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53 results

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Page 1
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.
Sahoo DK, Heilmann RM, Paital B, Patel A, Yadav VK, Wong D, Jergens AE. Sahoo DK, et al. Front Endocrinol (Lausanne). 2023 Aug 28;14:1217165. doi: 10.3389/fendo.2023.1217165. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37701897 Free PMC article. Review.
In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including …
In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phe …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3beta-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injur …
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activat …
Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3beta pathway.
Zhu L, Fan X, Cao C, Li K, Hou W, Ci X. Zhu L, et al. Biomed Pharmacother. 2023 Sep;165:115097. doi: 10.1016/j.biopha.2023.115097. Epub 2023 Jul 3. Biomed Pharmacother. 2023. PMID: 37406514 Free article.
RESULTS: In vitro, xanthohumol inhibited H(2)O(2)- and acetaminophen-induced cytotoxicity and oxidative stress. Xanthohumol up-regulated the expression of Nrf2. Further mechanistic studies showed that xanthohumol triggered Nrf2 activation via the AMPK/Akt/GSK …
RESULTS: In vitro, xanthohumol inhibited H(2)O(2)- and acetaminophen-induced cytotoxicity and oxidative stress. Xanthohumol up …
Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway.
Deng Y, Chu X, Li Q, Zhu G, Hu J, Sun J, Zeng H, Huang J, Ge G. Deng Y, et al. Phytomedicine. 2024 Apr;126:155458. doi: 10.1016/j.phymed.2024.155458. Epub 2024 Feb 22. Phytomedicine. 2024. PMID: 38394733
Previous studies have demonstrated that xanthohumol (Xh), a natural prenylflavonoid isolated from hops, exhibits anti-inflammatory, anti-antioxidative and hepatoprotective properties. ...
Previous studies have demonstrated that xanthohumol (Xh), a natural prenylflavonoid isolated from hops, exhibits anti-inflammatory, a …
Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster.
Wongchum N, Dechakhamphu A. Wongchum N, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Jun;244:108994. doi: 10.1016/j.cbpc.2021.108994. Epub 2021 Feb 4. Comp Biochem Physiol C Toxicol Pharmacol. 2021. PMID: 33549830
Aging is a significant risk factor that links to the genesis of human diseases. The capacity to scavenge free radicals and adapt to various stresses is essential for expanding living organisms' lifespan. ...Drosophila or fruit fly is one of the most effective models …
Aging is a significant risk factor that links to the genesis of human diseases. The capacity to scavenge free radicals and ada …
Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells.
Torrens-Mas M, Alorda-Clara M, Martínez-Vigara M, Roca P, Sastre-Serra J, Oliver J, Pons DG. Torrens-Mas M, et al. Int J Food Sci Nutr. 2022 Jun;73(4):471-479. doi: 10.1080/09637486.2021.2012561. Epub 2021 Dec 8. Int J Food Sci Nutr. 2022. PMID: 34879764
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-cancer agent. ...
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-ca …
Amyloid-beta Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capability of scavenging free radicals, suggesting its potential for the prevention of neurodegeneration. ...RESULTS: Among the 9 …
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capabil …
Redox active secondary metabolites.
Jacob C, Jamier V, Ba LA. Jacob C, et al. Curr Opin Chem Biol. 2011 Feb;15(1):149-55. doi: 10.1016/j.cbpa.2010.10.015. Epub 2010 Nov 4. Curr Opin Chem Biol. 2011. PMID: 21115388 Review.
Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell death. Natural isothiocyanates and xanthohumol, for instance, appear to act specifically in and against cells with a disturbed redox bal …
Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell dea …
Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells.
Carvalho DO, Freitas J, Nogueira P, Henriques SN, Carmo AM, Castro MA, Guido LF. Carvalho DO, et al. Food Chem Toxicol. 2018 Nov;121:450-457. doi: 10.1016/j.fct.2018.09.021. Epub 2018 Sep 18. Food Chem Toxicol. 2018. PMID: 30240731
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyroid cancer cells is reported. ...Furthermore, XN exposure triggered an increase in caspase-3 and caspase-7 activity, supporting its role in …
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyr …
Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice.
Chen X, Li Z, Hong H, Wang N, Chen J, Lu S, Zhang H, Zhang X, Bei C. Chen X, et al. Biomed Pharmacother. 2021 May;137:111238. doi: 10.1016/j.biopha.2021.111238. Epub 2021 Jan 28. Biomed Pharmacother. 2021. PMID: 33517187 Free article.
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related disease. The current in vivo and in vitro study aimed to investigate the therapeutic effect of XN on OA as well as its working mechanism. ...
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related dise …
53 results