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Reductive Metabolism of Xanthohumol and 8-Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus.
Paraiso IL, Plagmann LS, Yang L, Zielke R, Gombart AF, Maier CS, Sikora AE, Blakemore PR, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2019 Jan;63(2):e1800923. doi: 10.1002/mnfr.201800923. Epub 2018 Dec 3. Mol Nutr Food Res. 2019. PMID: 30471194 Free PMC article.
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and beer, as well as to identify pathways of metabolism of XN in the gut. ...CONCLUSION: Microbial metabolism is likely to affect both activity and …
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and bee …
Amyloid-β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS. Wang X, et al. Curr Alzheimer Res. 2019;16(9):836-842. doi: 10.2174/1567205016666190827123222. Curr Alzheimer Res. 2019. PMID: 31453789
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential for treating Alzheimer's disease (AD). ...CONCLUSION: Two derivatives have been identified to be biocompatible, non-toxic, neuroprot …
However, the bio-incompatibility and blood-brain barrier impermeability of xanthohumol hindered its in vivo efficacy potential for tr …
Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin.
Seliger JM, Martin HJ, Maser E, Hintzpeter J. Seliger JM, et al. Chem Biol Interact. 2019 May 25;305:156-162. doi: 10.1016/j.cbi.2019.02.031. Epub 2019 Mar 6. Chem Biol Interact. 2019. PMID: 30849340
The hop-derived prenylated chalcone xanthohumol (XN) and its physiological metabolites isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) have previously been reported to inhibit other DAUN reducing reductases and dehydrogenases including AKR1B1 and AKR1B10. ...This study i …
The hop-derived prenylated chalcone xanthohumol (XN) and its physiological metabolites isoxanthohumol (IX) and 8-prenylnaringenin (8- …
Xanthohumol feeding does not impair organ function and homoeostasis in mice.
Dorn C, Bataille F, Gaebele E, Heilmann J, Hellerbrand C. Dorn C, et al. Food Chem Toxicol. 2010 Jul;48(7):1890-7. doi: 10.1016/j.fct.2010.04.030. Epub 2010 Apr 26. Food Chem Toxicol. 2010. PMID: 20427021
Here, we fed female BALB/c mice with a standard diet supplemented with xanthohumol for 3 weeks, and thus, achieved a daily dose of approximately 1000 mg xanthohumol/kg body weight. ...Histopathological examination of liver, kidney, colon, lung, heart, spleen and thy …
Here, we fed female BALB/c mice with a standard diet supplemented with xanthohumol for 3 weeks, and thus, achieved a daily dose of ap …
Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration.
Henneman NF, Foster SL, Chrenek MA, Sellers JT, Wright CB, Schmidt RH, Nickerson JM, Boatright JH. Henneman NF, et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):45-53. doi: 10.1167/iovs.17-22132. Invest Ophthalmol Vis Sci. 2018. PMID: 29305606 Free PMC article.
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD). ...Retinal function was assessed by electroretinograms at 1, 2, an …
PURPOSE: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is …
Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregates.
Zhang M , Wu Q , Yao X , Zhao J , Zhong W , Liu Q , Xiao S . Zhang M , et al. Food Funct. 2019 Dec 11;10(12):7865-7874. doi: 10.1039/c9fo02133g. Food Funct. 2019. PMID: 31793596
Alzheimer's disease (AD) is a neurodegenerative disease. The molecular mechanisms of AD are not yet clear, and no effective treatments are available to cure AD. ...In this study, xanthohumol (XN), a natural botanic compound, is found to inhibit tau protein aggregati …
Alzheimer's disease (AD) is a neurodegenerative disease. The molecular mechanisms of AD are not yet clear, and no effective treatment …
Xanthohumol ameliorates 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cellular toxicity in cultured MC3T3-E1 osteoblastic cells.
Suh KS, Choi EM, Kim HS, Park SY, Chin SO, Rhee SY, Pak YK, Choe W, Ha J, Chon S. Suh KS, et al. J Appl Toxicol. 2018 Jul;38(7):1036-1046. doi: 10.1002/jat.3613. Epub 2018 Mar 8. J Appl Toxicol. 2018. PMID: 29516522
Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The aim of the current study was to explore the role of xanthohumol in modulating the toxicity of TCDD in MC3T3-E1 osteoblastic cells. ...We conclude that xanthohumol has a …
Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The aim of the current study was to explore the role …
Dose-Dependent Protective and Inductive Effects
of Xanthohumol on Oxidative DNA Damage in
Saccharomyces cerevisiae.
Carvalho DO, Oliveira R, Johansson B, Guido LF. Carvalho DO, et al. Food Technol Biotechnol. 2016 Mar;54(1):60-69. doi: 10.17113/ftb.54.01.16.4256. Food Technol Biotechnol. 2016. PMID: 27904394 Free PMC article.
Likewise, DNA damage assessed by the comet assay was significantly lower in cells co-incubated with xanthohumol and H(2)O(2). ...A yeast yap1 deletion mutant strain sensitive to oxidative stress grew more slowly in the presence of at least 5 mg/L of xanthohumol than …
Likewise, DNA damage assessed by the comet assay was significantly lower in cells co-incubated with xanthohumol and H(2)O(2). ...A ye …
Prenylated chalcones and flavonoids for the prevention and treatment of cancer.
Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Venturelli S, et al. Nutrition. 2016 Nov-Dec;32(11-12):1171-8. doi: 10.1016/j.nut.2016.03.020. Epub 2016 Apr 8. Nutrition. 2016. PMID: 27238957 Review.
Some representatives of this subclass of secondary plant compounds exert pronounced anti-tumor-initiating capacities and directly inhibit growth of cancer cells, whereas their toxic effects on healthy tissues are remarkably low. ...Provided here is a comprehensive summary …
Some representatives of this subclass of secondary plant compounds exert pronounced anti-tumor-initiating capacities and directly inhibit gr …
Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
Dorn C, Heilmann J, Hellerbrand C. Dorn C, et al. Int J Clin Exp Pathol. 2012;5(1):29-36. Epub 2012 Jan 1. Int J Clin Exp Pathol. 2012. PMID: 22295144 Free PMC article.
Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory properties. We have recently shown that xanthohumol inhibits hepatic inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis. ...Furthermore, xanthohu …
Xanthohumol, the major prenylated chalcone found in hops, is known for its anti-inflammatory properties. We have recently shown that …
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