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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
Chen CY, Kao CL, Liu CM. Chen CY, et al. Int J Mol Sci. 2018 Sep 12;19(9):2729. doi: 10.3390/ijms19092729. Int J Mol Sci. 2018. PMID: 30213077 Free PMC article. Review.
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune system. TLR triggering leads to the induction of pro-inflammatory cytokines and chemokines, driving the activation of both innate and adaptive …
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune syst …
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological efficacy of xanthohumol in a Western-type diet (WTD) induced model of obesity, diabetes and non-alcoholic fatty liver disea …
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and b …
Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines.
Engelsgjerd S, Kunnimalaiyaan S, Kandil E, Gamblin TC, Kunnimalaiyaan M. Engelsgjerd S, et al. PLoS One. 2019 Mar 14;14(3):e0213776. doi: 10.1371/journal.pone.0213776. eCollection 2019. PLoS One. 2019. PMID: 30870485 Free PMC article.
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various cancer types suggesting that XN could be a useful small molecule compound against cancer. The TNF-Related Apoptosis-Inducing Ligand (TRAIL) is a …
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various canc …
Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model.
Zhang W, Pan Y, Gou P, Zhou C, Ma L, Liu Q, Du Y, Yang J, Wang Q. Zhang W, et al. Oncol Rep. 2018 Jan;39(1):280-288. doi: 10.3892/or.2017.6094. Epub 2017 Nov 13. Oncol Rep. 2018. PMID: 29138867
Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous studies have reported that XN inhibits the growth of many types of cancer cells, but the effects of XN on tumor immunity have not yet b
Xanthohumol (XN), a prenylflavonoid found in the hop plant, Humulus lupulus, exhibits a variety of biological activities. Numerous st
Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages.
Cho YC, Kim HJ, Kim YJ, Lee KY, Choi HJ, Lee IS, Kang BY. Cho YC, et al. Int Immunopharmacol. 2008 Apr;8(4):567-73. doi: 10.1016/j.intimp.2007.12.017. Epub 2008 Jan 24. Int Immunopharmacol. 2008. PMID: 18328448
Macrophages are the main cells responsible for the innate immunity, and their activation by lipopolysaccharide (LPS) from Gram-negative bacteria or interferon (IFN)-gamma from host immune cells is important for controlling infections. ...This study investigated the …
Macrophages are the main cells responsible for the innate immunity, and their activation by lipopolysaccharide (LPS) from Gram-negati …
Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis.
Cho YC, You SK, Kim HJ, Cho CW, Lee IS, Kang BY. Cho YC, et al. Int Immunopharmacol. 2010 May;10(5):556-61. doi: 10.1016/j.intimp.2010.02.002. Epub 2010 Feb 6. Int Immunopharmacol. 2010. PMID: 20144742
Xanthohumol (XN) and its related compounds were evaluated for their effects on modulating the production of interleukin (IL)-12, the most important factor driving T helper 1 immune responses. ...Xanthohumol 4'-O-beta-D-glucopyranoside (XNG) inhibited IL-12 pr
Xanthohumol (XN) and its related compounds were evaluated for their effects on modulating the production of interleukin (IL)-12, the
Triggering of dendritic cell apoptosis by xanthohumol.
Xuan NT, Shumilina E, Gulbins E, Gu S, Götz F, Lang F. Xuan NT, et al. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S214-24. doi: 10.1002/mnfr.200900324. Mol Nutr Food Res. 2010. PMID: 20333722
Xanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol further has anti-inflammatory activity. However, little is known about the effect of xanthohumol on survival and function of
Xanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol
Angiogenesis and cancer prevention: a vision.
Noonan DM, Benelli R, Albini A. Noonan DM, et al. Recent Results Cancer Res. 2007;174:219-24. doi: 10.1007/978-3-540-37696-5_19. Recent Results Cancer Res. 2007. PMID: 17302199 Review.
We have shown that various molecules, such as flavonoids, antioxidants, and retinoids, act in the tumor microenvironment, inhibiting the recruitment and/or activation of endothelial cells and phagocytes of the innate immunity. N-acetyl-cysteine, and the green tea flavonoid …
We have shown that various molecules, such as flavonoids, antioxidants, and retinoids, act in the tumor microenvironment, inhibiting the rec …
Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2.
Fu W, Chen L, Wang Z, Zhao C, Chen G, Liu X, Dai Y, Cai Y, Li C, Zhou J, Liang G. Fu W, et al. Drug Des Devel Ther. 2016 Jan 27;10:455-63. doi: 10.2147/DDDT.S98466. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 26869767 Free PMC article.
It is recognized that myeloid differentiation protein 2 (MD-2), a coreceptor of toll-like receptor 4 (TLR4) for innate immunity, plays an essential role in activation of the lipopolysaccharide signaling pathway. ...Several studies have reported that xanthohumol (XN) …
It is recognized that myeloid differentiation protein 2 (MD-2), a coreceptor of toll-like receptor 4 (TLR4) for innate immunity, play …
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Prostate Cancer Cells after Treatment with Xanthohumol-A Natural Compound Present in Humulus lupulus L.
Kłósek M, Mertas A, Król W, Jaworska D, Szymszal J, Szliszka E. Kłósek M, et al. Int J Mol Sci. 2016 Jun 22;17(6):837. doi: 10.3390/ijms17060837. Int J Mol Sci. 2016. PMID: 27338375 Free PMC article.
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an endogenous ligand, which plays role in immune surveillance and anti-tumor immunity. ...The findings suggest that xanthohumol is a compound of potential use in chemoprevention of prostate ca …
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an endogenous ligand, which plays role in immune surveillance and …
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