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2005 3
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2021 5
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Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. ...
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.
Logan IE, Shulzhenko N, Sharpton TJ, Bobe G, Liu K, Nuss S, Jones ML, Miranda CL, Vasquez-Perez S, Pennington JM, Leonard SW, Choi J, Wu W, Gurung M, Kim JP, Lowry MB, Morgun A, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Mol Nutr Food Res. 2021 Nov;65(21):e2100389. doi: 10.1002/mnfr.202100389. Epub 2021 Oct 12. Mol Nutr Food Res. 2021. PMID: 34496124
SCOPE: The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid metabolism in diet-induced obesity animal models. ...METHODS AND RESULTS: To test the hypothesis, the study feeds conventional and germ-free male Swiss Webster mice either a low-fat diet …
SCOPE: The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid metabolism in diet-induced obesity animal mode …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipi …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. ...The findings suggest that xanthohumol ha …
There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plas …
Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010
Here, we investigate the potential of a newly synthesized compound as an inducer of EE for the management of diet-induced obesity and insulin resistance. Xanthohumol (XN), a prenylated flavonoid from hops, was used as a precursor for the synthesis of a pyrazole derivative …
Here, we investigate the potential of a newly synthesized compound as an inducer of EE for the management of diet-induced obesity and insuli …
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.
Gandhi GR, Vasconcelos ABS, Wu DT, Li HB, Antony PJ, Li H, Geng F, Gurgel RQ, Narain N, Gan RY. Gandhi GR, et al. Nutrients. 2020 Sep 23;12(10):2907. doi: 10.3390/nu12102907. Nutrients. 2020. PMID: 32977511 Free PMC article.
The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudach …
The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesp …
Synthesis of Rottlerone Analogues and Evaluation of Their α-Glucosidase and DPP-4 Dual Inhibitory and Glucose Consumption-Promoting Activity.
Zhang Y, Wang H, Wu Y, Zhao X, Yan Z, Dodd RH, Yu P, Lu K, Sun H. Zhang Y, et al. Molecules. 2021 Feb 15;26(4):1024. doi: 10.3390/molecules26041024. Molecules. 2021. PMID: 33672038 Free PMC article.
The results showed that compounds 4d and 5d irreversibly and potently inhibited alpha-glucosidase (IC(50) = 0.22 and 0.12 muM) and moderately inhibited DPP-4 (IC(50) = 23.59 and 26.19 muM), respectively. In addition, compounds 4d and 5d significantly promoted glucose consu …
The results showed that compounds 4d and 5d irreversibly and potently inhibited alpha-glucosidase (IC(50) = 0.22 and 0.12 muM) and moderatel …
Xanthohumol impairs glucose uptake by a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) and impacts the process of placentation.
Correia-Branco A, Azevedo CF, Araújo JR, Guimarães JT, Faria A, Keating E, Martel F. Correia-Branco A, et al. Mol Hum Reprod. 2015 Oct;21(10):803-15. doi: 10.1093/molehr/gav043. Epub 2015 Jul 20. Mol Hum Reprod. 2015. PMID: 26194608
The effects of XH upon cell viability and culture growth, but not the antimigratory effect, were mimicked by low extracellular glucose conditions and reversed by high extracellular glucose conditions. We thus suggest that XH, by inhibiting glucose cellular up …
The effects of XH upon cell viability and culture growth, but not the antimigratory effect, were mimicked by low extracellular glucose
Bioavailability and Cardiometabolic Effects of Xanthohumol: Evidence from Animal and Human Studies.
Neumann HF, Frank J, Venturelli S, Egert S. Neumann HF, et al. Mol Nutr Food Res. 2022 Mar;66(6):e2100831. doi: 10.1002/mnfr.202100831. Epub 2022 Jan 14. Mol Nutr Food Res. 2022. PMID: 34967501 Review.
This review summarizes the effects of xanthohumol supplementation on body weight, lipid and glucose metabolism, systemic inflammation, and redox status. In addition, it provides insights into the pharmacokinetics of xanthohumol intake. Animal studies show tha …
This review summarizes the effects of xanthohumol supplementation on body weight, lipid and glucose metabolism, systemic infla …
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. Weiskirchen R, et al. Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Front Physiol. 2015. PMID: 25999863 Free PMC article. Review.
Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the potential use of xanthohumol or a xanthohumol-enriched hop extract as therapeutic agent to combat the progression of chronic l …
Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the …
36 results