellitus (DM). The role of Gal3 in oxidative stress is, however, controversial, being considered in the literature to play …
BACKGROUND: Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in di …
Xanthohumol from Hop: Hope for cancer prevention and treatment.
Girisa S, Saikia Q, Bordoloi D, Banik K, Monisha J, Daimary UD, Verma E, Ahn KS, Kunnumakkara AB. Girisa S, et al. IUBMB Life. 2021 Aug;73(8):1016-1044. doi: 10.1002/iub.2522. Epub 2021 Jul 6. IUBMB Life. 2021. PMID: 34170599 Free article. Review.
The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies for the prevention and treatment of this disease. Xanthohumol (XN), a prenylated chalcone present in Hop (Humulus lupulus), has been …
The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies …
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological …
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The object …
Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.
Costa R, Rodrigues I, Guardão L, Lima JQ, Sousa E, Soares R, Negrão R. Costa R, et al. Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600488. Epub 2017 Jan 30. Mol Nutr Food Res. 2017. PMID: 27921359
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8-prenylnaringenin (8PN) beer polyphenols modulate angi …
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms gov …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skelet …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present …
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
Legette L, Ma L, Reed RL, Miranda CL, Christensen JM, Rodriguez-Proteau R, Stevens JF. Legette L, et al. Mol Nutr Food Res. 2012 Mar;56(3):466-74. doi: 10.1002/mnfr.201100554. Epub 2011 Dec 7. Mol Nutr Food Res. 2012. PMID: 22147307 Free PMC article.
SCOPE: Xanthohumol (XN), a dietary flavonoid found in hops, may have health-protective actions against cardiovascular disease and type 2 diabetes. ...
SCOPE: Xanthohumol (XN), a dietary flavonoid found in hops, may have health-protective actions against cardiovascular disease and typ …
Xanthohumol alleviates T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-kappaB signaling pathway.
Wang W, Chen Z, Zheng T, Zhang M. Wang W, et al. Future Med Chem. 2021 Dec;13(23):2069-2081. doi: 10.4155/fmc-2021-0241. Epub 2021 Sep 23. Future Med Chem. 2021. PMID: 34551612
Hyperglycemia-associated advanced glycation end products (AGEs) and the receptor for AGE (RAGE) contribute to nonalcoholic fatty liver disease (NAFLD). Xanthohumol (XH) exhibits protective activities against liver diseases. Aim: To investigate the effects of XH on Type II …
Hyperglycemia-associated advanced glycation end products (AGEs) and the receptor for AGE (RAGE) contribute to nonalcoholic fatty liver disea …
Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation.
Lu X, Liu M, Dong H, Miao J, Stagos D, Liu M. Lu X, et al. Food Chem Toxicol. 2022 Feb;160:112813. doi: 10.1016/j.fct.2022.112813. Epub 2022 Jan 6. Food Chem Toxicol. 2022. PMID: 34999176
Diabetic skin ulcer is one of the most common complications in patients suffering diabetes mellitus. Xanthohumol (XN), a hop-derived prenylated dietary flavonoid, has multiple health beneficial bioactivities. ...
Diabetic skin ulcer is one of the most common complications in patients suffering diabetes mellitus. Xanthohumol …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker …
Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohum …
44 results