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Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010 Free PMC article.
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess energy and weight gain. ...Together, these results suggest that XP, better than XN, affects mitochondrial respiration and cellular …
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess …
Acid-Base Properties of Xanthohumol: A Computational and Experimental Investigation.
Arczewska M, Kamiński DM, Gieroba B, Gagoś M. Arczewska M, et al. J Nat Prod. 2017 Dec 22;80(12):3194-3202. doi: 10.1021/acs.jnatprod.7b00530. Epub 2017 Nov 17. J Nat Prod. 2017. PMID: 29148787
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and 4-OH. Furthermore, the electronic and spectroscopic properties of xanthohumol have been investigated on the basis of the time-depend …
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and …
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives.
Orhan IE, Jedrejek D, Senol FS, Salmas RE, Durdagi S, Kowalska I, Pecio L, Oleszek W. Orhan IE, et al. Phytomedicine. 2018 Mar 15;42:25-33. doi: 10.1016/j.phymed.2018.03.009. Epub 2018 Mar 6. Phytomedicine. 2018. PMID: 29655693
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a moderate AChE inhibition in comparison to that of the reference (galanthamine, IC(50) = 2.52 0.15 M). In addition to 3-hydroxy-xanthohumol …
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a modera …
An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases.
Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Köhrle J, Schomburg L. Renko K, et al. Thyroid. 2015 Aug;25(8):962-8. doi: 10.1089/thy.2015.0058. Epub 2015 Jun 25. Thyroid. 2015. PMID: 25962824
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy metabolism, development, cell differentiation, and a number of other physiological processes. ...In a screening approach using established end …
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy me …
Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress.
Hou S, Song Y, Sun D, Zhu S, Wang Z. Hou S, et al. Int J Mol Sci. 2021 Apr 26;22(9):4506. doi: 10.3390/ijms22094506. Int J Mol Sci. 2021. PMID: 33925918 Free PMC article.
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. METHODS: To determine the effects of XN on C6 cells, cell proliferation and mortality after XN treatment were assessed by SRB assay and trypan bl …
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. METHO …
The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway.
Gupta KK, Sharma KK, Chandra H, Panwar H, Bhardwaj N, Altwaijry NA, Alsfouk AA, Dlamini Z, Afzal O, Altamimi ASA, Khan S, Mishra AP. Gupta KK, et al. Front Oncol. 2022 Dec 15;12:950835. doi: 10.3389/fonc.2022.950835. eCollection 2022. Front Oncol. 2022. PMID: 36591523 Free PMC article.
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targeting phosphoinositide-3-kinase (PI3K), serine/threonine kinase (AKT) receptors, and human epidermal growth factor receptor 2 (HER2) for breast …
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targetin …
Unlocking hot trub's potential: a simple method for extracting bitter acids and xanthohumol.
Silva KFCE, Feltre G, Zandonadi FS, Rabelo RS, Sussulini A, Hubinger MD. Silva KFCE, et al. J Sci Food Agric. 2024 Jul;104(9):5381-5390. doi: 10.1002/jsfa.13371. Epub 2024 Feb 20. J Sci Food Agric. 2024. PMID: 38334323
In this context, this study aimed to investigate the extraction of bitter acids' and xanthohumol from hot trub as well as identify the significance of parameters for the process. ...CONCLUSION: Ethanol concentration was found to have the most significant impact on the extr …
In this context, this study aimed to investigate the extraction of bitter acids' and xanthohumol from hot trub as well as identify th …
Chemoprotective Effects of Xanthohumol against the Carcinogenic Mycotoxin Aflatoxin B1.
Štern A, Furlan V, Novak M, Štampar M, Kolenc Z, Kores K, Filipič M, Bren U, Žegura B. Štern A, et al. Foods. 2021 Jun 9;10(6):1331. doi: 10.3390/foods10061331. Foods. 2021. PMID: 34207931 Free PMC article.
The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescences (hops) of the plant Humulus lupulus L., against the carcinogenic food contaminant aflatoxin B1 (AFB1). The chemical reactions of XN and it …
The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescence …
Micellar solubilization enhances the anti-inflammatory effect of xanthohumol.
Khayyal MT, El-Hazek RM, El-Sabbagh WA, Frank J, Behnam D, Abdel-Tawab M. Khayyal MT, et al. Phytomedicine. 2020 Jun;71:153233. doi: 10.1016/j.phymed.2020.153233. Epub 2020 May 16. Phytomedicine. 2020. PMID: 32454348 Free article.
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...The solubilized xanthohumol may prove to be a promising adjuvant tool for anti-inflammatory treatment and a potential anti-inflammatory alternative to synthe …
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...The solubilized xanth …
Novel Brazilian hop (Humulus lupulus L.) extracts through supercritical CO2 extraction: Enhancing hop processing for greater sustainability.
Pinto MBC, Vardanega R, Náthia-Neves G, de França PRL, Kurozawa LE, Meireles MAA, Schmidt FL. Pinto MBC, et al. Food Res Int. 2023 Oct;172:113169. doi: 10.1016/j.foodres.2023.113169. Epub 2023 Jun 26. Food Res Int. 2023. PMID: 37689922
Despite the hop process being well-established in the producer countries, there is still room for optimization to reduce energy consumption for a more sustainable process. This study's main purpose was to understand the influence of drying and supercritical CO(2) extractio …
Despite the hop process being well-established in the producer countries, there is still room for optimization to reduce energy consu …
25 results