Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1949 3
1950 11
1951 7
1952 8
1953 7
1954 3
1955 10
1956 4
1957 9
1958 9
1959 4
1960 1
1962 1
1963 1
1964 3
1965 2
1967 3
1968 2
1969 2
1970 1
1971 1
1972 3
1973 2
1974 3
1975 3
1976 2
1977 2
1978 2
1979 3
1980 4
1981 2
1982 7
1983 9
1984 7
1985 12
1986 14
1987 13
1988 27
1989 18
1990 48
1991 48
1992 78
1993 84
1994 129
1995 150
1996 247
1997 294
1998 310
1999 534
2000 657
2001 761
2002 890
2003 978
2004 1117
2005 1070
2006 1237
2007 1368
2008 1561
2009 1713
2010 1895
2011 2299
2012 2421
2013 2725
2014 2814
2015 2968
2016 3365
2017 3373
2018 3660
2019 4044
2020 4421
2021 4722
2022 4514
2023 4424
2024 4939
2025 5252
2026 1776

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

65,363 results

Results by year

Filters applied: . Clear all
Page 1
Glomage: A Multimodal Platform for High-Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models.
Schindler M, Lange T, Bach SM, Lienkamp SS, Endlich N. Schindler M, et al. Adv Sci (Weinh). 2026 Apr 16:e23662. doi: 10.1002/advs.202523662. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41988720
To overcome these limitations, Glomage was developed as a cross-species high-throughput platform for scalable 3D analysis of glomeruli. In zebrafish larvae, the workflow enables simultaneous isolation, staining, volumetric imaging, and RNA extraction of hundreds of glomeru …
To overcome these limitations, Glomage was developed as a cross-species high-throughput platform for scalable 3D analysis of glomeruli. In …
Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signaling Pathway.
Galeano-Otero I, Dominguez-Liste B, Aspron C, Fernández-Chacón M, Escacena-Izquierdo L, Del Toro R, Rojas-Torres M, Durán-Ruiz MC, Siegfried G, Ordóñez-Fernández A, Khatib AM, Rosado JA, Smani T. Galeano-Otero I, et al. Arterioscler Thromb Vasc Biol. 2026 Apr 16. doi: 10.1161/ATVBAHA.125.324231. Online ahead of print. Arterioscler Thromb Vasc Biol. 2026. PMID: 41988713
Consistently, Orai1 inhibition with CM4620 significantly impaired subintestinal venous plexus development in zebrafish embryos. Single-cell RNA sequencing confirmed Orai1 upregulation, particularly in tip cells and proliferating EC clusters, which was confirmed in peri-inf …
Consistently, Orai1 inhibition with CM4620 significantly impaired subintestinal venous plexus development in zebrafish embryos. Singl …
Leveraging developmental neurotoxicity data in zebrafish embryos through the use of artificial intelligence methods.
Heusinkveld HJ, Hessel EVS, Zwart EP, Gremmer ER, Pennings JLA. Heusinkveld HJ, et al. Front Toxicol. 2026 Apr 1;8:1789691. doi: 10.3389/ftox.2026.1789691. eCollection 2026. Front Toxicol. 2026. PMID: 41987914 Free PMC article.
INTRODUCTION: The zebrafish is a well-known whole organism model to study developmental effects of chemical exposure, including developmental neurotoxicity (DNT). One method used to screen for DNT effects is the zebrafish light-dark transition test (LDT), which meas …
INTRODUCTION: The zebrafish is a well-known whole organism model to study developmental effects of chemical exposure, including devel …
Dynamic wetting of co-assembled supramolecular herbicides on young hydrophobic leaves enables sustainable weed management.
Xiao Y, Wu C, Zhang C, Yin Q, Wang J, Gao Q, Liao M, Cao H. Xiao Y, et al. J Nanobiotechnology. 2026 Apr 15. doi: 10.1186/s12951-026-04446-7. Online ahead of print. J Nanobiotechnology. 2026. PMID: 41987027
Beyond enhanced retention, the nano-formulation exhibits temperature-responsive release, suppresses herbicide leaching, and achieves superior control of both broadleaf and grass weeds in pot trials, while markedly reducing toxicity to zebrafish, earthworms, and human cells …
Beyond enhanced retention, the nano-formulation exhibits temperature-responsive release, suppresses herbicide leaching, and achieves superio …
Fabrication and biological evaluation of a bioactive gelatin-sericin hydrogel for infected wound healing.
Rethinam S, Paulraj FP, Edwin GS, Pelluru GS. Rethinam S, et al. Int J Artif Organs. 2026 Apr 15:3913988261437251. doi: 10.1177/03913988261437251. Online ahead of print. Int J Artif Organs. 2026. PMID: 41987010
The hydrogels were prepared by blending gelatin and sericin, followed by crosslinking, and characterized using Fourier-transform infrared spectroscopy (FTIR) and High-resolution scanning electron microscopy (HRSEM), along with antimicrobial activity, MTT cytocompatibility assay, …
The hydrogels were prepared by blending gelatin and sericin, followed by crosslinking, and characterized using Fourier-transform infrared sp …
Benzyl-Spacer-Engineered Prodrug: Enabling NIR Fluorescent Activation for Cancer Therapy in a Zebrafish Gallbladder Model.
Jain N, Kim J, Roychaudhury A, Sonawane PM, Iwaoka M, Nimse SB, Kim CH, Churchill DG. Jain N, et al. J Med Chem. 2026 Apr 15. doi: 10.1021/acs.jmedchem.6c00043. Online ahead of print. J Med Chem. 2026. PMID: 41986242
Comparative studies reveal that our probe (i) is allowed to penetrate deeper into tissue (zebrafish), (ii) has less background signal interference, and (iii) involves greater specificity in biological systems than its predecessor. ...
Comparative studies reveal that our probe (i) is allowed to penetrate deeper into tissue (zebrafish), (ii) has less background signal …
Interactions Between Feeding Protocols, Larval Density, and Methylene Blue During Zebrafish Larval Development.
Almaghasilah A, Chavez de Paz Solis D, Frazer E, Hodgkin G, Hollinger-Levitsky S, Russano M, Henry CA. Almaghasilah A, et al. Zebrafish. 2026 Apr 15:15458547261434500. doi: 10.1177/15458547261434500. Online ahead of print. Zebrafish. 2026. PMID: 41986137
Conducting longitudinal experiments on zebrafish disease models has the potential to deepen understanding of disease progression. ...These data highlight factors that promote survival and growth of larval zebrafish raised in the laboratory for longitudinal studies.. …
Conducting longitudinal experiments on zebrafish disease models has the potential to deepen understanding of disease progression. ... …
Biological characterization of a multifunctional exopolysaccharides produced by a Kefir originated Lactiplantibacillus plantarum KFR54 and its anti-hyperuricemia mechanism.
Tan X, Jia C, Ma B, You L, Cui F, Li X, Li J. Tan X, et al. Int J Biol Macromol. 2026 Apr 13:151995. doi: 10.1016/j.ijbiomac.2026.151995. Online ahead of print. Int J Biol Macromol. 2026. PMID: 41985807
This research focused on the structural and biological characteristics, especially the anti-hyperuricemia (HUA) activity in HUA-cell and zebrafish models, as well as the potential anti-HUA mechanism of the extracellular exopolysaccharide (EPS54) produced by the Kefir grain …
This research focused on the structural and biological characteristics, especially the anti-hyperuricemia (HUA) activity in HUA-cell and …
The anoxia escape test as a novel and sensitive protocol to assess despair-like behavior in zebrafish.
da Silva Junior FC, de Sousa IP, Mamede JPM, Rosemberg DB, Luchiari A. da Silva Junior FC, et al. J Neurosci Methods. 2026 Apr 13:110775. doi: 10.1016/j.jneumeth.2026.110775. Online ahead of print. J Neurosci Methods. 2026. PMID: 41985567
BACKGROUND: Behavioral despair-like states are commonly modeled in rodents using inescapable stressors that suppress active coping, yet comparable paradigms for zebrafish remain limited. NEW METHOD: Here, we introduce and validate a simple anoxia escape test (AET) in juven …
BACKGROUND: Behavioral despair-like states are commonly modeled in rodents using inescapable stressors that suppress active coping, yet comp …
L-BMAA induces neurotoxicity through AMPK/Akt-TSC1/2-mTOR-mediated mitophagy dysregulation and apoptosis.
Yan T, Zheng X, Jia G, Liang Z, Guo L, Ding F, Fang Z, Li Y, Zhao Y. Yan T, et al. J Hazard Mater. 2026 Apr 13;509:142074. doi: 10.1016/j.jhazmat.2026.142074. Online ahead of print. J Hazard Mater. 2026. PMID: 41985289
In this study, we aimed to elucidate these mechanisms using both in vitro (human SH-SY5Y neuroblastoma cells) and in vivo (zebrafish) models, and utilized transcriptomics, biochemical assays, and behavioral analyses. ...Furthermore, transcriptomic analysis of zebrafish …
In this study, we aimed to elucidate these mechanisms using both in vitro (human SH-SY5Y neuroblastoma cells) and in vivo (zebrafish) …
Enhanced electron transfer and multiple reactive species formation via a reductive heterojunction photocatalyst/sulfite coupled process enabling efficient trichloroacetamide removal: Kinetics, mechanisms, and ecotoxicity evaluation.
Shen J, Yi M, Shi A, Nian W, Zhang H, Chen J, Fan G, Jiang Z. Shen J, et al. J Hazard Mater. 2026 Apr 13;509:142066. doi: 10.1016/j.jhazmat.2026.142066. Online ahead of print. J Hazard Mater. 2026. PMID: 41985288
Furthermore, the ecotoxicity evaluation based on quantitative structure-activity relationship predictions and zebrafish larvae behavioral assays reflected a significant detoxification of TCAcAm treated via the CFBP-SA process....
