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24,929 results

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Page 1
Did you mean enobiotic metabolic process (8,109,109 results)?
Microbial transformation of dietary xenobiotics shapes gut microbiome composition.
Culp EJ, Nelson NT, Verdegaal AA, Goodman AL. Culp EJ, et al. Cell. 2024 Oct 31;187(22):6327-6345.e20. doi: 10.1016/j.cell.2024.08.038. Epub 2024 Sep 24. Cell. 2024. PMID: 39321800 Free PMC article.
To mechanistically understand these relationships, here we map interactions between 150 small-molecule dietary xenobiotics and the gut microbiome, including the impacts of these compounds on community composition, the metabolic activities of human gut microbes on d …
To mechanistically understand these relationships, here we map interactions between 150 small-molecule dietary xenobiotics and the g …
Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.
Massart J, Begriche K, Corlu A, Fromenty B. Massart J, et al. Int J Mol Sci. 2022 Jan 19;23(3):1062. doi: 10.3390/ijms23031062. Int J Mol Sci. 2022. PMID: 35162986 Free PMC article. Review.
Besides nutritional and genetic factors, different xenobiotics such as pharmaceuticals and environmental toxicants are suspected to aggravate MAFLD in obese individuals. ...Although not typically considered as a xenobiotic, ethanol is also discussed because its abus …
Besides nutritional and genetic factors, different xenobiotics such as pharmaceuticals and environmental toxicants are suspected to a …
Vitamin E regulation.
Traber MG. Traber MG. Curr Opin Gastroenterol. 2005 Mar;21(2):223-7. doi: 10.1097/01.mog.0000153359.13525.b4. Curr Opin Gastroenterol. 2005. PMID: 15711217 Review.
RECENT FINDINGS: alpha-tocopherol regulatory proteins have been cloned and crystallized and their mechanisms of action are under intense scrutiny. Studies of vitamin E metabolism suggest that xenobiotic metabolism may not only regulate vitamin E concentration …
RECENT FINDINGS: alpha-tocopherol regulatory proteins have been cloned and crystallized and their mechanisms of action are under intense scr …
LC-MS-based metabolomics in drug metabolism.
Chen C, Gonzalez FJ, Idle JR. Chen C, et al. Drug Metab Rev. 2007;39(2-3):581-97. doi: 10.1080/03602530701497804. Drug Metab Rev. 2007. PMID: 17786640 Free PMC article. Review.
Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating signals for many pathophysiological events. ...Recent work in our lab has shown that LC-MS-based metabolomic techniques are useful tools for xenobiotic metabolism …
Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating signals for many pathophysiologi …
Metabolic zonation of liver parenchyma.
Jungermann K. Jungermann K. Semin Liver Dis. 1988 Nov;8(4):329-41. doi: 10.1055/s-2008-1040554. Semin Liver Dis. 1988. PMID: 3062788 Review.
Periportal and perivenous hepatocytes differ in their content of enzymes and subcellular structures and thus in their metabolic capacities. Therefore, the model of metabolic zonation proposes that: (1) periportal hepatocytes catalyze predominantly oxidative energy …
Periportal and perivenous hepatocytes differ in their content of enzymes and subcellular structures and thus in their metabolic capac …
The Roles of Xenobiotic Receptors: Beyond Chemical Disposition.
Mackowiak B, Hodge J, Stern S, Wang H. Mackowiak B, et al. Drug Metab Dispos. 2018 Sep;46(9):1361-1371. doi: 10.1124/dmd.118.081042. Epub 2018 May 14. Drug Metab Dispos. 2018. PMID: 29759961 Free PMC article. Review.
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are the xenobiotic receptors that have received the most attention since they regulate the expression of numerous proteins important to drug metabolism and clearance and formulate a central …
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are the xenobiotic receptors that have received the most …
Xenobiotic metabolism and transport in Caenorhabditis elegans.
Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MCK, Andersen EC, Taubert S, Meyer JN. Hartman JH, et al. J Toxicol Environ Health B Crit Rev. 2021 Feb 17;24(2):51-94. doi: 10.1080/10937404.2021.1884921. Epub 2021 Feb 22. J Toxicol Environ Health B Crit Rev. 2021. PMID: 33616007 Free PMC article. Review.
In addition, the following were discussed (1) regulation of xenobiotic metabolism; (2) review of published toxicokinetics for specific chemicals; and (3) genetic diversity of these processes in C. elegans. Finally, worm xenobiotic transport and metabolism …
In addition, the following were discussed (1) regulation of xenobiotic metabolism; (2) review of published toxicokinetics for …
PXR: More Than Just a Master Xenobiotic Receptor.
Oladimeji PO, Chen T. Oladimeji PO, et al. Mol Pharmacol. 2018 Feb;93(2):119-127. doi: 10.1124/mol.117.110155. Epub 2017 Nov 7. Mol Pharmacol. 2018. PMID: 29113993 Free PMC article. Review.
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xenobiotics and endotoxin …
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the express …
Xenobiotic transporter-adaptor network.
Kato Y. Kato Y. Drug Metab Pharmacokinet. 2007 Dec;22(6):401-8. doi: 10.2133/dmpk.22.401. Drug Metab Pharmacokinet. 2007. PMID: 18159127 Free article. Review.
It has recently been proposed that protein-protein interactions involving the xenobiotic transporters may affect their function, localization and expression on plasma membranes. ...Interaction with a PDZ adaptor is essential for the cell-surface localization of at least so …
It has recently been proposed that protein-protein interactions involving the xenobiotic transporters may affect their function, loca …
Metabolic and redox barriers in the skin exposed to drugs and xenobiotics.
Korkina L. Korkina L. Expert Opin Drug Metab Toxicol. 2016;12(4):377-88. doi: 10.1517/17425255.2016.1149569. Epub 2016 Feb 17. Expert Opin Drug Metab Toxicol. 2016. PMID: 26854731 Review.
Since skin is the largest extra-hepatic drug/xenobiotic metabolising organ where redox-dependent metabolic pathways prevail, in this review, publications on metabolic processes leading to redox imbalance (oxidative stress) and its autocrine/endocrine impact t …
Since skin is the largest extra-hepatic drug/xenobiotic metabolising organ where redox-dependent metabolic pathways prevail, i …
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