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Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes-associated oxidative stress by downregulating galectin-3.
Luís C, Costa R, Rodrigues I, Castela Â, Coelho P, Guerreiro S, Gomes J, Reis C, Soares R. Luís C, et al. Porto Biomed J. 2018 Aug 8;4(1):e23. doi: 10.1016/j.pbj.0000000000000023. eCollection 2019 Jan-Feb. Porto Biomed J. 2018. PMID: 31595252 Free PMC article.
BACKGROUND: Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in diabetes mellitus (DM). ...In conclusion, our results indicate that supplementation with 8-prenylnaringenin or xanthohumol r …
BACKGROUND: Galectin-3 (Gal3) expression is associated with accumulation of Advanced Glycation End products (AGE), a common feature in di
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological efficacy of xanthohumol in a Western-type diet (WTD) induced model of obesity, diabetes and non-alcoholic fatty live …
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and b …
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Gupta SC, et al. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Front Immunol. 2018. PMID: 30319623 Free PMC article. Review.
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. ...The …
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediate …
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.
Zhang Y, Bobe G, Revel JS, Rodrigues RR, Sharpton TJ, Fantacone ML, Raslan K, Miranda CL, Lowry MB, Blakemore PR, Morgun A, Shulzhenko N, Maier CS, Stevens JF, Gombart AF. Zhang Y, et al. Mol Nutr Food Res. 2020 Jan;64(1):e1900789. doi: 10.1002/mnfr.201900789. Epub 2019 Dec 15. Mol Nutr Food Res. 2020. PMID: 31755244
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet-induced obese murine model. .. …
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic …
Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.
Costa R, Rodrigues I, Guardão L, Lima JQ, Sousa E, Soares R, Negrão R. Costa R, et al. Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600488. Epub 2017 Jan 30. Mol Nutr Food Res. 2017. PMID: 27921359
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8-prenylnaringenin (8PN) beer polyphenols modulate angi …
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms gov …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skelet …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present …
Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway.
Zhao X, Jiang K, Liang B, Huang X. Zhao X, et al. Oncol Rep. 2016 Feb;35(2):669-75. doi: 10.3892/or.2015.4455. Epub 2015 Nov 26. Oncol Rep. 2016. PMID: 26718026 Free PMC article.
Xanthohumol may prevent and cure diabetes and atherosis, have oxidation resistance and antiviral function as well as anticancer effect preventing cancer cell metastasis. ...Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 µM xanthohumol for 4
Xanthohumol may prevent and cure diabetes and atherosis, have oxidation resistance and antiviral function as well as anticance
The hop-derived compounds xanthohumol, isoxanthohumol and 8-prenylnaringenin are tight-binding inhibitors of human aldo-keto reductases 1B1 and 1B10.
Seliger JM, Misuri L, Maser E, Hintzpeter J. Seliger JM, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):607-614. doi: 10.1080/14756366.2018.1437728. J Enzyme Inhib Med Chem. 2018. PMID: 29532688 Free PMC article.
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) gained increasing attention as potential anti-diabetic and cancer preventive compounds. ...activity relations
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8-
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.
Legette L, Ma L, Reed RL, Miranda CL, Christensen JM, Rodriguez-Proteau R, Stevens JF. Legette L, et al. Mol Nutr Food Res. 2012 Mar;56(3):466-74. doi: 10.1002/mnfr.201100554. Epub 2011 Dec 7. Mol Nutr Food Res. 2012. PMID: 22147307 Free PMC article.
SCOPE: Xanthohumol (XN), a dietary flavonoid found in hops, may have health-protective actions against cardiovascular disease and type 2 diabetes. ...
SCOPE: Xanthohumol (XN), a dietary flavonoid found in hops, may have health-protective actions against cardiovascular disease and typ …
Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo.
Liu X, Song M, Wang P, Zhao R, Chen H, Zhang M, Shi Y, Liu K, Liu F, Yang R, Li E, Bode AM, Dong Z, Lee MH. Liu X, et al. Int J Cancer. 2019 Aug 15;145(4):1007-1019. doi: 10.1002/ijc.32285. Epub 2019 Apr 3. Int J Cancer. 2019. PMID: 30887517 Free PMC article.
Xanthohumol, a prenylated flavonoid tested in clinical trials, is reported to exert anti-diabetes, anti-inflammation and anticancer activities. ...Taken together, our data suggest that the inhibition of ESCC tumor growth with xanthohumol is caused by targetin
Xanthohumol, a prenylated flavonoid tested in clinical trials, is reported to exert anti-diabetes, anti-inflammation and antic
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