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Xanthohumol from Hop: Hope for cancer prevention and treatment.
Girisa S, Saikia Q, Bordoloi D, Banik K, Monisha J, Daimary UD, Verma E, Ahn KS, Kunnumakkara AB. Girisa S, et al. IUBMB Life. 2021 Aug;73(8):1016-1044. doi: 10.1002/iub.2522. Epub 2021 Jul 6. IUBMB Life. 2021. PMID: 34170599 Free article. Review.
Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects. The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs nece …
Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause sev …
Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy.
Rajagopal C, Lankadasari MB, Aranjani JM, Harikumar KB. Rajagopal C, et al. Pharmacol Res. 2018 Apr;130:273-291. doi: 10.1016/j.phrs.2017.12.034. Epub 2018 Jan 4. Pharmacol Res. 2018. PMID: 29305909 Review.
Inflammation is one of the major causative factor of cancer and chronic inflammation is involved in all the major steps of cancer initiation, progression metastasis and drug resistance. The molecular mechanism of inflammation driven cancer is the complex interplay b …
Inflammation is one of the major causative factor of cancer and chronic inflammation is involved in all the major steps of cancer initiation …
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models.
Fan Y, Rodriguez-Proteau R. Fan Y, et al. Xenobiotica. 2008 Feb;38(2):107-29. doi: 10.1080/00498250701744625. Xenobiotica. 2008. PMID: 18197554
Cellular uptake of ketoconazole in the Caco-2 cells was significantly inhibited by CSA and digoxin, whereas epigallocatechin-3-gallate and xanthohumol exhibited biphasic responses. In conclusion, ketoconazole modulates the P(app) of P-glycoprotein substrates by interacting …
Cellular uptake of ketoconazole in the Caco-2 cells was significantly inhibited by CSA and digoxin, whereas epigallocatechin-3-gallate and …
Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol. from hops.
Lee SH, Kim HJ, Lee JS, Lee IS, Kang BY. Lee SH, et al. Arch Pharm Res. 2007 Nov;30(11):1435-9. doi: 10.1007/BF02977368. Arch Pharm Res. 2007. PMID: 18087812
The inhibition of topo I by XN might explain the cytotoxicity against the human cancer cell lines. Moreover, the expression of the drug efflux genes was investigated to predict the drug resistance. ...These results suggest that XN has anticancer properties by …
The inhibition of topo I by XN might explain the cytotoxicity against the human cancer cell lines. Moreover, the expression of the drug …
Antibacterial effects of biologically active ingredients in hop provide promising options to fight infections by pathogens including multi-drug resistant bacteria.
Fahle A, Bereswill S, Heimesaat MM. Fahle A, et al. Eur J Microbiol Immunol (Bp). 2022 Apr 13;12(1):22-30. doi: 10.1556/1886.2022.00006. Online ahead of print. Eur J Microbiol Immunol (Bp). 2022. PMID: 35417405 Free PMC article. Review.
Antibiotic resistance constitutes a global threat to the health care systems. The number of infections due to multidrug-resistant (MDR) bacteria increases progressively resulting in an estimated annual number of 750,000 fatal cases worldwide. ...This prompted us to perform …
Antibiotic resistance constitutes a global threat to the health care systems. The number of infections due to multidrug-resistant (MD …
Plant polyphenols and multidrug resistance: effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models.
Rodriguez-Proteau R, Mata JE, Miranda CL, Fan Y, Brown JJ, Buhler DR. Rodriguez-Proteau R, et al. Xenobiotica. 2006 Jan;36(1):41-58. doi: 10.1080/00498250500433545. Xenobiotica. 2006. PMID: 16507512
Xanthohumol significantly demonstrated (1) saturable efflux, (2) increased uptake of (3)H-digoxin and (3) decreased uptake of (3)H-CSA in the Caco-2 cells. The transport data suggests that xanthohumol effects transport of CSA in a manner that is distinct from the di …
Xanthohumol significantly demonstrated (1) saturable efflux, (2) increased uptake of (3)H-digoxin and (3) decreased uptake of (3)H-CS …
Integrated Pangenome Analysis and Pharmacophore Modeling Revealed Potential Novel Inhibitors against Enterobacter xiangfangensis.
Almuhayawi MS, Al Jaouni SK, Selim S, Alkhalifah DHM, Marc RA, Aslam S, Poczai P. Almuhayawi MS, et al. Int J Environ Res Public Health. 2022 Nov 10;19(22):14812. doi: 10.3390/ijerph192214812. Int J Environ Res Public Health. 2022. PMID: 36429532 Free PMC article.
Enterobacter xiangfangensis is a novel, multidrug-resistant pathogen belonging to the Enterobacter genus and has the ability to acquire resistance to multiple antibiotic classes. However, there is currently no registered E. xiangfangensis drug on the market t …
Enterobacter xiangfangensis is a novel, multidrug-resistant pathogen belonging to the Enterobacter genus and has the ability to acquire r …
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling.
Kubatka P, Koklesova L, Mazurakova A, Brockmueller A, Büsselberg D, Kello M, Shakibaei M. Kubatka P, et al. Cancer Metastasis Rev. 2023 Oct 4. doi: 10.1007/s10555-023-10134-x. Online ahead of print. Cancer Metastasis Rev. 2023. PMID: 37789138 Review.
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the multiple cancer defense mechanisms associated with therapy resistance and therapy evasion. ...Therefore, it denotes an attractive cellular target to …
Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the multiple cancer …
The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
Kang Y, Park MA, Heo SW, Park SY, Kang KW, Park PH, Kim JA. Kang Y, et al. Biochim Biophys Acta. 2013 Mar;1830(3):2638-48. doi: 10.1016/j.bbagen.2012.12.005. Biochim Biophys Acta. 2013. PMID: 23246576
BACKGROUND: Chemotherapeutic drug resistance remains a clinical obstacle in cancer management. ...Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression l …
BACKGROUND: Chemotherapeutic drug resistance remains a clinical obstacle in cancer management. ...Multi-drug …
Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells.
Lu X, Geng J, Zhang J, Miao J, Liu M. Lu X, et al. Antioxidants (Basel). 2019 Sep 16;8(9):402. doi: 10.3390/antiox8090402. Antioxidants (Basel). 2019. PMID: 31527518 Free PMC article.
Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical application and prognosis. A novel promising therapeutic strategy for CML therapy is to degrade BCR-ABL using small molecules. Antioxidant …
Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits its clinical …