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2010 4
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26 results

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7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
Xue F, Zhao Z, Gu Y, Han J, Ye K, Zhang Y. Xue F, et al. Among authors: ye k. Elife. 2021 Jul 6;10:e64872. doi: 10.7554/eLife.64872. Elife. 2021. PMID: 34227467 Free PMC article.
Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone (7,8-DHF), a plant-derived small molecular TrkB agonist, mimics the functions of BDNF. ...
Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone (7,8-DHF), …
Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice.
Ahuja P, Ng CF, Pang BPS, Chan WS, Tse MCL, Bi X, Kwan HR, Brobst D, Herlea-Pana O, Yang X, Du G, Saengnipanthkul S, Noh HL, Jiao B, Kim JK, Lee CW, Ye K, Chan CB. Ahuja P, et al. Among authors: ye k. Autophagy. 2022 Jun;18(6):1367-1384. doi: 10.1080/15548627.2021.1985257. Epub 2021 Oct 25. Autophagy. 2022. PMID: 34689722 Free PMC article.
In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy in the skeletal muscles. Hence, BDNF is an essential myokine to maintain mitochondrial quality and function, and its repression in obesity m …
In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy …
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.
Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K. Chen C, et al. Among authors: ye k. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583. doi: 10.1073/pnas.1718683115. Epub 2018 Jan 2. Proc Natl Acad Sci U S A. 2018. PMID: 29295929 Free PMC article.
The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer's disease (AD). ...
The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic effic …
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K. Liu X, et al. Among authors: ye k. J Med Chem. 2010 Dec 9;53(23):8274-86. doi: 10.1021/jm101206p. Epub 2010 Nov 12. J Med Chem. 2010. PMID: 21073191 Free PMC article.
7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. ...Hence, our data support that the synthetic 4'-dimethylamino-7,8-dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent …
7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. ...Hence, our data suppor …
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.
Liu X, Obianyo O, Chan CB, Huang J, Xue S, Yang JJ, Zeng F, Goodman M, Ye K. Liu X, et al. Among authors: ye k. J Biol Chem. 2014 Oct 3;289(40):27571-84. doi: 10.1074/jbc.M114.562561. Epub 2014 Aug 20. J Biol Chem. 2014. PMID: 25143381 Free PMC article.
7,8-dihydroxyflavone (7,8-DHF), a newly identified small molecular TrkB receptor agonist, rapidly activates TrkB in both primary neurons and the rodent brain and mimics the physiological functions of the cognate ligand BDNF. ...
7,8-dihydroxyflavone (7,8-DHF), a newly identified small molecular TrkB receptor agonist, rapidly activates TrkB in both primary neur …
7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.
Zhang Z, Liu X, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K. Zhang Z, et al. Among authors: ye k. Neuropsychopharmacology. 2014 Feb;39(3):638-50. doi: 10.1038/npp.2013.243. Epub 2013 Sep 11. Neuropsychopharmacology. 2014. PMID: 24022672 Free PMC article.
Deficits in brain-derived neurotrophic factor/tropomyosin-receptor-kinase B (TrkB) signaling contribute to the synaptic dysfunction of AD. We have recently identified 7,8-dihydroxyflavone (7,8-DHF) as a potent TrkB agonist that displays therapeutic efficacy toward various …
Deficits in brain-derived neurotrophic factor/tropomyosin-receptor-kinase B (TrkB) signaling contribute to the synaptic dysfunction of AD. W …
7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders.
Liu C, Chan CB, Ye K. Liu C, et al. Among authors: ye k. Transl Neurodegener. 2016 Jan 6;5:2. doi: 10.1186/s40035-015-0048-7. eCollection 2016. Transl Neurodegener. 2016. PMID: 26740873 Free PMC article. Review.
To address this challenge, we initiated a cell-based drug screening to search for small molecules that act as the TrkB agonist. 7,8-Dihydroxyflavone (7,8-DHF) is our first reported small molecular TrkB agonist, which has now been extensively validated in various biochemica …
To address this challenge, we initiated a cell-based drug screening to search for small molecules that act as the TrkB agonist. 7,8-Dihyd
7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.
Luo D, Shi Y, Wang J, Lin Q, Sun Y, Ye K, Yan Q, Zhang H. Luo D, et al. Among authors: ye k. Neurosci Lett. 2016 May 4;620:43-9. doi: 10.1016/j.neulet.2016.03.042. Epub 2016 Mar 24. Neurosci Lett. 2016. PMID: 27019033
However, its clinical usage is particularly limited. 7,8-dihydroxyflavone (7,8-DHF), which acts as a selective agonist of BDNF receptor TrkB, is reported to possess neuroprotective effects both in vitro and in vivo. ...
However, its clinical usage is particularly limited. 7,8-dihydroxyflavone (7,8-DHF), which acts as a selective agonist of BDNF recept …
Crosstalk between the muscular estrogen receptor alpha and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
Zhao Z, Xue F, Gu Y, Han J, Jia Y, Ye K, Zhang Y. Zhao Z, et al. Among authors: ye k. Mol Metab. 2021 Mar;45:101149. doi: 10.1016/j.molmet.2020.101149. Epub 2020 Dec 19. Mol Metab. 2021. PMID: 33352311 Free PMC article.
OBJECTIVE: 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain-derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity in female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). ...
OBJECTIVE: 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain-derived neurotrophic factor (BDNF), alleviates high-fat …
O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity.
Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K. Liu X, et al. Among authors: ye k. Pharmacology. 2013;91(3-4):185-200. doi: 10.1159/000346920. Epub 2013 Feb 21. Pharmacology. 2013. PMID: 23445871 Free PMC article.
7,8-Dihydroxyflavone (7,8-DHF) acts as a TrkB receptor-specific agonist. It mimics the physiological actions of brain-derived neurotrophic factor (BDNF) and demonstrates remarkable therapeutic efficacy in animal models of various neurological diseases. ...
7,8-Dihydroxyflavone (7,8-DHF) acts as a TrkB receptor-specific agonist. It mimics the physiological actions of brain-derived neurotr …
26 results