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15 results

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Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.
Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R. Costa R, et al. J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6. J Nutr Biochem. 2017. PMID: 28431322
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. ...Both XN and 8PN treatments prevented body weight gain; decrease …
The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in live …
Selective and iron-independent ferroptosis in cancer cells induced by manipulation of mitochondrial fatty acid oxidation.
Gao Y, Song Z, Gan W, Zou X, Bai Y, Zhao X, Chen D, Qiao M. Gao Y, et al. Biomaterials. 2025 Sep;320:123259. doi: 10.1016/j.biomaterials.2025.123259. Epub 2025 Mar 14. Biomaterials. 2025. PMID: 40112511
In this study, manipulation of fatty acids beta-oxidation (FAO) by combination of mild photodynamic therapy (PDT) and inhibition of triglycerides (TGs) synthesis was found to induce robust and iron-independent ferroptosis in cancer cells with dysregulated lipid metabolism …
In this study, manipulation of fatty acids beta-oxidation (FAO) by combination of mild photodynamic therapy (PDT) and inhibition of trigl …
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. ...Dietary XN caused a dose-dependent decrease in …
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and …
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.
Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF. Legette LL, et al. Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27. Phytochemistry. 2013. PMID: 22640929
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food …
There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received …
Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXRalpha/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models.
Gao WY, Chen PY, Hsu HJ, Liou JW, Wu CL, Wu MJ, Yen JH. Gao WY, et al. Biomed Pharmacother. 2024 May;174:116598. doi: 10.1016/j.biopha.2024.116598. Epub 2024 Apr 13. Biomed Pharmacother. 2024. PMID: 38615609 Free article.
Angiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular d …
Angiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoprote …
Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.
Karimi-Sales E, Mohaddes G, Alipour MR. Karimi-Sales E, et al. Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Pharmacol Res. 2018. PMID: 29175112 Review.
Chalcones improve adipocytes function and adiponectin secretion. They inhibit triglyceride synthesis, activating factors of hepatic stellate cells and extracellular matrix deposition and also elevate fatty acid oxidation. ...
Chalcones improve adipocytes function and adiponectin secretion. They inhibit triglyceride synthesis, activating factors of hepatic s …
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. ...METHODS AND RESULTS: XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic …
SCOPE: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and …
The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells.
Casaschi A, Maiyoh GK, Rubio BK, Li RW, Adeli K, Theriault AG. Casaschi A, et al. J Nutr. 2004 Jun;134(6):1340-6. doi: 10.1093/jn/134.6.1340. J Nutr. 2004. PMID: 15173394 Free article.
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) synthesis and secretion, using HepG2 cells as the model system. ...Whether the reduction in TG accumulation in the microsomal lumen is predomi …
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) sy …
Xanthohumol Effect on 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Japanese Quails in Terms of Serum Lipids, Liver Enzymes, Estradiol, and Thyroid Hormones.
Leśków A, Tarnowska MG, Rosińczuk J, Dobrzyński M, Kaliszewski K, Majda J, Żybura-Wszol A K, Sobolewska S, Diakowska D. Leśków A, et al. ACS Omega. 2020 Sep 18;5(38):24445-24452. doi: 10.1021/acsomega.0c02896. eCollection 2020 Sep 29. ACS Omega. 2020. PMID: 33015460 Free PMC article.
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, and binding with the aryl hydrocarbon receptor (AhR) leads to expression of cytochrome p-450 genes that in turn predisposes to mutations. Natural flavonoid …
TCDD is considered a carcinogen and has proinflammatory influence on animals and humans, promoting free radicals' formation, and binding wit …
SARS-CoV-2 Membrane Protein Induces MARCHF1/GPX4-Mediated Ferroptosis by Promoting Lipid Accumulation.
Sun P, Liu Q, Yuan S, Wang XT, Qiu Y, Ge XY. Sun P, et al. J Med Virol. 2025 Apr;97(4):e70328. doi: 10.1002/jmv.70328. J Med Virol. 2025. PMID: 40186530
Additionally, we uncovered the pivotal role of perilipin-2 and sterol regulatory element-binding protein 1 in M-induced lipid accumulation. Xanthohumol, a cost-effective and orally available diacylglycerol acyltransferase inhibitor, alleviated triglyceride and total …
Additionally, we uncovered the pivotal role of perilipin-2 and sterol regulatory element-binding protein 1 in M-induced lipid accumulation. …
15 results