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Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010 Free PMC article.
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess energy and weight gain. ...Together, these results suggest that XP, better than XN, affects mitochondrial respiration and cellular …
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess …
Antioxidant Potential of Xanthohumol in Disease Prevention: Evidence from Human and Animal Studies.
Piekara J, Piasecka-Kwiatkowska D. Piekara J, et al. Antioxidants (Basel). 2024 Dec 19;13(12):1559. doi: 10.3390/antiox13121559. Antioxidants (Basel). 2024. PMID: 39765887 Free PMC article. Review.
Xanthohumol (XN) is a phenolic compound found in the largest amount in the flowers of the hop plant, but also in the leaves and possibly in the stalks, which is successfully added to dietary supplements and cosmetics. ...However, existing data also indicate that XN may hav …
Xanthohumol (XN) is a phenolic compound found in the largest amount in the flowers of the hop plant, but also in the leaves and possi …
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives.
Orhan IE, Jedrejek D, Senol FS, Salmas RE, Durdagi S, Kowalska I, Pecio L, Oleszek W. Orhan IE, et al. Phytomedicine. 2018 Mar 15;42:25-33. doi: 10.1016/j.phymed.2018.03.009. Epub 2018 Mar 6. Phytomedicine. 2018. PMID: 29655693
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a moderate AChE inhibition in comparison to that of the reference (galanthamine, IC(50) = 2.52 0.15 M). In addition to 3-hydroxy-xanthohumol …
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a modera …
Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation.
Gholizadeh Siahmazgi Z, Irani S, Ghiaseddin A, Soutodeh F, Gohari Z, Afifeh J, Pashapouryeganeh A, Samimi H, Naderi M, Fallah P, Haghpanah V. Gholizadeh Siahmazgi Z, et al. Res Pharm Sci. 2024 Dec 15;19(6):669-682. doi: 10.4103/RPS.RPS_38_24. eCollection 2024 Dec. Res Pharm Sci. 2024. PMID: 39911899 Free PMC article.
BACKGROUND AND PURPOSE: Xanthohumol (Xn), a small molecule found in Humulus lupulus, has shown promise as an anti-cancer compound. ...FINDINGS/RESULTS: The docking results revealed that the best binding energies for MEK1-Xn (-10.70 Kcal/mol), MEK2-Xn (-9.41 Kcal/mol …
BACKGROUND AND PURPOSE: Xanthohumol (Xn), a small molecule found in Humulus lupulus, has shown promise as an anti-cancer compound. .. …
Acid-Base Properties of Xanthohumol: A Computational and Experimental Investigation.
Arczewska M, Kamiński DM, Gieroba B, Gagoś M. Arczewska M, et al. J Nat Prod. 2017 Dec 22;80(12):3194-3202. doi: 10.1021/acs.jnatprod.7b00530. Epub 2017 Nov 17. J Nat Prod. 2017. PMID: 29148787
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and 4-OH. Furthermore, the electronic and spectroscopic properties of xanthohumol have been investigated on the basis of the time-depend …
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and …
An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases.
Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Köhrle J, Schomburg L. Renko K, et al. Thyroid. 2015 Aug;25(8):962-8. doi: 10.1089/thy.2015.0058. Epub 2015 Jun 25. Thyroid. 2015. PMID: 25962824
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy metabolism, development, cell differentiation, and a number of other physiological processes. ...In a screening approach using established end …
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy me …
Unlocking hot trub's potential: a simple method for extracting bitter acids and xanthohumol.
Silva KFCE, Feltre G, Zandonadi FS, Rabelo RS, Sussulini A, Hubinger MD. Silva KFCE, et al. J Sci Food Agric. 2024 Jul;104(9):5381-5390. doi: 10.1002/jsfa.13371. Epub 2024 Feb 20. J Sci Food Agric. 2024. PMID: 38334323
In this context, this study aimed to investigate the extraction of bitter acids' and xanthohumol from hot trub as well as identify the significance of parameters for the process. ...CONCLUSION: Ethanol concentration was found to have the most significant impact on the extr …
In this context, this study aimed to investigate the extraction of bitter acids' and xanthohumol from hot trub as well as identify th …
The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule: Targeting cancer cells signaling PI3K and AKT kinase pathway.
Gupta KK, Sharma KK, Chandra H, Panwar H, Bhardwaj N, Altwaijry NA, Alsfouk AA, Dlamini Z, Afzal O, Altamimi ASA, Khan S, Mishra AP. Gupta KK, et al. Front Oncol. 2022 Dec 15;12:950835. doi: 10.3389/fonc.2022.950835. eCollection 2022. Front Oncol. 2022. PMID: 36591523 Free PMC article.
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targeting phosphoinositide-3-kinase (PI3K), serine/threonine kinase (AKT) receptors, and human epidermal growth factor receptor 2 (HER2) for breast …
METHODS: The current study aimed to analyze the efficacy of xanthohumol compared to the currently available anticancer drugs targetin …
Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress.
Hou S, Song Y, Sun D, Zhu S, Wang Z. Hou S, et al. Int J Mol Sci. 2021 Apr 26;22(9):4506. doi: 10.3390/ijms22094506. Int J Mol Sci. 2021. PMID: 33925918 Free PMC article.
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. METHODS: To determine the effects of XN on C6 cells, cell proliferation and mortality after XN treatment were assessed by SRB assay and trypan bl …
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. METHO …
Novel Brazilian hop (Humulus lupulus L.) extracts through supercritical CO2 extraction: Enhancing hop processing for greater sustainability.
Pinto MBC, Vardanega R, Náthia-Neves G, de França PRL, Kurozawa LE, Meireles MAA, Schmidt FL. Pinto MBC, et al. Food Res Int. 2023 Oct;172:113169. doi: 10.1016/j.foodres.2023.113169. Epub 2023 Jun 26. Food Res Int. 2023. PMID: 37689922 Free article.
Despite the hop process being well-established in the producer countries, there is still room for optimization to reduce energy consumption for a more sustainable process. This study's main purpose was to understand the influence of drying and supercritical CO(2) extractio …
Despite the hop process being well-established in the producer countries, there is still room for optimization to reduce energy consu …
30 results