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Xanthohumol Induces ROS through NADPH Oxidase, Causes Cell Cycle Arrest and Apoptosis.
Wang CM, Chen J, Zhao J, Hu SS, Zhang SQ, Mi XQ, Shi X, Cao XH, Li Z. Wang CM, et al. Oxid Med Cell Longev. 2021 Nov 10;2021:9877170. doi: 10.1155/2021/9877170. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34804373 Free PMC article.
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely related to the site of generation. Xanthohumol (XN) is an important natural product of hops (Humulus lupulus L.) and was reported to indu …
Reactive oxygen species (ROS) are either toxic in excess or essential for redox signalling at the physiological level, which is closely rela …
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic properties through an undefined mechanism. ...Thus, our results show that modification of cysteine residues of IKK and p65 by XN leads to inhi
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic pr
The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration.
Benelli R, Venè R, Ciarlo M, Carlone S, Barbieri O, Ferrari N. Benelli R, et al. Biochem Pharmacol. 2012 Jun 15;83(12):1634-42. doi: 10.1016/j.bcp.2012.03.006. Epub 2012 Mar 17. Biochem Pharmacol. 2012. PMID: 22445931
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leukemia will continue to be a common malignancy both in childhood and in adults, until new treatments are available. ...The prenylflavonoid …
Although the vast majority of patients with acute lymphocytic leukemia (ALL) attain remission with modern therapies, relapsed leuk
Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway.
Mi X, Wang C, Sun C, Chen X, Huo X, Zhang Y, Li G, Xu B, Zhang J, Xie J, Wang Z, Li J. Mi X, et al. Oncotarget. 2017 May 9;8(19):31297-31304. doi: 10.18632/oncotarget.16185. Oncotarget. 2017. PMID: 28415750 Free PMC article.
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, we showed that xanthohumol (XN) induces paraptosis of leukemia cells. The paraptosis is one cell death which is characterized
Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study,
Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma.
Li Y, Wang K, Yin S, Zheng H, Min D. Li Y, et al. Oncol Lett. 2016 Dec;12(6):5289-5294. doi: 10.3892/ol.2016.5313. Epub 2016 Oct 25. Oncol Lett. 2016. PMID: 28105237 Free PMC article.
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. ...Therefore, future studies that investigate xanthohumol as a potential therapeutic agent for laryngeal squamous cell carcinoma are required.
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. ...Theref
AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies.
Dell'Eva R, Ambrosini C, Vannini N, Piaggio G, Albini A, Ferrari N. Dell'Eva R, et al. Cancer. 2007 Nov 1;110(9):2007-11. doi: 10.1002/cncr.23017. Cancer. 2007. PMID: 17823911 Free article.
BACKGROUND: Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis. METHODS: The antiangiogenic Akt/NF-kappaB inhibitor xanthohumol (XN) has in vitro activity against acute and chronic myelogenous leukemia cell lines (AML, CML) and fresh samples …
BACKGROUND: Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis. METHODS: The antiangiogenic Akt/NF-kappaB inhibitor …
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
Monteghirfo S, Tosetti F, Ambrosini C, Stigliani S, Pozzi S, Frassoni F, Fassina G, Soverini S, Albini A, Ferrari N. Monteghirfo S, et al. Mol Cancer Ther. 2008 Sep;7(9):2692-702. doi: 10.1158/1535-7163.MCT-08-0132. Mol Cancer Ther. 2008. PMID: 18790751
We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N-acetylcysteine blunted xanthohumol-induced events. Fu …
We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol cause …
Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism.
Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F. Lust S, et al. Mol Nutr Food Res. 2005 Sep;49(9):844-50. doi: 10.1002/mnfr.200500045. Mol Nutr Food Res. 2005. PMID: 16144030
B-chronic lymphocytic leukemia (B-CLL) is an indolent lymphoid malignancy with variable prognosis. ...In contrast to diminished sensitivity to chemotherapy, Zap 70+ B-CLL cells retain their responsiveness to manipulation of signal transduction and monoclonals. Xanthohum
B-chronic lymphocytic leukemia (B-CLL) is an indolent lymphoid malignancy with variable prognosis. ...In contrast to diminished sensi …
Isoxanthohumol--Biologically active hop flavonoid.
Żołnierczyk AK, Mączka WK, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Żołnierczyk AK, et al. Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12. Fitoterapia. 2015. PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...It interferes with JAK/STAT signaling pathway and inhibits the expression of pro1inflammatory genes in the monoblastic leukemi
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i …
15 results