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Year Number of Results
1997 1
2000 1
2001 3
2005 5
2006 1
2007 2
2008 1
2009 2
2010 7
2011 3
2012 6
2013 8
2014 6
2015 9
2016 4
2017 8
2018 7
2019 6
2020 2
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70 results
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Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes-associated oxidative stress by downregulating galectin-3.
Luís C, Costa R, Rodrigues I, Castela Â, Coelho P, Guerreiro S, Gomes J, Reis C, Soares R. Luís C, et al. Porto Biomed J. 2018 Aug 8;4(1):e23. doi: 10.1016/j.pbj.0000000000000023. eCollection 2019 Jan-Feb. Porto Biomed J. 2018. PMID: 31595252 Free PMC article.
RESULTS: Gal3 expression was accompanied by 3-nitrotyrosine and AGE production in liver and kidney of diabetic mice compared to healthy animals (fed with standard diet). ...In conclusion, our results indicate that supplementation with 8-prenylnaringenin or xanthohumol
RESULTS: Gal3 expression was accompanied by 3-nitrotyrosine and AGE production in liver and kidney of diabetic mice compared to healt …
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological efficacy of xanthohumol in a Western-type diet (WTD) induced model of obesity, diabetes and non-alcoholic fatty liver
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and b …
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines.
Logan IE, Miranda CL, Lowry MB, Maier CS, Stevens JF, Gombart AF. Logan IE, et al. Int J Mol Sci. 2019 Mar 9;20(5):1203. doi: 10.3390/ijms20051203. Int J Mol Sci. 2019. PMID: 30857300 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host's hepatic cytochrome P450 enzymes metabolize it into the most potent phytoestrogen known, 8-pre
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises co
The influence of a single and double biotinylation of xanthohumol on its anticancer activity.
Stompor M, Świtalska M, Wietrzyk J. Stompor M, et al. Acta Biochim Pol. 2019 Dec 10;66(4):559-565. doi: 10.18388/abp.2019_2876. Acta Biochim Pol. 2019. PMID: 31820895 Free article.
Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types of tested breast cancer cells. Double biotinylated xanthohumol (3) proved to be the most active in inhibiting cell growth, with IC50 values equal to 5.35 …
Both biotinylated derivatives showed slightly higher anticancer activity than xanthohumol (1) towards all types of tested breast canc …
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.
Zhang Y, Bobe G, Revel JS, Rodrigues RR, Sharpton TJ, Fantacone ML, Raslan K, Miranda CL, Lowry MB, Blakemore PR, Morgun A, Shulzhenko N, Maier CS, Stevens JF, Gombart AF. Zhang Y, et al. Mol Nutr Food Res. 2020 Jan;64(1):e1900789. doi: 10.1002/mnfr.201900789. Epub 2019 Dec 15. Mol Nutr Food Res. 2020. PMID: 31755244
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet-induced obese murine model. ...Expres …
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic …
Xanthohumol exerts protective effects in liver alterations associated with aging.
Fernández-García C, Rancan L, Paredes SD, Montero C, de la Fuente M, Vara E, Tresguerres JAF. Fernández-García C, et al. Eur J Nutr. 2019 Mar;58(2):653-663. doi: 10.1007/s00394-018-1657-6. Epub 2018 Mar 13. Eur J Nutr. 2019. PMID: 29536163
In the present study, the possible protective effects of xanthohumol on liver alterations associated with aging were evaluated. ...CONCLUSIONS: XN was shown to modulate inflammation, apoptosis, and oxidative stress in aged livers, exerting a protective effect …
In the present study, the possible protective effects of xanthohumol on liver alterations associated with aging were evaluated …
Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway.
Zhao X, Jiang K, Liang B, Huang X. Zhao X, et al. Oncol Rep. 2016 Feb;35(2):669-75. doi: 10.3892/or.2015.4455. Epub 2015 Nov 26. Oncol Rep. 2016. PMID: 26718026 Free PMC article.
Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 µM xanthohumol for 48 h. The present study showed that the anticancer effect of xanthohumol was effective in inhibiting proliferation and inducing apoptosis of human liver cancer HepG2 c …
Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 µM xanthohumol for 48 h. The present study showed that the a …
Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis.
Jamnongkan W, Thanee M, Yongvanit P, Loilome W, Thanan R, Kimawaha P, Boonmars T, Silakit R, Namwat N, Techasen A. Jamnongkan W, et al. PeerJ. 2018 Jan 22;6:e4281. doi: 10.7717/peerj.4281. eCollection 2018. PeerJ. 2018. PMID: 29375936 Free PMC article.
Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in northeast Thailand. ...Our study used a natural product, xanthohumol (XN), which is an anti-oxidant and anti-inflammatory compound, to …
Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in no …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. ...At the end of the study, blood, liver and skeleta …
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in l
Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells.
Chen SF, Chen PY, Hsu HJ, Wu MJ, Yen JH. Chen SF, et al. J Agric Food Chem. 2017 Sep 13;65(36):7908-7918. doi: 10.1021/acs.jafc.7b02282. Epub 2017 Aug 28. J Agric Food Chem. 2017. PMID: 28812343
In this study, we aim to investigate the hypocholesterolemic effects and molecular mechanisms of xanthohumol in hepatic cells. ...We demonstrated that xanthohumol suppressed hepatic Mylip/Idol expression via counteracting liver X receptor (LXR) activation. .. …
In this study, we aim to investigate the hypocholesterolemic effects and molecular mechanisms of xanthohumol in hepatic cells. ...We …
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