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2002 1
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2005 3
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2009 5
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2012 3
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2020 1
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43 results
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Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights.
Wei T, Gong J, Qu G, Wang M, Xu H. Wei T, et al. BMC Immunol. 2019 Dec 16;20(1):48. doi: 10.1186/s12865-019-0329-5. BMC Immunol. 2019. PMID: 31842739 Free PMC article.
BACKGROUND: Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. ...A mechanistic model was proposed based on this heterotetrameric structure model: The LcrV homodimer separates the …
BACKGROUND: Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to …
The weak interaction of LcrV and TLR2 does not contribute to the virulence of Yersinia pestis.
Reithmeier-Rost D, Hill J, Elvin SJ, Williamson D, Dittmann S, Schmid A, Wilharm G, Sing A. Reithmeier-Rost D, et al. Microbes Infect. 2007 Jul;9(8):997-1002. doi: 10.1016/j.micinf.2007.04.003. Epub 2007 Apr 12. Microbes Infect. 2007. PMID: 17556003
Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica share the virulence-antigen LcrV. ...LcrVO:8 was much more potent in TLR2-activity than Y. pestis LcrV. To analyse the role of TLR2 in plague, we in
Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica share the virulence-an
MAP of F1 and V antigens from Yersinia pestis astride innate and adaptive immune response.
Rai R, Das B, Choudhary N, Talukdar A, Rao DN. Rai R, et al. Microb Pathog. 2015 Oct;87:13-20. doi: 10.1016/j.micpath.2015.07.012. Epub 2015 Jul 15. Microb Pathog. 2015. PMID: 26188288
Yersinia pestis, a causative agent of plague, has a plethora of armors to fight against major components of innate immunity and survive within host cells. ...This report is focused on the changes in DC activation and TLR2 and TLR4 expression on macrophages induced b
Yersinia pestis, a causative agent of plague, has a plethora of armors to fight against major components of innate immunity and survi
Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10.
Auerbuch V, Isberg RR. Auerbuch V, et al. Infect Immun. 2007 Jul;75(7):3561-70. doi: 10.1128/IAI.01497-06. Epub 2007 Apr 9. Infect Immun. 2007. PMID: 17420232 Free PMC article.
TLR2(-/-) mice were reported to be less susceptible to the enteropathogen Yersinia enterocolitica. To determine whether TLR2 also plays a role in recognition of the enteropathogen Yersinia pseudotuberculosis and whether this results in an immune respon
TLR2(-/-) mice were reported to be less susceptible to the enteropathogen Yersinia enterocolitica. To determine whether TLR
Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression.
Sing A, Rost D, Tvardovskaia N, Roggenkamp A, Wiedemann A, Kirschning CJ, Aepfelbacher M, Heesemann J. Sing A, et al. J Exp Med. 2002 Oct 21;196(8):1017-24. doi: 10.1084/jem.20020908. J Exp Med. 2002. PMID: 12391013 Free PMC article.
A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is the expression of the virulence (V)-antigen (LcrV). ...We conclude that …
A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yer
Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model.
Sing A, Tvardovskaia N, Rost D, Kirschning CJ, Wagner H, Heesemann J. Sing A, et al. Int J Med Microbiol. 2003 Nov;293(5):341-8. doi: 10.1078/1438-4221-00277. Int J Med Microbiol. 2003. PMID: 14695062
The impact of this immunosuppressive effect for Yersinia pathogenesis was underlined by the observation that IL-10- and TLR2-deficient mice were found to be less susceptible to Y. enterocolitica infection than isogenic C57BL/6 wild-type animals. ...By comparing Y. e …
The impact of this immunosuppressive effect for Yersinia pathogenesis was underlined by the observation that IL-10- and TLR2-d …
Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.
Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, Nùñez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M. Dessein R, et al. Gut. 2009 Jun;58(6):771-6. doi: 10.1136/gut.2008.168443. Epub 2009 Jan 27. Gut. 2009. PMID: 19174417
The role of microbiota in conditioning Peyer's patches against Yersinia through TLR2 was assessed by delivering, ad libitum, exogenous TLR2 agonists in drinking water to germ-free and streptomycin-treated animals. ...Consistently, Yersinia infection tr …
The role of microbiota in conditioning Peyer's patches against Yersinia through TLR2 was assessed by delivering, ad libitum, e …
Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2(-/-) Mouse Model.
O'Donnell KL, Knopick PL, Larsen R, Sarkar S, Nilles ML, Bradley DS. O'Donnell KL, et al. Infect Immun. 2020 Feb 20;88(3):e00792-19. doi: 10.1128/IAI.00792-19. Print 2020 Feb 20. Infect Immun. 2020. PMID: 31907194
Yersinia pestis is the causative agent of bubonic, pneumonic, and septicemic plague. We demonstrate that Toll-like receptor 2-deficient (TLR2(-/-)) mice are resistant to septicemic infection by the KIM5 strain of Y. pestis but not to infection by the CO92 Δpgm strai
Yersinia pestis is the causative agent of bubonic, pneumonic, and septicemic plague. We demonstrate that Toll-like receptor 2-deficie
Yersinia-triggered arthritis in IL-12p40-deficient mice: relevant antigens and local expression of Toll-like receptor mRNA.
Di Genaro MS, Cargnelutti DE, Castro DO, Eliçabe RJ, Gutiérrez JV, Correa SG, de Guzmán AM. Di Genaro MS, et al. Scand J Rheumatol. 2007 Jan-Feb;36(1):28-35. doi: 10.1080/03009740600906651. Scand J Rheumatol. 2007. PMID: 17454932
Induction of articular mRNA of TLR2, TLR4, and tumour necrosis factor (TNF)-alpha was analysed by reverse transcription-polymerase chain reaction (RT-PCR). ...Moreover, intra-articular immunoglobulins to Yersinia antigens were significantly higher in IL-12p40-/- mic …
Induction of articular mRNA of TLR2, TLR4, and tumour necrosis factor (TNF)-alpha was analysed by reverse transcription-polymerase ch …
Attachment of LcrV from Yersinia pestis at dual binding sites to human TLR-2 and human IFN-gamma receptor.
Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Khodyakova AV, Evstigneev VI, Uversky VN, Motin VL, Smirnov GB, Brubaker RR. Abramov VM, et al. J Proteome Res. 2007 Jun;6(6):2222-31. doi: 10.1021/pr070036r. Epub 2007 Apr 19. J Proteome Res. 2007. PMID: 17441749
The virulence antigen (V-antigen, LcrV) of Yersinia pestis, the causative agent of bubonic plague, is an established protective antigen known to regulate, target, and mediate type III translocation of cytotoxic yersiniae outer proteins termed Yops; LcrV also prompts …
The virulence antigen (V-antigen, LcrV) of Yersinia pestis, the causative agent of bubonic plague, is an established protective antig …
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