Furthermore, the ecotoxicity evaluation based on quantitative structure-activity relationship predictions and zebrafish larvae behavi …
Polyphyllin VI induces Forkhead box O3 nuclear liquid-liquid phase separation to promote mitophagy in breast cancer.
Zhan X, Zhong Y, Liu X, Peng W, Zhang X, Xiang K, Yu Q, Chai Y, Chen Y, Liu Y, Si Y. Zhan X, et al. Phytomedicine. 2026 Apr 6;155:158166. doi: 10.1016/j.phymed.2026.158166. Online ahead of print. Phytomedicine. 2026. PMID: 41985230
The in vivo anticancer activity of PPVI was evaluated using zebrafish and xenograft mouse models. Drug toxicity was assessed in zebrafish, while pharmacokinetics and tissue distribution were evaluated in rats. ...PPVI suppressed tumor growth in vivo but exhibited ca …
The in vivo anticancer activity of PPVI was evaluated using zebrafish and xenograft mouse models. Drug toxicity was assessed in ze …
A Method for the Detection of Tire Wear Microplastics in Zebrafish Guts by Laterally Resolved LA-ICP-MS-Based Elemental Fingerprinting and Chemometrics.
Brunnbauer L, Juračka Š, Vykypělová M, Vrlíková L, Eitenberger E, Pořízka P, Adamovsky O, Kaiser J, Kalčíková G, Limbeck A. Brunnbauer L, et al. Anal Chem. 2026 Apr 15. doi: 10.1021/acs.analchem.5c07035. Online ahead of print. Anal Chem. 2026. PMID: 41985070
We present a novel approach to address this gap using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) combined with elemental fingerprinting and machine learning. We apply this method to zebrafish gut tissue to differentiate TWPs from biological tis …
We present a novel approach to address this gap using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) combined with …
Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors.
Xiong F, Tentner AR, Nandagopal S, Hiscock TW, Huang P, Tsung-Megason SG. Xiong F, et al. Elife. 2026 Apr 15;13:RP96980. doi: 10.7554/eLife.96980. Elife. 2026. PMID: 41984520 Free PMC article.
Here, we use live imaging to track neural progenitors in developing zebrafish and quantify both Shh and fate reporters in single cells over time. We found that there is significant heterogeneity between Shh response and fate choice in single cells. ...
Here, we use live imaging to track neural progenitors in developing zebrafish and quantify both Shh and fate reporters in single cell …
Palmitoylation of Tspan4 is essential for migrasome formation.
Wang S, Wang W, Qiao J, Ali S, Jiang Z, Jiang D, Ma J, Huang Y. Wang S, et al. J Cell Biol. 2026 Jun 1;225(6):e202507023. doi: 10.1083/jcb.202507023. Epub 2026 Apr 15. J Cell Biol. 2026. PMID: 41984101
Notably, the palmitoylation-deficient Tspan4 mutant acts in a dominant-negative manner, suppressing migrasome formation not only in cultured cells but also in zebrafish embryos, where it disrupts left-right asymmetry and organ morphogenesis. Collectively, our study establi …
Notably, the palmitoylation-deficient Tspan4 mutant acts in a dominant-negative manner, suppressing migrasome formation not only in cultured …
Derepression of a Subset of Meiotic Proteins in Primordial Germ Cells of max Mutant Zebrafish.
Hasegawa Y, Kawasaki T, Imai Y, Matsui Y, Sakai N. Hasegawa Y, et al. Dev Growth Differ. 2026 Apr;68(3):e70053. doi: 10.1111/dgd.70053. Dev Growth Differ. 2026. PMID: 41983995
Germ cells in zebrafish are specified by a preformation mechanism, unlike in mice. Max (Myc associated factor X) and its associated PRC1.6 (polycomb repressive complex 1.6) act as negative regulators of germ cell- and meiosis-related genes in mice; however, their function …
Germ cells in zebrafish are specified by a preformation mechanism, unlike in mice. Max (Myc associated factor X) and its associated P …
Deficiency of pnkp in zebrafish causes microcephaly, seizures, and developmental delay through mitochondrial dysfunction.
Wang GH, Xiao LL, Jia WM, Liu ZX, Jia HB, Sun YX, Zi ZK, Zhang XQ. Wang GH, et al. Zool Res. 2026 Mar 18;47(2):429-443. doi: 10.24272/j.issn.2095-8137.2025.181. Zool Res. 2026. PMID: 41983441
The pnkp (-/-) zebrafish faithfully recapitulated key phenotypic traits observed in human PNKP deficiency, facilitating in-depth exploration of the molecular mechanisms contributing to disease. ...Drug screening performed using the pnkp (-/-) zebrafish model further …
The pnkp (-/-) zebrafish faithfully recapitulated key phenotypic traits observed in human PNKP deficiency, facilitating in-depth expl …
Genomic Insights Into Carnivorous Fish in the Characiformes.
Zhao S, Mei X, Zhang Z, Xia T, Zhou S, Dong Y, He S, Yao Z, Li Y, Yang X, Zhang H. Zhao S, et al. Ecol Evol. 2026 Apr 13;16(4):e73478. doi: 10.1002/ece3.73478. eCollection 2026 Apr. Ecol Evol. 2026. PMID: 41982404 Free PMC article.
In this study, we adopted comparative genomic approaches using 12 high-quality Characiformes genomes (covering nine subfamilies) with zebrafish as an outgroup. We first re-annotated the genomes of five Characiformes species, subsequently performing phylogenetic reconstruct …
In this study, we adopted comparative genomic approaches using 12 high-quality Characiformes genomes (covering nine subfamilies) with zeb …
Optimizing Equilibration Time to Enhance Post-Thaw Viability of Cryopreserved Zebrafish (Danio rerio) Ovarian Fragments.
Wade ML, Litvak MK. Wade ML, et al. Zebrafish. 2026 Apr 14:15458547261441744. doi: 10.1177/15458547261441744. Online ahead of print. Zebrafish. 2026. PMID: 41981818
Cryopreservation enables the long-term storage of viable biological material at ultra-low temperatures and forms the foundation for germplasm cryobanks that maintain valuable genetic lines of model organisms such as zebrafish (Danio rerio). However, reliable and reproducib …
Cryopreservation enables the long-term storage of viable biological material at ultra-low temperatures and forms the foundation for germplas …
Real-time characterisation of microbe-induced inflammation using a novel zebrafish larval corneal injury and infection model.
Cheng KKW, Tucker CS, Cholewa-Waclaw J, Mitchell S, Laidlaw F, Mills B, Rossi AG. Cheng KKW, et al. Commun Biol. 2026 Apr 14. doi: 10.1038/s42003-026-09985-1. Online ahead of print. Commun Biol. 2026. PMID: 41981209 Free article.
This gap reflects a critical unmet clinical need and is compounded by the lack of model systems capable of real-time high-resolution immune dynamics analysis. To address this, we developed a zebrafish larvae MK model utilising transgenic zebrafish lines with fluores …
This gap reflects a critical unmet clinical need and is compounded by the lack of model systems capable of real-time high-resolution immune …
Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.
Qian X, Ge R, Chu Y, Kuang T, Zhang X, Bennewitz K, Lou B, Hao W, Ast V, Klinke G, Poschet G, Morgenstern J, Fleming T, Hausser I, Szendroedi J, Nawroth PP, Kroll J. Qian X, et al. Nat Commun. 2026 Apr 14;17(1):3488. doi: 10.1038/s41467-026-71792-3. Nat Commun. 2026. PMID: 41980976 Free PMC article.
Here, we show that loss of the aldehyde dehydrogenase ALDH3B1 impairs 2-HD detoxification and leads to retinal vascular abnormalities in zebrafish, without affecting the trunk vasculature. Mechanistically, multi-omics analyses reveal that 2-HD accumulation disrupts iron ho …
Here, we show that loss of the aldehyde dehydrogenase ALDH3B1 impairs 2-HD detoxification and leads to retinal vascular abnormalities in …
Restorative macrophage-derived RNAseT2 stimulates muscle stem cell fusion via an SLK/N-WASP/actin bundling dependent axis.
Weiss-Gayet M, Juban G, Le Moal E, Moretta A, Farnetani C, Gobet C, Guillemaud J, Le Bihan MC, Shoseyov O, Adrait A, Ternka K, Boespflug-Tanguy O, Kettwig M, Couté Y, Mounier R, Acquati F, Knight RD, Chazaud B. Weiss-Gayet M, et al. Nat Commun. 2026 Apr 14. doi: 10.1038/s41467-026-71990-z. Online ahead of print. Nat Commun. 2026. PMID: 41980967 Free article.
In vivo, overexpressing RNAseT2 in regenerating muscle increases fusion in newly formed myofibers in mouse and zebrafish while macrophages deficient for RNAseT2 gene lead to fusion defect and smaller myofibers. ...
In vivo, overexpressing RNAseT2 in regenerating muscle increases fusion in newly formed myofibers in mouse and zebrafish while macrop …
Microbiota Composition Shaped by Seasonal Variation and Environmental Compartments Affects the Abundance of Antimicrobial-Resistant Bacteria in Indonesian Aquaculture.
Nakatani H, Hidhayati N, Anggorowati DA, Kaji A, Tobioka K, Ishiguro S, Yosiano SA, Apriastini M, Anam K, Susilaningsih D, Mitsui K, Yamamoto K, Tanaka S, Pratama IS, Ridwanudin A, Arakawa T, Okazaki F. Nakatani H, et al. Environ Microbiol Rep. 2026 Apr;18(2):e70337. doi: 10.1111/1758-2229.70337. Environ Microbiol Rep. 2026. PMID: 41980804
We investigated these factors through laboratory experiments and field surveys in Indonesia. In zebrafish aquaria, oxytetracycline exposure promoted the emergence of resistant bacteria and mainly affected the gut microbiota. ...
