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Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
Mahli A, Seitz T, Freese K, Frank J, Weiskirchen R, Abdel-Tawab M, Behnam D, Hellerbrand C. Mahli A, et al. Cells. 2019 Apr 17;8(4):359. doi: 10.3390/cells8040359. Cells. 2019. PMID: 30999670 Free PMC article.
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and biological efficacy of xanthohumol in a Western-type diet (WTD) induced model of obesity, diabetes and non-alcoholic fatty live …
The objective of this study was to determine whether a micellar solubilization of xanthohumol could enhance the bioavailability and b …
Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-β-cyclodextrin Complex Suitable for Parenteral Administration.
Kirchinger M, Bieler L, Tevini J, Vogl M, Haschke-Becher E, Felder TK, Couillard-Després S, Riepl H, Urmann C. Kirchinger M, et al. Planta Med. 2019 Nov;85(16):1233-1241. doi: 10.1055/a-1013-1276. Epub 2019 Oct 14. Planta Med. 2019. PMID: 31610603
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. Using 50 mM 2-hydroxypropyl-β-cyclodextrin, solubility was increased 650-fold. Furthermore, in vitro bioactivity of Xanthohumol C in free and complexed form did not signi …
The water solubility of Xanthohumol C increases with increasing concentrations of cyclodextrin. Using 50 mM 2-hydroxypropyl-β-cyclode …
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Gupta SC, et al. Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Front Immunol. 2018. PMID: 30319623 Free PMC article. Review.
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases, and neurological diseases. ...The …
Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediate …
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.
Zhang Y, Bobe G, Revel JS, Rodrigues RR, Sharpton TJ, Fantacone ML, Raslan K, Miranda CL, Lowry MB, Blakemore PR, Morgun A, Shulzhenko N, Maier CS, Stevens JF, Gombart AF. Zhang Y, et al. Mol Nutr Food Res. 2020 Jan;64(1):e1900789. doi: 10.1002/mnfr.201900789. Epub 2019 Dec 15. Mol Nutr Food Res. 2020. PMID: 31755244
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet-induced obese murine model. It …
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic …
Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.
Miyata S, Inoue J, Shimizu M, Sato R. Miyata S, et al. J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3. J Biol Chem. 2015. PMID: 26140926 Free PMC article.
Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces the de novo synthesis of fatty acid and cholesterol. ...Furthermore, in diet-induced obese mice, dietary XN suppressed SREBP-1 target gene expressio …
Here, we demonstrate that a prenylated flavonoid in hops, xanthohumol (XN), is a novel SREBP inactivator that reduces the de novo syn …
Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.
Samuels JS, Shashidharamurthy R, Rayalam S. Samuels JS, et al. Nutr Metab (Lond). 2018 Jun 15;15:42. doi: 10.1186/s12986-018-0277-8. eCollection 2018. Nutr Metab (Lond). 2018. PMID: 29946343 Free PMC article.
BACKGROUND: Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. ...The anti-obesity effects of XN are partly mediated by AMPK signaling pathway suggesting that XN may have po …
BACKGROUND: Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-i …
Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.
Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF. Miranda CL, et al. Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6. Sci Rep. 2018. PMID: 29330372 Free PMC article.
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). ...Taken together, DXN and TXN could ameliorate the neurocognitive-metabolic impairments associated with HFD-induced ob
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic
Role of Characteristic Components of Humulus lupulus in Promoting Human Health.
Lin M, Xiang D, Chen X, Huo H. Lin M, et al. J Agric Food Chem. 2019 Jul 31;67(30):8291-8302. doi: 10.1021/acs.jafc.9b03780. Epub 2019 Jul 18. J Agric Food Chem. 2019. PMID: 31287692 Review.
Over the next 50 years, the prevention and control of chronic diseases, such as obesity, cardiovascular disease, Alzheimer's disease, and many cancers, will be one of the most critical challenges in human health. ...This review sought to identify and understand the …
Over the next 50 years, the prevention and control of chronic diseases, such as obesity, cardiovascular disease, Alzheimer's d …
The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.
Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C. Weiskirchen R, et al. Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Front Physiol. 2015. PMID: 25999863 Free PMC article. Review.
It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating obesity, dysregulation of glucose metabolism and other components of the metabolic syndrome including hepatic steatosis. Thus, therapeu …
It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating …
Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.
Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. Rayalam S, et al. J Med Food. 2009 Aug;12(4):846-53. doi: 10.1089/jmf.2008.0158. J Med Food. 2009. PMID: 19735186
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. In the present study effects of the combination of XN + GS on 3T3-L1 adipocyte apoptosis and adipogenesis were investigated. ...Thus, combination of XN
Xanthohumol (XN) and guggulsterone (GS) have each been shown to inhibit adipogenesis and induce apoptosis in adipocytes. In the prese
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