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Page 1
ZFP57 dictates allelic expression switch of target imprinted genes.
Jiang W, Shi J, Zhao J, Wang Q, Cong D, Chen F, Zhang Y, Liu Y, Zhao J, Chen Q, Gu L, Zhou W, Wang C, Fang Z, Geng S, Xie W, Chen LN, Yang Y, Bai Y, Lin H, Li X. Jiang W, et al. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2005377118. doi: 10.1073/pnas.2005377118. Proc Natl Acad Sci U S A. 2021. PMID: 33500348 Free PMC article.
In this study, we found that DNA methylation was lost at most known ICRs in Zfp57 mutant embryos. Furthermore, loss of ZFP57 caused loss of parent-of-origin-dependent monoallelic expression of the target imprinted genes. The allelic expression switch occurred in the …
In this study, we found that DNA methylation was lost at most known ICRs in Zfp57 mutant embryos. Furthermore, loss of ZFP57 c …
ZFP57 suppress proliferation of breast cancer cells through down-regulation of MEST-mediated Wnt/beta-catenin signalling pathway.
Chen L, Wu X, Xie H, Yao N, Xia Y, Ma G, Qian M, Ge H, Cui Y, Huang Y, Wang S, Zheng M. Chen L, et al. Cell Death Dis. 2019 Feb 20;10(3):169. doi: 10.1038/s41419-019-1335-5. Cell Death Dis. 2019. PMID: 30787268 Free PMC article.
In this study, we found that ZFP57 had low expression in breast cancer, and overexpression of ZFP57 could inhibit the proliferation of breast cancer cells by inhibiting the Wnt/beta-catenin pathway. MEST was validated as the direct target gene of ZFP57 and ME …
In this study, we found that ZFP57 had low expression in breast cancer, and overexpression of ZFP57 could inhibit the prolifer …
Zfp57 Exerts Maternal and Sexually Dimorphic Effects on Genomic Imprinting.
Xu Z, Shi J, Zhang Y, Liu Y, Zhao J, Chen Q, Song C, Geng S, Xie W, Wu F, Bai Y, Yang Y, Li X. Xu Z, et al. Front Cell Dev Biol. 2022 Feb 2;10:784128. doi: 10.3389/fcell.2022.784128. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35252168 Free PMC article.
The DNA methylation imprint at many imprinting control regions (ICRs) is lost when both maternal and zygotic Zfp57 are absent in Zfp57 maternal-zygotic mutant mouse embryos. Interestingly, we found that DNA methylation at a few ICRs was partially lost without matern …
The DNA methylation imprint at many imprinting control regions (ICRs) is lost when both maternal and zygotic Zfp57 are absent in Z …
ZFP57 promotes ovarian cancer progression by transcriptionally regulating BRCA1 and managing G1 checkpoint.
Fan W, Xiong R, Zhou Z, Zhang C, Han Y, Shi T, Qiu J, Zhang R. Fan W, et al. J Cancer. 2023 Jul 9;14(11):2039-2050. doi: 10.7150/jca.84601. eCollection 2023. J Cancer. 2023. PMID: 37497403 Free PMC article.
Additionally, ZFP57 transcriptionally regulated BRCA1 expression in OC, indicating that ZFP57 may affect BRCA1 mediated G1 checkpoint to regulate the cell cycle of OC cells and further influence the progression of OC. Taken together, our present study discovered a n …
Additionally, ZFP57 transcriptionally regulated BRCA1 expression in OC, indicating that ZFP57 may affect BRCA1 mediated G1 che …
ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains.
Shi H, Strogantsev R, Takahashi N, Kazachenka A, Lorincz MC, Hemberger M, Ferguson-Smith AC. Shi H, et al. Epigenetics Chromatin. 2019 Aug 9;12(1):49. doi: 10.1186/s13072-019-0295-4. Epigenetics Chromatin. 2019. PMID: 31399135 Free PMC article.
