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Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway.
Mi X, Wang C, Sun C, Chen X, Huo X, Zhang Y, Li G, Xu B, Zhang J, Xie J, Wang Z, Li J. Mi X, et al. Oncotarget. 2017 May 9;8(19):31297-31304. doi: 10.18632/oncotarget.16185. Oncotarget. 2017. PMID: 28415750 Free PMC article.
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, we showed that xanthohumol (XN) induces paraptosis of leukemia cells. ...In conclusion, we for the first time demonstrated th
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study,
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic properties through an undefined mechanism. Whether examined by intracellular esterase activity, phosphatidylserine externalization, DNA strand
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic pr
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
Monteghirfo S, Tosetti F, Ambrosini C, Stigliani S, Pozzi S, Frassoni F, Fassina G, Soverini S, Albini A, Ferrari N. Monteghirfo S, et al. Mol Cancer Ther. 2008 Sep;7(9):2692-702. doi: 10.1158/1535-7163.MCT-08-0132. Mol Cancer Ther. 2008. PMID: 18790751 Free article.
We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N-acetylcysteine blunted xanthohumol-induced events. Fu …
We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol cause …
The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration.
Benelli R, Venè R, Ciarlo M, Carlone S, Barbieri O, Ferrari N. Benelli R, et al. Biochem Pharmacol. 2012 Jun 15;83(12):1634-42. doi: 10.1016/j.bcp.2012.03.006. Epub 2012 Mar 17. Biochem Pharmacol. 2012. PMID: 22445931
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leukemia will continue to be a common malignancy both in childhood and in adults, until new treatments are available. ...The prenylflavonoid …
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leuk
AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies.
Dell'Eva R, Ambrosini C, Vannini N, Piaggio G, Albini A, Ferrari N. Dell'Eva R, et al. Cancer. 2007 Nov 1;110(9):2007-11. doi: 10.1002/cncr.23017. Cancer. 2007. PMID: 17823911 Free article.
BACKGROUND: Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis. METHODS: The antiangiogenic Akt/NF-kappaB inhibitor xanthohumol (XN) has in vitro activity against acute and chronic myelogenous leukemia cell lines (AML, CML) and fresh samples …
BACKGROUND: Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis. METHODS: The antiangiogenic Akt/NF-kappaB inhibitor …
Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism.
Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F. Lust S, et al. Mol Nutr Food Res. 2005 Sep;49(9):844-50. doi: 10.1002/mnfr.200500045. Mol Nutr Food Res. 2005. PMID: 16144030
Xanthohumol (XA) has recently been documented to have an impact on breast cancer cell growth and invasiveness in vitro. Based on these observations, lymphocytes from patients with B-CLL were cultured in the presence of XA in vitro. ...Surprisingly, p 70(S 6 K) phosp
Xanthohumol (XA) has recently been documented to have an impact on breast cancer cell growth and invasiveness in vitro. Based on thes
Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma.
Li Y, Wang K, Yin S, Zheng H, Min D. Li Y, et al. Oncol Lett. 2016 Dec;12(6):5289-5294. doi: 10.3892/ol.2016.5313. Epub 2016 Oct 25. Oncol Lett. 2016. PMID: 28105237 Free PMC article.
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and t
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim o
An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells.
Wang CM, Huo X, Chen J, Liu JW, Yang TY, Mi XQ, Meng Y, Zhou L, Lin CJ, Liu J. Wang CM, et al. Toxicol In Vitro. 2020 Feb;62:104667. doi: 10.1016/j.tiv.2019.104667. Epub 2019 Oct 17. Toxicol In Vitro. 2020. PMID: 31629901
In the present study, we found an acute lytic cell death induced by xanthohumol (XN), which obstructed ROS detecting in human leukemia cell line HL-60 cells. ...
In the present study, we found an acute lytic cell death induced by xanthohumol (XN), which obstructed ROS detecting in human leuk
Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia.
Lust S, Vanhoecke B, VAN Gele M, Boelens J, VAN Melckebeke H, Kaileh M, Vanden Berghe W, Haegeman G, Philippé J, Bracke M, Offner F. Lust S, et al. Anticancer Res. 2009 Oct;29(10):3797-805. Anticancer Res. 2009. PMID: 19846911 Free article.
BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. ...PATIENTS AND METHODS: The involvement of the unfolded protein response (UPR) in the cell killing effect of xanthohumol (X) was …
BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherap …
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