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Page 1
Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF. Paraiso IL, et al. ACS Pharmacol Transl Sci. 2021 Nov 4;4(6):1782-1793. doi: 10.1021/acsptsci.1c00161. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927010 Free PMC article.
Here, we investigate the potential of a newly synthesized compound as an inducer of EE for the management of diet-induced obesity and insulin resistance. Xanthohumol (XN), a prenylated flavonoid from hops, was used as a precursor for the synthesis of a pyrazole deri …
Here, we investigate the potential of a newly synthesized compound as an inducer of EE for the management of diet-induced obesity and …
Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.
Miyata S, Inoue J, Shimizu M, Sato R. Miyata S, et al. J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3. J Biol Chem. 2015. PMID: 26140926 Free PMC article.
Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces the de novo synthesis of fatty acid and cholesterol. ...Our results suggest that XN impairs the endoplasmic reticulum-to-Golgi translocation of the SREBP c …
Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces the de novo syn …
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q. Sun W, et al. Heliyon. 2023 Oct 27;9(11):e21282. doi: 10.1016/j.heliyon.2023.e21282. eCollection 2023 Nov. Heliyon. 2023. PMID: 37964828 Free PMC article.
Xanthohumol (Xn), a bioactive prenylated chalcone, was shown to exhibit antioxidative, anti-inflammatory, and anti-obesity capacities in multiple diseases. However, a clear description of the preventive effects of Xn on obesity-associated OA is unavailable. T
Xanthohumol (Xn), a bioactive prenylated chalcone, was shown to exhibit antioxidative, anti-inflammatory, and anti-obesity cap
Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological
Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. ...The object
Adipose and non-adipose perspectives of plant derived natural compounds for mitigation of obesity.
Borah AK, Sharma P, Singh A, Kalita KJ, Saha S, Chandra Borah J. Borah AK, et al. J Ethnopharmacol. 2021 Nov 15;280:114410. doi: 10.1016/j.jep.2021.114410. Epub 2021 Jul 15. J Ethnopharmacol. 2021. PMID: 34273447 Review.
They have been affirmed as potential anti-obesity drugs of future because of their effectiveness yet having no threat to adipose or systemic insulin sensitivity. CONCLUSION: Due to high molecular diversity and a greater ratio of benefit to risk, plant derived compounds hol …
They have been affirmed as potential anti-obesity drugs of future because of their effectiveness yet having no threat to adipose or s …
Reducing gut microbiome-driven adipose tissue inflammation alleviates metabolic syndrome.
Newman NK, Zhang Y, Padiadpu J, Miranda CL, Magana AA, Wong CP, Hioki KA, Pederson JW, Li Z, Gurung M, Bruce AM, Brown K, Bobe G, Sharpton TJ, Shulzhenko N, Maier CS, Stevens JF, Gombart AF, Morgun A. Newman NK, et al. Microbiome. 2023 Sep 21;11(1):208. doi: 10.1186/s40168-023-01637-4. Microbiome. 2023. PMID: 37735685 Free PMC article.
The hops-derived prenylated flavonoid xanthohumol (XN) and its semi-synthetic derivative tetrahydroxanthohumol (TXN) attenuate high-fat diet-induced obesity, hepatosteatosis, and metabolic syndrome in C57Bl/6J mice. ...CONCLUSIONS: Our findings establish an importan …
The hops-derived prenylated flavonoid xanthohumol (XN) and its semi-synthetic derivative tetrahydroxanthohumol (TXN) attenuate high-f …
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. Weiskirchen R, et al. Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Front Physiol. 2015. PMID: 25999863 Free PMC article. Review.
It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating obesity, dysregulation of glucose metabolism and other components of the metabolic syndrome including hepatic steatosis. Thus, therapeu …
It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating …
Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-beta-cyclodextrin Complex Suitable for Parenteral Administration.
Kirchinger M, Bieler L, Tevini J, Vogl M, Haschke-Becher E, Felder TK, Couillard-Després S, Riepl H, Urmann C. Kirchinger M, et al. Planta Med. 2019 Nov;85(16):1233-1241. doi: 10.1055/a-1013-1276. Epub 2019 Oct 14. Planta Med. 2019. PMID: 31610603
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. Using 50 mM 2-hydroxypropyl-beta-cyclodextrin, solubility was increased 650-fold. Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not si …
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. Using 50 mM 2-hydroxypropyl-beta-cycl …
Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.
Samuels JS, Shashidharamurthy R, Rayalam S. Samuels JS, et al. Nutr Metab (Lond). 2018 Jun 15;15:42. doi: 10.1186/s12986-018-0277-8. eCollection 2018. Nutr Metab (Lond). 2018. PMID: 29946343 Free PMC article.
BACKGROUND: Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. ...The anti-obesity effects of XN are partly mediated by AMPK signaling pathway suggesting that XN may have po …
BACKGROUND: Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-i …
Hop bioactive compounds in prevention of nutrition-related noncommunicable diseases.
Iniguez AB, Zhu MJ. Iniguez AB, et al. Crit Rev Food Sci Nutr. 2021;61(11):1900-1913. doi: 10.1080/10408398.2020.1767537. Epub 2020 May 28. Crit Rev Food Sci Nutr. 2021. PMID: 32462886 Review.
Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This review summarizes those beneficial effects of bitter acids and xanthohumol on NR-NCDs, including inflammatory and immune diseases, …
Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This …
45 results