Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice.
Ahuja P, Ng CF, Pang BPS, Chan WS, Tse MCL, Bi X, Kwan HR, Brobst D, Herlea-Pana O, Yang X, Du G, Saengnipanthkul S, Noh HL, Jiao B, Kim JK, Lee CW, Ye K, Chan CB.
Ahuja P, et al. Among authors: ye k.
Autophagy. 2022 Jun;18(6):1367-1384. doi: 10.1080/15548627.2021.1985257. Epub 2021 Oct 25.
Autophagy. 2022.
PMID: 34689722
Free PMC article.
In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy in the skeletal muscles. Hence, BDNF is an essential myokine to maintain mitochondrial quality and function, and its repression in obesity m …
In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy …