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Page 1
Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid in mouse tuberculosis models.
Lou H, Zhang F, Lu L, Ding Y, Hao X. Lou H, et al. RSC Adv. 2020 Apr 1;10(22):13223-13231. doi: 10.1039/c9ra10347c. eCollection 2020 Mar 30. RSC Adv. 2020. PMID: 35492081 Free PMC article.
During the experiment, the uninfected group and the normal control group received an equal volume of saline, the xanthohumol group received an equal volume of xanthohumol only, and the isoniazid group received an equal volume of isoniazid only. ...In conclusion, …
During the experiment, the uninfected group and the normal control group received an equal volume of saline, the xanthohumol group re …
Microbial Conjugation Studies of Licochalcones and Xanthohumol.
Han F, Xiao Y, Lee IS. Han F, et al. Int J Mol Sci. 2021 Jun 26;22(13):6893. doi: 10.3390/ijms22136893. Int J Mol Sci. 2021. PMID: 34206985 Free PMC article.
Microbial conjugation studies of licochalcones (1-4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia coerulea. As a result, one new glucosylated metabolite was produced by M. hiemalis whereas four new and three known sulfated metabolites we …
Microbial conjugation studies of licochalcones (1-4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia …
Reductive Metabolism of Xanthohumol and 8-Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus.
Paraiso IL, Plagmann LS, Yang L, Zielke R, Gombart AF, Maier CS, Sikora AE, Blakemore PR, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2019 Jan;63(2):e1800923. doi: 10.1002/mnfr.201800923. Epub 2018 Dec 3. Mol Nutr Food Res. 2019. PMID: 30471194 Free PMC article.
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and beer, as well as to identify pathways of metabolism of XN in the gut. ...CONCLUSION: Microbial metabolism is likely to affect both activity and …
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and bee …
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy.
Turdo A, Glaviano A, Pepe G, Calapà F, Raimondo S, Fiori ME, Carbone D, Basilicata MG, Di Sarno V, Ostacolo C, Parrino B, Cascioferro S, Pecoraro C, Di Franco S, Bellavia D, Gaggianesi M, Veschi V, Lo Iacono M, Ganduscio G, Pantina VD, Mangiapane LR, Bongiorno MR, Alessandro R, Todaro M, De Maria R, Diana P, Campiglia P, Stassi G. Turdo A, et al. Cancers (Basel). 2021 Aug 4;13(16):3927. doi: 10.3390/cancers13163927. Cancers (Basel). 2021. PMID: 34439086 Free PMC article.
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tackled. Thus, new treatment approach …
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis forma …
Dose-Dependent Protective and Inductive Effectsof Xanthohumol on Oxidative DNA Damage inSaccharomyces cerevisiae.
Carvalho DO, Oliveira R, Johansson B, Guido LF. Carvalho DO, et al. Food Technol Biotechnol. 2016 Mar;54(1):60-69. doi: 10.17113/ftb.54.01.16.4256. Food Technol Biotechnol. 2016. PMID: 27904394 Free PMC article.
Yeast cultures under oxidative stress, induced by H(2)O(2), displayed stronger growth in the presence of 5 mg/L of xanthohumol than cultures with only H(2)O(2). Likewise, DNA damage assessed by the comet assay was significantly lower in cells co-incubated with xanthohum …
Yeast cultures under oxidative stress, induced by H(2)O(2), displayed stronger growth in the presence of 5 mg/L of xanthohumol than c …
Amyloid-beta Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
METHODS: We designed and synthesized a novel series of 9 xanthohumol derivatives. Their inhibitory effect on amyloid-beta (1-42), Abeta1-42, oligomerization and fibrillation as well as neuroprotection against amyloid-beta induced toxicities, were explored. ...CONCLU …
METHODS: We designed and synthesized a novel series of 9 xanthohumol derivatives. Their inhibitory effect on amyloid-beta (1-42), Abe …
Xanthohumol ameliorates 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular toxicity in cultured MC3T3-E1 osteoblastic cells.
Suh KS, Choi EM, Kim HS, Park SY, Chin SO, Rhee SY, Pak YK, Choe W, Ha J, Chon S. Suh KS, et al. J Appl Toxicol. 2018 Jul;38(7):1036-1046. doi: 10.1002/jat.3613. Epub 2018 Mar 8. J Appl Toxicol. 2018. PMID: 29516522
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant. Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The aim of the current study was to explore the role of xanthohumol in modulating the toxicity of TCDD …
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant. Xanthohumol is a prenylated flavonoid found in hops (Humu …
Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration.
Henneman NF, Foster SL, Chrenek MA, Sellers JT, Wright CB, Schmidt RH, Nickerson JM, Boatright JH. Henneman NF, et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):45-53. doi: 10.1167/iovs.17-22132. Invest Ophthalmol Vis Sci. 2018. PMID: 29305606 Free PMC article.
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD). METHODS: Mice (129S2/SvPasCrl) were intraperitoneally injected wit …
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is …
Xanthohumol feeding does not impair organ function and homoeostasis in mice.
Dorn C, Bataille F, Gaebele E, Heilmann J, Hellerbrand C. Dorn C, et al. Food Chem Toxicol. 2010 Jul;48(7):1890-7. doi: 10.1016/j.fct.2010.04.030. Epub 2010 Apr 26. Food Chem Toxicol. 2010. PMID: 20427021
Here, we fed female BALB/c mice with a standard diet supplemented with xanthohumol for 3 weeks, and thus, achieved a daily dose of approximately 1000 mg xanthohumol/kg body weight. There were no significant differences in body weight or food intake between mice on s …
Here, we fed female BALB/c mice with a standard diet supplemented with xanthohumol for 3 weeks, and thus, achieved a daily dose of ap …
Prenylated Flavonoids in Topical Infections and Wound Healing.
Sychrová A, Škovranová G, Čulenová M, Bittner Fialová S. Sychrová A, et al. Molecules. 2022 Jul 13;27(14):4491. doi: 10.3390/molecules27144491. Molecules. 2022. PMID: 35889363 Free PMC article. Review.
A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominantly Staphylococcus aureus strains, but only artocarpin, diplacone, isobavachalcone, licochalcone A, sophoraflavanone G, and xanthohumol …
A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominan …
70 results