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2007 1
2008 1
2009 1
2010 2
2011 1
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2019 2
2020 2
2021 4
2022 1
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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway.
Chen CY, Kao CL, Liu CM. Chen CY, et al. Int J Mol Sci. 2018 Sep 12;19(9):2729. doi: 10.3390/ijms19092729. Int J Mol Sci. 2018. PMID: 30213077 Free PMC article. Review.
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune system. TLR triggering leads to the induction of pro-inflammatory cytokines and chemokines, driving the activation of both innate and adaptive …
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune syst …
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Scagliarini A, Mathey A, Aires V, Delmas D. Scagliarini A, et al. Cells. 2020 Apr 10;9(4):932. doi: 10.3390/cells9040932. Cells. 2020. PMID: 32290112 Free PMC article.
Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the effect of anticancer compounds and/or at reducing their secondary effects on normal cells, thus enabling the host to better withstand chemoth …
Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the e …
Hop bioactive compounds in prevention of nutrition-related noncommunicable diseases.
Iniguez AB, Zhu MJ. Iniguez AB, et al. Crit Rev Food Sci Nutr. 2021;61(11):1900-1913. doi: 10.1080/10408398.2020.1767537. Epub 2020 May 28. Crit Rev Food Sci Nutr. 2021. PMID: 32462886 Review.
Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This review summarizes those beneficial effects of bitter acids and xanthohumol on NR-NCDs, including inflammatory and immune dise …
Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This …
Anticancer Activity of Natural and Synthetic Chalcones.
Constantinescu T, Lungu CN. Constantinescu T, et al. Int J Mol Sci. 2021 Oct 20;22(21):11306. doi: 10.3390/ijms222111306. Int J Mol Sci. 2021. PMID: 34768736 Free PMC article. Review.
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. ...The anticancer activity of chalcones is due to the ability of these compounds to act on many targets. N …
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or …
Redox and Anti-Inflammatory Properties from Hop Components in Beer-Related to Neuroprotection.
Vazquez-Cervantes GI, Ortega DR, Blanco Ayala T, Pérez de la Cruz V, Esquivel DFG, Salazar A, Pineda B. Vazquez-Cervantes GI, et al. Nutrients. 2021 Jun 10;13(6):2000. doi: 10.3390/nu13062000. Nutrients. 2021. PMID: 34200665 Free PMC article. Review.
Specifically, the hop cones used for beer brewing provide essential oils, bitter acids and flavonoids that are potent antioxidants and immune response modulators. This review focuses on the redox and anti-inflammatory properties of hop derivatives and summarizes the curren …
Specifically, the hop cones used for beer brewing provide essential oils, bitter acids and flavonoids that are potent antioxidants and im …
Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines.
Engelsgjerd S, Kunnimalaiyaan S, Kandil E, Gamblin TC, Kunnimalaiyaan M. Engelsgjerd S, et al. PLoS One. 2019 Mar 14;14(3):e0213776. doi: 10.1371/journal.pone.0213776. eCollection 2019. PLoS One. 2019. PMID: 30870485 Free PMC article.
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various cancer types suggesting that XN could be a useful small molecule compound against cancer. The TNF-Related Apoptosis-Inducing Ligand (TRAIL) is a …
Published data including ours have reported the anti-proliferative effect of Xanthohumol (XN), a prenylated chalcone, in various canc …
Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways.
Rahman SU, Ali T, Hao Q, He K, Li W, Ullah N, Zhang Z, Jiang Y, Li S. Rahman SU, et al. Neurochem Res. 2021 Dec;46(12):3135-3148. doi: 10.1007/s11064-021-03396-w. Epub 2021 Aug 16. Neurochem Res. 2021. PMID: 34398408
Depression is the most common psychiatric disorder associated with brain and immune system abnormalities. In recent years, xanthohumol (Xn) a bioactive prenylated flavonoid has received ample attention for its polypharmacological effects, therefore, here we aimed to …
Depression is the most common psychiatric disorder associated with brain and immune system abnormalities. In recent years, xanthoh …
Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential.
Tuli HS, Aggarwal V, Parashar G, Aggarwal D, Parashar NC, Tuorkey MJ, Varol M, Sak K, Kumar M, Buttar HS. Tuli HS, et al. Anticancer Agents Med Chem. 2022;22(3):418-432. doi: 10.2174/1871520621666210223095021. Anticancer Agents Med Chem. 2022. PMID: 33622230 Review.
In the last decade, xanthohumol has been investigated how it induces the anti- cancer effects at cellular and molecular levels. The different signalling cascades and targets of xanthohumol are summarized in this review. Overall, this review summarizes the current ad …
In the last decade, xanthohumol has been investigated how it induces the anti- cancer effects at cellular and molecular levels. The d …
Angiogenesis and cancer prevention: a vision.
Noonan DM, Benelli R, Albini A. Noonan DM, et al. Recent Results Cancer Res. 2007;174:219-24. doi: 10.1007/978-3-540-37696-5_19. Recent Results Cancer Res. 2007. PMID: 17302199 Review.
We have shown that various molecules, such as flavonoids, antioxidants, and retinoids, act in the tumor microenvironment, inhibiting the recruitment and/or activation of endothelial cells and phagocytes of the innate immunity. N-acetyl-cysteine, and the green tea flavonoid …
We have shown that various molecules, such as flavonoids, antioxidants, and retinoids, act in the tumor microenvironment, inhibiting the rec …
Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages.
Cho YC, Kim HJ, Kim YJ, Lee KY, Choi HJ, Lee IS, Kang BY. Cho YC, et al. Int Immunopharmacol. 2008 Apr;8(4):567-73. doi: 10.1016/j.intimp.2007.12.017. Epub 2008 Jan 24. Int Immunopharmacol. 2008. PMID: 18328448
Macrophages are the main cells responsible for the innate immunity, and their activation by lipopolysaccharide (LPS) from Gram-negative bacteria or interferon (IFN)-gamma from host immune cells is important for controlling infections. However, the overwhelming activ …
Macrophages are the main cells responsible for the innate immunity, and their activation by lipopolysaccharide (LPS) from Gram-negati …
21 results