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Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. ...Plasma levels of glucose, total
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. ...XN- or 8PN-enriched diet could ameliorate diabetic-associated m …
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in live …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. ...There was a dose-dependent effect on body weight and plasma glucose levels. The highest dose group (n=6) had signi …
Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commerc …
Xanthohumol impairs glucose uptake by a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) and impacts the process of placentation.
Correia-Branco A, Azevedo CF, Araújo JR, Guimarães JT, Faria A, Keating E, Martel F. Correia-Branco A, et al. Mol Hum Reprod. 2015 Oct;21(10):803-15. doi: 10.1093/molehr/gav043. Epub 2015 Jul 20. Mol Hum Reprod. 2015. PMID: 26194608
The effects of XH upon cell viability and culture growth, but not the antimigratory effect, were mimicked by low extracellular glucose conditions and reversed by high extracellular glucose conditions. We thus suggest that XH, by inhibiting glucose cellular up …
The effects of XH upon cell viability and culture growth, but not the antimigratory effect, were mimicked by low extracellular glucose
Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice.
Takahashi K, Osada K. Takahashi K, et al. J Oleo Sci. 2017 May 1;66(5):531-541. doi: 10.5650/jos.ess16234. Epub 2017 Apr 13. J Oleo Sci. 2017. PMID: 28413193 Free article.
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high-fat diet through regulation of fatty acid metabolism. In this study, we examined the effects of dietary purified xanthohumol from XR …
We previously showed that xanthohumol-rich hop extract (XRHE, ~18% xanthohumol) exerts anti-obesity effects in rats fed a high …
Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.
Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF. Miranda CL, et al. Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6. Sci Rep. 2018. PMID: 29330372 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). ...Mice administered XN, DXN or TXN showed improvements of impaired glucose tolerance compared to the contro
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of me
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological efficacy of xanthohumol in a Western-type diet (WTD) induced model of obesity, diabetes and non-alcoholic fatty liver disea …
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and b …
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. Weiskirchen R, et al. Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Front Physiol. 2015. PMID: 25999863 Free PMC article. Review.
Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the potential use of xanthohumol or a xanthohumol-enriched hop extract as therapeutic agent to combat the progression of chronic l …
Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the …
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. ...
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and …
Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.
Nozawa H. Nozawa H. Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. doi: 10.1016/j.bbrc.2005.08.159. Biochem Biophys Res Commun. 2005. PMID: 16140264
We have examined the modulating action of xanthohumol (XN) on the farnesoid X receptor (FXR) in vitro and in vivo. In the transient transfection assay, XN dose-dependently increased the BSEP promoter-driven luciferase activity. XN-fed KK-A(y) mice exhibited lowered levels …
We have examined the modulating action of xanthohumol (XN) on the farnesoid X receptor (FXR) in vitro and in vivo. In the transient t …
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