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The Effect of Xanthohumol Derivatives on Apoptosis Induction in Canine Lymphoma and Leukemia Cell Lines.
Grudzień M, Pawlak A, Tronina T, Kutkowska J, Kruszyńska A, Popłoński J, Huszcza E, Rapak A. Grudzień M, et al. Int J Mol Sci. 2023 Jul 21;24(14):11724. doi: 10.3390/ijms241411724. Int J Mol Sci. 2023. PMID: 37511484 Free PMC article.
Xanthohumol was reported as an effective agent against leukemia/lymphoma cells. In the present study, we investigated the effect of xanthohumol and its natural and semisynthetic derivatives against various canine leukemia/lymphoma cell lines. Xantho …
Xanthohumol was reported as an effective agent against leukemia/lymphoma cells. In the present study, we investigated the effe …
The AKT/NF-kappaB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration.
Benelli R, Venè R, Ciarlo M, Carlone S, Barbieri O, Ferrari N. Benelli R, et al. Biochem Pharmacol. 2012 Jun 15;83(12):1634-42. doi: 10.1016/j.bcp.2012.03.006. Epub 2012 Mar 17. Biochem Pharmacol. 2012. PMID: 22445931
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leukemia will continue to be a common malignancy both in childhood and in adults, until new treatments are available. ...The prenylflavonoid …
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leuk …
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic properties through an undefined mechanism. ...Thus, our results show that modification of cysteine residues of IKK and p65 by XN leads to inhi …
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic pr …
Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway.
Mi X, Wang C, Sun C, Chen X, Huo X, Zhang Y, Li G, Xu B, Zhang J, Xie J, Wang Z, Li J. Mi X, et al. Oncotarget. 2017 May 9;8(19):31297-31304. doi: 10.18632/oncotarget.16185. Oncotarget. 2017. PMID: 28415750 Free PMC article.
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, we showed that xanthohumol (XN) induces paraptosis of leukemia cells. The paraptosis is one cell death which is characterized …
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, …
Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis.
Wang CM, Chen J, Zhao J, Hu SS, Zhang SQ, Mi XQ, Shi X, Cao XH, Li Z. Wang CM, et al. Oxid Med Cell Longev. 2021 Nov 10;2021:9877170. doi: 10.1155/2021/9877170. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34804373 Free PMC article.
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (Humulus lupulus L.) and was reported to indu …
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely rela …
Isoxanthohumol--Biologically active hop flavonoid.
Żołnierczyk AK, Mączka WK, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Żołnierczyk AK, et al. Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12. Fitoterapia. 2015. PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...It interferes with JAK/STAT signaling pathway and inhibits the expression of pro1inflammatory genes in the monoblastic leukemi …
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i …
Prenylated Flavonoids with Selective Toxicity against Human Cancers.
Tronina T, Bartmańska A, Popłoński J, Rychlicka M, Sordon S, Filip-Psurska B, Milczarek M, Wietrzyk J, Huszcza E. Tronina T, et al. Int J Mol Sci. 2023 Apr 18;24(8):7408. doi: 10.3390/ijms24087408. Int J Mol Sci. 2023. PMID: 37108571 Free PMC article.
The antiproliferative activity of xanthohumol (1), a major prenylated chalcone naturally occurring in hops, and its aurone type derivative (Z)-6,4'-dihydroxy-4-methoxy-7-prenylaurone (2) were investigated. ...Prenylated flavonoids, especially the semisynthetic derivative o …
The antiproliferative activity of xanthohumol (1), a major prenylated chalcone naturally occurring in hops, and its aurone type deriv …
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood. 2009;113(9):2003-2013.
[No authors listed] [No authors listed] Blood. 2013 May 2;121(18):3778. doi: 10.1182/blood-2013-03-494401. Blood. 2013. PMID: 23640998 Free PMC article. No abstract available.
Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma.
Li Y, Wang K, Yin S, Zheng H, Min D. Li Y, et al. Oncol Lett. 2016 Dec;12(6):5289-5294. doi: 10.3892/ol.2016.5313. Epub 2016 Oct 25. Oncol Lett. 2016. PMID: 28105237 Free PMC article.
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. ...Therefore, future studies that investigate xanthohumol as a potential therapeutic agent for laryngeal squamous cell carcinoma are required. …
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. ...Theref …
Xanthohumol as a potential therapeutic strategy for acute myeloid leukemia: Targeting the FLT3/SRPK1 signaling axis.
Zhang DN, Yang WY, Hu XX, Song XM, Guo CJ, Peng F, Li YZ, Cao ZX. Zhang DN, et al. J Food Drug Anal. 2025 Mar 31;33(1):31-47. doi: 10.38212/2224-6614.3534. J Food Drug Anal. 2025. PMID: 40202412 Free PMC article.
Xanthohumol (XN) is an isoprene chalcone found in hops (Humulus lupulus L.), a food ingredient with a wide range of pharmacological activities. The aim of this study was to reveal the therapeutic effect of XN on acute myeloid leukemia (AML) and the potential underly …
Xanthohumol (XN) is an isoprene chalcone found in hops (Humulus lupulus L.), a food ingredient with a wide range of pharmacological a …
20 results