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Amyloid-β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capability of scavenging free radicals, suggesting its potential for the prevention of neurodegeneration. ...RESULTS: Among the 9 …
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capabil …
Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells.
Carvalho DO, Freitas J, Nogueira P, Henriques SN, Carmo AM, Castro MA, Guido LF. Carvalho DO, et al. Food Chem Toxicol. 2018 Nov;121:450-457. doi: 10.1016/j.fct.2018.09.021. Epub 2018 Sep 18. Food Chem Toxicol. 2018. PMID: 30240731
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyroid cancer cells is reported. ...Cell-free studies demonstrated that high concentrations of XN are responsible for an increase of …
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyr …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Xanthohumol (Xn), a principal prenylflavonoid, possesses anti-inflammation and anti-oxidant activities. However, whether Xn could protect from LPS-induced ALI through inducing AMPK/Nrf2 activation and its downstream signals, are still poorly elucidated. ...
Xanthohumol (Xn), a principal prenylflavonoid, possesses anti-inflammation and anti-oxidant activities. However, whether Xn could pro
Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I.
Zhang B, Chu W, Wei P, Liu Y, Wei T. Zhang B, et al. Free Radic Biol Med. 2015 Dec;89:486-97. doi: 10.1016/j.freeradbiomed.2015.09.021. Epub 2015 Oct 8. Free Radic Biol Med. 2015. PMID: 26453927
We also found that isoxanthohumol, the structural isomer of xanthohumol, is inactive to cells, suggesting that the reactive 2-hydroxyl group of xanthohumol is crucial for its targeting to the mitochondrial complex I. Together, the remodeling of cell metabolism revea …
We also found that isoxanthohumol, the structural isomer of xanthohumol, is inactive to cells, suggesting that the reactive 2-hydroxy …
Targeting oxidative stress to treat endometriosis.
Harlev A, Gupta S, Agarwal A. Harlev A, et al. Expert Opin Ther Targets. 2015;19(11):1447-64. doi: 10.1517/14728222.2015.1077226. Epub 2015 Aug 10. Expert Opin Ther Targets. 2015. PMID: 26256952 Review.
After establishing an association, a search for antioxidant agents that were investigated specifically on endometriosis patients are described including Vitamins C and E, melatonin, resveratrol, xanthohumol and epigallocatechin-3-gallate. ...
After establishing an association, a search for antioxidant agents that were investigated specifically on endometriosis patients are describ …
Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells.
Ambrož M, Lněničková K, Matoušková P, Skálová L, Boušová I. Ambrož M, et al. Nutrients. 2019 Apr 19;11(4):879. doi: 10.3390/nu11040879. Nutrients. 2019. PMID: 31010128 Free PMC article.
All the prenylflavonoids exerted substantial antiproliferative effects in all cell lines, with xanthohumol being the most effective (IC(50) ranging from 3.6 to 7.3 µM). ...
All the prenylflavonoids exerted substantial antiproliferative effects in all cell lines, with xanthohumol being the most effective ( …
Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression.
Blanquer-Rosselló MM, Oliver J, Valle A, Roca P. Blanquer-Rosselló MM, et al. J Cell Biochem. 2013 Dec;114(12):2785-94. doi: 10.1002/jcb.24627. J Cell Biochem. 2013. PMID: 23836544
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on certain cancer types. ...
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on c
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
Monteghirfo S, Tosetti F, Ambrosini C, Stigliani S, Pozzi S, Frassoni F, Fassina G, Soverini S, Albini A, Ferrari N. Monteghirfo S, et al. Mol Cancer Ther. 2008 Sep;7(9):2692-702. doi: 10.1158/1535-7163.MCT-08-0132. Mol Cancer Ther. 2008. PMID: 18790751 Free article.
The hop flavonoid xanthohumol inhibits tumor growth by targeting the nuclear factor-kappaB and Akt pathways and angiogenesis. ...We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused el …
The hop flavonoid xanthohumol inhibits tumor growth by targeting the nuclear factor-kappaB and Akt pathways and angiogenesis. ...We s …
Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing.
Costa R, Negrão R, Valente I, Castela Â, Duarte D, Guardão L, Magalhães PJ, Rodrigues JA, Guimarães JT, Gomes P, Soares R. Costa R, et al. J Nat Prod. 2013 Nov 22;76(11):2047-53. doi: 10.1021/np4002898. Epub 2013 Nov 7. J Nat Prod. 2013. PMID: 24200239
A wound-healing assay was performed in streptozotocin-induced diabetic Wistar rats drinking water, 5% ethanol, and stout beer with and without 10 mg/L xanthohumol (1), for a five-week period. ...These findings suggest that consumption of xanthohumol (1) by diabetic …
A wound-healing assay was performed in streptozotocin-induced diabetic Wistar rats drinking water, 5% ethanol, and stout beer with and witho …
Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release.
Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, Li K, Niu H, Lee KH, Huang W. Xin G, et al. Free Radic Biol Med. 2017 Jul;108:247-257. doi: 10.1016/j.freeradbiomed.2017.02.018. Epub 2017 Feb 8. Free Radic Biol Med. 2017. PMID: 28188927 Free PMC article.
Xanthohumol (XN), an antioxidant, is found at high concentrations in hop cones (Humulus lupulus L.) and is a common ingredient of beer. ...
Xanthohumol (XN), an antioxidant, is found at high concentrations in hop cones (Humulus lupulus L.) and is a common ingredient of bee
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