We investigated these factors through laboratory experiments and field surveys in Indonesia. In zebrafish aquaria, oxytetracycline ex …
Interferon regulatory factor 5 associated neutrophil reprogramming by trained immunity protects against lethal-dose bacterial sepsis.
Li L, Liu C, Zhang M, Gou Y, Zhang X, Qi Y, Liu L, Wang R, Jiang J, Wang R, Wang S, Shan W, Zhao X, Li H, Wang Z, Li J, Sun W. Li L, et al. Drug Resist Updat. 2026 Apr 5;87:101393. doi: 10.1016/j.drup.2026.101393. Online ahead of print. Drug Resist Updat. 2026. PMID: 41980372
Although innate immune memory (trained immunity) has been studied in monocytes and macrophages, its role in neutrophils is unclear. Here, using mouse and zebrafish models of bacterial peritonitis, we show that a low-dose bacterial exposure induces an interferon regulatory …
Although innate immune memory (trained immunity) has been studied in monocytes and macrophages, its role in neutrophils is unclear. Here, us …
A comprehensive evaluation of the effects and mechanisms of naringenin on zebrafish embryo development.
Ji R, Hu H, Zhang Y, Liu K, Du J, Ma Y, Song B, Han Y. Ji R, et al. Ecotoxicol Environ Saf. 2026 Apr 13;316:120131. doi: 10.1016/j.ecoenv.2026.120131. Online ahead of print. Ecotoxicol Environ Saf. 2026. PMID: 41980279
This study systematically evaluated the developmental toxicity of NGN in zebrafish embryos. Our results showed that NGN exposure caused dose-dependent increases in embryonic mortality and induced a range of developmental malformations, including reduced body length, impair …
This study systematically evaluated the developmental toxicity of NGN in zebrafish embryos. Our results showed that NGN exposure caus …
Time-Resolved Proteomic Analysis in Zebrafish Using Bioorthogonal Noncanonical Amino Acid Tagging.
Miller SE, Wang TY, Quan B, Cammidge T, Chou TF, Prober DA, Tirrell DA. Miller SE, et al. J Proteome Res. 2026 Apr 14. doi: 10.1021/acs.jproteome.5c00845. Online ahead of print. J Proteome Res. 2026. PMID: 41980224
Here, we describe BONCAT proteomic analysis in larval zebrafish, a model organism widely used for its genetic tractability and utility in developmental biology and neuroscience. ...Beyond the expected changes in synthesis of heat shock proteins, BONCAT identified different …
Here, we describe BONCAT proteomic analysis in larval zebrafish, a model organism widely used for its genetic tractability and utilit …
Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.
Brown DA, Koll KK, Brush E, Darner G, Curtis T Jr, Dvergsten T, Tran M, Milligan C, Wolfson DW, Gonzalez TJ, Jeffs S, Ehrhardt A, Bitolas R, Landau M, Reitz K, Salven DS, Slota-Burtt LA, Snee I, Singer-Freeman E, Bhatia S, Ou J, Asokan A, Currie JD, Poss KD. Brown DA, et al. Proc Natl Acad Sci U S A. 2026 Apr 28;123(17):e2532804123. doi: 10.1073/pnas.2532804123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980086
Here, we leveraged insights from species with a high endogenous capacity for appendage regeneration to design an enhancer-directed gene delivery platform that functions during mouse digit regeneration, a well-characterized model for partial limb regeneration in mammals. Single-ce …
Here, we leveraged insights from species with a high endogenous capacity for appendage regeneration to design an enhancer-directed gene deli …
Multiomics Analysis Reveals the Protective Effect of a Novel Bioactive Peptide (BP1) in Cardiomyopathy Using a Zebrafish Model.
Thakur S, Kumari S, Punia A, Patial V, Singh D, Kumar R. Thakur S, et al. J Proteome Res. 2026 Apr 14. doi: 10.1021/acs.jproteome.5c00809. Online ahead of print. J Proteome Res. 2026. PMID: 41980054
Results indicated that treatment with BP1 significantly reduced ISO-induced cardiac dysfunction in zebrafish larvae. Similarly, BP1 pretreatment effectively mitigated the DOX-induced pathological changes in the myocardium of zebrafish. ...Our results concluded that …
Results indicated that treatment with BP1 significantly reduced ISO-induced cardiac dysfunction in zebrafish larvae. Similarly, BP1 p …
N-Acetylcysteine Prevents Arsenic-Induced Apoptosis but Not Supernumerary Motor Neuron Development in Zebrafish Embryos: Assessment of Protein Carbonylation and the p53 Pathway.
Gu Q, Silva CS, Twaddle NC, Beland FA, Kanungo J. Gu Q, et al. Int J Mol Sci. 2026 Apr 3;27(7):3263. doi: 10.3390/ijms27073263. Int J Mol Sci. 2026. PMID: 41977442 Free PMC article.
We previously demonstrated that the antioxidant acetyl L-carnitine prevented sodium arsenite-induced apoptosis in zebrafish embryos. To gain more insight into the mechanism of arsenic-induced apoptosis, we explored the effect of another antioxidant, N-acetylcysteine (NAC). …
We previously demonstrated that the antioxidant acetyl L-carnitine prevented sodium arsenite-induced apoptosis in zebrafish embryos. …
Antioxidant Astaxanthin Co-Treatment Protects Zebrafish from Dimethomorph-Induced Cardiovascular Toxicity.
Wu CC, Saputra F, Vasquez RD, Roldan MJM, Lai YH, Hsiao CD, Hung CH. Wu CC, et al. Int J Mol Sci. 2026 Apr 1;27(7):3211. doi: 10.3390/ijms27073211. Int J Mol Sci. 2026. PMID: 41977394 Free PMC article.
This study aims to elucidate the toxicological effects of DIM on zebrafish, with a particular focus on its cardiovascular impacts. Zebrafish embryos were exposed to a range of DIM concentrations for 48 h, and their cardiac and vascular performance was meticulously a …
This study aims to elucidate the toxicological effects of DIM on zebrafish, with a particular focus on its cardiovascular impacts. …
Integrated Assessment of Neurobehavioral and Cardiotoxic Effects of Pyrrolidine-Containing Cathinones in Zebrafish: Structural Determinants of Functional Safety Profiles.
Aljabasini O, Tagkalidou N, Pazos MD, García-Díez G, Prats E, Seco R, Berzosa X, López-Arnau R, Raldua D. Aljabasini O, et al. Int J Mol Sci. 2026 Mar 30;27(7):3141. doi: 10.3390/ijms27073141. Int J Mol Sci. 2026. PMID: 41977329 Free PMC article.
This study employs a multiparametric New Approach Methodology (NAM) using zebrafish embryos to integrate neurobehavioral and cardiotoxic endpoints for comparative hazard prioritization. ...Overall, these data demonstrate that subtle structural changes within the pyrrolidin …
This study employs a multiparametric New Approach Methodology (NAM) using zebrafish embryos to integrate neurobehavioral and cardioto …
Tissue-Specific Expression of the EWSR1::FLI1 Fusion Protein Identifies col2a1a-Positive Cells as a Source of Ewing Sarcoma-like Tumors in Zebrafish.
Anderson RA, Chen X, Oyarbide U, Alvarez NJ, Sievers A, Schwartz GK, Corey SJ. Anderson RA, et al. Int J Mol Sci. 2026 Mar 30;27(7):3131. doi: 10.3390/ijms27073131. Int J Mol Sci. 2026. PMID: 41977317 Free PMC article.
Prior efforts to generate transgenic mouse models have been unsuccessful, and while zebrafish have emerged as a promising system, a tissue context capable of supporting EWSR1::FLI1-driven tumorigenesis has not been defined. Here, we report that tissue-specific expression o …
Prior efforts to generate transgenic mouse models have been unsuccessful, and while zebrafish have emerged as a promising system, a t …
BPA Disrupts Hepatic Lipid and Carbohydrate Metabolism in Female Zebrafish: Protective Effects of Probiotics Revealed by FTIRI and Lipidomics.
Giommi C, Santoni C, Carli F, Gastaldelli A, Maradonna F, Habibi HR, Giorgini E, Carnevali O. Giommi C, et al. Int J Mol Sci. 2026 Mar 25;27(7):2978. doi: 10.3390/ijms27072978. Int J Mol Sci. 2026. PMID: 41977165 Free PMC article.
This study examined whether sub-chronic BPA exposure disrupts hepatic lipid metabolism in female zebrafish (Danio rerio), and whether co-administration of probiotics mitigates these effects. ...
This study examined whether sub-chronic BPA exposure disrupts hepatic lipid metabolism in female zebrafish (Danio rerio), and whether …
Passion Fruit Seed Oil as a Natural Tyrosinase Inhibitor: Extraction Optimization, Multi-Mechanism Elucidation, and Efficacy Validation in Zebrafish.
Li J, Tao Z, Guo Q, Zhang Y, Zhang J, Deng Y, Wu K, Yu H, Chai X, Jiang Y, He D, Liu X, Duan X, Liu J. Li J, et al. Foods. 2026 Apr 6;15(7):1246. doi: 10.3390/foods15071246. Foods. 2026. PMID: 41976540 Free PMC article.
Therefore, this study aimed to: (1) optimize SC-CO(2) extraction of Passiflora edulis f. edulis seed oil (PFSO) for maximum yield and bioactive preservation; (2) comprehensively characterize its physicochemical and phytochemical profile; (3) elucidate the tyrosinase inhibition me …
Therefore, this study aimed to: (1) optimize SC-CO(2) extraction of Passiflora edulis f. edulis seed oil (PFSO) for maximum yield and bioact …
Caffeine Biotransformation in Zebrafish Larvae: Integrated LC-MS/MS Quantification and FTIR Spatial Mapping.
