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Xanthohumol alleviates T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-kappaB signaling pathway.
Wang W, Chen Z, Zheng T, Zhang M. Wang W, et al. Future Med Chem. 2021 Dec;13(23):2069-2081. doi: 10.4155/fmc-2021-0241. Epub 2021 Sep 23. Future Med Chem. 2021. PMID: 34551612
Hyperglycemia-associated advanced glycation end products (AGEs) and the receptor for AGE (RAGE) contribute to nonalcoholic fatty liver disease (NAFLD). Xanthohumol (XH) exhibits protective activities against liver diseases. Aim: To investigate the effects of …
Hyperglycemia-associated advanced glycation end products (AGEs) and the receptor for AGE (RAGE) contribute to nonalcoholic fatty liver
Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling.
Paraiso IL, Tran TQ, Magana AA, Kundu P, Choi J, Maier CS, Bobe G, Raber J, Kioussi C, Stevens JF. Paraiso IL, et al. Front Pharmacol. 2021 Apr 20;12:643857. doi: 10.3389/fphar.2021.643857. eCollection 2021. Front Pharmacol. 2021. PMID: 33959012 Free PMC article.
Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH). This study aimed to evaluate the effects of xanthohumol (XN), a hop-derived compound mitigating metabolic syndrome, on liver damage …
Hepatic FXR loss results in lipid and BA accumulation, and progression from hepatic steatosis to nonalcoholic steatohepatitis (NASH). This s …
Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
Dorn C, Heilmann J, Hellerbrand C. Dorn C, et al. Int J Clin Exp Pathol. 2012;5(1):29-36. Epub 2012 Jan 1. Int J Clin Exp Pathol. 2012. PMID: 22295144 Free PMC article.
The aim of this study was to investigate the effect of xanthohumol in an acute model of liver injury. Carbon tetrachloride (CCl(4)), an industrial solvent, is a hepatotoxic agent and its administration is widely used as an animal model of toxin-induced liver
The aim of this study was to investigate the effect of xanthohumol in an acute model of liver injury. Carbon tetrachloride (CC …
Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid in mouse tuberculosis models.
Lou H, Zhang F, Lu L, Ding Y, Hao X. Lou H, et al. RSC Adv. 2020 Apr 1;10(22):13223-13231. doi: 10.1039/c9ra10347c. eCollection 2020 Mar 30. RSC Adv. 2020. PMID: 35492081 Free PMC article.
The liver damage was induced by treatment with isoniazid daily for 8 weeks. ...Furthermore, other positive outcomes implied that isoniazid combined with xanthohumol obviously alleviated anti-tuberculosis drug induced liver damage as indicated by the declined …
The liver damage was induced by treatment with isoniazid daily for 8 weeks. ...Furthermore, other positive outcomes implied that ison …
Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal musc …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to …
Xanthohumol Effect on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Japanese Quails in Terms of Serum Lipids, Liver Enzymes, Estradiol, and Thyroid Hormones.
Leśków A, Tarnowska MG, Rosińczuk J, Dobrzyński M, Kaliszewski K, Majda J, Żybura-Wszol A K, Sobolewska S, Diakowska D. Leśków A, et al. ACS Omega. 2020 Sep 18;5(38):24445-24452. doi: 10.1021/acsomega.0c02896. eCollection 2020 Sep 29. ACS Omega. 2020. PMID: 33015460 Free PMC article.
The aim of the study was to compare the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and XN on lipid, liver enzyme, estradiol, and thyroid enzyme levels in the serum of Japanese quails. ...In comparison with the control group, 2,3,7,8-tetrachlorodibenzo-p-dioxin signific …
The aim of the study was to compare the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and XN on lipid, liver enzyme, estradiol, and …
Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-kappaB/p53-apoptosis signaling pathway.
Zhao X, Jiang K, Liang B, Huang X. Zhao X, et al. Oncol Rep. 2016 Feb;35(2):669-75. doi: 10.3892/or.2015.4455. Epub 2015 Nov 26. Oncol Rep. 2016. PMID: 26718026 Free PMC article.
Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 M xanthohumol for 48 h. ...Furthermore, the caspase-3 activity of human liver cancer HepG2 cells was increased by xanthohumol. In addition, 48-h treatment with xanthohumol suppres …
Human liver cancer HepG2 cell were treated with 10, 20, 30 and 40 M xanthohumol for 48 h. ...Furthermore, the caspase-3 activi …
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The object
Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3beta pathway.
Zhu L, Fan X, Cao C, Li K, Hou W, Ci X. Zhu L, et al. Biomed Pharmacother. 2023 Sep;165:115097. doi: 10.1016/j.biopha.2023.115097. Epub 2023 Jul 3. Biomed Pharmacother. 2023. PMID: 37406514 Free article.
METHODS: The hepatoprotective effects of xanthohumol were studied using APAP-induced HepG2 cells and acute liver injury of mouse, seperately. ...In addition, whether xanthohumol protected against acetaminophen-induced liver injury in Nrf2 knockout mice …
METHODS: The hepatoprotective effects of xanthohumol were studied using APAP-induced HepG2 cells and acute liver injury of mou …
Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis.
Jamnongkan W, Thanee M, Yongvanit P, Loilome W, Thanan R, Kimawaha P, Boonmars T, Silakit R, Namwat N, Techasen A. Jamnongkan W, et al. PeerJ. 2018 Jan 22;6:e4281. doi: 10.7717/peerj.4281. eCollection 2018. PeerJ. 2018. PMID: 29375936 Free PMC article.
Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in northeast Thailand. ...Notably, resistance to an activation of cell death in prolonged oxidative stress conditions can occur but some damaged/ …
Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in no …
91 results