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Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess energy and weight gain. ...Together, these results suggest that XP, better than XN, affects mitochondrial respiration and cellular …
The energy intake exceeding energy expenditure (EE) results in a positive energy balance, leading to storage of excess …
Acid-Base Properties of Xanthohumol: A Computational and Experimental Investigation.
Arczewska M, Kamiński DM, Gieroba B, Gagoś M. Arczewska M, et al. J Nat Prod. 2017 Dec 22;80(12):3194-3202. doi: 10.1021/acs.jnatprod.7b00530. Epub 2017 Nov 17. J Nat Prod. 2017. PMID: 29148787
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and 4-OH. Furthermore, the electronic and spectroscopic properties of xanthohumol have been investigated on the basis of the time-depend …
The order of the deprotonation site in the xanthohumol molecule was estimated by quantum mechanical calculations as 2'-OH, 4'-OH, and …
Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress.
Hou S, Song Y, Sun D, Zhu S, Wang Z. Hou S, et al. Int J Mol Sci. 2021 Apr 26;22(9):4506. doi: 10.3390/ijms22094506. Int J Mol Sci. 2021. PMID: 33925918 Free PMC article.
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. ...The content of succinic dehydrogenase per cell was significantly decreased after XN insults of 24, 48, and 72 h. The energy charge was …
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. ...Th …
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives.
Orhan IE, Jedrejek D, Senol FS, Salmas RE, Durdagi S, Kowalska I, Pecio L, Oleszek W. Orhan IE, et al. Phytomedicine. 2018 Mar 15;42:25-33. doi: 10.1016/j.phymed.2018.03.009. Epub 2018 Mar 6. Phytomedicine. 2018. PMID: 29655693
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a moderate AChE inhibition in comparison to that of the reference (galanthamine, IC(50) = 2.52 0.15 M). In addition to 3-hydroxy-xanthohumol …
RESULTS: Among them, 3-hydroxy-xanthohumol (IC(50) = 51.25 0.88 M) and xanthohumol (IC(50) = 71.34 2.09 M), displayed a modera …
Chemoprotective Effects of Xanthohumol against the Carcinogenic Mycotoxin Aflatoxin B1.
Štern A, Furlan V, Novak M, Štampar M, Kolenc Z, Kores K, Filipič M, Bren U, Žegura B. Štern A, et al. Foods. 2021 Jun 9;10(6):1331. doi: 10.3390/foods10061331. Foods. 2021. PMID: 34207931 Free PMC article.
The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescences (hops) of the plant Humulus lupulus L., against the carcinogenic food contaminant aflatoxin B1 (AFB1). The chemical reactions of XN and it …
The present study addresses the chemoprotective effects of xanthohumol (XN), a prenylated flavonoid found in the female inflorescence …
An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases.
Renko K, Schäche S, Hoefig CS, Welsink T, Schwiebert C, Braun D, Becker NP, Köhrle J, Schomburg L. Renko K, et al. Thyroid. 2015 Aug;25(8):962-8. doi: 10.1089/thy.2015.0058. Epub 2015 Jun 25. Thyroid. 2015. PMID: 25962824
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy metabolism, development, cell differentiation, and a number of other physiological processes. ...In a screening approach using established end …
BACKGROUND: Deiodinases (DIO1, 2, and 3) are key enzymes in thyroid hormone (TH) activation and inactivation with impact on energy me …
Micellar solubilization enhances the anti-inflammatory effect of xanthohumol.
Khayyal MT, El-Hazek RM, El-Sabbagh WA, Frank J, Behnam D, Abdel-Tawab M. Khayyal MT, et al. Phytomedicine. 2020 Jun;71:153233. doi: 10.1016/j.phymed.2020.153233. Epub 2020 May 16. Phytomedicine. 2020. PMID: 32454348 Free article.
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...The solubilized xanthohumol may prove to be a promising adjuvant tool for anti-inflammatory treatment and a potential anti-inflammatory alternative to synthe …
BACKGROUND: Xanthohumol is known to exert anti-inflammatory properties but has poor oral bioavailability. ...The solubilized xanth …
PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition.
Zhang J, Yan L, Wei P, Zhou R, Hua C, Xiao M, Tu Y, Gu Z, Wei T. Zhang J, et al. Eur J Pharmacol. 2021 Mar 15;895:173866. doi: 10.1016/j.ejphar.2021.173866. Epub 2021 Jan 14. Eur J Pharmacol. 2021. PMID: 33454376
In the present study, a graphene-based nanocomposite which probes and selectively inhibits cancer cell motility is described. By controllable coupling of prenylated chalcone xanthohumol, an efficient inhibitor of mitochondrial electron transport chain complex I, with PEGyl …
In the present study, a graphene-based nanocomposite which probes and selectively inhibits cancer cell motility is described. By controllabl …
Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.).
Mishra AK, Kocábek T, Sukumari Nath V, Awasthi P, Shrestha A, Kumar Killi U, Jakse J, Patzak J, Krofta K, Matoušek J. Mishra AK, et al. Int J Mol Sci. 2019 Dec 29;21(1):233. doi: 10.3390/ijms21010233. Int J Mol Sci. 2019. PMID: 31905722 Free PMC article.
Similarly, the expression levels of the transcription factors and structural genes that directly encode enzymes involved in xanthohumol, bitter acids, and terpenoids biosynthesis pathway were found to be significantly enhanced in lupulin glands, suggesting that production …
Similarly, the expression levels of the transcription factors and structural genes that directly encode enzymes involved in xanthohumol …
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.
Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF. Kirkwood JS, et al. J Biol Chem. 2013 Jun 28;288(26):19000-13. doi: 10.1074/jbc.M112.445452. Epub 2013 May 14. J Biol Chem. 2013. PMID: 23673658 Free PMC article.
Mild, mitochondrial uncoupling increases energy expenditure and can reduce the generation of reactive oxygen species (ROS). Activation of cellular, adaptive stress response pathways can result in an enhanced capacity to reduce oxidative damage. Together, these strategies t …
Mild, mitochondrial uncoupling increases energy expenditure and can reduce the generation of reactive oxygen species (ROS). Activatio …
19 results