Bartoszek A, Kozub-Pędrak A, Wielgosz A, Sumara A, Przykaza K, Kalisz G, Stachniuk A. Bartoszek A, et al. Molecules. 2026 Mar 26;31(7):1095. doi: 10.3390/molecules31071095. Molecules. 2026. PMID: 41976139 Free PMC article.
Zebrafish larvae at 4 days post fertilization (dpf) were exposed to CAF at concentrations of 15, 25, and 50 mg/L for 18 h. ...The findings support the utility of zebrafish larvae as a model for developmental pharmacokinetic studies....
Zebrafish larvae at 4 days post fertilization (dpf) were exposed to CAF at concentrations of 15, 25, and 50 mg/L for 18 h. ...The fin …
Homoplantaginin regulates various pharmacological pathways: Candidate drugs for multi-target relief of cognitive decline and pathological changes in Alzheimer's disease.
Luo L, Yan T, Liu W, Gao Y, Tang X, Yang L, Zhao M. Luo L, et al. Neural Regen Res. 2026 Apr 14. doi: 10.4103/NRR.NRR-D-25-00660. Online ahead of print. Neural Regen Res. 2026. PMID: 41975605 Free article.
NOD-like receptor protein 3 knockout hindered the improvement effect of homoplantaginin on cognitive deficits in Alzheimer's disease zebrafish induced by AlCl3 and D-gal, indicating that homoplantaginin enhances cognitive function by inhibiting activation of NOD-like recep …
NOD-like receptor protein 3 knockout hindered the improvement effect of homoplantaginin on cognitive deficits in Alzheimer's disease zebr …
Sophflarines F-K: matrine-based alkaloids with a rare aromatic system from Sophora flavescens and their anti-inflammatory and synergistic antibacterial effects.
Luo D, Wang LY, Zhao XF, Huang XL, Hu YY, Jing QY, Chen YJ, Tian H, Chen SY, Wang YY, Huang XH, Zeng ZL, Liao XP. Luo D, et al. Nat Prod Bioprospect. 2026 Apr 14;16(1):53. doi: 10.1007/s13659-026-00595-2. Nat Prod Bioprospect. 2026. PMID: 41974989 Free PMC article.
Compounds 1 and 2 represent highly modified 15,16-seco-17-nor-matrine derivatives incorporating a rare 4,5-dihydro-3H-pyrrolo[2,3,4-ij]quinolizine moiety, while compound 5 possesses an unusual 6/6/6-5 tetracyclic skeleton. A copper sulfate-induced zebrafish assay revealed …
Compounds 1 and 2 represent highly modified 15,16-seco-17-nor-matrine derivatives incorporating a rare 4,5-dihydro-3H-pyrrolo[2,3,4-ij]quino …
Single exposure to Ayahuasca reverses chronic stress effects on sociability, anxiety, cortisol, and BDNF in zebrafish.
Lodetti G, Inserra A, Redivo H, Teixeira AG, de Bitencourt RM, Rico EP. Lodetti G, et al. Psychopharmacology (Berl). 2026 Apr 14. doi: 10.1007/s00213-026-07058-z. Online ahead of print. Psychopharmacology (Berl). 2026. PMID: 41974985
AIM OF THE STUDY: Therefore, we evaluated the therapeutic potential of AYA in reversing or attenuating the behavioral and biochemical alterations induced by an unpredictable chronic stress (UCS) paradigm in adult zebrafish. METHODS: Zebrafish underwent an unpredicta …
AIM OF THE STUDY: Therefore, we evaluated the therapeutic potential of AYA in reversing or attenuating the behavioral and biochemical altera …
Chromosomal instability promotes cell migration and invasion via EFEMP1 secretion into extracellular vesicles.
Zheng S, Tian R, Siburian M, Haider Rubio A, Liu Y, Wardenaar R, Shirzai M, Kempe L, Dijkstra E, Warszawik E, Suarez Peredo Rodriguez M, Sjollema K, Bakker PL, Rijn PV, Borghesan M, Paridaen JT, Santaguida S, Foijer F. Zheng S, et al. EMBO J. 2026 Apr 13. doi: 10.1038/s44318-026-00766-4. Online ahead of print. EMBO J. 2026. PMID: 41974939 Free article.
Xenografting TNBC cells with EFEMP1-enriched cells promotes migration in zebrafish embryos, suggesting that EFEMP1 expression is a factor that promotes metastasis. ...
Xenografting TNBC cells with EFEMP1-enriched cells promotes migration in zebrafish embryos, suggesting that EFEMP1 expression is a fa …
Engineering of genetically encoded programmable calcium channel inhibitory binders.
Liu X, Ali S, Lan TH, Wang D, McKee B, Nonomura T, Liu S, Zhao F, Zhu MX, Huang Y, Deng Q, Ma G, Zhou Y. Liu X, et al. Nat Commun. 2026 Apr 13;17(1):3472. doi: 10.1038/s41467-026-71769-2. Nat Commun. 2026. PMID: 41974720 Free PMC article.
Guided by deep mutational scanning, we optimize a membrane-anchored CRAB variant that potently inhibits Ca(2+) influx and NFAT signaling, and rescues thrombocytopenia-like phenotypes in a zebrafish model of Stormorken syndrome. To enable tunable inhibition, we further desi …
Guided by deep mutational scanning, we optimize a membrane-anchored CRAB variant that potently inhibits Ca(2+) influx and NFAT signaling, an …
Exploring Self-Organization of Development in the Zebrafish Posterior Lateral Line Primordium with Computer Models.
Chitnis A. Chitnis A. Cold Spring Harb Perspect Biol. 2026 Apr 15:a041797. doi: 10.1101/cshperspect.a041797. Online ahead of print. Cold Spring Harb Perspect Biol. 2026. PMID: 41974535
The zebrafish posterior lateral line (pLL) primordium migrates under the skin, from the ear to the tip of the tail, periodically forming and depositing neuromasts to spearhead formation of the pLL system. ...
The zebrafish posterior lateral line (pLL) primordium migrates under the skin, from the ear to the tip of the tail, periodically form …
Toxic impact of Karenia mikimotoi on intestinal barrier disruption and aggravated the infection response to Vibrio parahaemolyticus in zebrafish larvae.
Yang S, Chen S, Niu X, Liu Y, Ye J, Lu J, Guan W. Yang S, et al. Environ Pollut. 2026 Apr 12;398:128126. doi: 10.1016/j.envpol.2026.128126. Online ahead of print. Environ Pollut. 2026. PMID: 41974410
The intestine is the main defense barrier of the fish against algal threats. Herein, zebrafish (Danio rerio) larvae were employed to investigate the toxicity of the ruptured cell solution (RCS) of K. mikimotoi to the intestine. ...The zebrafish larvae infected with …
The intestine is the main defense barrier of the fish against algal threats. Herein, zebrafish (Danio rerio) larvae were employed to …
Mechanisms and Key Active Ingredients of HeDan Capsules in Ameliorating MASLD via Bile Acid Metabolism Regulation.
Liu H, Wang S, Wang N, Wang F, Ren J, Zhou Z, Liu K, Wang X, Li Y, Fu C, Han L. Liu H, et al. J Ethnopharmacol. 2026 Apr 11:121639. doi: 10.1016/j.jep.2026.121639. Online ahead of print. J Ethnopharmacol. 2026. PMID: 41974237
Finally, the key active compounds of HD were validated in a zebrafish model, and their mechanism of action was investigated at the cellular level using inhibitors. ...
Finally, the key active compounds of HD were validated in a zebrafish model, and their mechanism of action was investigated at the ce …
Genome-wide identification and single-cell transcriptomic analysis of the mcm gene family in zebrafish reveals its role in TCDD-induced reproductive toxicity.
Jiang W, Li X, Zhao Y, Yang X, Jin M, Li J, Zhao J, Huang Y. Jiang W, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2026 Apr 11:110544. doi: 10.1016/j.cbpc.2026.110544. Online ahead of print. Comp Biochem Physiol C Toxicol Pharmacol. 2026. PMID: 41974218
In this study, we systematically analyzed the mcm gene family members in zebrafish through genome-wide identification. Combined with single-cell transcriptomic data (GSE193758) and molecular docking simulations, we investigated the impact of TCDD on mcm expression in testi …
In this study, we systematically analyzed the mcm gene family members in zebrafish through genome-wide identification. Combined with …
Mineral-microbiota interactions in aquaculture: implications for fish gut health and nutrition.
Aydin F, Çek Ş. Aydin F, et al. Vet Res Commun. 2026 Apr 13;50(4):268. doi: 10.1007/s11259-026-11207-2. Vet Res Commun. 2026. PMID: 41973308 Free PMC article. Review.
Studies conducted on yellow catfish, largemouth bass, golden pompano, grouper, Nile tilapia, Chinese tongue sole, Pacific white shrimp, channel catfish, zebrafish, and Oriental river prawn were comprehensively examined. Findings indicate that organic and nanoparticle miner …
Studies conducted on yellow catfish, largemouth bass, golden pompano, grouper, Nile tilapia, Chinese tongue sole, Pacific white shrimp, chan …
Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application.
Kagirova E, Enikeeva K, Mukhamadeev R, Asadullina D, Sharifyanova Y, Shmelkova P, Gainullina D, Trifonova D, Gattinger P, Docena G, Dubovets A, Tulaeva I, Karaulov A, Valenta R, Pavlov V. Kagirova E, et al. Front Immunol. 2026 Mar 27;17:1771006. doi: 10.3389/fimmu.2026.1771006. eCollection 2026. Front Immunol. 2026. PMID: 41972142 Free PMC article. Review.
Preclinical models, including genetically engineered mouse models, zebrafish, and various patient-derived xenograft (PDX) systems, are discussed as tools for studying tumor biology and testing immunotherapeutic strategies. ...
