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GABA(A) Receptor-Mediated Sleep-Promoting Effect of Saaz-Saphir Hops Mixture Containing Xanthohumol and Humulone.
Min B, Ahn Y, Cho HJ, Kwak WK, Suh HJ, Jo K. Min B, et al. Molecules. 2021 Nov 24;26(23):7108. doi: 10.3390/molecules26237108. Molecules. 2021. PMID: 34885687 Free PMC article.
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz-Saphir hops mixture was measured. ...Therefore, xanthohumol and humulone con …
Hops contain flavonoids that have sedative and sleep-promoting activities such as alpha-acid, beta-acid, and xanthohumol. In t …
Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA(A) receptor.
Lee H, Chung SH, Kwon DJ, Nam MJ, Choi JH, Suh HJ, Choi HS, Han SH. Lee H, et al. J Ethnopharmacol. 2025 Feb 10;338(Pt 2):119019. doi: 10.1016/j.jep.2024.119019. Epub 2024 Nov 9. J Ethnopharmacol. 2025. PMID: 39522843
A mixture of xanthohumol (1.49 mg) and humulone (2.75 mg) within Hongcheon-hop extract (200 mg) exhibited a sleep-enhancing effect comparable to that of the extract. CONCLUSION: These findings suggest that Hongcheon-hop extract, which contains xanthohumol and …
A mixture of xanthohumol (1.49 mg) and humulone (2.75 mg) within Hongcheon-hop extract (200 mg) exhibited a sleep-enhancing ef …
Chemical compositions and sleep-promoting activities of hop (Humulus lupulus L.) varieties.
Min B, Ahn Y, Cho HJ, Kwak WK, Jo K, Suh HJ. Min B, et al. J Food Sci. 2023 May;88(5):2217-2228. doi: 10.1111/1750-3841.16544. Epub 2023 Apr 11. J Food Sci. 2023. PMID: 37038885
In Drosophila melanogaster, Simcoe and Mosaic water extracts and Saphir and Simcoe alcohol extracts significantly increased total nighttime sleep. Total sleep time of mice with pentobarbital-induced sleep was significantly increased by Simcoe and Mosaic water …
In Drosophila melanogaster, Simcoe and Mosaic water extracts and Saphir and Simcoe alcohol extracts significantly increased total nighttime …
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice.
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K. Roberson SW, et al. Curr Neuropharmacol. 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. Curr Neuropharmacol. 2021. PMID: 33463474 Free PMC article. Review.
Other potential etiologic contributors include dysregulation of neurotransmission due to intravenous sedatives, seizures, organ failure, sleep cycle disruption or other delirium risk factors. Delirium screening can be accomplished in TBI patients and the presence of deliri …
Other potential etiologic contributors include dysregulation of neurotransmission due to intravenous sedatives, seizures, organ failure, …
Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action.
Abdi F, Mobedi H, Roozbeh N. Abdi F, et al. J Menopausal Med. 2016 Aug;22(2):62-4. doi: 10.6118/jmm.2016.22.2.62. Epub 2016 Aug 30. J Menopausal Med. 2016. PMID: 27617238 Free PMC article.
Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms affecting about 50% to 80% of middle-aged women. ...Many herbal treatments for menopause symptoms contain and its components such as 8-preny …
Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms …
Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster.
Choi HS, Ko BS, Kim HD, Hong KB, Suh HJ. Choi HS, et al. Biol Pharm Bull. 2017;40(7):1101-1110. doi: 10.1248/bpb.b17-00262. Biol Pharm Bull. 2017. PMID: 28674253 Free article.
The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 g/g of extract) and Xanthohumol (Cascade: 827.49 g/g, Hallertau: 763.60 g/g, Saaz: 186.93 g/g) were c …
The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis show …
Pharmacognostic and pharmacological profile of Humulus lupulus L.
Zanoli P, Zavatti M. Zanoli P, et al. J Ethnopharmacol. 2008 Mar 28;116(3):383-96. doi: 10.1016/j.jep.2008.01.011. Epub 2008 Jan 20. J Ethnopharmacol. 2008. PMID: 18308492 Review.
The female inflorescences of Humulus lupulus (hops), well-known as bittering agent in brewing industry, have long been used in traditional medicine mainly to treat sleep disturbances. However the sedative activity is still under investigation in order to recognize the acti …
The female inflorescences of Humulus lupulus (hops), well-known as bittering agent in brewing industry, have long been used in traditional m …
Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model.
Choi HS, Hong KB, Han SH, Suh HJ. Choi HS, et al. Biomed Pharmacother. 2018 Mar;99:913-920. doi: 10.1016/j.biopha.2018.01.159. Epub 2018 Feb 20. Biomed Pharmacother. 2018. PMID: 29710491
The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, …
The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarb …
Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation.
Wang S, Dunlap TL, Howell CE, Mbachu OC, Rue EA, Phansalkar R, Chen SN, Pauli GF, Dietz BM, Bolton JL. Wang S, et al. Chem Res Toxicol. 2016 Jul 18;29(7):1142-50. doi: 10.1021/acs.chemrestox.6b00112. Epub 2016 Jun 22. Chem Res Toxicol. 2016. PMID: 27269377 Free PMC article.
(hops) is a popular botanical dietary supplement used by women as a sleep aid and for postmenopausal symptom relief. In addition to its efficacy for menopausal symptoms, hops can also modulate the chemical estrogen carcinogenesis pathway and potentially protect women from …
(hops) is a popular botanical dietary supplement used by women as a sleep aid and for postmenopausal symptom relief. In addition to i …
Positive allosteric modulation of native and recombinant GABAA receptors by hops prenylflavonoids.
Benkherouf AY, Soini SL, Stompor M, Uusi-Oukari M. Benkherouf AY, et al. Eur J Pharmacol. 2019 Jun 5;852:34-41. doi: 10.1016/j.ejphar.2019.02.034. Epub 2019 Feb 21. Eur J Pharmacol. 2019. PMID: 30797788 Free article.
In addition to its wide range of bioactivity, it exhibits neuroactive properties as a sedative and sleeping aid. The compounds responsible for this activity are yet to be revealed and understood in terms of their pharmacological properties. ...Flumazenil sensitivity of GAB …
In addition to its wide range of bioactivity, it exhibits neuroactive properties as a sedative and sleeping aid. The compounds respon …