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Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster.
Wongchum N, Dechakhamphu A. Wongchum N, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Jun;244:108994. doi: 10.1016/j.cbpc.2021.108994. Epub 2021 Feb 4. Comp Biochem Physiol C Toxicol Pharmacol. 2021. PMID: 33549830
Aging is a significant risk factor that links to the genesis of human diseases. The capacity to scavenge free radicals and adapt to various stresses is essential for expanding living organisms' lifespan. ...The effects of XN on the improvement of the recovery from c …
Aging is a significant risk factor that links to the genesis of human diseases. The capacity to scavenge free radicals and ada …
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X. Lv H, et al. Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2. Redox Biol. 2017. PMID: 28285192 Free PMC article.
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the amelioration of various inflammation- and oxidative stress-induced diseases, including acute lung injur …
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2) and/or AMP-activated protein kinase (AMPK) activat …
Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice.
Chen X, Li Z, Hong H, Wang N, Chen J, Lu S, Zhang H, Zhang X, Bei C. Chen X, et al. Biomed Pharmacother. 2021 May;137:111238. doi: 10.1016/j.biopha.2021.111238. Epub 2021 Jan 28. Biomed Pharmacother. 2021. PMID: 33517187 Free article.
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related disease. The current in vivo and in vitro study aimed to investigate the therapeutic effect of XN on OA as well as its working mechanism. ...
In various maladies, an anti-inflammatory effect has been demonstrated for Xanthohumol (XN); while OA is an inflammation related dise …
Amyloid-β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capability of scavenging free radicals, suggesting its potential for the prevention of neurodegeneration. ...RESULTS: Among the 9 …
BACKGROUND: Xanthohumol has been reported to have cytoprotection through activation of Nrf2-ARE signaling pathway and; it has capabil …
Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis.
Wang CM, Chen J, Zhao J, Hu SS, Zhang SQ, Mi XQ, Shi X, Cao XH, Li Z. Wang CM, et al. Oxid Med Cell Longev. 2021 Nov 10;2021:9877170. doi: 10.1155/2021/9877170. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34804373 Free PMC article.
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (Humulus lupulus L.) and was reported to indu …
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely rela …
Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells.
Carvalho DO, Freitas J, Nogueira P, Henriques SN, Carmo AM, Castro MA, Guido LF. Carvalho DO, et al. Food Chem Toxicol. 2018 Nov;121:450-457. doi: 10.1016/j.fct.2018.09.021. Epub 2018 Sep 18. Food Chem Toxicol. 2018. PMID: 30240731
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyroid cancer cells is reported. ...Furthermore, XN exposure triggered an increase in caspase-3 and caspase-7 activity, supporting its role in …
The cell growth inhibitory potential of xanthohumol (XN), a natural prenylflavonoid present in hops and beer, on human papillary thyr …
Redox active secondary metabolites.
Jacob C, Jamier V, Ba LA. Jacob C, et al. Curr Opin Chem Biol. 2011 Feb;15(1):149-55. doi: 10.1016/j.cbpa.2010.10.015. Epub 2010 Nov 4. Curr Opin Chem Biol. 2011. PMID: 21115388 Review.
Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell death. Natural isothiocyanates and xanthohumol, for instance, appear to act specifically in and against cells with a disturbed redox bal …
Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell dea …
Xanthohumol Effect on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Japanese Quails in Terms of Serum Lipids, Liver Enzymes, Estradiol, and Thyroid Hormones.
Leśków A, Tarnowska MG, Rosińczuk J, Dobrzyński M, Kaliszewski K, Majda J, Żybura-Wszol A K, Sobolewska S, Diakowska D. Leśków A, et al. ACS Omega. 2020 Sep 18;5(38):24445-24452. doi: 10.1021/acsomega.0c02896. eCollection 2020 Sep 29. ACS Omega. 2020. PMID: 33015460 Free PMC article.
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, and binding with the aryl hydrocarbon receptor (AhR) leads to expression of cytochrome p-450 genes that in turn predisposes to mutations. Nat …
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, a …
Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress.
Hou S, Song Y, Sun D, Zhu S, Wang Z. Hou S, et al. Int J Mol Sci. 2021 Apr 26;22(9):4506. doi: 10.3390/ijms22094506. Int J Mol Sci. 2021. PMID: 33925918 Free PMC article.
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. ...
AIM: To investigate the underlying mechanisms of xanthohumol (XN) on the proliferation inhibition and death of C6 glioma cells. ...
Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression.
Blanquer-Rosselló MM, Oliver J, Valle A, Roca P. Blanquer-Rosselló MM, et al. J Cell Biochem. 2013 Dec;114(12):2785-94. doi: 10.1002/jcb.24627. J Cell Biochem. 2013. PMID: 23836544
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on certain cancer types. ...
Xanthohumol (XN) and 8-prenylnaringenin (8PN) are hop (Humulus lupulus L.) polyphenols studied for their chemopreventive effects on c
44 results