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Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3beta pathway.
Zhu L, Fan X, Cao C, Li K, Hou W, Ci X. Zhu L, et al. Biomed Pharmacother. 2023 Sep;165:115097. doi: 10.1016/j.biopha.2023.115097. Epub 2023 Jul 3. Biomed Pharmacother. 2023. PMID: 37406514 Free article.
RESULTS: In vitro, xanthohumol inhibited H(2)O(2)- and acetaminophen-induced cytotoxicity and oxidative stress. Xanthohumol up-regulated the expression of Nrf2. Further mechanistic studies showed that xanthohumol triggered Nrf2 activation via the AMPK/Akt/GSK …
RESULTS: In vitro, xanthohumol inhibited H(2)O(2)- and acetaminophen-induced cytotoxicity and oxidative stress. Xanthohumol up …
Xanthohumol prevents carbon tetrachloride-induced acute liver injury in rats.
Pinto C, Duque AL, Rodríguez-Galdón B, Cestero JJ, Macías P. Pinto C, et al. Food Chem Toxicol. 2012 Oct;50(10):3405-12. doi: 10.1016/j.fct.2012.07.035. Epub 2012 Aug 1. Food Chem Toxicol. 2012. PMID: 22884764
Xanthohumol (XN), a prenyl flavonoid present in beer, prevents the acute hepatic injury induced by carbon tetrachloride (CCl4) in rats. ...
Xanthohumol (XN), a prenyl flavonoid present in beer, prevents the acute hepatic injury induced by carbon tetrachloride (CCl4) in rat
Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms.
Wang YJ, Dou J, Cross KP, Valerio LG Jr. Wang YJ, et al. Regul Toxicol Pharmacol. 2011 Feb;59(1):111-24. doi: 10.1016/j.yrtph.2010.09.012. Epub 2010 Oct 12. Regul Toxicol Pharmacol. 2011. PMID: 20920542
Specifically, protocatechuic acid from black cohosh, benzofuran and 4-vinylphenol from chasteberry, and xanthohumol I from hops were botanical constituents predicted positive for liver toxicity endpoints and were also confirmed with literature findings. ...
Specifically, protocatechuic acid from black cohosh, benzofuran and 4-vinylphenol from chasteberry, and xanthohumol I from hops were …
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus.
Henderson MC, Miranda CL, Stevens JF, Deinzer ML, Buhler DR. Henderson MC, et al. Xenobiotica. 2000 Mar;30(3):235-51. doi: 10.1080/004982500237631. Xenobiotica. 2000. PMID: 10752639
At 10 microM, the prenylated chalcone, xanthohumol (XN), almost completely inhibited the 7-ethoxyresorufin O-deethylase (EROD) activity of CYP1A1. ...
At 10 microM, the prenylated chalcone, xanthohumol (XN), almost completely inhibited the 7-ethoxyresorufin O-deethylase (EROD) activi …