Preclinical models, including genetically engineered mouse models, zebrafish, and various patient-derived xenograft (PDX) systems, ar …
Combating Drug Resistance in Mycobacterium Tuberculosis: A Combinatorial in Silico and Experimental Modeling Approach Toward Novel ATP Synthase Inhibitor Discovery.
El-Zoheiry HH, Bhowmik R, Manaithiya A, Ray R, Samantaray M, Ramaswamy A, Aspatwar A. El-Zoheiry HH, et al. Bioinform Biol Insights. 2026 Apr 8;20:11779322261438313. doi: 10.1177/11779322261438313. eCollection 2026. Bioinform Biol Insights. 2026. PMID: 41971764 Free PMC article.
In addition, toxicity evaluations using a zebrafish model confirmed the safety and favorable tolerability of these molecules, supporting their potential as viable candidates for further preclinical and in vivo drug development studies....
In addition, toxicity evaluations using a zebrafish model confirmed the safety and favorable tolerability of these molecules, support …
The selective serotonin reuptake inhibitor sertraline causes ocular toxicity in larvae of zebrafish (Danio rerio).
Jafari M, Stehly Y, Pampanin DM. Jafari M, et al. Front Physiol. 2026 Mar 27;17:1736110. doi: 10.3389/fphys.2026.1736110. eCollection 2026. Front Physiol. 2026. PMID: 41971665 Free PMC article.
METHODS: To close this knowledge gap, zebrafish (Danio rerio) embryos were exposed to the SSRI sertraline (SER) at sublethal concentrations of 1, 10, 100 and 1000 g/L. ...
METHODS: To close this knowledge gap, zebrafish (Danio rerio) embryos were exposed to the SSRI sertraline (SER) at sublethal concentr …
Glabrol-an impurity in licorice extract-causes toxicity in muscle, bone, and immune tissues through activation of the AP-1 signaling pathway.
Jiang C, Feng X, Qi M, Wu S, Wang Q, Zhou Y, Zheng X, Liang Z, Tan J, Zhang Y, Guo Q, Zhao H. Jiang C, et al. Front Pharmacol. 2026 Mar 27;17:1795069. doi: 10.3389/fphar.2026.1795069. eCollection 2026. Front Pharmacol. 2026. PMID: 41971075 Free PMC article.
To investigate the toxicological mechanism of glabrol, RNA - seq was performed on zebrafish embryos exposed to glabrol. Morphological and histopathological evaluations in zebrafish treated with the glabrol standard were carried out using phalloidin staining, transmi …
To investigate the toxicological mechanism of glabrol, RNA - seq was performed on zebrafish embryos exposed to glabrol. Morphological …
Pre-clinical anti-tumor activity and preliminary safety of METTL3 inhibitors STM2457 and UZH1a in neuroblastoma.
Lin T, Chen X, Huang H, Zhang J, Xu Y, Lin J. Lin T, et al. Transl Cancer Res. 2026 Mar 31;15(3):186. doi: 10.21037/tcr-2025-aw-2392. Epub 2026 Mar 24. Transl Cancer Res. 2026. PMID: 41969484 Free PMC article.
For zebrafish, acute-toxicity screening, hepatic enzyme measurement, and xenograft establishment were conducted. ...In vivo, 15 g/mL STM2457 and UZH1a effectively inhibiting the growth and migration of zebrafish xenograft tumors, and no mortality or hepatic toxicit …
For zebrafish, acute-toxicity screening, hepatic enzyme measurement, and xenograft establishment were conducted. ...In vivo, 15 g/mL …
Delivery System Based on Akkermansia Muciniphila Loaded Salidroside for the Treatment of Osteoporosis in Zebrafish Model.
Ma J, Ruan J, Yi J, Zhang S, Ma Y, Chen R, Wang H, Luo L, Fang B, Wu W, Yang Q, Sun D. Ma J, et al. Adv Healthc Mater. 2026 Apr 12:e04437. doi: 10.1002/adhm.202504437. Online ahead of print. Adv Healthc Mater. 2026. PMID: 41968607
This construct effectively retains probiotic activity, shields the cargo through gastric transit, and shows prolonged intracellular retention with gradual release. In Dex-challenged zebrafish, SAL@AKK@EL100 reversed behavioral dysregulation and improved skeletal mineraliza …
This construct effectively retains probiotic activity, shields the cargo through gastric transit, and shows prolonged intracellular retentio …
Zebrafish Model Reveals Early Electrocardiographic and Molecular Signatures of Doxorubicin-Induced Cardiotoxicity.
Lai ZY, Lee CY, Chiu YC, Lin CH, Yang CC, Ho CC, Liu LY, Chuang YJ. Lai ZY, et al. Cardiovasc Toxicol. 2026 Apr 13;26(4):39. doi: 10.1007/s12012-026-10113-y. Cardiovasc Toxicol. 2026. PMID: 41968204 Free PMC article.
Consistent with human and mammalian models, DOX administration in adult zebrafish resulted in ventricular enlargement, myocardial fiber disarray, and elevated troponin I levels. ...These findings identify the PR interval as a sensitive, early index of conduction impairment …
Consistent with human and mammalian models, DOX administration in adult zebrafish resulted in ventricular enlargement, myocardial fib …
URP70-1, a novel polysaccharide from the roots of Uncaria rhynchophylla induced apoptosis by regulating GRP78/CHOP-ERK-Bax/Bcl-2 pathway.
Wu Z, Li J, Xu X, Dong G, Jiao Y, Zhang S. Wu Z, et al. Int J Biol Macromol. 2026 Apr 10:151962. doi: 10.1016/j.ijbiomac.2026.151962. Online ahead of print. Int J Biol Macromol. 2026. PMID: 41967535
Methylation and NMR spectroscopic analyses further elucidated its primary structure, comprising a backbone of 3,5)-L-Araf-(1 , 4)-D-Galp-(1 , and 2,5)-L-Araf-(1 residues, with side chains containing 3)-L-Araf-(1 , 5)-L-Araf-(1 , 6)-D-Galp-(1 , L-Araf-(1 , D-Xylp-(1 , and …
Methylation and NMR spectroscopic analyses further elucidated its primary structure, comprising a backbone of 3,5)-L-Araf-(1 , 4)-D-Galp-( …
Toxicological Assessment and Physiological Responses to Dichloro-Octylisothiazolinone and Octylisothiazolinone in Zebrafish Larvae.
Rizzo MG, Multisanti CR, Faggio C, Angelozzi G, Gentile W, Sulcanese L, Perugini M. Rizzo MG, et al. J Appl Toxicol. 2026 Apr 12. doi: 10.1002/jat.70208. Online ahead of print. J Appl Toxicol. 2026. PMID: 41967508
In this study, the toxicity of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) and 2-octyl-2H-isothiazol-3-one (OIT), tested individually and in combination, was investigated using the zebrafish (Danio rerio) fish embryo toxicity (FET) test coupled with targeted gene e …
In this study, the toxicity of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) and 2-octyl-2H-isothiazol-3-one (OIT), tested individuall …
Tachycardia induced by chiral citalopram in adult zebrafish: Mechanistic insights into exacerbation by its demethylated metabolites.
Chai T, Xu L, Zhang L, Wu Y, Cui F. Chai T, et al. J Hazard Mater. 2026 Apr 9;509:142024. doi: 10.1016/j.jhazmat.2026.142024. Online ahead of print. J Hazard Mater. 2026. PMID: 41967440
After enantiomer-specific exposure, our electrocardiographic analysis in adult zebrafish revealed that the primary demethylated metabolite at 1 mug/L, S-didesmethyl-citalopram, induced exacerbated tachycardia relative to the parent citalopram. ...
After enantiomer-specific exposure, our electrocardiographic analysis in adult zebrafish revealed that the primary demethylated metab …
Comparative phenotypic analysis of rhodopsin supports stepwise evolution of dim-light vision in early vertebrates.
Cui Y, Lu X, Wei P, Shuai M, Sun L, Xie Y, Xie Y, Dong R, Shi L, Rossiter SJ, Xu S, Liu Y. Cui Y, et al. Mol Biol Evol. 2026 Apr 9:msag096. doi: 10.1093/molbev/msag096. Online ahead of print. Mol Biol Evol. 2026. PMID: 41967125
Finally, to validate these phenotypic consequences in vivo, we compared zebrafish overexpressing RH, RH1 or the mutant RH-S295A, and recorded increased locomotor rebound following light-intensity reduction in the latter two treatments. ...
Finally, to validate these phenotypic consequences in vivo, we compared zebrafish overexpressing RH, RH1 or the mutant RH-S295A, and …
Systemic crosstalk between liver and brain is associated with microplastic-induced neurobehavioral toxicity in zebrafish.
Xu Z, Lin Z, Wang Y, Wang L, Huang R, Du R, Kang X, Chen X, She S, Xu Z, Xiao S, Yu R. Xu Z, et al. Environ Pollut. 2026 Apr 10;398:128082. doi: 10.1016/j.envpol.2026.128082. Online ahead of print. Environ Pollut. 2026. PMID: 41966363
Microplastics (MPs) are widespread environmental contaminants that have entered the human food chain, whose systemic health effects remain largely unknown. Using zebrafish as a vertebrate model, we investigated the mechanistic impacts of MPs on the liver-brain axis. After …
Microplastics (MPs) are widespread environmental contaminants that have entered the human food chain, whose systemic health effects remain l …
Polyethylene microplastics differently induced gut microbiota dysbiosis and hepatic metabolism in male and female adult zebrafish.
