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Evaluation of the Antitumour and Antiproliferative Effect of Xanthohumol-Loaded PLGA Nanoparticles on Melanoma.
Fonseca M, Macedo AS, Lima SAC, Reis S, Soares R, Fonte P. Fonseca M, et al. Materials (Basel). 2021 Oct 26;14(21):6421. doi: 10.3390/ma14216421. Materials (Basel). 2021. PMID: 34771946 Free PMC article.
In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antiproliferative, antitumour, and migration effect on B16F10, malignant cutaneous melanoma, and RAW 264.7, macrophagic, mouse cell lines. PLGA nanoparticles had a size of 312 41 …
In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antiproliferative, antitumour, and migration e …
Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells.
Seitz T, Hackl C, Freese K, Dietrich P, Mahli A, Thasler RM, Thasler WE, Lang SA, Bosserhoff AK, Hellerbrand C. Seitz T, et al. Cancers (Basel). 2021 Jan 29;13(3):511. doi: 10.3390/cancers13030511. Cancers (Basel). 2021. PMID: 33572775 Free PMC article.
Melanoma is one of the most aggressive and lethal cancers worldwide. Despite recent progress in melanoma therapy, the prognosis for metastasized melanoma continues to be poor. ...In conclusion, XN inhibits tumorigenicity of melanoma cells in vitro and …
Melanoma is one of the most aggressive and lethal cancers worldwide. Despite recent progress in melanoma therapy, the prognosi …
Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells.
Krajnović T, Pantelić NĐ, Wolf K, Eichhorn T, Maksimović-Ivanić D, Mijatović S, Wessjohann LA, Kaluđerović GN. Krajnović T, et al. Materials (Basel). 2022 Jul 19;15(14):5028. doi: 10.3390/ma15145028. Materials (Basel). 2022. PMID: 35888494 Free PMC article.
In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma …
In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by st …
A Novel Look at Mechanisms and Applications of Xanthohumol (XN) in Dermatology and Cosmetology.
Kołodziejczak A, Dziedzic M, Algiert-Zielińska B, Mucha P, Rotsztejn H. Kołodziejczak A, et al. Int J Mol Sci. 2024 Nov 6;25(22):11938. doi: 10.3390/ijms252211938. Int J Mol Sci. 2024. PMID: 39596008 Free PMC article. Review.
Xanthohumol (XN), representing the group of chalcones, is a hydroxyl and superoxide free radical scavenger. ...XN shows antitumoral activity, e.g., in the case of skin melanoma, which is associated with the antioxidant, pro-apoptotic, anti-angiogenic and immunostimu …
Xanthohumol (XN), representing the group of chalcones, is a hydroxyl and superoxide free radical scavenger. ...XN shows antitumoral a …
Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes.
Goenka S, Simon SR. Goenka S, et al. Biochem Biophys Rep. 2021 Feb 24;26:100955. doi: 10.1016/j.bbrep.2021.100955. eCollection 2021 Jul. Biochem Biophys Rep. 2021. PMID: 33681480 Free PMC article.
Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown to have depigmenting effects in B16F10 mouse melanoma cells; however, studies of its depigmenting efficacy in human melanocytes are s …
Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown …
Xanthohumol Sensitizes Melanoma Cells to Vemurafenib by Lowering Membrane Cholesterol and Increasing Membrane Fluidity.
Devinat M, Thevenard-Devy J, Ghilane F, Devy J, Chazee L, Terryn C, Duca L, Devarenne-Charpentier E, El Btaouri H. Devinat M, et al. Int J Mol Sci. 2025 Mar 4;26(5):2290. doi: 10.3390/ijms26052290. Int J Mol Sci. 2025. PMID: 40076912 Free PMC article.
Identifying new natural molecules to enhance chemotherapy treatment or improve sensitization to conventional therapies has become a key objective. Here, we evaluated the effect of Xanthohumol (XN) extracted from hop on SKMEL-28 melanoma cells and their sensitization …
Identifying new natural molecules to enhance chemotherapy treatment or improve sensitization to conventional therapies has become a key obje …
Synergistic Proliferation Effects of Xanthohumol and Niflumic Acid on Merkel and Glioblastoma Cancer Cells: Role of Cell Membrane Interactions.
Stompor-Gorący M, Włoch A, Sengupta P, Nasulewicz-Goldeman A, Wietrzyk J. Stompor-Gorący M, et al. Int J Mol Sci. 2024 Oct 13;25(20):11015. doi: 10.3390/ijms252011015. Int J Mol Sci. 2024. PMID: 39456799 Free PMC article.
In addition, the IC(50) values for niflumic acid and xanthohumol applied separately were determined by cell proliferation tests for the following human cancer cell lines: 5637 (urinary bladder carcinoma), A-431 (epidermoid carcinoma), UM-SCC-17A (head and neck squamous car …
In addition, the IC(50) values for niflumic acid and xanthohumol applied separately were determined by cell proliferation tests for t …
Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.
Zhang YM, Shi XB, Xu B, Yuan CS, Zheng W, Li G, Li J, Wang ZH. Zhang YM, et al. J Asian Nat Prod Res. 2020 Sep;22(9):850-863. doi: 10.1080/10286020.2019.1644623. Epub 2019 Jul 25. J Asian Nat Prod Res. 2020. PMID: 31345059
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. ...
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. ...
Effect of xanthohumol on melanogenesis in B16 melanoma cells.
Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW. Koo JH, et al. Exp Mol Med. 2008 Jun 30;40(3):313-9. doi: 10.3858/emm.2008.40.3.313. Exp Mol Med. 2008. PMID: 18587269 Free PMC article.
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. ...
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanth …
Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol. from hops.
Lee SH, Kim HJ, Lee JS, Lee IS, Kang BY. Lee SH, et al. Arch Pharm Res. 2007 Nov;30(11):1435-9. doi: 10.1007/BF02977368. Arch Pharm Res. 2007. PMID: 18087812
Xanthohumol (XN) and its related compounds were evaluated for their cytotoxicity against four different human cancer cell lines, A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), and HCT-15 (colon) using a sulforhodamine B assay. ...Isoxanthohumol, 8-prenylnaring …
Xanthohumol (XN) and its related compounds were evaluated for their cytotoxicity against four different human cancer cell lines, A549 …
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