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Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells.
Seitz T, Hackl C, Freese K, Dietrich P, Mahli A, Thasler RM, Thasler WE, Lang SA, Bosserhoff AK, Hellerbrand C. Seitz T, et al. Cancers (Basel). 2021 Jan 29;13(3):511. doi: 10.3390/cancers13030511. Cancers (Basel). 2021. PMID: 33572775 Free PMC article.
Melanoma is one of the most aggressive and lethal cancers worldwide. Despite recent progress in melanoma therapy, the prognosis for metastasized melanoma continues to be poor. ...
Melanoma is one of the most aggressive and lethal cancers worldwide. Despite recent progress in melanoma therapy, the prognosi …
Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells.
Krajnović T, Pantelić NĐ, Wolf K, Eichhorn T, Maksimović-Ivanić D, Mijatović S, Wessjohann LA, Kaluđerović GN. Krajnović T, et al. Materials (Basel). 2022 Jul 19;15(14):5028. doi: 10.3390/ma15145028. Materials (Basel). 2022. PMID: 35888494 Free PMC article.
In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma …
In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by st …
Evaluation of the Antitumour and Antiproliferative Effect of Xanthohumol-Loaded PLGA Nanoparticles on Melanoma.
Fonseca M, Macedo AS, Lima SAC, Reis S, Soares R, Fonte P. Fonseca M, et al. Materials (Basel). 2021 Oct 26;14(21):6421. doi: 10.3390/ma14216421. Materials (Basel). 2021. PMID: 34771946 Free PMC article.
In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antiproliferative, antitumour, and migration effect on B16F10, malignant cutaneous melanoma, and RAW 264.7, macrophagic, mouse cell lines. PLGA nanoparticles had a size of 312 41 …
In this work, we developed PLGA nanoparticles encapsulating xanthohumol and tested its antiproliferative, antitumour, and migration e …
Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes.
Goenka S, Simon SR. Goenka S, et al. Biochem Biophys Rep. 2021 Feb 24;26:100955. doi: 10.1016/j.bbrep.2021.100955. eCollection 2021 Jul. Biochem Biophys Rep. 2021. PMID: 33681480 Free PMC article.
Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown to have depigmenting effects in B16F10 mouse melanoma cells; however, studies of its depigmenting efficacy in human melanocytes are s …
Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (Humulus lupulus L.) and has previously been shown …
Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.
Zhang YM, Shi XB, Xu B, Yuan CS, Zheng W, Li G, Li J, Wang ZH. Zhang YM, et al. J Asian Nat Prod Res. 2020 Sep;22(9):850-863. doi: 10.1080/10286020.2019.1644623. Epub 2019 Jul 25. J Asian Nat Prod Res. 2020. PMID: 31345059
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. ...
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. ...
Effect of xanthohumol on melanogenesis in B16 melanoma cells.
Koo JH, Kim HT, Yoon HY, Kwon KB, Choi IW, Jung SH, Kim HU, Park BH, Park JW. Koo JH, et al. Exp Mol Med. 2008 Jun 30;40(3):313-9. doi: 10.3858/emm.2008.40.3.313. Exp Mol Med. 2008. PMID: 18587269 Free PMC article.
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. ...
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanth …
Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol. from hops.
Lee SH, Kim HJ, Lee JS, Lee IS, Kang BY. Lee SH, et al. Arch Pharm Res. 2007 Nov;30(11):1435-9. doi: 10.1007/BF02977368. Arch Pharm Res. 2007. PMID: 18087812
Xanthohumol (XN) and its related compounds were evaluated for their cytotoxicity against four different human cancer cell lines, A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), and HCT-15 (colon) using a sulforhodamine B assay. XN showed the most active cytotox …
Xanthohumol (XN) and its related compounds were evaluated for their cytotoxicity against four different human cancer cell lines, A549 …
Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo.
Krajnović T, Kaluđerović GN, Wessjohann LA, Mijatović S, Maksimović-Ivanić D. Krajnović T, et al. Pharmacol Res. 2016 Mar;105:62-73. doi: 10.1016/j.phrs.2016.01.011. Epub 2016 Jan 16. Pharmacol Res. 2016. PMID: 26784390
Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, …
Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidan …
Co-Application of Statin and Flavonoids as an Effective Strategy to Reduce the Activity of Voltage-Gated Potassium Channels Kv1.3 and Induce Apoptosis in Human Leukemic T Cell Line Jurkat.
Teisseyre A, Chmielarz M, Uryga A, Środa-Pomianek K, Palko-Łabuz A. Teisseyre A, et al. Molecules. 2022 May 18;27(10):3227. doi: 10.3390/molecules27103227. Molecules. 2022. PMID: 35630703 Free PMC article.
Lipophilic non-toxic organic inhibitors of Kv1.3 channels, such as statins and flavonoids, may have clinical applications in supporting the therapy of some cancer diseases, such as breast, pancreas, and lung cancer; melanoma; or chronic lymphocytic leukemia. This study foc …
Lipophilic non-toxic organic inhibitors of Kv1.3 channels, such as statins and flavonoids, may have clinical applications in supporting the …