Bao Z, Luo T, Zhao Y, Yang G, Jin Y. Bao Z, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2026 Apr 9:110545. doi: 10.1016/j.cbpc.2026.110545. Online ahead of print. Comp Biochem Physiol C Toxicol Pharmacol. 2026. PMID: 41966288
The toxic effects of polyethylene (PE) MPs on different-sex zebrafish and the possibility of recovery in MPs-free water remain unclear. In this study, adult male and female zebrafish were exposed to PE-MPs (1-4 mum) with 0, 10 and 100 mug/L for 21 days. ...Male z …
The toxic effects of polyethylene (PE) MPs on different-sex zebrafish and the possibility of recovery in MPs-free water remain unclea …
Embryonic exposure to bisphenol A glycidyl methacrylate induces craniofacial cartilage malformation via NLR signaling pathway in zebrafish.
Luo W, Zhang J, Wu S, Liao X, Xi W. Luo W, et al. Ecotoxicol Environ Saf. 2026 Apr 10;316:120121. doi: 10.1016/j.ecoenv.2026.120121. Online ahead of print. Ecotoxicol Environ Saf. 2026. PMID: 41966015 Free article.
This study evaluated the effect of Bis-GMA on cranio-maxillofacial cartilage using zebrafish as a model organism. Six to 120 h after fertilization, zebrafish embryos exposed to 0.8, 1.6 or 2.4 mg/L Bis-GMA presented with craniomaxillofacial dysplasia accompanied by …
This study evaluated the effect of Bis-GMA on cranio-maxillofacial cartilage using zebrafish as a model organism. Six to 120 h after …
The subunit composition of the mammalian Mediator complex is not conserved in all vertebrates: Insights from evolutionary plasticity of fish genomes.
Symonová R, Near TJ, Kubečka J. Symonová R, et al. Protein Sci. 2026 May;35(5):e70566. doi: 10.1002/pro.70566. Protein Sci. 2026. PMID: 41964436 Free PMC article.
Genes encoding fish Mediator subunits remain unknown even for zebrafish that is otherwise the best explored fish species. Here, we first reconstructed genes encoding Mediator subunits from 12 brain transcriptomes of a percid fish, pikeperch (Sander lucioperca). ...
Genes encoding fish Mediator subunits remain unknown even for zebrafish that is otherwise the best explored fish species. Here, we fi …
Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.
Keating MK, Jaime J, Mumme-Monheit A, Neukirch LA, Gustafson GE, Bailon-Zambrano R, Rice MC, Gagnon JA, Nichols JT. Keating MK, et al. Dev Dyn. 2026 Apr 11. doi: 10.1002/dvdy.70133. Online ahead of print. Dev Dyn. 2026. PMID: 41964409
High levels of ultraviolet B radiation can cause DNA and protein damage. Zebrafish have become a popular model to investigate the impact of ultraviolet B radiation. ...CONCLUSIONS: Ultraviolet B exposure early in zebrafish development variably damages the larval fin …
High levels of ultraviolet B radiation can cause DNA and protein damage. Zebrafish have become a popular model to investigate the imp …
DIAPH1 regulates the Wnt/β-catenin pathway resulting in microcephaly and visual impairment.
Wang D, Lai P, Wang K, Wu Z, Li X. Wang D, et al. BMC Med Genomics. 2026 Apr 10. doi: 10.1186/s12920-026-02364-z. Online ahead of print. BMC Med Genomics. 2026. PMID: 41963888 Free article.
METHODS: Whole exome sequencing was performed on a patient's peripheral blood to identify DIAPH1 mutations. A zebrafish model was established by microinjecting mutant human DIAPH1 cDNA into one-cell embryos (no zebrafish DIAPH1 homolog exists). ...CONCLUSIONS: DIAPH …
METHODS: Whole exome sequencing was performed on a patient's peripheral blood to identify DIAPH1 mutations. A zebrafish model was est …
Alternative Developmental Toxicity Screening Methods Using Chick Embryo-Based Models.
Kim JH, Park C, Kim D, Jeong W, Lee J. Kim JH, et al. J Appl Toxicol. 2026 Apr 10. doi: 10.1002/jat.70193. Online ahead of print. J Appl Toxicol. 2026. PMID: 41963253 Review.
Consequently, alternative models, including in vitro human cell cultures, stem cell differentiation, 3D organoids, and zebrafish, are actively being studied; however, they have limitations in replicating whole-body physiological complexity and homeostasis. ...
Consequently, alternative models, including in vitro human cell cultures, stem cell differentiation, 3D organoids, and zebrafish, are …
Pharmacological targeting of the mycothiol cysteine ligase MshC in Mycobacterium abscessus.
Nguyen TQ, Hamela C, Pang L, Liu Y, Giannini GC, Boeck L, Larrouy-Maumus G, Kremer L. Nguyen TQ, et al. J Biol Chem. 2026 Apr 8:111433. doi: 10.1016/j.jbc.2026.111433. Online ahead of print. J Biol Chem. 2026. PMID: 41962868 Free article.
CRISPRi was used to demonstrate that mshC is essential in vitro and during infection in zebrafish larvae. Subsequently, in silico drug screening identified three potential MshC-binding molecules, namely rebastinib, olverembatinib and SB-224289, significantly inhibiting M. …
CRISPRi was used to demonstrate that mshC is essential in vitro and during infection in zebrafish larvae. Subsequently, in silico dru …
Enhanced photoreduction of perfluorooctane sulfonate via a confined nitrilotriacetic acid system augmented by CTAB.
Zhai Z, Zhao Y, Zhang C, Zhou X, Zhang Y, Lin S, Xu X, Liu X, Huang D, Huang Y, Gu C. Zhai Z, et al. J Hazard Mater. 2026 Apr 7;509:142009. doi: 10.1016/j.jhazmat.2026.142009. Online ahead of print. J Hazard Mater. 2026. PMID: 41962373
Under an air atmosphere at pH 7.0, the system achieved 98.56% PFOS degradation with 42.88% defluorination within 10 h (using a 16 W low-pressure mercury UV lamp). Zebrafish toxicological assays confirmed a significant reduction in the biological toxicity of the treated wat …
Under an air atmosphere at pH 7.0, the system achieved 98.56% PFOS degradation with 42.88% defluorination within 10 h (using a 16 W low-pres …
A Novel Antioxidant Peptide Cath-Np Derived from Nanorana parkeri Attenuates UVB-Induced Skin Photodamage in Mice.
Liao H, Shen X, Chai J, Wang K, Wu J, Yang J, Chen M, Mo G, Xu X. Liao H, et al. Integr Zool. 2026 Apr 10. doi: 10.1111/1749-4877.70101. Online ahead of print. Integr Zool. 2026. PMID: 41962043
Cath-Np was also able to reduce the abnormal elevation of reactive oxygen species and neutrophil migration in zebrafish. Notably, Cath-Np significantly reduced the oxidative damage, inhibited inflammatory factor production by suppressing the activation of mitogen-activated …
Cath-Np was also able to reduce the abnormal elevation of reactive oxygen species and neutrophil migration in zebrafish. Notably, Cat …
Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.
Emond A, Laflamme C, Therrien M, Liao M, Maios C, Labarre A, Drapeau P, Parker JA. Emond A, et al. PLoS One. 2026 Apr 10;21(4):e0346613. doi: 10.1371/journal.pone.0346613. eCollection 2026. PLoS One. 2026. PMID: 41961863 Free PMC article.
Motivated by the shared motor phenotype, 2 of those compounds were tested in our zebrafish C9orf72 LOF model. Pizotifen malate was found to significantly improve motor deficits in C9orf72 LOF zebrafish larvae. We introduce a novel zebrafish C9orf72 knockout m …
Motivated by the shared motor phenotype, 2 of those compounds were tested in our zebrafish C9orf72 LOF model. Pizotifen malate was fo …
An Integrated Approach Combining Regulatory Tests in tg(cyp19a1b:GFP) Zebrafish Embryos to Assess Toxicity, Developmental Effects, and Estrogenic Activity of Chemicals: A Case Study with Bisphenol A Substitutes.
Geffroy F, Christophe A, Piccini B, Hinfray N, Chadili E, Maillot-Marechal E, Cousin X, Blanc-Legendre M, Charlier TD, Pandard P, Aït-Aïssa S, Brion F. Geffroy F, et al. Environ Sci Technol. 2026 Apr 10. doi: 10.1021/acs.est.5c17875. Online ahead of print. Environ Sci Technol. 2026. PMID: 41961730
Several bisphenols were more toxic than BPA, inducing developmental effects on zebrafish embryos, with some showing potential teratogenicity. Increased GFP intensity was also detected for ten bisphenols, suggesting estrogenic activity. ...All bisphenols also activated zfER …
Several bisphenols were more toxic than BPA, inducing developmental effects on zebrafish embryos, with some showing potential teratog …
Cis- and Trans-Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa.
Cui C, Nakagawa K, Tateno T, Dan A, Meng D, Omori Y, Tomihara S, Okamoto S, Sato S, Tsujikawa M. Cui C, et al. Adv Sci (Weinh). 2026 Apr 10:e20828. doi: 10.1002/advs.202520828. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41961469
In this study, we identified two distinct genetic mechanisms influencing RP severity using a transgenic zebrafish model expressing the human rhodopsin S334X mutation. The first mechanism is tightly linked to RP onset and results in a benign phenotype. ...
In this study, we identified two distinct genetic mechanisms influencing RP severity using a transgenic zebrafish model expressing th …
Endoplasmic reticulum targeted photosensitizer with high photostability and dual ROS generation for breast cancer PDT via apoptosis and pyroptosis.
Shang W, Yang C, Sun L, Wang S, Xu Y, Tang BZ, Su H. Shang W, et al. Mater Today Bio. 2026 Mar 25;38:103066. doi: 10.1016/j.mtbio.2026.103066. eCollection 2026 Jun. Mater Today Bio. 2026. PMID: 41960156 Free PMC article.
