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Page 1
GNAS mutations in adrenal aldosterone-producing adenomas.
Nakajima Y, Okamura T, Horiguchi K, Gohko T, Miyamoto T, Satoh T, Ozawa A, Ishii S, Yamada E, Hashimoto K, Okada S, Takata D, Horiguchi J, Yamada M. Nakajima Y, et al. Endocr J. 2016;63(2):199-204. doi: 10.1507/endocrj.EJ15-0642. Epub 2016 Jan 6. Endocr J. 2016. PMID: 26743443 Free article.
However, mutations have not yet been examined in aldosterone-producing adenomas (APAs). Therefore, we herein investigated mutations in the GNAS gene in APAs. ...
However, mutations have not yet been examined in aldosterone-producing adenomas (APAs). Therefore, we herein investigated mutations i …
Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations.
Okamura T, Nakajima Y, Katano-Toki A, Horiguchi K, Matsumoto S, Yoshino S, Yamada E, Tomaru T, Ishii S, Saito T, Ozawa A, Shibusawa N, Satoh T, Okada S, Nagaoka R, Takada D, Horiguchi J, Oyama T, Yamada M. Okamura T, et al. Among authors: nakajima y. Endocr J. 2017 Jan 30;64(1):39-47. doi: 10.1507/endocrj.EJ16-0243. Epub 2016 Sep 28. Endocr J. 2017. PMID: 27681703 Free article.
Somatic mutations in KCNJ5 gene have been identified in patients with adrenal aldosterone-producing adenomas (APAs). We previously reported that Japanese patients with APAs had distinct characteristics from patients in Western countries; i.e. they had a high frequency of K …
Somatic mutations in KCNJ5 gene have been identified in patients with adrenal aldosterone-producing adenomas (APAs). We previously re …
Age-Dependent Progression of Renal Dysfunction After Adrenalectomy for Aldosterone-Producing Adenomas in Japan.
Yoshioka M, Nakajima Y, Miyamoto T, Igarashi T, Sakamaki K, Akuzawa M, Ishida E, Horiguchi K, Yamada E, Saito T, Ozawa A, Shimomura Y, Kobayashi I, Andou Y, Shirabe K, Yamada M. Yoshioka M, et al. Among authors: nakajima y. J Endocr Soc. 2018 Dec 17;3(3):577-589. doi: 10.1210/js.2018-00260. eCollection 2019 Mar 1. J Endocr Soc. 2018. PMID: 30805569 Free PMC article.
CONTEXT: In patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase in blood potassium levels; however, the effects of these intensive metabolic changes on kidney function with age have not yet been examined …
CONTEXT: In patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase …
KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas.
Yamada M, Nakajima Y, Taguchi R, Okamura T, Ishii S, Tomaru T, Ozawa A, Shibusawa N, Yoshino S, Toki A, Ishida E, Hashimoto K, Satoh T, Mori M. Yamada M, et al. Among authors: nakajima y. Endocr J. 2012;59(8):735-41. doi: 10.1507/endocrj.ej12-0247. Epub 2012 Aug 3. Endocr J. 2012. PMID: 22863749 Free article.
Adrenal aldosterone-producing adenomas (APA) are rarely associated with the clear co-secretion of cortisol. ...These findings suggested that at least some aldosterone- and cortisol-co-secreting adrenal tumors have mutations of the KCNJ5 gene, suggesting the origin t …
Adrenal aldosterone-producing adenomas (APA) are rarely associated with the clear co-secretion of cortisol. ...These findings suggest …
Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas.
Taguchi R, Yamada M, Nakajima Y, Satoh T, Hashimoto K, Shibusawa N, Ozawa A, Okada S, Rokutanda N, Takata D, Koibuchi Y, Horiguchi J, Oyama T, Takeyoshi I, Mori M. Taguchi R, et al. Among authors: nakajima y. J Clin Endocrinol Metab. 2012 Apr;97(4):1311-9. doi: 10.1210/jc.2011-2885. Epub 2012 Jan 25. J Clin Endocrinol Metab. 2012. PMID: 22278422
CONTEXT: Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). OBJECTIVE: Our objective was to investigate the expression and mutations of the KCNJ5 gene in Japanese patients with APA. ...
CONTEXT: Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). OBJECTIVE: …
Regulation of the KCNJ5 gene by SF-1 in the adrenal cortex: Complete genomic organization and promoter function.
Nishikido A, Okamura T, Nakajima Y, Ishida E, Miyamoto T, Toki AK, Matsumoto S, Yoshino S, Horiguchi K, Saito T, Yamada E, Ozawa A, Shimoda Y, Oyama T, Yamada M. Nishikido A, et al. Among authors: nakajima y. Mol Cell Endocrinol. 2020 Feb 5;501:110657. doi: 10.1016/j.mce.2019.110657. Epub 2019 Nov 18. Mol Cell Endocrinol. 2020. PMID: 31751625
Activating mutations in the KCNJ5 gene are responsible for the significant number of aldosterone-producing adenomas. To elucidate the molecular mechanisms underlying KCNJ5 expression, we characterized the entire human KCNJ5 gene. ...
Activating mutations in the KCNJ5 gene are responsible for the significant number of aldosterone-producing adenomas. To elucidate the …
Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion.
Nakajima Y, Yamada M, Taguchi R, Satoh T, Hashimoto K, Ozawa A, Shibusawa N, Okada S, Monden T, Mori M. Nakajima Y, et al. J Clin Endocrinol Metab. 2011 Aug;96(8):2512-8. doi: 10.1210/jc.2010-2743. Epub 2011 May 18. J Clin Endocrinol Metab. 2011. PMID: 21593113
CONTEXT: Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol. OBJECTIVE: Our objective was to investigate the effect of autonomous cortisol secretion on the prevalence of cardiovascular events (CVE) in patients with PA. ...Other fac …
CONTEXT: Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol. OBJECTIVE: Our objective was t …
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Nakajima Y, Okamura T, Gohko T, Satoh T, Hashimoto K, Shibusawa N, Ozawa A, Ishii S, Tomaru T, Horiguchi K, Okada S, Takata D, Rokutanda N, Horiguchi J, Tsushima Y, Oyama T, Takeyoshi I, Yamada M. Nakajima Y, et al. Endocr J. 2014;61(8):825-32. doi: 10.1507/endocrj.ej14-0282. Epub 2014 Jul 25. Endocr J. 2014. PMID: 25069672 Free article.
Since we recently reported higher prevalence of mutations of the KCNJ5 gene and associations with autonomous cortisol secretion in Japanese aldosterone-producing adenomas than in Western countries, there might be different features of CPAs between Japan and the West. We th …
Since we recently reported higher prevalence of mutations of the KCNJ5 gene and associations with autonomous cortisol secretion in Japanese …