Here we conduct RNA-seq and ChIP-seq analyses in normal and ZFP57 mutant mouse ES cells to understand the relative importance of ZFP57 at imprints, unique and repetitive regions of the genome. RESULTS: Over 80% of ZFP57 targets are TEs, however, ZFP57 …
Here we conduct RNA-seq and ChIP-seq analyses in normal and ZFP57 mutant mouse ES cells to understand the relative importance of Z …
ZFP57 and the Targeted Maintenance of Postfertilization Genomic Imprints.
Takahashi N, Gray D, Strogantsev R, Noon A, Delahaye C, Skarnes WC, Tate PH, Ferguson-Smith AC. Takahashi N, et al. Cold Spring Harb Symp Quant Biol. 2015;80:177-87. doi: 10.1101/sqb.2015.80.027466. Cold Spring Harb Symp Quant Biol. 2015. PMID: 27325708 Review.
Kruppel-associated box zinc finger proteins (KRAB-ZFPs) are proteins that have the potential to mediate this. ZFP57, one of the best characterized proteins in this family, has been shown to target and maintain epigenetic states at imprinting control regions after fertiliza …
Kruppel-associated box zinc finger proteins (KRAB-ZFPs) are proteins that have the potential to mediate this. ZFP57, one of the best …
ZFP57 regulates DNA methylation of imprinted genes to facilitate embryonic development of somatic cell nuclear transfer embryos in Holstein cows.
Yu T, Meng R, Song W, Sun H, An Q, Zhang C, Zhang Y, Su J. Yu T, et al. J Dairy Sci. 2023 Jan;106(1):769-782. doi: 10.3168/jds.2022-22427. Epub 2022 Nov 16. J Dairy Sci. 2023. PMID: 36400613 Free article.
The ZFP57 expression was capable of maintaining the correct degree of methylation at several imprinting control regions and correcting abnormal hypomethylation. ...We concluded that overexpression of ZFP57 in donor cells provided an effective method for enhancing nu …
The ZFP57 expression was capable of maintaining the correct degree of methylation at several imprinting control regions and correctin …
Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
Zhao J, Zhao J. Zhao J, et al. Dev Dyn. 2024 Jan;253(1):144-156. doi: 10.1002/dvdy.530. Epub 2022 Sep 10. Dev Dyn. 2024. PMID: 36004502 Free article.
RESULTS: Here, we describe novel roles of maternal and zygotic Zfp57 during cardiovascular system development. We found that maternal and zygotic Zfp57 was required for coronary vascular development. ...Furthermore, loss of Zfp57 and failed vasculature distur …
RESULTS: Here, we describe novel roles of maternal and zygotic Zfp57 during cardiovascular system development. We found that maternal …
Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?
Sparago A, Cerrato F, Riccio A. Sparago A, et al. Clin Epigenetics. 2018 Feb 21;10:23. doi: 10.1186/s13148-018-0454-7. eCollection 2018. Clin Epigenetics. 2018. PMID: 29484033 Free PMC article.
By comparing the extension of the H19/IGF2:IG-DMR deletions with the binding profile of ZFP57, we propose that the effect of the deletions on DNA methylation and clinical phenotype is dependent on their interference with ZFP57 binding. ...TESTING THE HYPOTHESIS: The …
By comparing the extension of the H19/IGF2:IG-DMR deletions with the binding profile of ZFP57, we propose that the effect of the dele …
Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
Acurzio B, Verma A, Polito A, Giaccari C, Cecere F, Fioriniello S, Della Ragione F, Fico A, Cerrato F, Angelini C, Feil R, Riccio A. Acurzio B, et al. Sci Rep. 2021 Jul 5;11(1):13802. doi: 10.1038/s41598-021-93297-3. Sci Rep. 2021. PMID: 34226608 Free PMC article.
ZFP57 is required to maintain the germline-marked differential methylation at imprinting control regions (ICRs) in mouse embryonic stem cells (ESCs). ...Since neural differentiation was partially impaired in Zfp57-mutant cells, this study also indicates that imprint …
ZFP57 is required to maintain the germline-marked differential methylation at imprinting control regions (ICRs) in mouse embryonic st …
174 results