Furthermore, compound 3 could rapidly infiltrate living zebrafish embryos through the eggshell and penetrate the deeper layers. Moreover, compound 3 exhibits excellent imaging performance under two-photon excitation. ...
Furthermore, compound 3 could rapidly infiltrate living zebrafish embryos through the eggshell and penetrate the deeper layers. Moreo …
FRMPD4 , a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss.
Liedtke D, Rak K, Schrode KM, Hehlert P, Chamanrou N, Bengl D, Katana R, Heydaran S, Doll J, Han M, Nanda I, Senthilan PR, Jürgens L, Bieniussa L, Voelker J, Neuner C, Hofrichter MA, Schröder J, Schellens RTW, de Vrieze E, van Wijk E, Zechner U, Herms S, Hoffmann P, Müller T, Dittrich M, Bartsch O, Krawitz PM, Klopocki E, Shehata-Dieler W, Maroofian R, Wang T, Worley PF, Göpfert MC, Galehdari H, Lauer AM, Haaf T, Vona B. Liedtke D, et al. medRxiv [Preprint]. 2026 Mar 30:2026.03.27.26349271. doi: 10.64898/2026.03.27.26349271. medRxiv. 2026. PMID: 41959831 Free PMC article. Preprint.
Cross-species expression analyses were conducted in Drosophila , zebrafish, and mouse. Functional characterization included quantitative evaluation of sound-evoked responses in Drosophila nicht gut horend ( ngh ) mutants, assessment of neuronal development and acoustic sta …
Cross-species expression analyses were conducted in Drosophila , zebrafish, and mouse. Functional characterization included quantitat …
Hapln1-HA signaling promotes progenitor cell proliferation and spinal cord regeneration.
Xu Y, Zhou L, Saraswathy V, McAdow R, Mokalled MH. Xu Y, et al. bioRxiv [Preprint]. 2026 Mar 31:2026.03.28.714985. doi: 10.64898/2026.03.28.714985. bioRxiv. 2026. PMID: 41959443 Free PMC article. Preprint.
Adult zebrafish exhibit scarless repair and functional recovery following spinal cord injury. ...This study reveals that, in addition to lacking anti-regenerative ECM components around SC lesions, zebrafish can also leverage pro-regenerative ECM molecules to enhance …
Adult zebrafish exhibit scarless repair and functional recovery following spinal cord injury. ...This study reveals that, in addition …
TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis.
Sharma N, Tanwar A, Zheng C, Ambudkar I, Motiani RK. Sharma N, et al. bioRxiv [Preprint]. 2026 Mar 11:2026.03.09.710699. doi: 10.64898/2026.03.09.710699. bioRxiv. 2026. PMID: 41959096 Free PMC article. Preprint.
Pharmacological inhibition, genetic silencing, and gain-of-function approaches demonstrate that TRPM2 negatively regulates melanogenesis in vitro . Notably, TRPM2-deficient zebrafish and TRPM2-/- mice exhibit enhanced pigmentation in vivo , establishing physiological relev …
Pharmacological inhibition, genetic silencing, and gain-of-function approaches demonstrate that TRPM2 negatively regulates melanogenesis in …
When feeling is better than seeing : Adult Zebrafish Ignore Wide-Field Optic-Flow in Laminar, but not Turbulent Hydrodynamic Environments.
Dave S, Liao JC. Dave S, et al. bioRxiv [Preprint]. 2026 Apr 1:2026.03.30.715425. doi: 10.64898/2026.03.30.715425. bioRxiv. 2026. PMID: 41959079 Free PMC article. Preprint.
To disentangle these visual and mechanosensory contributions, we developed a virtual reality assay targeting the optomotor response in adult wild-type zebrafish swimming against flow. By projecting dynamic visual patterns onto the walls of a variable-speed flow tank, we de …
To disentangle these visual and mechanosensory contributions, we developed a virtual reality assay targeting the optomotor response in adult …
Efficient Generation of Functional TCRαβ + Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation.
Kubaczka C, Kambli N, Windisch R, Yu K, Zhao Y, Wu S, Frenis K, Walcheck MT, Falchetti M, Najia M, LeBlanc ZC, North TE, Rowe RG, Daley GQ, Schlaeger TM. Kubaczka C, et al. bioRxiv [Preprint]. 2026 Apr 1:2026.03.31.715684. doi: 10.64898/2026.03.31.715684. bioRxiv. 2026. PMID: 41959015 Free PMC article. Preprint.
We also demonstrate that the Oct4-activating compound OAC1 functions as a weak AHR inhibitor, partially recapitulating the effects of canonical AHR blockers in both cellular and zebrafish AHR reporter systems. Collectively, our findings define key molecular circuits govern …
We also demonstrate that the Oct4-activating compound OAC1 functions as a weak AHR inhibitor, partially recapitulating the effects of canoni …
Zebrafish as a multimodal platforms for anti-inflammatory phytomedicine discovery and translation.
Tan X, Liu H, Liang F, Chen G. Tan X, et al. Front Pharmacol. 2026 Mar 25;17:1775366. doi: 10.3389/fphar.2026.1775366. eCollection 2026. Front Pharmacol. 2026. PMID: 41958929 Free PMC article. Review.
We argue that this convergent multimodal strategy transforms zebrafish from a correlative screening tool into a predictive, mechanism-resolving, and patient-relevant avatar system. ...This framework positions zebrafish-centered platforms as a cornerstone of next-gen …
We argue that this convergent multimodal strategy transforms zebrafish from a correlative screening tool into a predictive, mechanism …
Chronic inorganic arsenic exposure impairs locomotor performance and socio-affective behavior in zebrafish.
Ionescu C, Lungu PF, Chelaru IA, Nicoara MN, Plavan G, Balmus IM, Rarinca V, Ciobica A, Novac B, Gheban D, Tomița DI, Savuca A, Gurzu B. Ionescu C, et al. Biomol Biomed. 2026 Apr 10. doi: 10.17305/bb.2026.14094. Online ahead of print. Biomol Biomed. 2026. PMID: 41958399 Free article.
This study examines whether chronic exposure to environmentally relevant concentrations of iAs affects locomotor performance and socio-affective behavior in adult zebrafish (Danio rerio). Zebrafish were exposed to 10, 50, or 300 g/L of iAs for 21 consecutive days, …
This study examines whether chronic exposure to environmentally relevant concentrations of iAs affects locomotor performance and socio-affec …
Multi-transmitter characteristics and functional specialization of oxytocin neuron subpopulations in zebrafish.
Liu ST, Liao BK, Shaio MS, Chen YL, Huang YF, Chou MY. Liu ST, et al. J Exp Biol. 2026 Apr 10:jeb.252228. doi: 10.1242/jeb.252228. Online ahead of print. J Exp Biol. 2026. PMID: 41958327
To test this possibility, we systematically examined neurotransmitter characteristics and activity patterns of OXT neuron subtypes in adult zebrafish brain. We found that OXT neurons are distributed across the parvocellular preoptic nucleus (anterior, PPa; posterior, PPp) …
To test this possibility, we systematically examined neurotransmitter characteristics and activity patterns of OXT neuron subtypes in adult …
Network Pharmacology and Molecular Docking Reveals Mechanism of Camphor on Liver Toxicity in Zebrafish.
Wei M, Xie L, Gan J, Xia Z, Du Z. Wei M, et al. Basic Clin Pharmacol Toxicol. 2026 May;138(5):e70222. doi: 10.1111/bcpt.70222. Basic Clin Pharmacol Toxicol. 2026. PMID: 41957937
OBJECTIVE: This study aimed to investigate the hepatotoxicity of camphor on zebrafish and its mechanism of toxicity. METHODS: We calculated concentration-response curves for zebrafish larvae treated with camphor at 72-h postexposure (hpe) and observed its toxic effe …
OBJECTIVE: This study aimed to investigate the hepatotoxicity of camphor on zebrafish and its mechanism of toxicity. METHODS: We calc …
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia.
Villani A, Wittmann J, Wyss T, Mallona I, Santisteban Ortiz I, Tichy N, Biermeier CM, Pena M, Pal AA, Gilmour D, Schafer ST, Peri F. Villani A, et al. Commun Biol. 2026 Apr 9. doi: 10.1038/s42003-026-09948-6. Online ahead of print. Commun Biol. 2026. PMID: 41957412 Free article.
Thus, we developed HuZIBRA, a scalable in vivo xenotransplantation model in which human iPSC-derived microglia-like cells (iMGLs) are introduced into the developing zebrafish brain (zf-hiMG), a system characterized by high levels of neuronal cell death and amenable to prec …
Thus, we developed HuZIBRA, a scalable in vivo xenotransplantation model in which human iPSC-derived microglia-like cells (iMGLs) are introd …
PGC-derived migrasomes couple PGC proliferation with migration.
Liu B, Jiang Z, Song W, Zhai Z, Li Y, Zhang W, Meng A, Yu L. Liu B, et al. Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71616-4. Online ahead of print. Nat Commun. 2026. PMID: 41957360 Free article.
Here, we reveal that primordial germ cells (PGCs) in zebrafish employ migrasomes-vesicular organelles formed during migration-to couple their proliferation with migration, ensuring germline expansion. ...
Here, we reveal that primordial germ cells (PGCs) in zebrafish employ migrasomes-vesicular organelles formed during migration-to coup …
Distinct distributed neural dynamics predict pallium-dependent social approach.
Lifshitz I, Prag A, Livneh N, Moshkovitz M, Karmi A, Avitan L. Lifshitz I, et al. Nat Commun. 2026 Apr 9. doi: 10.1038/s41467-026-71666-8. Online ahead of print. Nat Commun. 2026. PMID: 41957349 Free article.
We developed an experimental assay in which a head-fixed, tail-free zebrafish interacts with a freely swimming conspecific, enabling precise behavioral quantification alongside large-scale functional imaging at cellular resolution. ...
