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Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipi …
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to …
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. ...Dietary XN caused a dose-dependent decrease in body weight gain. Plasma levels of glucose, total triglycerides, total cholesterol, and MCP-1 were significantly decreased in mice …
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. ...Dietary XN caused a dose-dependent decrease i …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food …
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received …
Xanthohumol Effect on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Japanese Quails in Terms of Serum Lipids, Liver Enzymes, Estradiol, and Thyroid Hormones.
Leśków A, Tarnowska MG, Rosińczuk J, Dobrzyński M, Kaliszewski K, Majda J, Żybura-Wszol A K, Sobolewska S, Diakowska D. Leśków A, et al. ACS Omega. 2020 Sep 18;5(38):24445-24452. doi: 10.1021/acsomega.0c02896. eCollection 2020 Sep 29. ACS Omega. 2020. PMID: 33015460 Free PMC article.
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, and binding with the aryl hydrocarbon receptor (AhR) leads to expression of cytochrome p-450 genes that in turn predisposes to mutations. Natural flavonoid …
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, and binding wit …
Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.
Karimi-Sales E, Mohaddes G, Alipour MR. Karimi-Sales E, et al. Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Pharmacol Res. 2018. PMID: 29175112 Review.
Chalcones improve adipocytes function and adiponectin secretion. They inhibit triglyceride synthesis, activating factors of hepatic stellate cells and extracellular matrix deposition and also elevate fatty acid oxidation. ...
Chalcones improve adipocytes function and adiponectin secretion. They inhibit triglyceride synthesis, activating factors of hepatic s …
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. ...METHODS AND RESULTS: XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic …
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and …
The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells.
Casaschi A, Maiyoh GK, Rubio BK, Li RW, Adeli K, Theriault AG. Casaschi A, et al. J Nutr. 2004 Jun;134(6):1340-6. doi: 10.1093/jn/134.6.1340. J Nutr. 2004. PMID: 15173394
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) synthesis and secretion, using HepG2 cells as the model system. ...To determine the mechanism underlying this effect, we examined triglycer …
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) sy …
Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.
Nozawa H. Nozawa H. Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. doi: 10.1016/j.bbrc.2005.08.159. Biochem Biophys Res Commun. 2005. PMID: 16140264
We have examined the modulating action of xanthohumol (XN) on the farnesoid X receptor (FXR) in vitro and in vivo. ...XN-fed KK-A(y) mice exhibited lowered levels of plasma glucose, plasma, and hepatic triglyceride. They also showed decreased amounts of water intake …
We have examined the modulating action of xanthohumol (XN) on the farnesoid X receptor (FXR) in vitro and in vivo. ...XN-fed KK-A(y) …
Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.
Yui K, Kiyofuji A, Osada K. Yui K, et al. J Oleo Sci. 2014;63(2):159-68. doi: 10.5650/jos.ess13136. Epub 2014 Jan 14. J Oleo Sci. 2014. PMID: 24420065 Free article.
We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. ...The excreted of triacylglycerol into feces also was promoted by dietary xanthohumol-rich hop extract. Plasma adiponectin levels in the rats …
We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. ...The exc …
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Goto K, Asai T, Hara S, Namatame I, Tomoda H, Ikemoto M, Oku N. Goto K, et al. Cancer Lett. 2005 Mar 10;219(2):215-22. doi: 10.1016/j.canlet.2004.07.034. Cancer Lett. 2005. PMID: 15723722
Cancer chemotherapy for hypoxic tumor cells is thought to be an important issue, since hypoxia is related to tumor growth, apoptosis, angiogenesis and metastasis. Here, the bioactivities of xanthohumol (XN), a diacylglycerol acyltransferase inhibitor, against hypoxic cells …
Cancer chemotherapy for hypoxic tumor cells is thought to be an important issue, since hypoxia is related to tumor growth, apoptosis, angiog …
11 results