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Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation.
Lu X, Liu M, Dong H, Miao J, Stagos D, Liu M. Lu X, et al. Food Chem Toxicol. 2022 Feb;160:112813. doi: 10.1016/j.fct.2022.112813. Epub 2022 Jan 6. Food Chem Toxicol. 2022. PMID: 34999176
In the present study, we reported XN alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation. In vitro, XN attenuated hydrogen peroxide (H(2)O(2))-induced cytotoxicity, ROS production, cell apoptosis, as well as high glucose-induced ce …
In the present study, we reported XN alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation. I …
Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing.
Costa R, Negrão R, Valente I, Castela Â, Duarte D, Guardão L, Magalhães PJ, Rodrigues JA, Guimarães JT, Gomes P, Soares R. Costa R, et al. J Nat Prod. 2013 Nov 22;76(11):2047-53. doi: 10.1021/np4002898. Epub 2013 Nov 7. J Nat Prod. 2013. PMID: 24200239
This study has evaluated the effect of phenol-rich beverage consumption in diabetic rats on wound healing, through angiogenesis, inflammation, and oxidative stress modulation. A wound-healing assay was performed in streptozotocin-induced diabetic Wista …
This study has evaluated the effect of phenol-rich beverage consumption in diabetic rats on wound healing, through angiogenesi …
Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes.
Negrão R, Costa R, Duarte D, Gomes TT, Coelho P, Guimarães JT, Guardão L, Azevedo I, Soares R. Negrão R, et al. J Cell Biochem. 2012 Jan;113(1):100-9. doi: 10.1002/jcb.23332. J Cell Biochem. 2012. PMID: 21898537
Angiogenesis and inflammation are two intermingled processes that play a role in wound healing. Nevertheless, whenever exacerbated, these processes result in nonhealing wounds. ...This study shows that XN intake in its natural beer context reduced inflammation, oxid …
Angiogenesis and inflammation are two intermingled processes that play a role in wound healing. Nevertheless, whenever exacerb …
Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.
Liu R, Heiss EH, Schachner D, Jiang B, Liu W, Breuss JM, Dirsch VM, Atanasov AG. Liu R, et al. J Nat Prod. 2017 Jul 28;80(7):2146-2150. doi: 10.1021/acs.jnatprod.7b00268. Epub 2017 Jun 19. J Nat Prod. 2017. PMID: 28627872 Free PMC article.
Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was to examine its influence on platelet-derived growth factor (PDGF)-BB-triggered vascular smooth muscle cell (VSMC) proliferation and migration in vitro and on experimentally induced
Xanthohumol (1) is a principal prenylated chalcone found in hops. The aim of this study was to examine its influence on platelet-deri
Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells.
Negrão R, Costa R, Duarte D, Taveira Gomes T, Mendanha M, Moura L, Vasques L, Azevedo I, Soares R. Negrão R, et al. J Cell Biochem. 2010 Dec 1;111(5):1270-9. doi: 10.1002/jcb.22850. J Cell Biochem. 2010. PMID: 20803553
Opposite in vitro effects were observed between 8PN, stimulating endothelial and smooth muscle cell (SMC) growth, motility, invasion and capillary-like structures formation, and XN and IXN, which inhibited them. Mouse matrigel plug and rat skin wound-healing assays …
Opposite in vitro effects were observed between 8PN, stimulating endothelial and smooth muscle cell (SMC) growth, motility, invasion and cap …
Xanthohumol, a prenylated flavonoid from Hops, exerts anticancer effects against gastric cancer in vitro.
Wei S, Sun T, Du J, Zhang B, Xiang D, Li W. Wei S, et al. Oncol Rep. 2018 Dec;40(6):3213-3222. doi: 10.3892/or.2018.6723. Epub 2018 Sep 21. Oncol Rep. 2018. PMID: 30272303 Free PMC article.
Xanthohumol (Xn), a prenylated flavonoid isolated from Hops (Humulus lupulus L.), has demonstrated potent anticancer activity in multiple types of cancer. ...Xn treatment increased the number of apoptotic cells, downregulated the expression of Bcl-2 and upregulated the exp
Xanthohumol (Xn), a prenylated flavonoid isolated from Hops (Humulus lupulus L.), has demonstrated potent anticancer activity in mult