We developed an experimental assay in which a head-fixed, tail-free zebrafish interacts with a freely swimming conspecific, enabling …
Heterointerface-engineered ZnO/CuO bimetallic sites enable pollutant-directed conversion with in situ catalyst regeneration.
Zhang ZQ, Xu XW, Duan PJ, Shao Y, Wang Q, Qin ZH, Bai CW, Chen XJ, Wang J, Yang FQ, Chen F. Zhang ZQ, et al. Nat Commun. 2026 Apr 9. doi: 10.1038/s41467-026-71644-0. Online ahead of print. Nat Commun. 2026. PMID: 41957009 Free article.
Toxicological profiling across multiple biological models, supported by metabolomics, confirmed effective detoxification of multi-pollutant wastewater, including restoration of normal metabolic function in zebrafish (e.g., lipid and glutathione metabolism). This study esta …
Toxicological profiling across multiple biological models, supported by metabolomics, confirmed effective detoxification of multi-pollutant …
Vps34 Knockdown Alleviated the Long-Term Effect of Nano-Alumina on Cognitive Impairment in Zebrafish When in Embryos.
Zhang Y, Zhao J, Huang T, Gao X, Zhang L, Wang Y, Guo X, Zhang L, Niu Q, Zhang Q. Zhang Y, et al. J Appl Toxicol. 2026 Apr 9. doi: 10.1002/jat.70186. Online ahead of print. J Appl Toxicol. 2026. PMID: 41956485
This study aimed to investigate the effects and mechanisms of Vps34 knockdown on the long-term cognitive impairment of AlNPs in the zebrafish brain. A 500 muL of morpholino oligonucleotide at 1 mmol/L was microinjected into embryos within 1 h postfertilization (hpf). These …
This study aimed to investigate the effects and mechanisms of Vps34 knockdown on the long-term cognitive impairment of AlNPs in the zebra …
Structural Conservation, Functional Decline: The Fate of Human OHCU Decarboxylase.
Rodrigues JT, Pereira MS, Bleicher L, Brandão TADS, de Magalhães MTQ. Rodrigues JT, et al. Biochimie. 2026 Apr 7:S0300-9084(26)00082-9. doi: 10.1016/j.biochi.2026.04.002. Online ahead of print. Biochimie. 2026. PMID: 41956358

Spectroscopic and structural analyses revealed a well-folded alpha-helical protein with high similarity to zebrafish OHCUd (52% sequence identity, RMSD < 0.8 A), but with reduced stability. Functional assays showed that rhOHCUd exhibits markedly lower catalytic activity

…
Spectroscopic and structural analyses revealed a well-folded alpha-helical protein with high similarity to zebrafish OHCUd (52% seque …
Toxicological effects of polypropylene nanoparticles similar in size to nanoplastics in plastic-bottled injections on mice and zebrafish.
Sun HM, Wang J, Wu XF, Chen ZL, Yang HY, Lin Z, Li SX, Qu Z, Chen H, Yao SC. Sun HM, et al. Sci Total Environ. 2026 Apr 8;1029:181770. doi: 10.1016/j.scitotenv.2026.181770. Online ahead of print. Sci Total Environ. 2026. PMID: 41956033
Based on the amount of nanoplastic from PP-bottled injections introduced by intravenous infusion average daily in infants (31.5 ng) and adolescents (157.5 ng), we explored the toxicological effects of PP-NPs on the organ development of zebrafish. We also investigated the t …
Based on the amount of nanoplastic from PP-bottled injections introduced by intravenous infusion average daily in infants (31.5 ng) and adol …
A synergistic ZIF-8/RGO/Pt nanozyme sensor for sensitive electrochemical detection of H(2)O(2) and real-time monitoring of oxidative stress in zebrafish embryos.
Pi Z, Zhang Y, Yang R, Liu L, Huang Y, Wu Y, Gou T, Kang H, Zhang T, Yang X, Liao X. Pi Z, et al. Bioelectrochemistry. 2026 Apr 1;171:109294. doi: 10.1016/j.bioelechem.2026.109294. Online ahead of print. Bioelectrochemistry. 2026. PMID: 41956024
Importantly, the sensor was successfully applied for the real-time, in-situ monitoring of H(2)O(2) released from zebrafish embryos under cadmium ion (Cd(2+)) induced oxidative stress. This work offers a promising tool for the early assessment of heavy metal-induced oxidati …
Importantly, the sensor was successfully applied for the real-time, in-situ monitoring of H(2)O(2) released from zebrafish embryos un …
Oxytocin modulates social preference and anxiety-like locomotor behavior in albino and non-albino zebrafish.
Danila AM, Savuca A, Nicoara MN, Ciobica AS, Novac B, Chiriac S, Tomita D, Ilie OD. Danila AM, et al. Biomol Biomed. 2026 Apr 9. doi: 10.17305/bb.2026.13819. Online ahead of print. Biomol Biomed. 2026. PMID: 41954491 Free article.
Socio-emotional and exploratory behaviors in zebrafish (Danio rerio) are shaped by conserved neuromodulators such as oxytocin (OXT), yet phenotypic variation (e.g., albinism) may modify sensitivity to OXT-dependent regulation. ...Collectively, OXT exerts context- and dosin …
Socio-emotional and exploratory behaviors in zebrafish (Danio rerio) are shaped by conserved neuromodulators such as oxytocin (OXT), …
Antinociceptive Benzothiazine and Benzothiazole Natural Products from Marine Croceibacter atlanticus.
Marshall EM, Zhu C, Mayhood L, Khalid Z, Yao H, Panieri G, Cediel-Becerra JDD, Chevrette MG, Strother JA, Loesgen S. Marshall EM, et al. J Nat Prod. 2026 Apr 9. doi: 10.1021/acs.jnatprod.6c00098. Online ahead of print. J Nat Prod. 2026. PMID: 41954290
With the goal of identifying new therapeutic leads to treat pain, we screened a library of microbial chemical extracts using the Embryonic Zebrafish Irritant-evoked Hyperlocomotion (EZIH) assay, an in vivo phenotypic assay for analgesic/antinociceptive activity. ...
With the goal of identifying new therapeutic leads to treat pain, we screened a library of microbial chemical extracts using the Embryonic …
Extraction, isolation, structural characterization, antioxidant activity and cardiomyocyte protective activity of polysaccharide from Bletilla striata leaves.
Shi G, Li K, Yang N, Yang D, Li S, Ding J, Tuo H, Liu H, Liu Y, Pan F. Shi G, et al. J Sci Food Agric. 2026 Apr 9. doi: 10.1002/jsfa.70650. Online ahead of print. J Sci Food Agric. 2026. PMID: 41954229
Additionally, toxicity assessments in a zebrafish model confirmed no observable adverse effects across a broad concentration range (100-900 mug mL(-1)). ...
Additionally, toxicity assessments in a zebrafish model confirmed no observable adverse effects across a broad concentration range (1 …
Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.
Li S, Zhang X, Zhang P, Wang X, Yang Y, Qin D, Law BY, Pan Y, Tang Y. Li S, et al. Mol Nutr Food Res. 2026 Apr;70(7):e70452. doi: 10.1002/mnfr.70452. Mol Nutr Food Res. 2026. PMID: 41954172
CRSE efficacy was evaluated in Abeta(1-42) stimulated BV-2 microglia, 3 Tg-AD mice, and Tg (apoeb: lynEGFP) zebrafish larvae. We found that CRSE significantly suppressed Abeta-induced microglial activation, NLRP3 inflammasome signaling, and pro-inflammatory cytokine releas …
CRSE efficacy was evaluated in Abeta(1-42) stimulated BV-2 microglia, 3 Tg-AD mice, and Tg (apoeb: lynEGFP) zebrafish larvae. We foun …
Models of the human heart for biomedical research: Opportunities and challenges.
Streckfuss-Bömeke K, Zelarayán LC, Schnabel RB, Kränkel N, Maack C, Eschenhagen T, Kappler HE, Klingmüller U, Kramann R, Loewe A, Milting H, Molina CE, Panáková D, Podesser BK, Schnieke A, Schröder K, Seidel T, Sossalla S, Zgierski-Johnston C, Zimmermann WH, Rog-Zielinska EA, Kohl P. Streckfuss-Bömeke K, et al. Physiol Rep. 2026 Apr;14(7):e70845. doi: 10.14814/phy2.70845. Physiol Rep. 2026. PMID: 41954020 Free PMC article. Review.
While non-human vertebrate models, from zebrafish to pig, remain vital to cardiovascular research, the translatability of findings to human patients is often limited. ...
While non-human vertebrate models, from zebrafish to pig, remain vital to cardiovascular research, the translatability of findings to …
Safety Evaluation of Spray-Dried Curcuma longa L. Extract for Pharmacopuncture: acute toxicity and neurobehavioral assessment in zebrafish.
Rullyansyah S, Kusumawati I, Ismail IS, Purwanto DA, Isadiartuti D, Bustaman MSBA, Ngadni MAB, Rahmawan RR, Fitri AP, Pattymahu CVP. Rullyansyah S, et al. J Pharmacopuncture. 2026 Mar 31;29(1):136-148. doi: 10.3831/KPI.2026.29.1.136. J Pharmacopuncture. 2026. PMID: 41953547 Free PMC article.
Acute toxicity (LC(50)), survival, and locomotor behavior were determined using probit regression and automated EthoVision XT tracking following a 96-hour exposure of adult zebrafish to SDCLE (0-500 mg/L). RESULTS: SDCLE, formulated to contain 10% (w/w) NCLE, exhibited a c …
Acute toxicity (LC(50)), survival, and locomotor behavior were determined using probit regression and automated EthoVision XT tracking follo …
65,363 results
You have reached the last available page of results. Please see the User Guide for more information.